| MeSH term | MeSH ID | Detail |
|---|---|---|
| Urinary Bladder, Overactive | D053201 | 2 associated lipids |
| Epidermolysis Bullosa | D004820 | 3 associated lipids |
| Radiodermatitis | D011855 | 3 associated lipids |
| Keratosis, Actinic | D055623 | 3 associated lipids |
| Neoplasms, Radiation-Induced | D009381 | 3 associated lipids |
| Nasopharyngeal Neoplasms | D009303 | 4 associated lipids |
| Lymphoma, T-Cell, Cutaneous | D016410 | 4 associated lipids |
| Choroidal Neovascularization | D020256 | 5 associated lipids |
| Neoplasm Recurrence, Local | D009364 | 5 associated lipids |
| Eye Injuries | D005131 | 7 associated lipids |
hypericin
hypericin is a lipid of Polyketides (PK) class. Hypericin is associated with abnormalities such as Dermatitis, Phototoxic, Dehydration, Photosensitization, Morphologically altered structure and Myocardial Infarction. The involved functions are known as Cell Cycle Checkpoints, Apoptosis, Acetylation, Cell Survival and Caspase Activation. Hypericin often locates in insoluble fraction, Cytoplasmic matrix, Protoplasm, Tissue membrane and Cytoplasm. The associated genes with hypericin are CDC37 gene, HSPA8 gene, RAF1 gene, cyclin H and FK228. The related lipids are Phosphatidylserines.
Cross Reference
Introduction
To understand associated biological information of hypericin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with hypericin?
hypericin is suspected in Dermatitis, Phototoxic, Photosensitization, Pneumonia, Psoriasis, Phototoxicity, Chronic infectious disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with hypericin
PubChem Associated disorders and diseases
What pathways are associated with hypericin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with hypericin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with hypericin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with hypericin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with hypericin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with hypericin?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with hypericin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zubek S et al. | Hypericin and pseudohypericin concentrations of a valuable medicinal plant Hypericum perforatum L. are enhanced by arbuscular mycorrhizal fungi. | 2012 | Mycorrhiza | pmid:21626142 |
| López-Chicón P et al. | On the mechanism of Candida spp. photoinactivation by hypericin. | 2012 | Photochem. Photobiol. Sci. | pmid:22566080 |
| Kairyte K et al. | Effective inactivation of food pathogens Listeria monocytogenes and Salmonella enterica by combined treatment of hypericin-based photosensitization and high power pulsed light. | 2012 | J. Appl. Microbiol. | pmid:22469030 |
| Camas N et al. | Secondary metabolites of Hypericum leptophyllum Hochst., an endemic Turkish species. | 2012 | ScientificWorldJournal | pmid:22649295 |
| Mañero FJ et al. | Elicitation of secondary metabolism in Hypericum perforatum by rhizosphere bacteria and derived elicitors in seedlings and shoot cultures. | 2012 | Pharm Biol | pmid:22900596 |
| Rubio N et al. | Spatiotemporal autophagic degradation of oxidatively damaged organelles after photodynamic stress is amplified by mitochondrial reactive oxygen species. | 2012 | Autophagy | pmid:22889744 |
| Eriksson ES and Eriksson LA | Identifying the sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) as a potential target for hypericin--a theoretical study. | 2012 | Phys Chem Chem Phys | pmid:22892582 |
| Olivo M et al. | New frontier in hypericin-mediated diagnosis of cancer with current optical technologies. | 2012 | Ann Biomed Eng | pmid:22124793 |
