hypericin is a lipid of Polyketides (PK) class. Hypericin is associated with abnormalities such as Dermatitis, Phototoxic, Dehydration, Photosensitization, Morphologically altered structure and Myocardial Infarction. The involved functions are known as Cell Cycle Checkpoints, Apoptosis, Acetylation, Cell Survival and Caspase Activation. Hypericin often locates in insoluble fraction, Cytoplasmic matrix, Protoplasm, Tissue membrane and Cytoplasm. The associated genes with hypericin are CDC37 gene, HSPA8 gene, RAF1 gene, cyclin H and FK228. The related lipids are Phosphatidylserines.
To understand associated biological information of hypericin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
hypericin is suspected in Dermatitis, Phototoxic, Photosensitization, Pneumonia, Psoriasis, Phototoxicity, Chronic infectious disease and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with hypericin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Kersten B et al. | The application of the micronucleus test in Chinese hamster V79 cells to detect drug-induced photogenotoxicity. | 1999 | Mutat. Res. | pmid:10521691 |
Kamuhabwa AR et al. | In vitro transport and uptake of protohypericin and hypericin in the Caco-2 model. | 1999 | Int J Pharm | pmid:10528085 |
Mirossay L et al. | Hypericin-induced phototoxicity of human leukemic cell line HL-60 is potentiated by omeprazole, an inhibitor of H+K+-ATPase and 5'-(N,N-dimethyl)-amiloride, an inhibitor of Na+/H+ exchanger. | 1999 | Physiol Res | pmid:10534017 |
Hudson JB et al. | Bromohypericins are potent photoactive antiviral agents. | 1999 | Photochem. Photobiol. | pmid:10568175 |
Chaloupka R et al. | Over-expression of Bcl-2 does not protect cells from hypericin photo-induced mitochondrial membrane depolarization, but delays subsequent events in the apoptotic pathway. | 1999 | FEBS Lett. | pmid:10622714 |
Delaey EM et al. | Photocytotoxicity of protohypericin after photoconversion to hypericin. | 1999 | Planta Med. | pmid:10630113 |
Kraus GA et al. | Phenanthrenequinone antiretroviral agents. | 2000 | Bioorg. Med. Chem. Lett. | pmid:10636231 |
Martens A et al. | In vitro and in vivo evaluation of hypericin for photodynamic therapy of equine sarcoids. | 2000 | Vet. J. | pmid:10640414 |
Kamuhabwa AR et al. | Skin photosensitization with topical hypericin in hairless mice. | 1999 Nov-Dec | J. Photochem. Photobiol. B, Biol. | pmid:10672536 |
Prince AM et al. | Strategies for evaluation of enveloped virus inactivation in red cell concentrates using hypericin. | 2000 | Photochem. Photobiol. | pmid:10687393 |