Cracowski JL et al. |
Involvement of cytochrome epoxygenase metabolites in cutaneous postocclusive hyperemia in humans. |
2013 |
J. Appl. Physiol. |
pmid:23172029
|
Herse F et al. |
Cytochrome P450 subfamily 2J polypeptide 2 expression and circulating epoxyeicosatrienoic metabolites in preeclampsia. |
2012 |
Circulation |
pmid:23155181
|
Sander AL et al. |
Soluble epoxide hydrolase disruption as therapeutic target for wound healing. |
2013 |
J. Surg. Res. |
pmid:23122666
|
Wang SB et al. |
Protection of salvianolic acid A on rat brain from ischemic damage via soluble epoxide hydrolase inhibition. |
2012 |
J Asian Nat Prod Res |
pmid:23106500
|
Pritchard KA et al. |
14, 15-Epoxyeicosatrienoic acid promotes endothelial cell dependent adhesion of human monocytic tumor U937 cells. |
1990 |
Biochem. Biophys. Res. Commun. |
pmid:2310385
|
Li R et al. |
Cytochrome P450 2J2 is protective against global cerebral ischemia in transgenic mice. |
2012 |
Prostaglandins Other Lipid Mediat. |
pmid:23041291
|
Oni-Orisan A et al. |
Dual modulation of cyclooxygenase and CYP epoxygenase metabolism and acute vascular inflammation in mice. |
2013 Jul-Aug |
Prostaglandins Other Lipid Mediat. |
pmid:23000418
|
Chaudhary KR et al. |
Differential effects of soluble epoxide hydrolase inhibition and CYP2J2 overexpression on postischemic cardiac function in aged mice. |
2013 Jul-Aug |
Prostaglandins Other Lipid Mediat. |
pmid:22922020
|
Terashvili M et al. |
The protective effect of astrocyte-derived 14,15-epoxyeicosatrienoic acid on hydrogen peroxide-induced cell injury in astrocyte-dopaminergic neuronal cell line co-culture. |
2012 |
Neuroscience |
pmid:22863680
|
Decker M et al. |
EH3 (ABHD9): the first member of a new epoxide hydrolase family with high activity for fatty acid epoxides. |
2012 |
J. Lipid Res. |
pmid:22798687
|
Chadderdon SM et al. |
Activity restriction, impaired capillary function, and the development of insulin resistance in lean primates. |
2012 |
Am. J. Physiol. Endocrinol. Metab. |
pmid:22739105
|
Gupta NC et al. |
Soluble epoxide hydrolase: sex differences and role in endothelial cell survival. |
2012 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:22723436
|
Theken KN et al. |
Evaluation of cytochrome P450-derived eicosanoids in humans with stable atherosclerotic cardiovascular disease. |
2012 |
Atherosclerosis |
pmid:22503544
|
Gross GJ et al. |
Factors mediating remote preconditioning of trauma in the rat heart: central role of the cytochrome p450 epoxygenase pathway in mediating infarct size reduction. |
2013 |
J. Cardiovasc. Pharmacol. Ther. |
pmid:22407888
|
Zhang D et al. |
Homocysteine upregulates soluble epoxide hydrolase in vascular endothelium in vitro and in vivo. |
2012 |
Circ. Res. |
pmid:22354938
|
Shao J et al. |
P-450-dependent epoxygenase pathway of arachidonic acid is involved in myeloma-induced angiogenesis of endothelial cells. |
2011 |
J. Huazhong Univ. Sci. Technol. Med. Sci. |
pmid:22038346
|
Catella F et al. |
Endogenous biosynthesis of arachidonic acid epoxides in humans: increased formation in pregnancy-induced hypertension. |
1990 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:2198572
|
Sarkar P et al. |
Differential effect of amyloid β on the cytochrome P450 epoxygenase activity in rat brain. |
2011 |
Neuroscience |
pmid:21843605
|
Senouvo FY et al. |
Improved bioavailability of epoxyeicosatrienoic acids reduces TP-receptor agonist-induced tension in human bronchi. |
2011 |
Am. J. Physiol. Lung Cell Mol. Physiol. |
pmid:21821730
|
Zhu P et al. |
Development of a semi-automated LC/MS/MS method for the simultaneous quantitation of 14,15-epoxyeicosatrienoic acid, 14,15-dihydroxyeicosatrienoic acid, leukotoxin and leukotoxin diol in human plasma as biomarkers of soluble epoxide hydrolase activity in vivo. |
