hypericin is a lipid of Polyketides (PK) class. Hypericin is associated with abnormalities such as Dermatitis, Phototoxic, Dehydration, Photosensitization, Morphologically altered structure and Myocardial Infarction. The involved functions are known as Cell Cycle Checkpoints, Apoptosis, Acetylation, Cell Survival and Caspase Activation. Hypericin often locates in insoluble fraction, Cytoplasmic matrix, Protoplasm, Tissue membrane and Cytoplasm. The associated genes with hypericin are CDC37 gene, HSPA8 gene, RAF1 gene, cyclin H and FK228. The related lipids are Phosphatidylserines.
To understand associated biological information of hypericin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
hypericin is suspected in Dermatitis, Phototoxic, Photosensitization, Pneumonia, Psoriasis, Phototoxicity, Chronic infectious disease and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with hypericin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Theodossiou TA et al. | The diverse roles of glutathione-associated cell resistance against hypericin photodynamic therapy. | 2017 | Redox Biol | pmid:28254657 |
Misuth M et al. | The flashlights on a distinct role of protein kinase C δ: Phosphorylation of regulatory and catalytic domain upon oxidative stress in glioma cells. | 2017 | Cell. Signal. | pmid:28237688 |
Lazzara S et al. | Arbuscular mycorrhizal fungi altered the hypericin, pseudohypericin, and hyperforin content in flowers of Hypericum perforatum grown under contrasting P availability in a highly organic substrate. | 2017 | Mycorrhiza | pmid:27999964 |
Li X et al. | Hypericin-mediated sonodynamic therapy induces autophagy and decreases lipids in THP-1 macrophage by promoting ROS-dependent nuclear translocation of TFEB. | 2016 | Cell Death Dis | pmid:28005078 |
Miranda Cona M et al. | Differential diagnosis of gallstones by using hypericin as a fluorescent optical imaging agent. | 2016 | World J. Gastroenterol. | pmid:27547012 |
Singh S and Dubey VK | Quantitative Proteome Analysis of Leishmania donovani under Spermidine Starvation. | 2016 | PLoS ONE | pmid:27123864 |
Wang Q et al. | Discovery of Radioiodinated Monomeric Anthraquinones as a Novel Class of Necrosis Avid Agents for Early Imaging of Necrotic Myocardium. | 2016 | Sci Rep | pmid:26878909 |
Zhang M et al. | Hypericin inhibits oligomeric amyloid β42-induced inflammation response in microglia and ameliorates cognitive deficits in an amyloid β injection mouse model of Alzheimer's disease by suppressing MKL1. | 2016 | Biochem. Biophys. Res. Commun. | pmid:27825966 |
BurÃková M et al. | Hypericin fluorescence kinetics in the presence of low density lipoproteins: study on quail CAM assay for topical delivery. | 2016 | Gen. Physiol. Biophys. | pmid:27447402 |
Maslaňáková M et al. | Anti- and Pro-apoptotic Bcl2 Proteins Distribution and Metabolic Profile in Human Coronary Aorta Endothelial Cells Before and After HypPDT. | 2016 | Cell Biochem. Biophys. | pmid:27314518 |