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Methodological aspects of biologically active compounds quantification in the genus Hypericum. |
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J Pharm Biomed Anal |
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Hypericin inhibits hepatitis C virus replication via deacetylation and down-regulation of heme oxygenase-1. |
2018 |
Phytomedicine |
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Facile fabrication of hypericin-entrapped glyconanoparticles for targeted photodynamic therapy. |
2018 |
Int J Nanomedicine |
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Life Sci. |
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Solution-combustion synthesis of doped TiO compounds and its potential antileishmanial activity mediated by photodynamic therapy. |
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J. Photochem. Photobiol. B, Biol. |
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Hypericin affects cancer side populations via competitive inhibition of BCRP. |
2018 |
Biomed. Pharmacother. |
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Mechanistic and structural insights into the in vitro inhibitory action of hypericin on glutathione reductase purified from baker's yeast. |
2018 |
J. Biochem. Mol. Toxicol. |
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St. John's Wort Regulates Proliferation and Apoptosis in MCF-7 Human Breast Cancer Cells by Inhibiting AMPK/mTOR and Activating the Mitochondrial Pathway. |
2018 |
Int J Mol Sci |
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Monoamine Oxidase-A Inhibition and Associated Antioxidant Activity in Plant Extracts with Potential Antidepressant Actions. |
2018 |
Biomed Res Int |
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2018 |
Spectrochim Acta A Mol Biomol Spectrosc |
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Synthesis of calcium phosphate nanostructures by combustion in solution as a potential encapsulant system of drugs with photodynamic properties for the treatment of cutaneous leishmaniasis. |
2018 |
Photodiagnosis Photodyn Ther |
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2018 |
J. Photochem. Photobiol. B, Biol. |
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Effect of photodynamic inactivation of Escherichia coli by hypericin. |
2018 |
World J. Microbiol. Biotechnol. |
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Topically applied hypericin exhibits skin penetrability on nude mice. |
2018 |
Lasers Med Sci |
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2018 |
Phytother Res |
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2018 |
Vet Comp Oncol |
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2017 |
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2017 |
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2017 |
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2017 |
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Assessing light-independent effects of hypericin on cell viability, ultrastructure and metabolism in human glioma and endothelial cells. |
2017 |
Toxicol In Vitro |
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Clinical use of Hypericum perforatum (St John's wort) in depression: A meta-analysis. |
2017 |
J Affect Disord |
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Photoactivated hypericin increases the expression of SOD-2 and makes MCF-7 cells resistant to photodynamic therapy. |
2017 |
Biomed. Pharmacother. |
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A combination of photodynamic therapy and chemotherapy displays a differential cytotoxic effect on human metastatic melanoma cells. |
2017 |
J. Photochem. Photobiol. B, Biol. |
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Semi-synthesis and PDT activities of a new amphiphilic chlorin derivative. |
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Photodiagnosis Photodyn Ther |
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Estimation of PKCδ autophosphorylation in U87 MG glioma cells: combination of experimental, conceptual and numerical approaches. |
2017 |
J Biophotonics |
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Synergism between PKCδ regulators hypericin and rottlerin enhances apoptosis in U87 MG glioma cells after light stimulation. |
2017 |
Photodiagnosis Photodyn Ther |
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Histone deacetylase inhibitors potentiate photodynamic therapy in colon cancer cells marked by chromatin-mediated epigenetic regulation of . |
2017 |
Clin Epigenetics |
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Susceptibility of Melanoma Skin Cancer to Photoactivated Hypericin versus Aluminium(III) Phthalocyanine Chloride Tetrasulphonate. |
2017 |
Biomed Res Int |
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Hypericin cytotoxicity in tumor and non-tumor cell lines: A chemometric study. |
2017 |
Photodiagnosis Photodyn Ther |
