hypericin is a lipid of Polyketides (PK) class. Hypericin is associated with abnormalities such as Dermatitis, Phototoxic, Dehydration, Photosensitization, Morphologically altered structure and Myocardial Infarction. The involved functions are known as Cell Cycle Checkpoints, Apoptosis, Acetylation, Cell Survival and Caspase Activation. Hypericin often locates in insoluble fraction, Cytoplasmic matrix, Protoplasm, Tissue membrane and Cytoplasm. The associated genes with hypericin are CDC37 gene, HSPA8 gene, RAF1 gene, cyclin H and FK228. The related lipids are Phosphatidylserines.
To understand associated biological information of hypericin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
hypericin is suspected in Dermatitis, Phototoxic, Photosensitization, Pneumonia, Psoriasis, Phototoxicity, Chronic infectious disease and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with hypericin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Guella G et al. | Structures, biological activities and phylogenetic relationships of terpenoids from marine ciliates of the genus Euplotes. | 2010 | Mar Drugs | pmid:20714425 |
Cui XH et al. | Production of adventitious roots and secondary metabolites by Hypericum perforatum L. in a bioreactor. | 2010 | Bioresour. Technol. | pmid:20171884 |
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Filippini R et al. | Study of dynamic accumulation of secondary metabolites in three subspecies of Hypericum perforatum. | 2010 | Fitoterapia | pmid:19686808 |
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Sobolewski C et al. | The role of cyclooxygenase-2 in cell proliferation and cell death in human malignancies. | 2010 | Int J Cell Biol | pmid:20339581 |
Bramanti E et al. | Effects of hypericin on the structure and aggregation properties of β-amyloid peptides. | 2010 | Eur. Biophys. J. | pmid:20473492 |
Wang Y et al. | Hypericin prolongs action potential duration in hippocampal neurons by acting on K+ channels. | 2010 | Br. J. Pharmacol. | pmid:20233218 |
Vardapetyan HR et al. | Interaction between hypericin and hemoglobin. | 2010 | J. Photochem. Photobiol. B, Biol. | pmid:20634087 |
Tuna G et al. | Inhibition characteristics of hypericin on rat small intestine glutathione-S-transferases. | 2010 | Chem. Biol. Interact. | pmid:20637187 |
Berlanda J et al. | Comparative in vitro study on the characteristics of different photosensitizers employed in PDT. | 2010 | J. Photochem. Photobiol. B, Biol. | pmid:20599390 |
Wang X et al. | Cellular and molecular mechanisms of photodynamic hypericin therapy for nasopharyngeal carcinoma cells. | 2010 | J. Pharmacol. Exp. Ther. | pmid:20551295 |
da Conceição AO et al. | Effect of St. John's Wort standardized extract and hypericin on in vitro placental calcium transport. | 2010 | J Med Food | pmid:20553141 |
Boiy A et al. | Topical treatment of disseminated superficial actinic porokeratosis with hypericin-photodynamic therapy: a case report. | 2010 | Photodiagnosis Photodyn Ther | pmid:20510308 |
Chang Y and Wang SJ | Hypericin, the active component of St. John's wort, inhibits glutamate release in the rat cerebrocortical synaptosomes via a mitogen-activated protein kinase-dependent pathway. | 2010 | Eur. J. Pharmacol. | pmid:20193678 |
Aboukhatwa M et al. | Antidepressants are a rational complementary therapy for the treatment of Alzheimer's disease. | 2010 | Mol Neurodegener | pmid:20226030 |
Karppinen K et al. | Optimization of protein extraction from Hypericum perforatum tissues and immunoblotting detection of Hyp-1 at different stages of leaf development. | 2010 | Mol. Biotechnol. | pmid:20563670 |
