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Hypericin and pseudohypericin concentrations of a valuable medicinal plant Hypericum perforatum L. are enhanced by arbuscular mycorrhizal fungi. |
2012 |
Mycorrhiza |
pmid:21626142
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Olivo M et al. |
Altered expression of cell adhesion molecules leads to differential uptake of hypericin in urothelial cancer. |
2012 |
Urol. Oncol. |
pmid:20933443
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López-Chicón P et al. |
On the mechanism of Candida spp. photoinactivation by hypericin. |
2012 |
Photochem. Photobiol. Sci. |
pmid:22566080
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Sharma KV and Davids LM |
Depigmentation in melanomas increases the efficacy of hypericin-mediated photodynamic-induced cell death. |
2012 |
Photodiagnosis Photodyn Ther |
pmid:22594986
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Kairyte K et al. |
Effective inactivation of food pathogens Listeria monocytogenes and Salmonella enterica by combined treatment of hypericin-based photosensitization and high power pulsed light. |
2012 |
J. Appl. Microbiol. |
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Camas N et al. |
Secondary metabolites of Hypericum leptophyllum Hochst., an endemic Turkish species. |
2012 |
ScientificWorldJournal |
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Mañero FJ et al. |
Elicitation of secondary metabolism in Hypericum perforatum by rhizosphere bacteria and derived elicitors in seedlings and shoot cultures. |
2012 |
Pharm Biol |
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Rubio N et al. |
Spatiotemporal autophagic degradation of oxidatively damaged organelles after photodynamic stress is amplified by mitochondrial reactive oxygen species. |
2012 |
Autophagy |
pmid:22889744
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Eriksson ES and Eriksson LA |
Identifying the sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) as a potential target for hypericin--a theoretical study. |
2012 |
Phys Chem Chem Phys |
pmid:22892582
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Li JJ et al. |
A single-dose toxicity study on non-radioactive iodinated hypericin for a targeted anticancer therapy in mice. |
2012 |
Acta Pharmacol. Sin. |
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Weberschock T et al. |
Interventions for mycosis fungoides. |
2012 |
Cochrane Database Syst Rev |
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Ritz R et al. |
Hypericin for visualization of high grade gliomas: first clinical experience. |
2012 |
Eur J Surg Oncol |
pmid:22284346
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van den Berg NS et al. |
Fluorescence guidance in urologic surgery. |
2012 |
Curr Opin Urol |
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Richard AJ et al. |
St. John's Wort inhibits insulin signaling in murine and human adipocytes. |
2012 |
Biochim. Biophys. Acta |
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Vanlangenakker N et al. |
Many stimuli pull the necrotic trigger, an overview. |
2012 |
Cell Death Differ. |
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Brechner ML et al. |
Effects of UV-B on secondary metabolites of St. John's Wort (Hypericum perforatum L.) grown in controlled environments. |
2011 May-Jun |
Photochem. Photobiol. |
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Mondon K et al. |
MPEG-hexPLA micelles as novel carriers for hypericin, a fluorescent marker for use in cancer diagnostics. |
2011 Mar-Apr |
Photochem. Photobiol. |
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Buriankova L et al. |
Kinetics of hypericin association with low-density lipoproteins. |
2011 Jan-Feb |
Photochem. Photobiol. |
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Vandepitte J et al. |
Biodistribution and photodynamic effects of polyvinylpyrrolidone-hypericin using multicellular spheroids composed of normal human urothelial and T24 transitional cell carcinoma cells. |
2011 Jan-Feb |
J Biomed Opt |
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Schug TT |
Targeting transcription through inhibition of TBP. |
2011 Jan-Feb |
Oncotarget |
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Morachis JM et al. |
Identification of kinase inhibitors that target transcription initiation by RNA polymerase II. |
2011 Jan-Feb |
Oncotarget |