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Phototoxicity in a laryngeal cancer cell line enhanced by a targeting amphiphilic chlorin photosensitizer. |
2017 |
Photodiagnosis Photodyn Ther |
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Preparation and characterization of bioadhesive system containing hypericin for local photodynamic therapy. |
2017 |
Photodiagnosis Photodyn Ther |
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One-pot method to prepare a theranostic nanosystem with magnetic resonance imaging function and anticancer activity through multiple mechanisms. |
2017 |
Dalton Trans |
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Deciphering the photosensitization mechanisms of hypericin towards biological membranes. |
2017 |
Phys Chem Chem Phys |
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Analysis of Hypericin-Mediated Effects and Implications for Targeted Photodynamic Therapy. |
2017 |
Int J Mol Sci |
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Radioiodinated hypericin disulfonic acid sodium salts as a DNA-binding probe for early imaging of necrotic myocardium. |
2017 |
Eur J Pharm Biopharm |
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The diverse roles of glutathione-associated cell resistance against hypericin photodynamic therapy. |
2017 |
Redox Biol |
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The flashlights on a distinct role of protein kinase C δ: Phosphorylation of regulatory and catalytic domain upon oxidative stress in glioma cells. |
2017 |
Cell. Signal. |
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Arbuscular mycorrhizal fungi altered the hypericin, pseudohypericin, and hyperforin content in flowers of Hypericum perforatum grown under contrasting P availability in a highly organic substrate. |
2017 |
Mycorrhiza |
pmid:27999964
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Optimized and Validated HPLC Analysis of St. John's Wort Extract and Final Products by Simultaneous Determination of Major Ingredients. |
2017 |
J Chromatogr Sci |
pmid:28472287
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Li X et al. |
Hypericin-mediated sonodynamic therapy induces autophagy and decreases lipids in THP-1 macrophage by promoting ROS-dependent nuclear translocation of TFEB. |
2016 |
Cell Death Dis |
pmid:28005078
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Differential diagnosis of gallstones by using hypericin as a fluorescent optical imaging agent. |
2016 |
World J. Gastroenterol. |
pmid:27547012
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Singh S and Dubey VK |
Quantitative Proteome Analysis of Leishmania donovani under Spermidine Starvation. |
2016 |
PLoS ONE |
pmid:27123864
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Discovery of Radioiodinated Monomeric Anthraquinones as a Novel Class of Necrosis Avid Agents for Early Imaging of Necrotic Myocardium. |
2016 |
Sci Rep |
pmid:26878909
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Hypericin inhibits oligomeric amyloid β42-induced inflammation response in microglia and ameliorates cognitive deficits in an amyloid β injection mouse model of Alzheimer's disease by suppressing MKL1. |
2016 |
Biochem. Biophys. Res. Commun. |
pmid:27825966
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Hypericin fluorescence kinetics in the presence of low density lipoproteins: study on quail CAM assay for topical delivery. |
2016 |
Gen. Physiol. Biophys. |
pmid:27447402
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Anti- and Pro-apoptotic Bcl2 Proteins Distribution and Metabolic Profile in Human Coronary Aorta Endothelial Cells Before and After HypPDT. |
2016 |
Cell Biochem. Biophys. |
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Drug membrane transporters and CYP3A4 are affected by hypericin, hyperforin or aristoforin in colon adenocarcinoma cells. |
2016 |
Biomed. Pharmacother. |
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YM155, a small molecule inhibitor of survivin expression, sensitizes cancer cells to hypericin-mediated photodynamic therapy. |
2016 |
Photochem. Photobiol. Sci. |
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Construction of Hypericin Gland-Specific cDNA Library via Suppression Subtractive Hybridization. |
2016 |
Methods Mol. Biol. |
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Bruňáková K and Čellárová E |
Shoot Tip Meristem Cryopreservation of Hypericum Species. |
2016 |
Methods Mol. Biol. |
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Application of mathematical models for bacterial inactivation curves using Hypericin-based photosensitization. |
2016 |
J. Appl. Microbiol. |
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Deeper insights into the drug defense of glioma cells against hydrophobic molecules. |
2016 |
Int J Pharm |
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Dendritic cell vaccines based on immunogenic cell death elicit danger signals and T cell-driven rejection of high-grade glioma. |