2011 |
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. |
pmid:21798825
|
Farr H and David T |
Models of neurovascular coupling via potassium and EET signalling. |
2011 |
J. Theor. Biol. |
pmid:21781976
|
Gauthier KM et al. |
Soluble epoxide hydrolase contamination of specific catalase preparations inhibits epoxyeicosatrienoic acid vasodilation of rat renal arterioles. |
2011 |
Am. J. Physiol. Renal Physiol. |
pmid:21753077
|
Pavlov TS et al. |
Effects of cytochrome P-450 metabolites of arachidonic acid on the epithelial sodium channel (ENaC). |
2011 |
Am. J. Physiol. Renal Physiol. |
pmid:21697242
|
Ward NC et al. |
Cytochrome P450 metabolites of arachidonic acid are elevated in stroke patients compared with healthy controls. |
2011 |
Clin. Sci. |
pmid:21689071
|
Harris RC et al. |
Epoxyeicosatrienoic acids activate Na+/H+ exchange and are mitogenic in cultured rat glomerular mesangial cells. |
1990 |
J. Cell. Physiol. |
pmid:2167900
|
Henrich WL et al. |
Inhibition of renin release by 14,15-epoxyeicosatrienoic acid in renal cortical slices. |
1990 |
Am. J. Physiol. |
pmid:2154933
|
Schebb NH et al. |
Development of an online SPE-LC-MS-based assay using endogenous substrate for investigation of soluble epoxide hydrolase (sEH) inhibitors. |
2011 |
Anal Bioanal Chem |
pmid:21479549
|
Chen Y et al. |
20-Iodo-14,15-epoxyeicosa-8(Z)-enoyl-3-azidophenylsulfonamide: photoaffinity labeling of a 14,15-epoxyeicosatrienoic acid receptor. |
2011 |
Biochemistry |
pmid:21469660
|
Mitra R et al. |
CYP3A4 mediates growth of estrogen receptor-positive breast cancer cells in part by inducing nuclear translocation of phospho-Stat3 through biosynthesis of (±)-14,15-epoxyeicosatrienoic acid (EET). |
2011 |
J. Biol. Chem. |
pmid:21402692
|
Sridar C et al. |
Anandamide oxidation by wild-type and polymorphically expressed CYP2B6 and CYP2D6. |
2011 |
Drug Metab. Dispos. |
pmid:21289075
|
Ellis EF et al. |
Dilation of cerebral arterioles by cytochrome P-450 metabolites of arachidonic acid. |
1990 |
Am. J. Physiol. |
pmid:2121049
|
Kopf PG et al. |
Angiotensin II regulates adrenal vascular tone through zona glomerulosa cell-derived EETs and DHETs. |
2011 |
Hypertension |
pmid:21199991
|
Skepner JE et al. |
Chronic treatment with epoxyeicosatrienoic acids modulates insulin signaling and prevents insulin resistance in hepatocytes. |
2011 |
Prostaglandins Other Lipid Mediat. |
pmid:21040800
|
Bukhari IA et al. |
14,15-Dihydroxy-eicosa-5(Z)-enoic acid selectively inhibits 14,15-epoxyeicosatrienoic acid-induced relaxations in bovine coronary arteries. |
2011 |
J. Pharmacol. Exp. Ther. |
pmid:20881018
|
Imaizumi S et al. |
L-4F differentially alters plasma levels of oxidized fatty acids resulting in more anti-inflammatory HDL in mice. |
2010 |
Drug Metab Lett |
pmid:20642447
|
Yang C et al. |
14,15-Epoxyeicosatrienoic acid induces vasorelaxation through the prostaglandin EP(2) receptors in rat mesenteric artery. |
2010 |
Prostaglandins Other Lipid Mediat. |
pmid:20601071
|
Gross GJ et al. |
Evidence for a role of opioids in epoxyeicosatrienoic acid-induced cardioprotection in rat hearts. |
2010 |
Am. J. Physiol. Heart Circ. Physiol. |
pmid:20400686
|
Townsley MI et al. |
Impact of epoxyeicosatrienoic acids in lung ischemia-reperfusion injury. |
2010 |
Microcirculation |
pmid:20163540
|
Planagumà A et al. |
Lovastatin decreases acute mucosal inflammation via 15-epi-lipoxin A4. |
2010 |
Mucosal Immunol |
pmid:20130564
|
Lamb DC et al. |
Streptomyces coelicolor A3(2) CYP102 protein, a novel fatty acid hydroxylase encoded as a heme domain without an N-terminal redox partner. |