| Li JJ et al. | A single-dose toxicity study on non-radioactive iodinated hypericin for a targeted anticancer therapy in mice. | 2012 | Acta Pharmacol. Sin. | pmid:23103619 |
| Van de Putte M et al. | Radiolabeled iodohypericin as tumor necrosis avid tracer: diagnostic and therapeutic potential. | 2012 | Int. J. Cancer | pmid:22038886 |
| Weberschock T et al. | Interventions for mycosis fungoides. | 2012 | Cochrane Database Syst Rev | pmid:22972128 |
| Ritz R et al. | Hypericin for visualization of high grade gliomas: first clinical experience. | 2012 | Eur J Surg Oncol | pmid:22284346 |
| van den Berg NS et al. | Fluorescence guidance in urologic surgery. | 2012 | Curr Opin Urol | pmid:22262249 |
| Richard AJ et al. | St. John's Wort inhibits insulin signaling in murine and human adipocytes. | 2012 | Biochim. Biophys. Acta | pmid:22198320 |
| Vanlangenakker N et al. | Many stimuli pull the necrotic trigger, an overview. | 2012 | Cell Death Differ. | pmid:22075985 |
| Brechner ML et al. | Effects of UV-B on secondary metabolites of St. John's Wort (Hypericum perforatum L.) grown in controlled environments. | 2011 May-Jun | Photochem. Photobiol. | pmid:21275996 |
| Mondon K et al. | MPEG-hexPLA micelles as novel carriers for hypericin, a fluorescent marker for use in cancer diagnostics. | 2011 Mar-Apr | Photochem. Photobiol. | pmid:21166812 |
| Buriankova L et al. | Kinetics of hypericin association with low-density lipoproteins. | 2011 Jan-Feb | Photochem. Photobiol. | pmid:21114669 |
| Vandepitte J et al. | Biodistribution and photodynamic effects of polyvinylpyrrolidone-hypericin using multicellular spheroids composed of normal human urothelial and T24 transitional cell carcinoma cells. | 2011 Jan-Feb | J Biomed Opt | pmid:21280926 |
| Schug TT | Targeting transcription through inhibition of TBP. | 2011 Jan-Feb | Oncotarget | pmid:21378415 |
| Morachis JM et al. | Identification of kinase inhibitors that target transcription initiation by RNA polymerase II. | 2011 Jan-Feb | Oncotarget | pmid:21378408 |
| Ghazanfarpour M et al. | Hypericum perforatum for the treatment of premenstrual syndrome. | 2011 | Int J Gynaecol Obstet | pmid:21315349 |
| Couldwell WT et al. | A phase 1/2 study of orally administered synthetic hypericin for treatment of recurrent malignant gliomas. | 2011 | Cancer | pmid:21456013 |
| Patel P et al. | Emerging endoscopic and photodynamic techniques for bladder cancer detection and surveillance. | 2011 | ScientificWorldJournal | pmid:22235185 |
| Song S et al. | Small-animal PET of tumor damage induced by photothermal ablation with 64Cu-bis-DOTA-hypericin. | 2011 | J. Nucl. Med. | pmid:21498539 |
| Xu M et al. | Enhancing hypericin production of Hypericum perforatum cell suspension culture by ozone exposure. | 2011 | Biotechnol. Prog. | pmid:21538976 |
| Sharma KV et al. | Photodynamic therapy-induced killing is enhanced in depigmented metastatic melanoma cells. | 2011 | Cell Biol. Int. | pmid:21542806 |
| Engelhardt V et al. | Lipophilic rather than hydrophilic photosensitizers show strong adherence to standard cell culture microplates under cell-free conditions. | 2011 | J. Photochem. Photobiol. B, Biol. | pmid:21507674 |
| Mikeš J et al. | Lower sensitivity of FHC fetal colon epithelial cells to photodynamic therapy compared to HT-29 colon adenocarcinoma cells despite higher intracellular accumulation of hypericin. | 2011 | Photochem. Photobiol. Sci. | pmid:21298151 |
| Vuong TT et al. | Hypericin incorporation and localization in fixed HeLa cells for various conditions of fixation and incubation. | 2011 | Photochem. Photobiol. Sci. | pmid:21243156 |
