11,12-epoxy-8-hydroxyeicosa-5,9,14-trienoic acid

11,12-epoxy-8-hydroxyeicosa-5,9,14-trienoic acid is a lipid of Fatty Acyls (FA) class.

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Current reference collection contains 293 references associated with 11,12-epoxy-8-hydroxyeicosa-5,9,14-trienoic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Douda DN et al. A lipid mediator hepoxilin A3 is a natural inducer of neutrophil extracellular traps in human neutrophils. 2015 Mediators Inflamm. pmid:25784781
Pazos MA et al. Distinct cellular sources of hepoxilin A3 and leukotriene B4 are used to coordinate bacterial-induced neutrophil transepithelial migration. 2015 J. Immunol. pmid:25548217
Bou Ghanem EN et al. The α-tocopherol form of vitamin E reverses age-associated susceptibility to streptococcus pneumoniae lung infection by modulating pulmonary neutrophil recruitment. 2015 J. Immunol. pmid:25512603
Kubala SA et al. Pathogen induced chemo-attractant hepoxilin A3 drives neutrophils, but not eosinophils across epithelial barriers. 2014 Prostaglandins Other Lipid Mediat. pmid:24315875
Stenson WF The universe of arachidonic acid metabolites in inflammatory bowel disease: can we tell the good from the bad? 2014 Curr. Opin. Gastroenterol. pmid:24837228
Bhowmick R et al. Systemic disease during Streptococcus pneumoniae acute lung infection requires 12-lipoxygenase-dependent inflammation. 2013 J. Immunol. pmid:24089193
Gregus AM et al. Spinal 12-lipoxygenase-derived hepoxilin A3 contributes to inflammatory hyperalgesia via activation of TRPV1 and TRPA1 receptors. 2012 Proc. Natl. Acad. Sci. U.S.A. pmid:22493235
Tamang DL et al. Hepoxilin A(3) facilitates neutrophilic breach of lipoxygenase-expressing airway epithelial barriers. 2012 J. Immunol. pmid:23045615
Hurley BP et al. Selective eicosanoid-generating capacity of cytoplasmic phospholipase A2 in Pseudomonas aeruginosa-infected epithelial cells. 2011 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:21097525
Zafiriou MP et al. Hepoxilin A(3) protects β-cells from apoptosis in contrast to its precursor, 12-hydroperoxyeicosatetraenoic acid. 2011 Biochim. Biophys. Acta pmid:21420506
Cronin A et al. Mammalian soluble epoxide hydrolase is identical to liver hepoxilin hydrolase. 2011 J. Lipid Res. pmid:21217101
Mumy KL and McCormick BA The role of neutrophils in the event of intestinal inflammation. 2009 Curr Opin Pharmacol pmid:19854677
Mumy KL et al. Distinct isoforms of phospholipase A2 mediate the ability of Salmonella enterica serotype typhimurium and Shigella flexneri to induce the transepithelial migration of neutrophils. 2008 Infect. Immun. pmid:18505810
Pazos M et al. Multidrug resistance-associated transporter 2 regulates mucosal inflammation by facilitating the synthesis of hepoxilin A3. 2008 J. Immunol. pmid:19017997
Hurley BP et al. Adhesion molecules involved in hepoxilin A3-mediated neutrophil transepithelial migration. 2008 Clin. Exp. Immunol. pmid:18005361
Zafiriou MP et al. Biological role of hepoxilins: upregulation of phospholipid hydroperoxide glutathione peroxidase as a cellular response to oxidative stress? 2007 Oct-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:17997296
McCormick BA Bacterial-induced hepoxilin A3 secretion as a pro-inflammatory mediator. 2007 FEBS J. pmid:17608718
Yu Z et al. Epidermal lipoxygenase products of the hepoxilin pathway selectively activate the nuclear receptor PPARalpha. 2007 Lipids pmid:17436029
Pace-Asciak CR et al. Hepoxilin analogs, potential new therapeutics in disease. 2006 Curr. Pharm. Des. pmid:16533163
Savidge TC et al. Lipopolysaccharide-induced human enterocyte tolerance to cytokine-mediated interleukin-8 production may occur independently of TLR-4/MD-2 signaling. 2006 Pediatr. Res. pmid:16326999
Hurley BP et al. Involvement of phospholipase A2 in Pseudomonas aeruginosa-mediated PMN transepithelial migration. 2006 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:16272174
Nigam S and Zafiriou MP Hepoxilin A3 synthase. 2005 Biochem. Biophys. Res. Commun. pmid:16198304
Nigam S et al. The rat leukocyte-type 12-lipoxygenase exhibits an intrinsic hepoxilin A3 synthase activity. 2004 J. Biol. Chem. pmid:15123652
