| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cataract | D002386 | 34 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Neoplasm Recurrence, Local | D009364 | 5 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Hypersensitivity | D006967 | 22 associated lipids |
| Osteolysis | D010014 | 8 associated lipids |
| Brain Neoplasms | D001932 | 15 associated lipids |
hypericin
hypericin is a lipid of Polyketides (PK) class. Hypericin is associated with abnormalities such as Dermatitis, Phototoxic, Dehydration, Photosensitization, Morphologically altered structure and Myocardial Infarction. The involved functions are known as Cell Cycle Checkpoints, Apoptosis, Acetylation, Cell Survival and Caspase Activation. Hypericin often locates in insoluble fraction, Cytoplasmic matrix, Protoplasm, Tissue membrane and Cytoplasm. The associated genes with hypericin are CDC37 gene, HSPA8 gene, RAF1 gene, cyclin H and FK228. The related lipids are Phosphatidylserines.
Cross Reference
Introduction
To understand associated biological information of hypericin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with hypericin?
hypericin is suspected in Dermatitis, Phototoxic, Photosensitization, Pneumonia, Psoriasis, Phototoxicity, Chronic infectious disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with hypericin
PubChem Associated disorders and diseases
What pathways are associated with hypericin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with hypericin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with hypericin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with hypericin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with hypericin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with hypericin?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with hypericin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Huntosova V et al. | Assessing light-independent effects of hypericin on cell viability, ultrastructure and metabolism in human glioma and endothelial cells. | 2017 | Toxicol In Vitro | pmid:28087315 |
| Ng QX et al. | Clinical use of Hypericum perforatum (St John's wort) in depression: A meta-analysis. | 2017 | J Affect Disord | pmid:28064110 |
| Kimáková P et al. | Photoactivated hypericin increases the expression of SOD-2 and makes MCF-7 cells resistant to photodynamic therapy. | 2017 | Biomed. Pharmacother. | pmid:27923686 |
| Zhang M et al. | Hypericin inhibits oligomeric amyloid β42-induced inflammation response in microglia and ameliorates cognitive deficits in an amyloid β injection mouse model of Alzheimer's disease by suppressing MKL1. | 2016 | Biochem. Biophys. Res. Commun. | pmid:27825966 |
| BurÃková M et al. | Hypericin fluorescence kinetics in the presence of low density lipoproteins: study on quail CAM assay for topical delivery. | 2016 | Gen. Physiol. Biophys. | pmid:27447402 |
| Maslaňáková M et al. | Anti- and Pro-apoptotic Bcl2 Proteins Distribution and Metabolic Profile in Human Coronary Aorta Endothelial Cells Before and After HypPDT. | 2016 | Cell Biochem. Biophys. | pmid:27314518 |
| Šemeláková M et al. | Drug membrane transporters and CYP3A4 are affected by hypericin, hyperforin or aristoforin in colon adenocarcinoma cells. | 2016 | Biomed. Pharmacother. | pmid:27261575 |
| Gyurászová K et al. | YM155, a small molecule inhibitor of survivin expression, sensitizes cancer cells to hypericin-mediated photodynamic therapy. | 2016 | Photochem. Photobiol. Sci. | pmid:27241169 |
| Singh RK et al. | Construction of Hypericin Gland-Specific cDNA Library via Suppression Subtractive Hybridization. | 2016 | Methods Mol. Biol. | pmid:27108327 |
| Bruňáková K and Čellárová E | Shoot Tip Meristem Cryopreservation of Hypericum Species. | 2016 | Methods Mol. Biol. | pmid:27108308 |
| Dementavicius D et al. | Application of mathematical models for bacterial inactivation curves using Hypericin-based photosensitization. | 2016 | J. Appl. Microbiol. | pmid:26972682 |
| Verebova V et al. | Deeper insights into the drug defense of glioma cells against hydrophobic molecules. | 2016 | Int J Pharm | pmid:26940808 |
| Garg AD et al. | Dendritic cell vaccines based on immunogenic cell death elicit danger signals and T cell-driven rejection of high-grade glioma. | 2016 | Sci Transl Med | pmid:26936504 |
| Feruszová J et al. | Photoactivated hypericin is not genotoxic. | 2016 | Gen. Physiol. Biophys. | pmid:26891274 |
| KucharÃková A et al. | Interspecific variation in localization of hypericins and phloroglucinols in the genus Hypericum as revealed by desorption electrospray ionization mass spectrometry imaging. | 2016 | Physiol Plant | pmid:26822391 |
| Lin S et al. | Enhancement of oxaliplatin sensitivity in human colorectal cancer by hypericin mediated photodynamic therapy via ROS-related mechanism. | 2016 | Int. J. Biochem. Cell Biol. | pmid:26673998 |
| Florea AM et al. | An innovative approach to prepare hypericin molecularly imprinted pearls using a "phyto-template". | 2016 | Talanta | pmid:26653421 |
| Silva SM et al. | Effects of Hypericum perforatum extract and its main bioactive compounds on the cytotoxicity and expression of CYP1A2 and CYP2D6 in hepatic cells. | 2016 | Life Sci. | pmid:26612349 |
| Zhang D et al. | Effects of skeleton structure on necrosis targeting and clearance properties of radioiodinated dianthrones. | 2016 | J Drug Target | pmid:26586010 |
| Hu W et al. | Fluorescence Detection of DNA Based on Non-covalent π-π Stacking Interaction between 1-Pyrenebutanoic Acid and Hypericin. | 2016 | Anal Sci | pmid:27169651 |