Volak LP and Court MH | Role for protein kinase C delta in the functional activity of human UGT1A6: implications for drug-drug interactions between PKC inhibitors and UGT1A6. | 2010 | Xenobiotica | pmid:20196639 |
Canning S et al. | The efficacy of Hypericum perforatum (St John's wort) for the treatment of premenstrual syndrome: a randomized, double-blind, placebo-controlled trial. | 2010 | CNS Drugs | pmid:20155996 |
Prakash DJ et al. | Effect of nanohypericum (Hypericum perforatum gold nanoparticles) treatment on restraint stressinduced behavioral and biochemical alteration in male albino mice. | 2010 | Pharmacognosy Res | pmid:21713134 |
Lee SY et al. | TP53 regulates human AlkB homologue 2 expression in glioma resistance to Photofrin-mediated photodynamic therapy. | 2010 | Br. J. Cancer | pmid:20661249 |
Kumar A et al. | Effect of St. John's Wort (Hypericum perforatum) treatment on restraint stress-induced behavioral and biochemical alteration in mice. | 2010 | BMC Complement Altern Med | pmid:20459658 |
Verfaillie T et al. | Linking ER Stress to Autophagy: Potential Implications for Cancer Therapy. | 2010 | Int J Cell Biol | pmid:20145727 |
Cheng YW et al. | Proliferation of retinal pigment epithelial cells induced by (R,R)-XY-10 and (S,S)-XY-10 and their action mechanisms. | 2010 | Int J Ophthalmol | pmid:22553508 |
Devi VK et al. | Importance of novel drug delivery systems in herbal medicines. | 2010 | Pharmacogn Rev | pmid:22228938 |
Kello M et al. | PUFAs enhance oxidative stress and apoptosis in tumour cells exposed to hypericin-mediated PDT. | 2010 | Photochem. Photobiol. Sci. | pmid:20714672 |
Kim DS et al. | Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method. | 2010 | Healthc Inform Res | pmid:21818443 |
Chan PS et al. | Role of p38 MAPKs in hypericin photodynamic therapy-induced apoptosis of nasopharyngeal carcinoma cells. | 2009 Sep-Oct | Photochem. Photobiol. | pmid:19496992 |
Hager B et al. | Cationic hypericin derivatives as novel agents with photobactericidal activity: synthesis and photodynamic inactivation of Propionibacterium acnes. | 2009 Sep-Oct | Photochem. Photobiol. | pmid:19659921 |
Machado RA et al. | [Experimental study of vitreoretinal proliferation inhibition by the use of hypericin]. | 2009 Sep-Oct | Arq Bras Oftalmol | pmid:20027403 |
Theodossiou TA et al. | The multifaceted photocytotoxic profile of hypericin. | 2009 Nov-Dec | Mol. Pharm. | pmid:19739671 |
Gbur P et al. | Time-resolved luminescence and singlet oxygen formation after illumination of the hypericin-low-density lipoprotein complex. | 2009 May-Jun | Photochem. Photobiol. | pmid:19076308 |
Youssef T | Fluorescence study on the interaction between hypericin and lens protein "alpha-crystallin". | 2009 Jul-Aug | Photochem. Photobiol. | pmid:19175752 |
Alali FQ et al. | LC-MS and LC-PDA analysis of Hypericum empetrifolium and Hypericum sinaicum. | 2009 Jul-Aug | Z. Naturforsch., C, J. Biosci. | pmid:19791496 |
Liu J et al. | Study of interaction of hypericin and its pharmaceutical preparation by fluorescence techniques. | 2009 Jan-Feb | J Biomed Opt | pmid:19256691 |
Guo L et al. | Role of protein kinase C in 15-HETE-induced hypoxic pulmonary vasoconstriction. | 2009 Feb-Mar | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19186045 |
Bhuvaneswari R et al. | Targeting EGFR with photodynamic therapy in combination with Erbitux enhances in vivo bladder tumor response. | 2009 | Mol. Cancer | pmid:19878607 |