2010 |
Appl. Environ. Microbiol. |
pmid:20097805
|
Morin C et al. |
17,18-epoxyeicosatetraenoic acid targets PPARγ and p38 mitogen-activated protein kinase to mediate its anti-inflammatory effects in the lung: role of soluble epoxide hydrolase. |
2010 |
Am. J. Respir. Cell Mol. Biol. |
pmid:20008283
|
Merkel MJ et al. |
Inhibition of soluble epoxide hydrolase preserves cardiomyocytes: role of STAT3 signaling. |
2010 |
Am. J. Physiol. Heart Circ. Physiol. |
pmid:20008276
|
Chen Y et al. |
20-125Iodo-14,15-epoxyeicosa-5(Z)-enoic acid: a high-affinity radioligand used to characterize the epoxyeicosatrienoic acid antagonist binding site. |
2009 |
J. Pharmacol. Exp. Ther. |
pmid:19762546
|
Falck JR et al. |
14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxide hydrolase inhibition. |
2009 |
J. Med. Chem. |
pmid:19653681
|
Force T et al. |
Noncyclooxygenase metabolites of arachidonic acid amplify the vasopressin-induced Ca2+ signal in glomerular mesangial cells by releasing Ca2+ from intracellular stores. |
1991 |
J. Biol. Chem. |
pmid:1900289
|
Pfister SL et al. |
Enhanced synthesis of epoxyeicosatrienoic acids by cholesterol-fed rabbit aorta. |
1991 |
Am. J. Physiol. |
pmid:1887929
|
Behm DJ et al. |
Epoxyeicosatrienoic acids function as selective, endogenous antagonists of native thromboxane receptors: identification of a novel mechanism of vasodilation. |
2009 |
J. Pharmacol. Exp. Ther. |
pmid:18836067
|
Motoki A et al. |
Soluble epoxide hydrolase inhibition and gene deletion are protective against myocardial ischemia-reperfusion injury in vivo. |
2008 |
Am. J. Physiol. Heart Circ. Physiol. |
pmid:18835921
|
Smith HE et al. |
Role of cytochrome P450 2C8 and 2J2 genotypes in calcineurin inhibitor-induced chronic kidney disease. |
2008 |
Pharmacogenet. Genomics |
pmid:18769365
|
Morin C et al. |
CPI-17 silencing-reduced responsiveness in control and TNF-alpha-treated human bronchi. |
2008 |
Am. J. Respir. Cell Mol. Biol. |
pmid:18757304
|
Snider NT et al. |
The endocannabinoid anandamide is a substrate for the human polymorphic cytochrome P450 2D6. |
2008 |
J. Pharmacol. Exp. Ther. |
pmid:18698000
|
Terashvili M et al. |
Antinociception produced by 14,15-epoxyeicosatrienoic acid is mediated by the activation of beta-endorphin and met-enkephalin in the rat ventrolateral periaqueductal gray. |
2008 |
J. Pharmacol. Exp. Ther. |
pmid:18492947
|
Gross GJ et al. |
Effects of the selective EET antagonist, 14,15-EEZE, on cardioprotection produced by exogenous or endogenous EETs in the canine heart. |
2008 |
Am. J. Physiol. Heart Circ. Physiol. |
pmid:18441205
|
Cheranov SY et al. |
An essential role for SRC-activated STAT-3 in 14,15-EET-induced VEGF expression and angiogenesis. |
2008 |
Blood |
pmid:18408167
|
Michaelis UR et al. |
Role of cytochrome P450 2C epoxygenases in hypoxia-induced cell migration and angiogenesis in retinal endothelial cells. |
2008 |
Invest. Ophthalmol. Vis. Sci. |
pmid:18326754
|
Ghosh S et al. |
Oral delivery of 1,3-dicyclohexylurea nanosuspension enhances exposure and lowers blood pressure in hypertensive rats. |
2008 |
Basic Clin. Pharmacol. Toxicol. |
pmid:18312493
|
Morin C et al. |
EET displays anti-inflammatory effects in TNF-alpha stimulated human bronchi: putative role of CPI-17. |
2008 |
Am. J. Respir. Cell Mol. Biol. |
pmid:17872494
|
Heizer ML et al. |
14,15-Epoxyeicosatrienoic acid inhibits platelet aggregation in mouse cerebral arterioles. |
1991 |
Stroke |
pmid:1750047
|
Koerner IP et al. |
Polymorphisms in the human soluble epoxide hydrolase gene EPHX2 linked to neuronal survival after ischemic injury. |
2007 |
J. Neurosci. |
pmid:17460077
|
Bernstrom K et al. |
Incorporation and distribution of epoxyeicosatrienoic acids into cellular phospholipids. |
