| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetic Nephropathies | D003928 | 39 associated lipids |
| Hyperemia | D006940 | 25 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Liver Cirrhosis | D008103 | 67 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Pre-Eclampsia | D011225 | 16 associated lipids |
| Hypertrophy | D006984 | 16 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Lung Injury | D055370 | 14 associated lipids |
14,15-eet
14,15-eet is a lipid of Fatty Acyls (FA) class. 14,15-eet is associated with abnormalities such as Heart failure, Chronic Obstructive Airway Disease, Pneumonia and Fatty Liver. The involved functions are known as chromophore, Stereochemistry, Cell Respiration, cell transformation and oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. 14,15-eet often locates in Lambda, Cardiovascular system, Blood, Body tissue and Protoplasm. The associated genes with 14,15-eet are CCL2 gene, Cytokine Gene, CYP2C18 gene, CYP2C19 gene and TEK gene. The related lipids are Palmitates.
Cross Reference
Introduction
To understand associated biological information of 14,15-eet, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 14,15-eet?
14,15-eet is suspected in Heart failure, Chronic Obstructive Airway Disease, Pneumonia, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Am. J. Physiol. Endocrinol. Metab. (1)
- Am. J. Physiol. Lung Cell Mol. Physiol. (1)
- Prostaglandins Other Lipid Mediat. (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 14,15-eet
PubChem Associated disorders and diseases
What pathways are associated with 14,15-eet
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 14,15-eet?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- Am. J. Physiol. Lung Cell Mol. Physiol. (2)
- Am. J. Physiol. Endocrinol. Metab. (1)
- Hypertension (1)
- Others (2)
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with 14,15-eet?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 14,15-eet?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with 14,15-eet?
Related references are published most in these journals:
- Am. J. Physiol. Endocrinol. Metab. (1)
- Am. J. Physiol. Lung Cell Mol. Physiol. (1)
- Hypertension (1)
- Others (1)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 14,15-eet?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with 14,15-eet
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Motoki A et al. | Soluble epoxide hydrolase inhibition and gene deletion are protective against myocardial ischemia-reperfusion injury in vivo. | 2008 | Am. J. Physiol. Heart Circ. Physiol. | pmid:18835921 |
| Terashvili M et al. | Antinociception produced by 14,15-epoxyeicosatrienoic acid is mediated by the activation of beta-endorphin and met-enkephalin in the rat ventrolateral periaqueductal gray. | 2008 | J. Pharmacol. Exp. Ther. | pmid:18492947 |
| Smith HE et al. | Role of cytochrome P450 2C8 and 2J2 genotypes in calcineurin inhibitor-induced chronic kidney disease. | 2008 | Pharmacogenet. Genomics | pmid:18769365 |
| Snider NT et al. | The endocannabinoid anandamide is a substrate for the human polymorphic cytochrome P450 2D6. | 2008 | J. Pharmacol. Exp. Ther. | pmid:18698000 |
| Morin C et al. | EET displays anti-inflammatory effects in TNF-alpha stimulated human bronchi: putative role of CPI-17. | 2008 | Am. J. Respir. Cell Mol. Biol. | pmid:17872494 |
| Michaelis UR et al. | Role of cytochrome P450 2C epoxygenases in hypoxia-induced cell migration and angiogenesis in retinal endothelial cells. | 2008 | Invest. Ophthalmol. Vis. Sci. | pmid:18326754 |
| Ghosh S et al. | Oral delivery of 1,3-dicyclohexylurea nanosuspension enhances exposure and lowers blood pressure in hypertensive rats. | 2008 | Basic Clin. Pharmacol. Toxicol. | pmid:18312493 |
| Gross GJ et al. | Effects of the selective EET antagonist, 14,15-EEZE, on cardioprotection produced by exogenous or endogenous EETs in the canine heart. | 2008 | Am. J. Physiol. Heart Circ. Physiol. | pmid:18441205 |