Karioti A et al. | Rapid and efficient purification of naphthodianthrones from St. John's wort extract by using liquid-liquid extraction and SEC. | 2009 | J Sep Sci | pmid:19360729 |
Zeisser-Labouèbe M et al. | Screening of nanoparticulate delivery systems for the photodetection of cancer in a simple and cost-effective model. | 2009 | Nanomedicine (Lond) | pmid:19193181 |
Stupáková V et al. | Photodynamic effect of hypericin in primary cultures of human umbilical endothelial cells and glioma cell lines. | 2009 | Phytother Res | pmid:19173218 |
Wang XD et al. | Impact of the haplotypes of the human pregnane X receptor gene on the basal and St John's wort-induced activity of cytochrome P450 3A4 enzyme. | 2009 | Br J Clin Pharmacol | pmid:19173680 |
De Saint-Hubert M et al. | Molecular imaging of cell death. | 2009 | Methods | pmid:19362149 |
Zeisser-Labouèbe M et al. | Benefits of nanoencapsulation for the hypercin-mediated photodetection of ovarian micrometastases. | 2009 | Eur J Pharm Biopharm | pmid:18977296 |
Karakas O et al. | Effects of different concentrations of benzylaminopurine on shoot regeneration and hypericin content in Hypericum triquetrifolium Turra. | 2009 | Nat. Prod. Res. | pmid:18985513 |
Hill K and Schaefer M | Ultraviolet light and photosensitising agents activate TRPA1 via generation of oxidative stress. | 2009 | Cell Calcium | pmid:18814910 |
Breitenbach T et al. | Photosensitized production of singlet oxygen: spatially-resolved optical studies in single cells. | 2009 | Photochem. Photobiol. Sci. | pmid:19337656 |
Zhou C et al. | The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism. | 2009 | Nucl Recept Signal | pmid:19240808 |
Sanovic R et al. | Time-resolved gene expression profiling of human squamous cell carcinoma cells during the apoptosis process induced by photodynamic treatment with hypericin. | 2009 | Int. J. Oncol. | pmid:19724930 |
Kusari S et al. | Light-independent metabolomics of endophytic Thielavia subthermophila provides insight into microbial hypericin biosynthesis. | 2009 | J. Nat. Prod. | pmid:19746917 |
Tadros MG et al. | Involvement of serotoninergic 5-HT1A/2A, alpha-adrenergic and dopaminergic D1 receptors in St. John's wort-induced prepulse inhibition deficit: a possible role of hyperforin. | 2009 | Behav. Brain Res. | pmid:19136030 |
Schneider-Yin X et al. | Hypericin and 5-aminolevulinic acid-induced protoporphyrin IX induce enhanced phototoxicity in human endometrial cancer cells with non-coherent white light. | 2009 | Photodiagnosis Photodyn Ther | pmid:19447367 |
Roelants M et al. | In vitro study of the photocytotoxicity of bathochromically-shifted hypericin derivatives. | 2009 | Photochem. Photobiol. Sci. | pmid:19492110 |
Shibata Y | Comment on "Hypericin uptake: a prognostic marker for survival in high-grade glioma". | 2009 | J Clin Neurosci | pmid:19595595 |
Davids LM et al. | Melanomas display increased cytoprotection to hypericin-mediated cytotoxicity through the induction of autophagy. | 2009 | Cell Biol. Int. | pmid:19596456 |
Zeisser-Labouèbe M et al. | Quenching-induced deactivation of photosensitizer by nanoencapsulation to improve phototherapy of cancer. | 2009 | J Drug Target | pmid:19589125 |
Lavialle F et al. | Nanovesicles released by Dictyostelium cells: a potential carrier for drug delivery. | 2009 | Int J Pharm | pmid:19589376 |
Sarris J and Kavanagh DJ | Kava and St. John's Wort: current evidence for use in mood and anxiety disorders. | 2009 | J Altern Complement Med | pmid:19614563 |
Kusari S et al. | Positive correlations between hypericin and putative precursors detected in the quantitative secondary metabolite spectrum of Hypericum. | 2009 | Phytochemistry | pmid:19683774 |
