hypericin is a lipid of Polyketides (PK) class. Hypericin is associated with abnormalities such as Dermatitis, Phototoxic, Dehydration, Photosensitization, Morphologically altered structure and Myocardial Infarction. The involved functions are known as Cell Cycle Checkpoints, Apoptosis, Acetylation, Cell Survival and Caspase Activation. Hypericin often locates in insoluble fraction, Cytoplasmic matrix, Protoplasm, Tissue membrane and Cytoplasm. The associated genes with hypericin are CDC37 gene, HSPA8 gene, RAF1 gene, cyclin H and FK228. The related lipids are Phosphatidylserines.
To understand associated biological information of hypericin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
hypericin is suspected in Dermatitis, Phototoxic, Photosensitization, Pneumonia, Psoriasis, Phototoxicity, Chronic infectious disease and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with hypericin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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de Andrade GP et al. | Comparative in vitro study of photodynamic activity of hypericin and hypericinates in MCF-7 cells. | 2017 | J. Photochem. Photobiol. B, Biol. | pmid:28865319 |
Singh S et al. | Molecular events leading to death of Leishmania donovani under spermidine starvation after hypericin treatment. | 2017 | Chem Biol Drug Des | pmid:28509385 |
Montanha MC et al. | Response surface method optimization of a novel Hypericin formulation in P123 micelles for colorectal cancer and antimicrobial photodynamic therapy. | 2017 | J. Photochem. Photobiol. B, Biol. | pmid:28454049 |
Lin S et al. | Endoplasmic reticulum-targeting photosensitizer Hypericin confers chemo-sensitization towards oxaliplatin through inducing pro-death autophagy. | 2017 | Int. J. Biochem. Cell Biol. | pmid:28392376 |
Joniova J et al. | Formation of Large Hypericin Aggregates in Giant Unilamellar Vesicles-Experiments and Modeling. | 2017 | Biophys. J. | pmid:28297655 |
Huntosova V et al. | Assessing light-independent effects of hypericin on cell viability, ultrastructure and metabolism in human glioma and endothelial cells. | 2017 | Toxicol In Vitro | pmid:28087315 |
Ng QX et al. | Clinical use of Hypericum perforatum (St John's wort) in depression: A meta-analysis. | 2017 | J Affect Disord | pmid:28064110 |
Kimáková P et al. | Photoactivated hypericin increases the expression of SOD-2 and makes MCF-7 cells resistant to photodynamic therapy. | 2017 | Biomed. Pharmacother. | pmid:27923686 |
Biteghe FN and Davids LM | A combination of photodynamic therapy and chemotherapy displays a differential cytotoxic effect on human metastatic melanoma cells. | 2017 | J. Photochem. Photobiol. B, Biol. | pmid:27852006 |
Lazzara S et al. | Arbuscular mycorrhizal fungi altered the hypericin, pseudohypericin, and hyperforin content in flowers of Hypericum perforatum grown under contrasting P availability in a highly organic substrate. | 2017 | Mycorrhiza | pmid:27999964 |