| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cataract | D002386 | 34 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Neoplasm Recurrence, Local | D009364 | 5 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Hypersensitivity | D006967 | 22 associated lipids |
| Osteolysis | D010014 | 8 associated lipids |
| Brain Neoplasms | D001932 | 15 associated lipids |
hypericin
hypericin is a lipid of Polyketides (PK) class. Hypericin is associated with abnormalities such as Dermatitis, Phototoxic, Dehydration, Photosensitization, Morphologically altered structure and Myocardial Infarction. The involved functions are known as Cell Cycle Checkpoints, Apoptosis, Acetylation, Cell Survival and Caspase Activation. Hypericin often locates in insoluble fraction, Cytoplasmic matrix, Protoplasm, Tissue membrane and Cytoplasm. The associated genes with hypericin are CDC37 gene, HSPA8 gene, RAF1 gene, cyclin H and FK228. The related lipids are Phosphatidylserines.
Cross Reference
Introduction
To understand associated biological information of hypericin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with hypericin?
hypericin is suspected in Dermatitis, Phototoxic, Photosensitization, Pneumonia, Psoriasis, Phototoxicity, Chronic infectious disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with hypericin
PubChem Associated disorders and diseases
What pathways are associated with hypericin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with hypericin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with hypericin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with hypericin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with hypericin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with hypericin?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with hypericin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kirakosyan A et al. | Stimulation of the production of hypericins by mannan in Hypericum perforatum shoot cultures. | 2000 | Phytochemistry | pmid:10703055 |
| Lavie G et al. | Inhibition of the CD8+ T cell-mediated cytotoxicity reaction by hypericin: potential for treatment of T cell-mediated diseases. | 2000 | Int. Immunol. | pmid:10744649 |
| Lee KT et al. | Hypericin induces both differentiation and apoptosis in human promyelocytic leukemia HL-60 cells. | 1999 | Biol. Pharm. Bull. | pmid:10746153 |
| Chen B and de Witte PA | Photodynamic therapy efficacy and tissue distribution of hypericin in a mouse P388 lymphoma tumor model. | 2000 | Cancer Lett. | pmid:10755394 |
| Vandenbogaerde A et al. | Evidence that total extract of Hypericum perforatum affects exploratory behavior and exerts anxiolytic effects in rats. | 2000 | Pharmacol. Biochem. Behav. | pmid:10764915 |
| Puchner MJ and Giese A | Tamoxifen-resistant glioma-cell sub-populations are characterized by increased migration and proliferation. | 2000 | Int. J. Cancer | pmid:10797257 |
| Geng Y et al. | Chlamydia pneumoniae inhibits apoptosis in human peripheral blood mononuclear cells through induction of IL-10. | 2000 | J. Immunol. | pmid:10799921 |
| Agostinis P et al. | Apoptotic and anti-apoptotic signaling pathways induced by photodynamic therapy with hypericin. | 2000 | Adv. Enzyme Regul. | pmid:10828351 |
| Colasanti A et al. | Hypericin photosensitization of tumor and metastatic cell lines of human prostate. | 2000 | J. Photochem. Photobiol. B, Biol. | pmid:10836538 |
| Moore LB et al. | St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10852961 |