Ozmen A et al. | In vitro anti-neoplastic activity of the ethno-pharmaceutical plant Hypericum adenotrichum Spach endemic to Western Turkey. | 2009 | Oncol. Rep. | pmid:19724864 |
Booth JN and McGwin G | The association between self-reported cataracts and St. John's Wort. | 2009 | Curr. Eye Res. | pmid:19895314 |
Jendzelovský R et al. | Drug efflux transporters, MRP1 and BCRP, affect the outcome of hypericin-mediated photodynamic therapy in HT-29 adenocarcinoma cells. | 2009 | Photochem. Photobiol. Sci. | pmid:20024169 |
Mikes J et al. | The role of p53 in the efficiency of photodynamic therapy with hypericin and subsequent long-term survival of colon cancer cells. | 2009 | Photochem. Photobiol. Sci. | pmid:19862414 |
Thong PS et al. | Clinical application of fluorescence endoscopic imaging using hypericin for the diagnosis of human oral cavity lesions. | 2009 | Br. J. Cancer | pmid:19809432 |
Hölscher D et al. | Matrix-free UV-laser desorption/ionization (LDI) mass spectrometric imaging at the single-cell level: distribution of secondary metabolites of Arabidopsis thaliana and Hypericum species. | 2009 | Plant J. | pmid:19732382 |
Maury W et al. | Identification of light-independent inhibition of human immunodeficiency virus-1 infection through bioguided fractionation of Hypericum perforatum. | 2009 | Virol. J. | pmid:19594941 |
Hecka A et al. | Study of active naphtodianthrone St John's Wort compounds by electrospray ionization Fourier transform ion cyclotron resonance and multi-stage mass spectrometry in sustained off-resonance irradiation collision-induced dissociation and infrared multiphoton dissociation modes. | 2009 | Rapid Commun. Mass Spectrom. | pmid:19224526 |
Ho YF et al. | Lipid-mediated preferential localization of hypericin in lipid membranes. | 2009 | Biochim. Biophys. Acta | pmid:19366588 |
Cirak C et al. | Chemical constituents of Hypericum adenotrichum Spach, an endemic Turkish species. | 2009 | Nat. Prod. Res. | pmid:19731137 |
Kurihara T et al. | Retinal phototoxicity in a novel murine model of intraocular lens implantation. | 2009 | Mol. Vis. | pmid:20019883 |
Wildeman MA et al. | Photodynamic therapy in the therapy for recurrent/persistent nasopharyngeal cancer. | 2009 | Head Neck Oncol | pmid:20017928 |
Gao Q et al. | PKC alpha affects cell cycle progression and proliferation in human RPE cells through the downregulation of p27kip1. | 2009 | Mol. Vis. | pmid:20011080 |
Borrelli F and Izzo AA | Herb-drug interactions with St John's wort (Hypericum perforatum): an update on clinical observations. | 2009 | AAPS J | pmid:19859815 |
Fornaro M et al. | Medicine and psychiatry in Western culture: Ancient Greek myths and modern prejudices. | 2009 | Ann Gen Psychiatry | pmid:19811642 |
Wright KE et al. | Peripheral neural cell sensitivity to mTHPC-mediated photodynamic therapy in a 3D in vitro model. | 2009 | Br. J. Cancer | pmid:19638975 |
Witjes JA | Topic issue on new treatments in bladder cancer. | 2009 | World J Urol | pmid:19229539 |
Galanou MC et al. | Interactive transport, subcellular relocation and enhanced phototoxicity of hypericin encapsulated in guanidinylated liposomes via molecular recognition. | 2008 Sep-Oct | Photochem. Photobiol. | pmid:18627515 |
Kah JC et al. | Endoscopic image analysis of photosensitizer fluorescence as a promising noninvasive approach for pathological grading of bladder cancer in situ. | 2008 Sep-Oct | J Biomed Opt | pmid:19021402 |
Kubin A et al. | Fluorescence diagnosis of bladder cancer with new water soluble hypericin bound to polyvinylpyrrolidone: PVP-hypericin. | 2008 Nov-Dec | Photochem. Photobiol. | pmid:18627521 |
