hypericin is a lipid of Polyketides (PK) class. Hypericin is associated with abnormalities such as Dermatitis, Phototoxic, Dehydration, Photosensitization, Morphologically altered structure and Myocardial Infarction. The involved functions are known as Cell Cycle Checkpoints, Apoptosis, Acetylation, Cell Survival and Caspase Activation. Hypericin often locates in insoluble fraction, Cytoplasmic matrix, Protoplasm, Tissue membrane and Cytoplasm. The associated genes with hypericin are CDC37 gene, HSPA8 gene, RAF1 gene, cyclin H and FK228. The related lipids are Phosphatidylserines.
To understand associated biological information of hypericin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
hypericin is suspected in Dermatitis, Phototoxic, Photosensitization, Pneumonia, Psoriasis, Phototoxicity, Chronic infectious disease and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with hypericin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Kako MD et al. | Studies of sheep experimentally poisoned with Hypericum perforatum. | 1993 | Vet Hum Toxicol | pmid:8236746 |
Angerhofer A et al. | Lowest excited triplet states of hypericin and isohypericin. | 1993 | J. Photochem. Photobiol. B, Biol. | pmid:8271114 |
Diwu Z and Lown JW | Photosensitization with anticancer agents. 17. EPR studies of photodynamic action of hypericin: formation of semiquinone radical and activated oxygen species on illumination. | 1993 | Free Radic. Biol. Med. | pmid:8381107 |
Stevenson NR and Lenard J | Antiretroviral activities of hypericin and rose bengal: photodynamic effects on Friend leukemia virus infection of mice. | 1993 | Antiviral Res. | pmid:8338350 |
Hudson JB et al. | The importance of light in the anti-HIV effect of hypericin. | 1993 | Antiviral Res. | pmid:8460933 |
Lenard J et al. | Photodynamic inactivation of infectivity of human immunodeficiency virus and other enveloped viruses using hypericin and rose bengal: inhibition of fusion and syncytia formation. | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7678335 |
Moraleda G et al. | Inhibition of duck hepatitis B virus replication by hypericin. | 1993 | Antiviral Res. | pmid:8470884 |
Degar S et al. | Photodynamic inactivation of radiation leukemia virus produced from hypericin-treated cells. | 1993 | Virology | pmid:7504371 |
Couldwell WT et al. | Hypericin: a potential antiglioma therapy. | 1994 | Neurosurgery | pmid:7808614 |
Senthil V et al. | Hypericin photosensitization in aqueous model systems. | 1994 | Photochem. Photobiol. | pmid:8127939 |