| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cataract | D002386 | 34 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Neoplasm Recurrence, Local | D009364 | 5 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Hypersensitivity | D006967 | 22 associated lipids |
| Osteolysis | D010014 | 8 associated lipids |
| Brain Neoplasms | D001932 | 15 associated lipids |
hypericin
hypericin is a lipid of Polyketides (PK) class. Hypericin is associated with abnormalities such as Dermatitis, Phototoxic, Dehydration, Photosensitization, Morphologically altered structure and Myocardial Infarction. The involved functions are known as Cell Cycle Checkpoints, Apoptosis, Acetylation, Cell Survival and Caspase Activation. Hypericin often locates in insoluble fraction, Cytoplasmic matrix, Protoplasm, Tissue membrane and Cytoplasm. The associated genes with hypericin are CDC37 gene, HSPA8 gene, RAF1 gene, cyclin H and FK228. The related lipids are Phosphatidylserines.
Cross Reference
Introduction
To understand associated biological information of hypericin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with hypericin?
hypericin is suspected in Dermatitis, Phototoxic, Photosensitization, Pneumonia, Psoriasis, Phototoxicity, Chronic infectious disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with hypericin
PubChem Associated disorders and diseases
What pathways are associated with hypericin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with hypericin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with hypericin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with hypericin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with hypericin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with hypericin?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with hypericin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Dresler S et al. | Methodological aspects of biologically active compounds quantification in the genus Hypericum. | 2018 | J Pharm Biomed Anal | pmid:29621655 |
| Shih CM et al. | Hypericin inhibits hepatitis C virus replication via deacetylation and down-regulation of heme oxygenase-1. | 2018 | Phytomedicine | pmid:30097118 |
| Shao C et al. | Facile fabrication of hypericin-entrapped glyconanoparticles for targeted photodynamic therapy. | 2018 | Int J Nanomedicine | pmid:30087563 |
| Geng C et al. | Sonodynamic therapy: A potential treatment for atherosclerosis. | 2018 | Life Sci. | pmid:29940244 |
| Lopera AA et al. | Solution-combustion synthesis of doped TiO compounds and its potential antileishmanial activity mediated by photodynamic therapy. | 2018 | J. Photochem. Photobiol. B, Biol. | pmid:29689488 |
| Vargová J et al. | Hypericin affects cancer side populations via competitive inhibition of BCRP. | 2018 | Biomed. Pharmacother. | pmid:29665654 |
| Dalmizrak O et al. | Mechanistic and structural insights into the in vitro inhibitory action of hypericin on glutathione reductase purified from baker's yeast. | 2018 | J. Biochem. Mol. Toxicol. | pmid:29660796 |
| Kimáková K et al. | Relation between hypericin content and morphometric leaf parameters in Hypericum spp.: A case of cubic degree polynomial function. | 2018 | Plant Sci. | pmid:29650162 |
| Xu F et al. | Yield enhancement strategies of rare pharmaceutical metabolites from endophytes. | 2018 | Biotechnol. Lett. | pmid:29605937 |
| You MK et al. | St. John's Wort Regulates Proliferation and Apoptosis in MCF-7 Human Breast Cancer Cells by Inhibiting AMPK/mTOR and Activating the Mitochondrial Pathway. | 2018 | Int J Mol Sci | pmid:29570671 |
| Herraiz T and Guillén H | Monoamine Oxidase-A Inhibition and Associated Antioxidant Activity in Plant Extracts with Potential Antidepressant Actions. | 2018 | Biomed Res Int | pmid:29568754 |
| Keša P et al. | Excitation of triplet states of hypericin in water mediated by hydrotropic cromolyn sodium salt. | 2018 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:29241053 |
| Lopera AA et al. | Synthesis of calcium phosphate nanostructures by combustion in solution as a potential encapsulant system of drugs with photodynamic properties for the treatment of cutaneous leishmaniasis. | 2018 | Photodiagnosis Photodyn Ther | pmid:29198762 |
| Roschger C et al. | Reduction of cancer cell viability by synergistic combination of photodynamic treatment with the inhibition of the Id protein family. | 2018 | J. Photochem. Photobiol. B, Biol. | pmid:29245122 |
| Zhang JN et al. | Effect of photodynamic inactivation of Escherichia coli by hypericin. | 2018 | World J. Microbiol. Biotechnol. | pmid:29926201 |
| Li ZH et al. | Topically applied hypericin exhibits skin penetrability on nude mice. | 2018 | Lasers Med Sci | pmid:29915976 |
| Valletta E et al. | Distinct Hypericum perforatum L. total extracts exert different antitumour activity on erythroleukemic K562 cells. | 2018 | Phytother Res | pmid:29785769 |
| Abma E et al. | Biodistribution and tolerance of intravenous iodine-131-labelled hypericin in healthy dogs. | 2018 | Vet Comp Oncol | pmid:29314561 |
| Misuth M et al. | The flashlights on a distinct role of protein kinase C δ: Phosphorylation of regulatory and catalytic domain upon oxidative stress in glioma cells. | 2017 | Cell. Signal. | pmid:28237688 |
| Lazzara S et al. | Arbuscular mycorrhizal fungi altered the hypericin, pseudohypericin, and hyperforin content in flowers of Hypericum perforatum grown under contrasting P availability in a highly organic substrate. | 2017 | Mycorrhiza | pmid:27999964 |