| Solár P et al. | Photoactivated hypericin induces downregulation of HER2 gene expression. | 2011 | Radiat. Res. | pmid:21175347 |
| Ni G et al. | The possible use of hypericin to overcome drug resistance in cancer treatment. | 2011 | Chem. Biol. Interact. | pmid:21168397 |
| Barliya T et al. | Degradation of HIF-1alpha under hypoxia combined with induction of Hsp90 polyubiquitination in cancer cells by hypericin: a unique cancer therapy. | 2011 | PLoS ONE | pmid:21949677 |
| SaÄková V et al. | Enhanced antiproliferative and apoptotic response of HT-29 adenocarcinoma cells to combination of photoactivated hypericin and farnesyltransferase inhibitor manumycin A. | 2011 | Int J Mol Sci | pmid:22272079 |
| Dewaele M et al. | Autophagy pathways activated in response to PDT contribute to cell resistance against ROS damage. | 2011 | J. Cell. Mol. Med. | pmid:20626525 |
| Vandepitte J et al. | Biodistribution of PVP-hypericin and hexaminolevulinate-induced PpIX in normal and orthotopic tumor-bearing rat urinary bladder. | 2011 | Cancer Chemother. Pharmacol. | pmid:20532886 |
| Cao X et al. | Isolation and purification of series bioactive components from Hypericum perforatum L. by counter-current chromatography. | 2011 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:21306961 |
| Bánó G et al. | On the diffusion of hypericin in dimethylsulfoxide/water mixtures-the effect of aggregation. | 2011 | J Phys Chem B | pmid:21332112 |
| Bhuvaneswari R et al. | Antiangiogenesis agents avastin and erbitux enhance the efficacy of photodynamic therapy in a murine bladder tumor model. | 2011 | Lasers Surg Med | pmid:22057493 |
| Helmja K et al. | Variation in the composition of the essential oils, phenolic compounds and mineral elements of Hypericum perforatum L. growing in Estonia. | 2011 | Nat. Prod. Res. | pmid:21391113 |
| Rainha N et al. | Comparison of the endemic Azorean Hypericum foliosum with other Hypericum species: antioxidant activity and phenolic profile. | 2011 | Nat. Prod. Res. | pmid:21246439 |
| Park S et al. | Immunomodulatory Effects of Hypocrellin A on MHC-restricted Antigen Processing. | 2011 | Immune Netw | pmid:22346783 |
| Shrestha R et al. | A high-precision micropipette sensor for cellular-level real-time thermal characterization. | 2011 | Sensors (Basel) | pmid:22164108 |
| Zdunić G et al. | Isolation and identification of phenolic compounds from Hypericum richeri Vill. and their antioxidant capacity. | 2011 | Nat. Prod. Res. | pmid:19764002 |
| de Vries E et al. | Dissection of the influenza A virus endocytic routes reveals macropinocytosis as an alternative entry pathway. | 2011 | PLoS Pathog. | pmid:21483486 |
| Pimentel MR et al. | The use of endophytes to obtain bioactive compounds and their application in biotransformation process. | 2011 | Biotechnol Res Int | pmid:21350663 |
| Crupi R et al. | Hypericum perforatum treatment: effect on behaviour and neurogenesis in a chronic stress model in mice. | 2011 | BMC Complement Altern Med | pmid:21272291 |
| Kumagai A et al. | A potent inhibitor of SIK2, 3, 3', 7-trihydroxy-4'-methoxyflavon (4'-O-methylfisetin), promotes melanogenesis in B16F10 melanoma cells. | 2011 | PLoS ONE | pmid:22022544 |
| Merhi F et al. | Hyperforin inhibits Akt1 kinase activity and promotes caspase-mediated apoptosis involving Bad and Noxa activation in human myeloid tumor cells. | 2011 | PLoS ONE | pmid:21998731 |
| Martirosyan AS et al. | Biphasic dose-response of antioxidants in hypericin-induced photohemolysis. | 2011 | Photodiagnosis Photodyn Ther | pmid:21864803 |