MeSH term | MeSH ID | Detail |
---|---|---|
Lung Diseases | D008171 | 37 associated lipids |
Inflammation | D007249 | 119 associated lipids |
Total
2
Hxa3 is a lipid of Fatty Acyls (FA) class.
We collected disease MeSH terms mapped to the references associated with Hxa3
MeSH term | MeSH ID | Detail |
---|---|---|
Lung Diseases | D008171 | 37 associated lipids |
Inflammation | D007249 | 119 associated lipids |
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Douda DN et al. | A lipid mediator hepoxilin A3 is a natural inducer of neutrophil extracellular traps in human neutrophils. | 2015 | Mediators Inflamm. | pmid:25784781 |
Pazos MA et al. | Distinct cellular sources of hepoxilin A3 and leukotriene B4 are used to coordinate bacterial-induced neutrophil transepithelial migration. | 2015 | J. Immunol. | pmid:25548217 |
Bou Ghanem EN et al. | The α-tocopherol form of vitamin E reverses age-associated susceptibility to streptococcus pneumoniae lung infection by modulating pulmonary neutrophil recruitment. | 2015 | J. Immunol. | pmid:25512603 |
Kubala SA et al. | Pathogen induced chemo-attractant hepoxilin A3 drives neutrophils, but not eosinophils across epithelial barriers. | 2014 | Prostaglandins Other Lipid Mediat. | pmid:24315875 |
Stenson WF | The universe of arachidonic acid metabolites in inflammatory bowel disease: can we tell the good from the bad? | 2014 | Curr. Opin. Gastroenterol. | pmid:24837228 |
Bhowmick R et al. | Systemic disease during Streptococcus pneumoniae acute lung infection requires 12-lipoxygenase-dependent inflammation. | 2013 | J. Immunol. | pmid:24089193 |
Gregus AM et al. | Spinal 12-lipoxygenase-derived hepoxilin A3 contributes to inflammatory hyperalgesia via activation of TRPV1 and TRPA1 receptors. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22493235 |
Tamang DL et al. | Hepoxilin A(3) facilitates neutrophilic breach of lipoxygenase-expressing airway epithelial barriers. | 2012 | J. Immunol. | pmid:23045615 |
Hurley BP et al. | Selective eicosanoid-generating capacity of cytoplasmic phospholipase A2 in Pseudomonas aeruginosa-infected epithelial cells. | 2011 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:21097525 |
Zafiriou MP et al. | Hepoxilin A(3) protects β-cells from apoptosis in contrast to its precursor, 12-hydroperoxyeicosatetraenoic acid. | 2011 | Biochim. Biophys. Acta | pmid:21420506 |
Cronin A et al. | Mammalian soluble epoxide hydrolase is identical to liver hepoxilin hydrolase. | 2011 | J. Lipid Res. | pmid:21217101 |
Mumy KL and McCormick BA | The role of neutrophils in the event of intestinal inflammation. | 2009 | Curr Opin Pharmacol | pmid:19854677 |
Mumy KL et al. | Distinct isoforms of phospholipase A2 mediate the ability of Salmonella enterica serotype typhimurium and Shigella flexneri to induce the transepithelial migration of neutrophils. | 2008 | Infect. Immun. | pmid:18505810 |
Pazos M et al. | Multidrug resistance-associated transporter 2 regulates mucosal inflammation by facilitating the synthesis of hepoxilin A3. | 2008 | J. Immunol. | pmid:19017997 |
Hurley BP et al. | Adhesion molecules involved in hepoxilin A3-mediated neutrophil transepithelial migration. | 2008 | Clin. Exp. Immunol. | pmid:18005361 |
Zafiriou MP et al. | Biological role of hepoxilins: upregulation of phospholipid hydroperoxide glutathione peroxidase as a cellular response to oxidative stress? | 2007 Oct-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17997296 |
McCormick BA | Bacterial-induced hepoxilin A3 secretion as a pro-inflammatory mediator. | 2007 | FEBS J. | pmid:17608718 |
Yu Z et al. | Epidermal lipoxygenase products of the hepoxilin pathway selectively activate the nuclear receptor PPARalpha. | 2007 | Lipids | pmid:17436029 |
Pace-Asciak CR et al. | Hepoxilin analogs, potential new therapeutics in disease. | 2006 | Curr. Pharm. Des. | pmid:16533163 |
Hurley BP et al. | Involvement of phospholipase A2 in Pseudomonas aeruginosa-mediated PMN transepithelial migration. | 2006 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:16272174 |
Nigam S and Zafiriou MP | Hepoxilin A3 synthase. | 2005 | Biochem. Biophys. Res. Commun. | pmid:16198304 |
Hurley BP et al. | Polymorphonuclear cell transmigration induced by Pseudomonas aeruginosa requires the eicosanoid hepoxilin A3. | 2004 | J. Immunol. | pmid:15494523 |
Mrsny RJ et al. | Identification of hepoxilin A3 in inflammatory events: a required role in neutrophil migration across intestinal epithelia. | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15123795 |