2016 |
Sci Transl Med |
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Photoactivated hypericin is not genotoxic. |
2016 |
Gen. Physiol. Biophys. |
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Interspecific variation in localization of hypericins and phloroglucinols in the genus Hypericum as revealed by desorption electrospray ionization mass spectrometry imaging. |
2016 |
Physiol Plant |
pmid:26822391
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Enhancement of oxaliplatin sensitivity in human colorectal cancer by hypericin mediated photodynamic therapy via ROS-related mechanism. |
2016 |
Int. J. Biochem. Cell Biol. |
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An innovative approach to prepare hypericin molecularly imprinted pearls using a "phyto-template". |
2016 |
Talanta |
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Effects of Hypericum perforatum extract and its main bioactive compounds on the cytotoxicity and expression of CYP1A2 and CYP2D6 in hepatic cells. |
2016 |
Life Sci. |
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Effects of skeleton structure on necrosis targeting and clearance properties of radioiodinated dianthrones. |
2016 |
J Drug Target |
pmid:26586010
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Synthesis and Preclinical Evaluation of Radioiodinated Hypericin Dicarboxylic Acid as a Necrosis Avid Agent in Rat Models of Induced Hepatic, Muscular, and Myocardial Necroses. |
2016 |
Mol. Pharm. |
pmid:26568406
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Li Y et al. |
Co-delivery of siRNA and hypericin into cancer cells by hyaluronic acid modified PLGA-PEI nanoparticles. |
2016 |
Drug Dev Ind Pharm |
pmid:26472259
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Hu W et al. |
Fluorescence Detection of DNA Based on Non-covalent π-π Stacking Interaction between 1-Pyrenebutanoic Acid and Hypericin. |
2016 |
Anal Sci |
pmid:27169651
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Gao L et al. |
Improved therapeutic outcomes of thermal ablation on rat orthotopic liver allograft sarcoma models by radioiodinated hypericin induced necrosis targeted radiotherapy. |
2016 |
Oncotarget |
pmid:27285983
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Zhang Q et al. |
Hypericin-photodynamic therapy induces human umbilical vein endothelial cell apoptosis. |
2015 |
Sci Rep |
pmid:26673286
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Unterweger H et al. |
Hypericin-bearing magnetic iron oxide nanoparticles for selective drug delivery in photodynamic therapy. |
2015 |
Int J Nanomedicine |
pmid:26648714
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Xu Y et al. |
Hypericin-mediated photodynamic therapy induces apoptosis in K562 human leukemia cells through JNK pathway modulation. |
2015 |
Mol Med Rep |
pmid:26330116
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Garg AD et al. |
Resistance to anticancer vaccination effect is controlled by a cancer cell-autonomous phenotype that disrupts immunogenic phagocytic removal. |
2015 |
Oncotarget |
pmid:26314964
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Furuta A et al. |
Identification of Hydroxyanthraquinones as Novel Inhibitors of Hepatitis C Virus NS3 Helicase. |
2015 |
Int J Mol Sci |
pmid:26262613
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Yi J et al. |
Photoactivation of hypericin decreases the viability of RINm5F insulinoma cells through reduction in JNK/ERK phosphorylation and elevation of caspase-9/caspase-3 cleavage and Bax-to-Bcl-2 ratio. |
2015 |
Biosci. Rep. |
pmid:26182357
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Montoya A et al. |
Development of a novel formulation with hypericin to treat cutaneous leishmaniasis based on photodynamic therapy in in vitro and in vivo studies. |
2015 |
Antimicrob. Agents Chemother. |
pmid:26169411
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Shao H et al. |
Necrosis targeted radiotherapy with iodine-131-labeled hypericin to improve anticancer efficacy of vascular disrupting treatment in rabbit VX2 tumor models. |
2015 |
Oncotarget |
pmid:26036625
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Li Y et al. |
Biliary and duodenal drainage for reducing the radiotoxic risk of antineoplastic 131I-hypericin in rat models. |
2015 |
Exp. Biol. Med. (Maywood) |
pmid:25956680
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Zhu M et al. |
Evaluation of the therapeutic efficacy of sequential therapy involving percutaneous microwave ablation in combination with 131I-hypericin using the VX2 rabbit breast solid tumor model. |
2015 |
PLoS ONE |
pmid:25799220
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Li X et al. |
The efficacy and mechanism of apoptosis induction by hypericin-mediated sonodynamic therapy in THP-1 macrophages. |
2015 |
Int J Nanomedicine |
pmid:25653524
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Singh S et al. |