pmid:21378408
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Zhao J et al. |
Plant-derived bioactive compounds produced by endophytic fungi. |
2011 |
Mini Rev Med Chem |
pmid:21222580
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Dinarvand R et al. |
Polylactide-co-glycolide nanoparticles for controlled delivery of anticancer agents. |
2011 |
Int J Nanomedicine |
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Boiy A et al. |
Photodynamic therapy using topically applied hypericin: comparative effect with methyl-aminolevulinic acid on UV induced skin tumours. |
2011 |
J. Photochem. Photobiol. B, Biol. |
pmid:21035351
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Roelants M et al. |
Human serum albumin as key mediator of the differential accumulation of hypericin in normal urothelial cell spheroids versus urothelial cell carcinoma spheroids. |
2011 |
Photochem. Photobiol. Sci. |
pmid:21103512
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Sorrentino F et al. |
Hypericins and thioredoxin reductase: Biochemical and docking studies disclose the molecular basis for effective inhibition by naphthodianthrones. |
2011 |
Bioorg. Med. Chem. |
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Li J et al. |
A dual-targeting anticancer approach: soil and seed principle. |
2011 |
Radiology |
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Selective enrichment of hypericin in malignant glioma: pioneering in vivo results. |
2011 |
Int. J. Oncol. |
pmid:21399870
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Ghazanfarpour M et al. |
Hypericum perforatum for the treatment of premenstrual syndrome. |
2011 |
Int J Gynaecol Obstet |
pmid:21315349
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Couldwell WT et al. |
A phase 1/2 study of orally administered synthetic hypericin for treatment of recurrent malignant gliomas. |
2011 |
Cancer |
pmid:21456013
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Patel P et al. |
Emerging endoscopic and photodynamic techniques for bladder cancer detection and surveillance. |
2011 |
ScientificWorldJournal |
pmid:22235185
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Song S et al. |
Small-animal PET of tumor damage induced by photothermal ablation with 64Cu-bis-DOTA-hypericin. |
2011 |
J. Nucl. Med. |
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Xu M et al. |
Enhancing hypericin production of Hypericum perforatum cell suspension culture by ozone exposure. |
2011 |
Biotechnol. Prog. |
pmid:21538976
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Sharma KV et al. |
Photodynamic therapy-induced killing is enhanced in depigmented metastatic melanoma cells. |
2011 |
Cell Biol. Int. |
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Engelhardt V et al. |
Lipophilic rather than hydrophilic photosensitizers show strong adherence to standard cell culture microplates under cell-free conditions. |
2011 |
J. Photochem. Photobiol. B, Biol. |
pmid:21507674
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Mikeš J et al. |
Lower sensitivity of FHC fetal colon epithelial cells to photodynamic therapy compared to HT-29 colon adenocarcinoma cells despite higher intracellular accumulation of hypericin. |
2011 |
Photochem. Photobiol. Sci. |
pmid:21298151
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Vuong TT et al. |
Hypericin incorporation and localization in fixed HeLa cells for various conditions of fixation and incubation. |
2011 |
Photochem. Photobiol. Sci. |
pmid:21243156
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Solár P et al. |
Photoactivated hypericin induces downregulation of HER2 gene expression. |
2011 |
Radiat. Res. |
pmid:21175347
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Ni G et al. |
The possible use of hypericin to overcome drug resistance in cancer treatment. |
2011 |
Chem. Biol. Interact. |
pmid:21168397
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Barliya T et al. |
Degradation of HIF-1alpha under hypoxia combined with induction of Hsp90 polyubiquitination in cancer cells by hypericin: a unique cancer therapy. |
2011 |
PLoS ONE |
pmid:21949677
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SaÄková V et al. |
Enhanced antiproliferative and apoptotic response of HT-29 adenocarcinoma cells to combination of photoactivated hypericin and farnesyltransferase inhibitor manumycin A. |
2011 |
Int J Mol Sci |
