hypericin is a lipid of Polyketides (PK) class. Hypericin is associated with abnormalities such as Dermatitis, Phototoxic, Dehydration, Photosensitization, Morphologically altered structure and Myocardial Infarction. The involved functions are known as Cell Cycle Checkpoints, Apoptosis, Acetylation, Cell Survival and Caspase Activation. Hypericin often locates in insoluble fraction, Cytoplasmic matrix, Protoplasm, Tissue membrane and Cytoplasm. The associated genes with hypericin are CDC37 gene, HSPA8 gene, RAF1 gene, cyclin H and FK228. The related lipids are Phosphatidylserines.
To understand associated biological information of hypericin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
hypericin is suspected in Dermatitis, Phototoxic, Photosensitization, Pneumonia, Psoriasis, Phototoxicity, Chronic infectious disease and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with hypericin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Rayburn WF et al. | Impact of hypericum (St.-John's-wort) given prenatally on cognition of mice offspring. | Neurotoxicol Teratol | pmid:11792531 | |
Li ZH et al. | Hypericin damages the ectatic capillaries in a Roman cockscomb model and inhibits the growth of human endothelial cells more potently than hematoporphyrin does through induction of apoptosis. | Photochem. Photobiol. | pmid:25065502 | |
StaniÄová J et al. | Interaction of a Potential Anticancer Agent Hypericin and its Model Compound Emodin with DNA and Bovine Serum Albumin. | In Vivo | pmid:30150427 | |
StaniÄová J et al. | Potential anticancer agent hypericin and its model compound emodin: interaction with DNA. | Ceska Slov Farm | pmid:27118502 | |
pmid: | ||||
Lavie G et al. | "Competitive quenching": a mechanism by which perihydroxylated perylenequinone photosensitizers can prevent adverse phototoxic damage caused by verteporfin during photodynamic therapy. | Photochem. Photobiol. | pmid:17880523 | |
Lobban CS et al. | Photophysics and multifunctionality of hypericin-like pigments in heterotrich ciliates: a phylogenetic perspective. | Photochem. Photobiol. | pmid:17880503 | |
Zobayed SM et al. | Temperature stress can alter the photosynthetic efficiency and secondary metabolite concentrations in St. John's wort. | Plant Physiol. Biochem. | pmid:16310362 | |
Krishnamoorthy G et al. | Synthesis of hydroxy and methoxy perylene quinones, their spectroscopic and computational characterization, and their antiviral activity. | Photochem. Photobiol. | pmid:15884972 | |
Kanofsky JR and Sima PD | Structural requirements for efficient cellular photoprotection by carotenoid derivatives. | Photochem. Photobiol. | pmid:15623338 |