Kacerovská D et al. | Photodynamic therapy of nonmelanoma skin cancer with topical hypericum perforatum extract--a pilot study. | 2008 May-Jun | Photochem. Photobiol. | pmid:18179625 |
Mukherjee P et al. | Accumulation and interaction of hypericin in low-density lipoprotein--a photophysical study. | 2008 May-Jun | Photochem. Photobiol. | pmid:18435618 |
Ritz R et al. | Subcellular colocalization of hypericin with respect to endoplasmic reticulum and Golgi apparatus in glioblastoma cells. | 2008 Jul-Aug | Anticancer Res. | pmid:18751371 |
Kascakova S et al. | High level of low-density lipoprotein receptors enhance hypericin uptake by U-87 MG cells in the presence of LDL. | 2008 Jan-Feb | Photochem. Photobiol. | pmid:18173711 |
Wessels JT et al. | Photosensitizing and radiosensitizing effects of hypericin on human renal carcinoma cells in vitro. | 2008 Jan-Feb | Photochem. Photobiol. | pmid:18173725 |
Li S et al. | Chemical markers for the quality control of herbal medicines: an overview. | 2008 | Chin Med | pmid:18588699 |
Sgarbossa A et al. | In vitro perturbation of aggregation processes in beta-amyloid peptides: a spectroscopic study. | 2008 | FEBS Lett. | pmid:18805418 |
Theodossiou TA et al. | Molecular modeling and experimental evidence for hypericin as a substrate for mitochondrial complex III; mitochondrial photodamage as demonstrated using specific inhibitors. | 2008 | Free Radic. Biol. Med. | pmid:18852042 |
Xenophontos M et al. | Influence of the habitat altitude on the (proto)hypericin and (proto)pseudohypericin levels of hypericum plants from Crete. | 2008 | Planta Med. | pmid:18671196 |
Minnes R et al. | The effect of solution electrolytes on the uptake of photosensitizers by liposomal membranes: a salting-out effect. | 2008 | Chem. Phys. Lipids | pmid:18606157 |
Van de Putte M et al. | Hypericin as a marker for determination of tissue viability after intratumoral ethanol injection in a murine liver tumor model. | 2008 | Acad Radiol | pmid:18078913 |
Boiy A et al. | Photosensitizing activity of hypericin and hypericin acetate after topical application on normal mouse skin. | 2008 | Br. J. Dermatol. | pmid:18047507 |
Zhao J et al. | Photodynamic effect of hypericin on the conformation and catalytic activity of hemoglobin. | 2008 | Int J Mol Sci | pmid:19325739 |
Aleisa AM | Cytological and biochemical effects of St. John's Wort supplement (a complex mixture of St. John's Wort, Rosemary and Spirulina) on somatic and germ cells of Swiss Albino mice. | 2008 | Int J Environ Res Public Health | pmid:19151436 |
Guo X et al. | Increased p38-MAPK is responsible for chemotherapy resistance in human gastric cancer cells. | 2008 | BMC Cancer | pmid:19091131 |
Radauer C et al. | The Bet v 1 fold: an ancient, versatile scaffold for binding of large, hydrophobic ligands. | 2008 | BMC Evol. Biol. | pmid:18922149 |
Morgan AJ and Jorm AF | Self-help interventions for depressive disorders and depressive symptoms: a systematic review. | 2008 | Ann Gen Psychiatry | pmid:18710579 |
Solár P et al. | Erythropoietin inhibits apoptosis induced by photodynamic therapy in ovarian cancer cells. | 2008 | Mol. Cancer Ther. | pmid:18687658 |
Clauson KA et al. | Clinically relevant safety issues associated with St. John's wort product labels. | 2008 | BMC Complement Altern Med | pmid:18637192 |
Weber W et al. | Hypericum perforatum (St John's wort) for attention-deficit/hyperactivity disorder in children and adolescents: a randomized controlled trial. | 2008 | JAMA | pmid:18544723 |