1992 |
J. Biol. Chem. |
pmid:1740420
|
Yang W et al. |
Characterization of 14,15-epoxyeicosatrienoyl-sulfonamides as 14,15-epoxyeicosatrienoic acid agonists: use for studies of metabolism and ligand binding. |
2007 |
J. Pharmacol. Exp. Ther. |
pmid:17327488
|
Seki K et al. |
Epoxyeicosatrienoic acid stimulates ADP-ribosylation of a 52 kDa protein in rat liver cytosol. |
1992 |
Biochem. J. |
pmid:1731754
|
Carroll MA et al. |
Cyclooxygenase dependency of the renovascular actions of cytochrome P450-derived arachidonate metabolites. |
1992 |
J. Pharmacol. Exp. Ther. |
pmid:1731035
|
Amruthesh SC et al. |
Brain synthesis and cerebrovascular action of epoxygenase metabolites of arachidonic acid. |
1992 |
J. Neurochem. |
pmid:1729396
|
Chen J et al. |
Mitogenic activity and signaling mechanism of 2-(14,15- epoxyeicosatrienoyl)glycerol, a novel cytochrome p450 arachidonate metabolite. |
2007 |
Mol. Cell. Biol. |
pmid:17283047
|
Morin C et al. |
Epoxyeicosatrienoic acid relaxing effects involve Ca2+-activated K+ channel activation and CPI-17 dephosphorylation in human bronchi. |
2007 |
Am. J. Respir. Cell Mol. Biol. |
pmid:17237191
|
Gross GJ et al. |
Mechanisms by which epoxyeicosatrienoic acids (EETs) elicit cardioprotection in rat hearts. |
2007 |
J. Mol. Cell. Cardiol. |
pmid:17217955
|
Jiang JG et al. |
Regulation of endothelial nitric-oxide synthase activity through phosphorylation in response to epoxyeicosatrienoic acids. |
2007 |
Prostaglandins Other Lipid Mediat. |
pmid:17164144
|
Morin C and Rousseau E |
Effects of 5-oxo-ETE and 14,15-EET on reactivity and Ca2+ sensitivity in guinea pig bronchi. |
2007 |
Prostaglandins Other Lipid Mediat. |
pmid:17164130
|
Wang XL et al. |
Inhibition of ATP binding to the carboxyl terminus of Kir6.2 by epoxyeicosatrienoic acids. |
2006 |
Biochim. Biophys. Acta |
pmid:16904368
|
Sacerdoti D et al. |
Rat mesenteric arterial dilator response to 11,12-epoxyeicosatrienoic acid is mediated by activating heme oxygenase. |
2006 |
Am. J. Physiol. Heart Circ. Physiol. |
pmid:16798831
|
Ye D et al. |
Mechanism of rat mesenteric arterial KATP channel activation by 14,15-epoxyeicosatrienoic acid. |
2006 |
Am. J. Physiol. Heart Circ. Physiol. |
pmid:16537788
|
Wei S et al. |
Chiral resolution of the epoxyeicosatrienoic acids, arachidonic acid epoxygenase metabolites. |
2006 |
Anal. Biochem. |
pmid:16480681
|
Zhang B et al. |
Fibroblast growth factor-2 is a downstream mediator of phosphatidylinositol 3-kinase-Akt signaling in 14,15-epoxyeicosatrienoic acid-induced angiogenesis. |
2006 |
J. Biol. Chem. |
pmid:16286479
|
Campbell WB et al. |
Regulation of potassium channels in coronary smooth muscle by adenoviral expression of cytochrome P-450 epoxygenase. |
2006 |
Am. J. Physiol. Heart Circ. Physiol. |
pmid:16143653
|
Fang X et al. |
14,15-Dihydroxyeicosatrienoic acid activates peroxisome proliferator-activated receptor-alpha. |
2006 |
Am. J. Physiol. Heart Circ. Physiol. |
pmid:16113065
|
Alvarez DF et al. |
Resistance to store depletion-induced endothelial injury in rat lung after chronic heart failure. |
2005 |
Am. J. Respir. Crit. Care Med. |
pmid:16051904
|
Dunn LK et al. |
Chick chorioallantoic membrane as an in vivo model to study vasoreactivity: characterization of development-dependent hyperemia induced by epoxyeicosatrienoic acids (EETs). |
2005 |
Anat Rec A Discov Mol Cell Evol Biol |
pmid:15952186
|
Jiang JG et al. |
Cytochrome P450 2J2 promotes the neoplastic phenotype of carcinoma cells and is up-regulated in human tumors. |
2005 |
Cancer Res. |
pmid:15930289
|
Fang X et al. |
Activation of peroxisome proliferator-activated receptor alpha by substituted urea-derived soluble epoxide hydrolase inhibitors. |