pmid:22272079
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Kammerer R et al. |
Induction of immune mediators in glioma and prostate cancer cells by non-lethal photodynamic therapy. |
2011 |
PLoS ONE |
pmid:21738796
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Dewaele M et al. |
Autophagy pathways activated in response to PDT contribute to cell resistance against ROS damage. |
2011 |
J. Cell. Mol. Med. |
pmid:20626525
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Fang R et al. |
Design and characterization of protein-quercetin bioactive nanoparticles. |
2011 |
J Nanobiotechnology |
pmid:21586116
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Vandepitte J et al. |
Biodistribution of PVP-hypericin and hexaminolevulinate-induced PpIX in normal and orthotopic tumor-bearing rat urinary bladder. |
2011 |
Cancer Chemother. Pharmacol. |
pmid:20532886
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Cao X et al. |
Isolation and purification of series bioactive components from Hypericum perforatum L. by counter-current chromatography. |
2011 |
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. |
pmid:21306961
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Bánó G et al. |
On the diffusion of hypericin in dimethylsulfoxide/water mixtures-the effect of aggregation. |
2011 |
J Phys Chem B |
pmid:21332112
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Bhuvaneswari R et al. |
Antiangiogenesis agents avastin and erbitux enhance the efficacy of photodynamic therapy in a murine bladder tumor model. |
2011 |
Lasers Surg Med |
pmid:22057493
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Sanovic R et al. |
Low dose hypericin-PDT induces complete tumor regression in BALB/c mice bearing CT26 colon carcinoma. |
2011 |
Photodiagnosis Photodyn Ther |
pmid:22122915
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Mozaffari S et al. |
Effects of Hypericum perforatum extract on rat irritable bowel syndrome. |
2011 |
Pharmacogn Mag |
pmid:21969792
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Hao PF et al. |
[Study on the enzyme extraction process of hypericin by pectinase]. |
2011 |
Zhong Yao Cai |
pmid:22066412
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Antioxidant activity relationship of phenolic compounds in Hypericum perforatum L. |
2011 |
Chem Cent J |
pmid:21702979
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Marysael T et al. |
Influence of the vascular damaging agents DMXAA and ZD6126 on hypericin distribution and accumulation in RIF-1 tumors. |
2011 |
J. Cancer Res. Clin. Oncol. |
pmid:21858709
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Onoue S et al. |
In vitro photochemical and phototoxicological characterization of major constituents in St. John's Wort (Hypericum perforatum) extracts. |
2011 |
Phytochemistry |
pmid:21782201
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Crockett SL and Boevé JL |
Flavonoid glycosides and naphthodianthrones in the sawfly Tenthredo zonula and its host-plants, Hypericum perforatum and H. hirsutum. |
2011 |
J. Chem. Ecol. |
pmid:21814831
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Helmja K et al. |
Variation in the composition of the essential oils, phenolic compounds and mineral elements of Hypericum perforatum L. growing in Estonia. |
2011 |
Nat. Prod. Res. |
pmid:21391113
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Rainha N et al. |
Comparison of the endemic Azorean Hypericum foliosum with other Hypericum species: antioxidant activity and phenolic profile. |
2011 |
Nat. Prod. Res. |
pmid:21246439
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Schwarz D et al. |
Inhibition of 17β-estradiol activation by CYP1A1: genotype- and regioselective inhibition by St. John's Wort and several natural polyphenols. |
2011 |
Biochim. Biophys. Acta |
pmid:20883830
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Park S et al. |
Immunomodulatory Effects of Hypocrellin A on MHC-restricted Antigen Processing. |
2011 |
Immune Netw |
pmid:22346783
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Shrestha R et al. |
A high-precision micropipette sensor for cellular-level real-time thermal characterization. |
2011 |
Sensors (Basel) |
pmid:22164108
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Zdunić G et al. |
Isolation and identification of phenolic compounds from Hypericum richeri Vill. and their antioxidant capacity. |
