hypericin is a lipid of Polyketides (PK) class. Hypericin is associated with abnormalities such as Dermatitis, Phototoxic, Dehydration, Photosensitization, Morphologically altered structure and Myocardial Infarction. The involved functions are known as Cell Cycle Checkpoints, Apoptosis, Acetylation, Cell Survival and Caspase Activation. Hypericin often locates in insoluble fraction, Cytoplasmic matrix, Protoplasm, Tissue membrane and Cytoplasm. The associated genes with hypericin are CDC37 gene, HSPA8 gene, RAF1 gene, cyclin H and FK228. The related lipids are Phosphatidylserines.
To understand associated biological information of hypericin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
hypericin is suspected in Dermatitis, Phototoxic, Photosensitization, Pneumonia, Psoriasis, Phototoxicity, Chronic infectious disease and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with hypericin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Dresler S et al. | Methodological aspects of biologically active compounds quantification in the genus Hypericum. | 2018 | J Pharm Biomed Anal | pmid:29621655 |
Shao C et al. | Facile fabrication of hypericin-entrapped glyconanoparticles for targeted photodynamic therapy. | 2018 | Int J Nanomedicine | pmid:30087563 |
Geng C et al. | Sonodynamic therapy: A potential treatment for atherosclerosis. | 2018 | Life Sci. | pmid:29940244 |
Lopera AA et al. | Solution-combustion synthesis of doped TiO compounds and its potential antileishmanial activity mediated by photodynamic therapy. | 2018 | J. Photochem. Photobiol. B, Biol. | pmid:29689488 |
Vargová J et al. | Hypericin affects cancer side populations via competitive inhibition of BCRP. | 2018 | Biomed. Pharmacother. | pmid:29665654 |
Dalmizrak O et al. | Mechanistic and structural insights into the in vitro inhibitory action of hypericin on glutathione reductase purified from baker's yeast. | 2018 | J. Biochem. Mol. Toxicol. | pmid:29660796 |
Kimáková K et al. | Relation between hypericin content and morphometric leaf parameters in Hypericum spp.: A case of cubic degree polynomial function. | 2018 | Plant Sci. | pmid:29650162 |
Xu F et al. | Yield enhancement strategies of rare pharmaceutical metabolites from endophytes. | 2018 | Biotechnol. Lett. | pmid:29605937 |
You MK et al. | St. John's Wort Regulates Proliferation and Apoptosis in MCF-7 Human Breast Cancer Cells by Inhibiting AMPK/mTOR and Activating the Mitochondrial Pathway. | 2018 | Int J Mol Sci | pmid:29570671 |
Herraiz T and Guillén H | Monoamine Oxidase-A Inhibition and Associated Antioxidant Activity in Plant Extracts with Potential Antidepressant Actions. | 2018 | Biomed Res Int | pmid:29568754 |