| Cheranov SY et al. | An essential role for SRC-activated STAT-3 in 14,15-EET-induced VEGF expression and angiogenesis. | 2008 | Blood | pmid:18408167 |
| Behm DJ et al. | Epoxyeicosatrienoic acids function as selective, endogenous antagonists of native thromboxane receptors: identification of a novel mechanism of vasodilation. | 2009 | J. Pharmacol. Exp. Ther. | pmid:18836067 |
| Chen Y et al. | 20-125Iodo-14,15-epoxyeicosa-5(Z)-enoic acid: a high-affinity radioligand used to characterize the epoxyeicosatrienoic acid antagonist binding site. | 2009 | J. Pharmacol. Exp. Ther. | pmid:19762546 |
| Falck JR et al. | 14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxide hydrolase inhibition. | 2009 | J. Med. Chem. | pmid:19653681 |
| Gross GJ et al. | Evidence for a role of opioids in epoxyeicosatrienoic acid-induced cardioprotection in rat hearts. | 2010 | Am. J. Physiol. Heart Circ. Physiol. | pmid:20400686 |
| Merkel MJ et al. | Inhibition of soluble epoxide hydrolase preserves cardiomyocytes: role of STAT3 signaling. | 2010 | Am. J. Physiol. Heart Circ. Physiol. | pmid:20008276 |
| Morin C et al. | 17,18-epoxyeicosatetraenoic acid targets PPARγ and p38 mitogen-activated protein kinase to mediate its anti-inflammatory effects in the lung: role of soluble epoxide hydrolase. | 2010 | Am. J. Respir. Cell Mol. Biol. | pmid:20008283 |
| Yang C et al. | 14,15-Epoxyeicosatrienoic acid induces vasorelaxation through the prostaglandin EP(2) receptors in rat mesenteric artery. | 2010 | Prostaglandins Other Lipid Mediat. | pmid:20601071 |
| Imaizumi S et al. | L-4F differentially alters plasma levels of oxidized fatty acids resulting in more anti-inflammatory HDL in mice. | 2010 | Drug Metab Lett | pmid:20642447 |
| Townsley MI et al. | Impact of epoxyeicosatrienoic acids in lung ischemia-reperfusion injury. | 2010 | Microcirculation | pmid:20163540 |
| Planagumà A et al. | Lovastatin decreases acute mucosal inflammation via 15-epi-lipoxin A4. | 2010 | Mucosal Immunol | pmid:20130564 |
| Lamb DC et al. | Streptomyces coelicolor A3(2) CYP102 protein, a novel fatty acid hydroxylase encoded as a heme domain without an N-terminal redox partner. | 2010 | Appl. Environ. Microbiol. | pmid:20097805 |
| Ward NC et al. | Cytochrome P450 metabolites of arachidonic acid are elevated in stroke patients compared with healthy controls. | 2011 | Clin. Sci. | pmid:21689071 |
| Pavlov TS et al. | Effects of cytochrome P-450 metabolites of arachidonic acid on the epithelial sodium channel (ENaC). | 2011 | Am. J. Physiol. Renal Physiol. | pmid:21697242 |
| Mitra R et al. | CYP3A4 mediates growth of estrogen receptor-positive breast cancer cells in part by inducing nuclear translocation of phospho-Stat3 through biosynthesis of (±)-14,15-epoxyeicosatrienoic acid (EET). | 2011 | J. Biol. Chem. | pmid:21402692 |
| Schebb NH et al. | Development of an online SPE-LC-MS-based assay using endogenous substrate for investigation of soluble epoxide hydrolase (sEH) inhibitors. | 2011 | Anal Bioanal Chem | pmid:21479549 |
| Chen Y et al. | 20-Iodo-14,15-epoxyeicosa-8(Z)-enoyl-3-azidophenylsulfonamide: photoaffinity labeling of a 14,15-epoxyeicosatrienoic acid receptor. | 2011 | Biochemistry | pmid:21469660 |
| Bukhari IA et al. | 14,15-Dihydroxy-eicosa-5(Z)-enoic acid selectively inhibits 14,15-epoxyeicosatrienoic acid-induced relaxations in bovine coronary arteries. | 2011 | J. Pharmacol. Exp. Ther. | pmid:20881018 |
| Sridar C et al. | Anandamide oxidation by wild-type and polymorphically expressed CYP2B6 and CYP2D6. | 2011 | Drug Metab. Dispos. | pmid:21289075 |
| Kopf PG et al. | Angiotensin II regulates adrenal vascular tone through zona glomerulosa cell-derived EETs and DHETs. | 2011 | Hypertension | pmid:21199991 |
| Skepner JE et al. | Chronic treatment with epoxyeicosatrienoic acids modulates insulin signaling and prevents insulin resistance in hepatocytes. | 2011 | Prostaglandins Other Lipid Mediat. | pmid:21040800 |