2011 |
Nat. Prod. Res. |
pmid:19764002
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Cárdenas C et al. |
Anti-angiogenic and anti-inflammatory properties of kahweol, a coffee diterpene. |
2011 |
PLoS ONE |
pmid:21858104
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Koeberle A et al. |
Hyperforin, an Anti-Inflammatory Constituent from St. John's Wort, Inhibits Microsomal Prostaglandin E(2) Synthase-1 and Suppresses Prostaglandin E(2) Formation in vivo. |
2011 |
Front Pharmacol |
pmid:21687502
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de Vries E et al. |
Dissection of the influenza A virus endocytic routes reveals macropinocytosis as an alternative entry pathway. |
2011 |
PLoS Pathog. |
pmid:21483486
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Pimentel MR et al. |
The use of endophytes to obtain bioactive compounds and their application in biotransformation process. |
2011 |
Biotechnol Res Int |
pmid:21350663
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Crupi R et al. |
Hypericum perforatum treatment: effect on behaviour and neurogenesis in a chronic stress model in mice. |
2011 |
BMC Complement Altern Med |
pmid:21272291
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Kumagai A et al. |
A potent inhibitor of SIK2, 3, 3', 7-trihydroxy-4'-methoxyflavon (4'-O-methylfisetin), promotes melanogenesis in B16F10 melanoma cells. |
2011 |
PLoS ONE |
pmid:22022544
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Merhi F et al. |
Hyperforin inhibits Akt1 kinase activity and promotes caspase-mediated apoptosis involving Bad and Noxa activation in human myeloid tumor cells. |
2011 |
PLoS ONE |
pmid:21998731
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Martirosyan AS et al. |
Biphasic dose-response of antioxidants in hypericin-induced photohemolysis. |
2011 |
Photodiagnosis Photodyn Ther |
pmid:21864803
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Khan AU et al. |
Pharmacological studies on Hypericum perforatum fractions and constituents. |
2011 |
Pharm Biol |
pmid:20738215
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Kuliková L et al. |
NF-κB is not directly responsible for photoresistance induced by fractionated light delivery in HT-29 colon adenocarcinoma cells. |
2010 Nov-Dec |
Photochem. Photobiol. |
pmid:20718930
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Anyzewska M et al. |
Determination of total hypericins in St. John's wort and herbal medicinal products. |
2010 Nov-Dec |
Acta Pol Pharm |
pmid:21229872
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Kapinus EI |
[Absorption and fluorescence spectra of hypericin sodium salt in complexes with albumins]. |
2010 Mar-Apr |
Biofizika |
pmid:20429274
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Bhuvaneswari R et al. |
Evaluation of hypericin-mediated photodynamic therapy in combination with angiogenesis inhibitor bevacizumab using in vivo fluorescence confocal endomicroscopy. |
2010 Jan-Feb |
J Biomed Opt |
pmid:20210440
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Koval J et al. |
Degradation of HER2 receptor through hypericin-mediated photodynamic therapy. |
2010 Jan-Feb |
Photochem. Photobiol. |
pmid:19912559
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Theodossiou TA et al. |
Hypericin hydroquinone: potential as a red-far red photosensitizer? |
2010 Jan-Feb |
Photochem. Photobiol. |
pmid:20003155
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Matias EF et al. |
Screening for in vitro phototoxic activity of methanol extracts of Croton campestris A., Ocimum gratissimum L. & Cordia verbenaceae DC. |
2010 |
Indian J. Med. Res. |
pmid:21150001
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Süntar IP et al. |
Investigations on the in vivo wound healing potential of Hypericum perforatum L. |
2010 |
J Ethnopharmacol |
pmid:19833187
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Rook AH et al. |
A phase II placebo-controlled study of photodynamic therapy with topical hypericin and visible light irradiation in the treatment of cutaneous T-cell lymphoma and psoriasis. |
2010 |
J. Am. Acad. Dermatol. |
pmid:20889234
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Galeotti N et al. |
A prolonged protein kinase C-mediated, opioid-related antinociceptive effect of st John's Wort in mice. |
2010 |
J Pain |
pmid:19945352