Hurley BP et al. Polymorphonuclear cell transmigration induced by Pseudomonas aeruginosa requires the eicosanoid hepoxilin A3. 2004 J. Immunol. pmid:15494523
Mrsny RJ et al. Identification of hepoxilin A3 in inflammatory events: a required role in neutrophil migration across intestinal epithelia. 2004 Proc. Natl. Acad. Sci. U.S.A. pmid:15123795
Yu Z et al. The lipoxygenase gene ALOXE3 implicated in skin differentiation encodes a hydroperoxide isomerase. 2003 Proc. Natl. Acad. Sci. U.S.A. pmid:12881489
Vogan CL et al. Hepoxilins and trioxilins in barnacles: an analysis of their potential roles in egg hatching and larval settlement. 2003 J. Exp. Biol. pmid:12909703
Murphy RC and Zarini S Glutathione adducts of oxyeicosanoids. 2002 Prostaglandins Other Lipid Mediat. pmid:12432937
Reynaud D et al. Hepoxilin signaling in intact human neutrophils: biphasic elevation of intracellular calcium by unesterified hepoxilin A3. 1999 FEBS Lett. pmid:10100848
Wang MM et al. In vivo stimulation of 12(S)-lipoxygenase in the rat skin by bradykinin and platelet activating factor: formation of 12(S)-HETE and hepoxilins, and actions on vascular permeability. 1999 Biochim. Biophys. Acta pmid:9989266
Antón R et al. Occurrence of hepoxilins and trioxilins in psoriatic lesions. 1998 J. Invest. Dermatol. pmid:9540966
Reynaud D and Pace-Asciak CR Docosahexaenoic acid causes accumulation of free arachidonic acid in rat pineal gland and hippocampus to form hepoxilins from both substrates. 1997 Biochim. Biophys. Acta pmid:9219915
Reynaud D et al. Hepoxilin A3 is oxidized by human neutrophils into its omega-hydroxy metabolite by an activity independent of LTB4 omega-hydroxylase. 1997 Biochim. Biophys. Acta pmid:9366245
Mills L et al. Hepoxilin-evoked intracellular reorganization of calcium in human neutrophils: a confocal microscopy study. 1997 Exp. Cell Res. pmid:9024792
Reynaud D et al. Hepoxilin A3-specific binding in human neutrophils. 1996 Biochem. J. pmid:8573089
Reynaud D et al. Hepoxilin binding in human neutrophils. 1995 Biochem. Biophys. Res. Commun. pmid:7857263
Pace-Asciak CR et al. Mechanistic aspects of hepoxilin biosynthesis. 1995 J Lipid Mediat Cell Signal pmid:8777574
Demin P et al. Extractive derivatization of the 12-lipoxygenase products, hepoxilins, and related compounds into fluorescent anthryl esters for their complete high-performance liquid chromatography profiling in biological systems. 1995 Anal. Biochem. pmid:7793626
Margalit A and Granot Y Endogenous hepoxilin A3, produced under short duration of high shear-stress, inhibits thrombin-induced aggregation in human platelets. 1994 Biochim. Biophys. Acta pmid:8110811
Reynaud D et al. Formation, metabolism, and action of hepoxilin A3 in the rat pineal gland. 1994 J. Neurochem. pmid:8263512
Carlen PL et al. Formation and electrophysiological actions of the arachidonic acid metabolites, hepoxilins, at nanomolar concentrations in rat hippocampal slices. 1994 Neuroscience pmid:7909586
Pace-Asciak CR Hepoxilins: a review on their cellular actions. 1994 Biochim. Biophys. Acta pmid:7947989
Pace-Asciak CR Hepoxilins. 1993 Gen. Pharmacol. pmid:8224734
Pace-Asciak CR et al. Enzymatic formation of hepoxilins A3 and B3. 1993 Biochem. Biophys. Res. Commun. pmid:8267626
Laneuville O et al. Hepoxilin A3 inhibits the rise in free intracellular calcium evoked by formyl-methionyl-leucyl-phenylalanine, platelet-activating factor and leukotriene B4. 1993 Biochem. J. pmid:8240236
Margalit A et al. Hepoxilin A3 is the endogenous lipid mediator opposing hypotonic swelling of intact human platelets. 1993 Proc. Natl. Acad. Sci. U.S.A. pmid:8464865
Laneuville O et al. Hepoxilins sensitize blood vessels to noradrenaline--stereospecificity of action. 1992 Br. J. Pharmacol. pmid:1559126
Laneuville O et al. Neurokinin A-induced contraction of guinea-pig isolated trachea: potentiation by hepoxilins. 1992 Br. J. Pharmacol. pmid:1335339
Laneuville O et al. Hepoxilin A3 (HxA3) is formed by the rat aorta and is metabolized into HxA3-C, a glutathione conjugate. 1991 Biochim. Biophys. Acta pmid:1675872
Lin Z et al. Hepoxilin A3 induces heat shock protein (HSP72) expression in human neutrophils. 1991 Biochem. Biophys. Res. Commun. pmid:1883378

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