Vogan CL et al. | Hepoxilins and trioxilins in barnacles: an analysis of their potential roles in egg hatching and larval settlement. | 2003 | J. Exp. Biol. | pmid:12909703 |
Reynaud D et al. | Hepoxilin signaling in intact human neutrophils: biphasic elevation of intracellular calcium by unesterified hepoxilin A3. | 1999 | FEBS Lett. | pmid:10100848 |
Wang MM et al. | In vivo stimulation of 12(S)-lipoxygenase in the rat skin by bradykinin and platelet activating factor: formation of 12(S)-HETE and hepoxilins, and actions on vascular permeability. | 1999 | Biochim. Biophys. Acta | pmid:9989266 |
Antón R et al. | Occurrence of hepoxilins and trioxilins in psoriatic lesions. | 1998 | J. Invest. Dermatol. | pmid:9540966 |
Reynaud D and Pace-Asciak CR | Docosahexaenoic acid causes accumulation of free arachidonic acid in rat pineal gland and hippocampus to form hepoxilins from both substrates. | 1997 | Biochim. Biophys. Acta | pmid:9219915 |
Reynaud D et al. | Hepoxilin A3 is oxidized by human neutrophils into its omega-hydroxy metabolite by an activity independent of LTB4 omega-hydroxylase. | 1997 | Biochim. Biophys. Acta | pmid:9366245 |
Mills L et al. | Hepoxilin-evoked intracellular reorganization of calcium in human neutrophils: a confocal microscopy study. | 1997 | Exp. Cell Res. | pmid:9024792 |
Reynaud D et al. | Hepoxilin A3-specific binding in human neutrophils. | 1996 | Biochem. J. | pmid:8573089 |
Reynaud D et al. | Hepoxilin binding in human neutrophils. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7857263 |
Pace-Asciak CR et al. | Mechanistic aspects of hepoxilin biosynthesis. | 1995 | J Lipid Mediat Cell Signal | pmid:8777574 |
Demin P et al. | Extractive derivatization of the 12-lipoxygenase products, hepoxilins, and related compounds into fluorescent anthryl esters for their complete high-performance liquid chromatography profiling in biological systems. | 1995 | Anal. Biochem. | pmid:7793626 |
Margalit A and Granot Y | Endogenous hepoxilin A3, produced under short duration of high shear-stress, inhibits thrombin-induced aggregation in human platelets. | 1994 | Biochim. Biophys. Acta | pmid:8110811 |
Reynaud D et al. | Formation, metabolism, and action of hepoxilin A3 in the rat pineal gland. | 1994 | J. Neurochem. | pmid:8263512 |
Carlen PL et al. | Formation and electrophysiological actions of the arachidonic acid metabolites, hepoxilins, at nanomolar concentrations in rat hippocampal slices. | 1994 | Neuroscience | pmid:7909586 |
Pace-Asciak CR | Hepoxilins: a review on their cellular actions. | 1994 | Biochim. Biophys. Acta | pmid:7947989 |
Pace-Asciak CR | Hepoxilins. | 1993 | Gen. Pharmacol. | pmid:8224734 |
Pace-Asciak CR et al. | Enzymatic formation of hepoxilins A3 and B3. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8267626 |
Laneuville O et al. | Hepoxilin A3 inhibits the rise in free intracellular calcium evoked by formyl-methionyl-leucyl-phenylalanine, platelet-activating factor and leukotriene B4. | 1993 | Biochem. J. | pmid:8240236 |
Margalit A et al. | Hepoxilin A3 is the endogenous lipid mediator opposing hypotonic swelling of intact human platelets. | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8464865 |
Laneuville O et al. | Hepoxilins sensitize blood vessels to noradrenaline--stereospecificity of action. | 1992 | Br. J. Pharmacol. | pmid:1559126 |
Laneuville O et al. | Neurokinin A-induced contraction of guinea-pig isolated trachea: potentiation by hepoxilins. | 1992 | Br. J. Pharmacol. | pmid:1335339 |
Laneuville O et al. | Hepoxilin A3 (HxA3) is formed by the rat aorta and is metabolized into HxA3-C, a glutathione conjugate. | 1991 | Biochim. Biophys. Acta | pmid:1675872 |
Lin Z et al. | Hepoxilin A3 induces heat shock protein (HSP72) expression in human neutrophils. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1883378 |
Piomelli D | Metabolism of arachidonic acid in nervous system of marine mollusk Aplysia californica. | 1991 | Am. J. Physiol. | pmid:1903603 |
Laneuville O et al. | Isozyme specificity in the conversion of hepoxilin A3 (HxA3) into a glutathionyl hepoxilin (HxA3-C) by the Yb2 subunit of rat liver glutathione S-transferase. | 1990 | J. Biol. Chem. | pmid:2254303 |
Pace-Asciak CR et al. | Hepoxilin A3 blocks the release of norepinephrine from rat hippocampal slices. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2268355 |
Nigam S et al. | Receptor-mediated action of hepoxilin A3 releases diacylglycerol and arachidonic acid from human neutrophils. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2171511 |