Probing the molecular mechanism of hypericin-induced parasite death provides insight into the role of spermidine beyond redox metabolism in Leishmania donovani. |
2015 |
Antimicrob. Agents Chemother. |
pmid:25313212
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Turk S et al. |
Purification of Glutathione S-Transferase pi from Erythrocytes and Evaluation of the Inhibitory Effect of Hypericin. |
2015 |
Protein J. |
pmid:26614503
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Intracellular localization and dynamics of Hypericin loaded PLLA nanocarriers by image correlation spectroscopy. |
2015 |
J Control Release |
pmid:26435453
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Alnawaiseh M et al. |
[Effect of Hypericin on the Function of the Neuroretina: An Electroretinographic Study]. |
2015 |
Klin Monbl Augenheilkd |
pmid:26197957
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Differential susceptibility of primary cultured human skin cells to hypericin PDT in an in vitro model. |
2015 |
J. Photochem. Photobiol. B, Biol. |
pmid:26114219
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Permeation Characteristics of Hypericin across Caco-2 Monolayers in the Absence or Presence of Quercitrin - A Mass Balance Study. |
2015 |
Planta Med. |
pmid:26018919
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Kuchárová B et al. |
Potentiation of hypericin-mediated photodynamic therapy cytotoxicity by MK-886: focus on ABC transporters, GDF-15 and redox status. |
2015 |
Photodiagnosis Photodyn Ther |
pmid:26003114
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Zhai XJ et al. |
LC-MS/MS based studies on the anti-depressant effect of hypericin in the chronic unpredictable mild stress rat model. |
2015 |
J Ethnopharmacol |
pmid:25957811
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Kusari S et al. |
Spatial chemo-profiling of hypericin and related phytochemicals in Hypericum species using MALDI-HRMS imaging. |
2015 |
Anal Bioanal Chem |
pmid:25912460
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Bernal C et al. |
Photodynamic efficiency of hypericin compared with chlorin and hematoporphyrin derivatives in HEp-2 and Vero epithelial cell lines. |
2015 |
Photodiagnosis Photodyn Ther |
pmid:25910552
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Kashef N et al. |
Phototoxic effect of hypericin alone and in combination with acetylcysteine on Staphylococcus aureus biofilms. |
2015 |
Photodiagnosis Photodyn Ther |
pmid:25892001
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Hohmann MS et al. |
Hypericum perforatum Reduces Paracetamol-Induced Hepatotoxicity and Lethality in Mice by Modulating Inflammation and Oxidative Stress. |
2015 |
Phytother Res |
pmid:25851311
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GarcÃa I et al. |
Antimicrobial photodynamic activity of hypericin against methicillin-susceptible and resistant Staphylococcus aureus biofilms. |
2015 |
Future Microbiol |
pmid:25812458
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Liu W et al. |
Biodistribution and anti-tumor efficacy of intratumorally injected necrosis-avid theranostic agent radioiodinated hypericin in rodent tumor models. |
2015 |
J Drug Target |
pmid:25572455
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RodrÃguez-Amigo B et al. |
The complex of hypericin with β-lactoglobulin has antimicrobial activity with potential applications in dairy industry. |
2015 |
J. Dairy Sci. |
pmid:25465550
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Liu X et al. |
Evaluation of hypericin: effect of aggregation on targeting biodistribution. |
2015 |
J Pharm Sci |
pmid:25395358
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Straub M et al. |
A phase IIA dose-finding study of PVP-hypericin fluorescence cystoscopy for detection of nonmuscle-invasive bladder cancer. |
2015 |
J. Endourol. |
pmid:25222735
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Successful in vivo tumor visualization using fluorescence laparoscopy in a mouse model of disseminated alveolar rhabdomyosarcoma. |
2015 |
Surg Endosc |
pmid:25149634
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Qi X et al. |
Radiopharmaceutical study on Iodine-131-labelled hypericin in a canine model of hepatic RFA-induced coagulative necrosis. |
2015 |
Radiol Med |
pmid:25012473
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Laffers W et al. |
Photosensitizing effects of hypericin on head neck squamous cell carcinoma in vitro. |
2015 |
Eur Arch Otorhinolaryngol |
pmid:24687800
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Cona MM et al. |
Sodium cholate, a solubilizing agent for the necrosis avid radioiodinated hypericin in rabbits with acute myocardial infarction. |
2015 |
Drug Deliv |
pmid:24417698
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Choi YM et al. |
Photodynamic therapy for psoriasis. |
2015 |
J Dermatolog Treat |
pmid:24881473
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