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Paterniti I et al. |
Effects of Hypericum Perforatum, in a rodent model of periodontitis. |
2010 |
BMC Complement Altern Med |
pmid:21092263
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Miadokova E et al. |
Genotoxicity and antigenotoxicity evaluation of non-photoactivated hypericin. |
2010 |
Phytother Res |
pmid:19585477
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Ciogli A et al. |
Determination of enantiomerization barriers of hypericin and pseudohypericin by dynamic high-performance liquid chromatography on immobilized polysaccharide-type chiral stationary phases and off-column racemization experiments. |
2010 |
Chirality |
pmid:19644936
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Ghasemzadeh A et al. |
Synthesis of phenolics and flavonoids in ginger (Zingiber officinale Roscoe) and their effects on photosynthesis rate. |
2010 |
Int J Mol Sci |
pmid:21151455
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Engelhardt V et al. |
Antibacterial photodynamic therapy using water-soluble formulations of hypericin or mTHPC is effective in inactivation of Staphylococcus aureus. |
2010 |
Photochem. Photobiol. Sci. |
pmid:20221463
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Fagundes LL et al. |
Pharmacological properties of the ethanol extract of Muehlenbeckia platyclada (F. Muell.) meisn. leaves. |
2010 |
Int J Mol Sci |
pmid:21152311
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Fadel M et al. |
Photodynamic efficacy of hypericin targeted by two delivery techniques to hepatocellular carcinoma cells. |
2010 |
Lasers Med Sci |
pmid:20393766
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Karioti A and Bilia AR |
Hypericins as potential leads for new therapeutics. |
2010 |
Int J Mol Sci |
pmid:20386655
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Lakhan SE and Vieira KF |
Nutritional and herbal supplements for anxiety and anxiety-related disorders: systematic review. |
2010 |
Nutr J |
pmid:20929532
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Ferenc P et al. |
Down-regulation of Bcl-2 and Akt induced by combination of photoactivated hypericin and genistein in human breast cancer cells. |
2010 |
J. Photochem. Photobiol. B, Biol. |
pmid:19932626
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Michalska K et al. |
Crystal structure of Hyp-1, a St. John's wort protein implicated in the biosynthesis of hypericin. |
2010 |
J. Struct. Biol. |
pmid:19853038
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Huntosova V et al. |
Interaction dynamics of hypericin with low-density lipoproteins and U87-MG cells. |
2010 |
Int J Pharm |
pmid:20083174
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Galeotti N et al. |
St. John's Wort reduces neuropathic pain through a hypericin-mediated inhibition of the protein kinase Cgamma and epsilon activity. |
2010 |
Biochem. Pharmacol. |
pmid:20045676
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Yasuda T et al. |
Anti-influenza virus principles from Muehlenbeckia hastulata. |
2010 |
J Nat Med |
pmid:20082146
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Burris HA and Hurtig J |
Radiation recall with anticancer agents. |
2010 |
Oncologist |
pmid:21045191
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Sørensen MG et al. |
Screening of protein kinase inhibitors identifies PKC inhibitors as inhibitors of osteoclastic acid secretion and bone resorption. |
2010 |
BMC Musculoskelet Disord |
pmid:20977756
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He Y et al. |
Luteinizing hormone-releasing hormone receptor-mediated delivery of mitoxantrone using LHRH analogs modified with PEGylated liposomes. |
2010 |
Int J Nanomedicine |
pmid:20957221
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Schreiber S et al. |
Bilateral posterior RION after concomitant radiochemotherapy with temozolomide in a patient with glioblastoma multiforme: a case report. |
2010 |
BMC Cancer |
pmid:20920315
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Dolan LC et al. |
Naturally occurring food toxins. |
2010 |
Toxins (Basel) |
pmid:22069686
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Rozanova Torshina N et al. |
Catalytic therapy of cancer with ascorbate and extracts of medicinal herbs. |
2010 |
Evid Based Complement Alternat Med |
pmid:18955293
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