2005 |
J. Pharmacol. Exp. Ther. |
pmid:15798002
|
Gauthier KM et al. |
14,15-epoxyeicosatrienoic acid represents a transferable endothelium-dependent relaxing factor in bovine coronary arteries. |
2005 |
Hypertension |
pmid:15699460
|
Spiecker M and Liao JK |
Vascular protective effects of cytochrome p450 epoxygenase-derived eicosanoids. |
2005 |
Arch. Biochem. Biophys. |
pmid:15581597
|
Gauthier KM et al. |
Endothelium-derived 2-arachidonylglycerol: an intermediate in vasodilatory eicosanoid release in bovine coronary arteries. |
2005 |
Am. J. Physiol. Heart Circ. Physiol. |
pmid:15528233
|
Karara A et al. |
Arachidonic acid epoxygenase: structural characterization and quantification of epoxyeicosatrienoates in plasma. |
1992 |
Biochem. Biophys. Res. Commun. |
pmid:1540175
|
Ye D et al. |
Activation of rat mesenteric arterial KATP channels by 11,12-epoxyeicosatrienoic acid. |
2005 |
Am. J. Physiol. Heart Circ. Physiol. |
pmid:15331373
|
Fang X et al. |
Effect of soluble epoxide hydrolase inhibition on epoxyeicosatrienoic acid metabolism in human blood vessels. |
2004 |
Am. J. Physiol. Heart Circ. Physiol. |
pmid:15284062
|
Gauthier KM et al. |
14,15-EET analogs: characterization of structural requirements for agonist and antagonist activity in bovine coronary arteries. |
2004 |
Pharmacol. Res. |
pmid:15026029
|
Krötz F et al. |
Membrane-potential-dependent inhibition of platelet adhesion to endothelial cells by epoxyeicosatrienoic acids. |
2004 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:14715644
|
Alvarez DF et al. |
Role of EETs in regulation of endothelial permeability in rat lung. |
2004 |
Am. J. Physiol. Lung Cell Mol. Physiol. |
pmid:14578116
|
Malcolm KC and Fitzpatrick FA |
Epoxyeicosatrienoic acids inhibit Ca2+ entry into platelets stimulated by thapsigargin and thrombin. |
1992 |
J. Biol. Chem. |
pmid:1400301
|
Gauthier KM et al. |
14,15-epoxyeicosa-5(Z)-enoic-mSI: a 14,15- and 5,6-EET antagonist in bovine coronary arteries. |
2003 |
Hypertension |
pmid:12953017
|
Ladd PA et al. |
Epoxyeicosatrienoic acids activate transglutaminases in situ and induce cornification of epidermal keratinocytes. |
2003 |
J. Biol. Chem. |
pmid:12840027
|
Miyazono M et al. |
Increased epoxyeicosatrienoic acid formation in the rat kidney during liver cirrhosis. |
2003 |
J. Am. Soc. Nephrol. |
pmid:12819236
|
Wang D et al. |
Contributions of nitric oxide, EDHF, and EETs to endothelium-dependent relaxation in renal afferent arterioles. |
2003 |
Kidney Int. |
pmid:12753306
|
Fang X et al. |
Differences in positional esterification of 14,15-epoxyeicosatrienoic acid in phosphatidylcholine of porcine coronary artery endothelial and smooth muscle cells. |
2003 |
Prostaglandins Other Lipid Mediat. |
pmid:12749592
|
Oleksiak MF et al. |
Identification and regulation of a new vertebrate cytochrome P450 subfamily, the CYP2Ps, and functional characterization of CYP2P3, a conserved arachidonic acid epoxygenase/19-hydroxylase. |
2003 |
Arch. Biochem. Biophys. |
pmid:12623071
|
Liu YC and Wu SN |
Block of erg current by linoleoylamide, a sleep-inducing agent, in pituitary GH3 cells. |
2003 |
Eur. J. Pharmacol. |
pmid:12498905
|
Zhang C and Harder DR |
Cerebral capillary endothelial cell mitogenesis and morphogenesis induced by astrocytic epoxyeicosatrienoic Acid. |
2002 |
Stroke |
pmid:12468797
|
Fang X et al. |
Human coronary endothelial cells convert 14,15-EET to a biologically active chain-shortened epoxide. |
2002 |
Am. J. Physiol. Heart Circ. Physiol. |
pmid:12388281
|
Medhora M et al. |
Epoxygenase-driven angiogenesis in human lung microvascular endothelial cells. |
2003 |
Am. J. Physiol. Heart Circ. Physiol. |
pmid:12388259
|