| Shao J et al. | P-450-dependent epoxygenase pathway of arachidonic acid is involved in myeloma-induced angiogenesis of endothelial cells. | 2011 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:22038346 |
| Zhu P et al. | Development of a semi-automated LC/MS/MS method for the simultaneous quantitation of 14,15-epoxyeicosatrienoic acid, 14,15-dihydroxyeicosatrienoic acid, leukotoxin and leukotoxin diol in human plasma as biomarkers of soluble epoxide hydrolase activity in vivo. | 2011 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:21798825 |
| Gauthier KM et al. | Soluble epoxide hydrolase contamination of specific catalase preparations inhibits epoxyeicosatrienoic acid vasodilation of rat renal arterioles. | 2011 | Am. J. Physiol. Renal Physiol. | pmid:21753077 |
| Farr H and David T | Models of neurovascular coupling via potassium and EET signalling. | 2011 | J. Theor. Biol. | pmid:21781976 |
| Senouvo FY et al. | Improved bioavailability of epoxyeicosatrienoic acids reduces TP-receptor agonist-induced tension in human bronchi. | 2011 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:21821730 |
| Sarkar P et al. | Differential effect of amyloid β on the cytochrome P450 epoxygenase activity in rat brain. | 2011 | Neuroscience | pmid:21843605 |
| Chadderdon SM et al. | Activity restriction, impaired capillary function, and the development of insulin resistance in lean primates. | 2012 | Am. J. Physiol. Endocrinol. Metab. | pmid:22739105 |
| Gupta NC et al. | Soluble epoxide hydrolase: sex differences and role in endothelial cell survival. | 2012 | Arterioscler. Thromb. Vasc. Biol. | pmid:22723436 |
| Decker M et al. | EH3 (ABHD9): the first member of a new epoxide hydrolase family with high activity for fatty acid epoxides. | 2012 | J. Lipid Res. | pmid:22798687 |
| Theken KN et al. | Evaluation of cytochrome P450-derived eicosanoids in humans with stable atherosclerotic cardiovascular disease. | 2012 | Atherosclerosis | pmid:22503544 |
| Zhang D et al. | Homocysteine upregulates soluble epoxide hydrolase in vascular endothelium in vitro and in vivo. | 2012 | Circ. Res. | pmid:22354938 |
| Terashvili M et al. | The protective effect of astrocyte-derived 14,15-epoxyeicosatrienoic acid on hydrogen peroxide-induced cell injury in astrocyte-dopaminergic neuronal cell line co-culture. | 2012 | Neuroscience | pmid:22863680 |
| Wang SB et al. | Protection of salvianolic acid A on rat brain from ischemic damage via soluble epoxide hydrolase inhibition. | 2012 | J Asian Nat Prod Res | pmid:23106500 |
| Herse F et al. | Cytochrome P450 subfamily 2J polypeptide 2 expression and circulating epoxyeicosatrienoic metabolites in preeclampsia. | 2012 | Circulation | pmid:23155181 |
| Li R et al. | Cytochrome P450 2J2 is protective against global cerebral ischemia in transgenic mice. | 2012 | Prostaglandins Other Lipid Mediat. | pmid:23041291 |
| Gross GJ et al. | Factors mediating remote preconditioning of trauma in the rat heart: central role of the cytochrome p450 epoxygenase pathway in mediating infarct size reduction. | 2013 | J. Cardiovasc. Pharmacol. Ther. | pmid:22407888 |
| Tabet Y et al. | Relationship between bradykinin-induced relaxation and endogenous epoxyeicosanoid synthesis in human bronchi. | 2013 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:23418089 |
| Gross GJ et al. | Roles of endothelial nitric oxide synthase (eNOS) and mitochondrial permeability transition pore (MPTP) in epoxyeicosatrienoic acid (EET)-induced cardioprotection against infarction in intact rat hearts. | 2013 | J. Mol. Cell. Cardiol. | pmid:23419451 |
| Eid S et al. | 20-HETE and EETs in diabetic nephropathy: a novel mechanistic pathway. | 2013 | PLoS ONE | pmid:23936373 |
| Samokhvalov V et al. | Epoxyeicosatrienoic acids protect cardiac cells during starvation by modulating an autophagic response. | 2013 | Cell Death Dis | pmid:24157879 |
| Yang T et al. | The role of 14,15-dihydroxyeicosatrienoic acid levels in inflammation and its relationship to lipoproteins. | 2013 | Lipids Health Dis | pmid:24148690 |