hypericin
hypericin is a lipid of Polyketides (PK) class. Hypericin is associated with abnormalities such as Dermatitis, Phototoxic, Dehydration, Photosensitization, Morphologically altered structure and Myocardial Infarction. The involved functions are known as Cell Cycle Checkpoints, Apoptosis, Acetylation, Cell Survival and Caspase Activation. Hypericin often locates in insoluble fraction, Cytoplasmic matrix, Protoplasm, Tissue membrane and Cytoplasm. The associated genes with hypericin are CDC37 gene, HSPA8 gene, RAF1 gene, cyclin H and FK228. The related lipids are Phosphatidylserines.
Cross Reference
Introduction
To understand associated biological information of hypericin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with hypericin?
hypericin is suspected in Dermatitis, Phototoxic, Photosensitization, Pneumonia, Psoriasis, Phototoxicity, Chronic infectious disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with hypericin
PubChem Associated disorders and diseases
What pathways are associated with hypericin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with hypericin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with hypericin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with hypericin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with hypericin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with hypericin?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with hypericin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Borrelli F and Izzo AA | Herb-drug interactions with St John's wort (Hypericum perforatum): an update on clinical observations. | 2009 | AAPS J | pmid:19859815 |
| Van de Putte M et al. | Hypericin as a marker for determination of tissue viability after intratumoral ethanol injection in a murine liver tumor model. | 2008 | Acad Radiol | pmid:18078913 |
| Qian J et al. | Preparation of a polyclonal antibody against hypericin synthase and localization of the enzyme in red-pigmented Hypericum perforatum L. plantlets. | 2012 | Acta Biochim. Pol. | pmid:23162805 |
| Fernandes H et al. | Crystallization and preliminary crystallographic studies of Hyp-1, a St John's wort protein implicated in the biosynthesis of hypericin. | 2008 | Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. | pmid:18453712 |
| Mareková M et al. | Light-induced photoactivation of hypericin inhibits cellular growth in pituitary adenoma cell line AtT20/D16v-F2 (hypericin inhibits cellular growth of AtT20/D16v-F2). | 2001 | Acta Medica (Hradec Kralove) | pmid:11367893 |
| Kiniczky M | [Hyperici herba (Hypericum perforatum L]. | 2001 | Acta Pharm Hung | pmid:11769089 |
| Li JJ et al. | A single-dose toxicity study on non-radioactive iodinated hypericin for a targeted anticancer therapy in mice. | 2012 | Acta Pharmacol. Sin. | pmid:23103619 |
| Sloley BD et al. | Chemical and pharmacological evaluation of Hypericum perforatum extracts. | 2000 | Acta Pharmacol. Sin. | pmid:11603291 |
| Anyzewska M et al. | Determination of total hypericins in St. John's wort and herbal medicinal products. | 2010 Nov-Dec | Acta Pol Pharm | pmid:21229872 |