hypericin is a lipid of Polyketides (PK) class. Hypericin is associated with abnormalities such as Dermatitis, Phototoxic, Dehydration, Photosensitization, Morphologically altered structure and Myocardial Infarction. The involved functions are known as Cell Cycle Checkpoints, Apoptosis, Acetylation, Cell Survival and Caspase Activation. Hypericin often locates in insoluble fraction, Cytoplasmic matrix, Protoplasm, Tissue membrane and Cytoplasm. The associated genes with hypericin are CDC37 gene, HSPA8 gene, RAF1 gene, cyclin H and FK228. The related lipids are Phosphatidylserines.
To understand associated biological information of hypericin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
hypericin is suspected in Dermatitis, Phototoxic, Photosensitization, Pneumonia, Psoriasis, Phototoxicity, Chronic infectious disease and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with hypericin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Shih CM et al. | Hypericin inhibits hepatitis C virus replication via deacetylation and down-regulation of heme oxygenase-1. | 2018 | Phytomedicine | pmid:30097118 |
You MK et al. | St. John's Wort Regulates Proliferation and Apoptosis in MCF-7 Human Breast Cancer Cells by Inhibiting AMPK/mTOR and Activating the Mitochondrial Pathway. | 2018 | Int J Mol Sci | pmid:29570671 |
Herraiz T and Guillén H | Monoamine Oxidase-A Inhibition and Associated Antioxidant Activity in Plant Extracts with Potential Antidepressant Actions. | 2018 | Biomed Res Int | pmid:29568754 |
Keša P et al. | Excitation of triplet states of hypericin in water mediated by hydrotropic cromolyn sodium salt. | 2018 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:29241053 |
Lopera AA et al. | Synthesis of calcium phosphate nanostructures by combustion in solution as a potential encapsulant system of drugs with photodynamic properties for the treatment of cutaneous leishmaniasis. | 2018 | Photodiagnosis Photodyn Ther | pmid:29198762 |
Roschger C et al. | Reduction of cancer cell viability by synergistic combination of photodynamic treatment with the inhibition of the Id protein family. | 2018 | J. Photochem. Photobiol. B, Biol. | pmid:29245122 |
Zhang JN et al. | Effect of photodynamic inactivation of Escherichia coli by hypericin. | 2018 | World J. Microbiol. Biotechnol. | pmid:29926201 |
Li ZH et al. | Topically applied hypericin exhibits skin penetrability on nude mice. | 2018 | Lasers Med Sci | pmid:29915976 |
Valletta E et al. | Distinct Hypericum perforatum L. total extracts exert different antitumour activity on erythroleukemic K562 cells. | 2018 | Phytother Res | pmid:29785769 |
Abma E et al. | Biodistribution and tolerance of intravenous iodine-131-labelled hypericin in healthy dogs. | 2018 | Vet Comp Oncol | pmid:29314561 |