| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uterine Cervical Neoplasms | D002583 | 10 associated lipids |
| Neoplasms, Experimental | D009374 | 10 associated lipids |
| Neoplasms, Radiation-Induced | D009381 | 3 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Carcinoma, Squamous Cell | D002294 | 14 associated lipids |
| Skin Neoplasms | D012878 | 12 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
hypericin
hypericin is a lipid of Polyketides (PK) class. Hypericin is associated with abnormalities such as Dermatitis, Phototoxic, Dehydration, Photosensitization, Morphologically altered structure and Myocardial Infarction. The involved functions are known as Cell Cycle Checkpoints, Apoptosis, Acetylation, Cell Survival and Caspase Activation. Hypericin often locates in insoluble fraction, Cytoplasmic matrix, Protoplasm, Tissue membrane and Cytoplasm. The associated genes with hypericin are CDC37 gene, HSPA8 gene, RAF1 gene, cyclin H and FK228. The related lipids are Phosphatidylserines.
Cross Reference
Introduction
To understand associated biological information of hypericin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with hypericin?
hypericin is suspected in Dermatitis, Phototoxic, Photosensitization, Pneumonia, Psoriasis, Phototoxicity, Chronic infectious disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with hypericin
PubChem Associated disorders and diseases
What pathways are associated with hypericin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with hypericin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with hypericin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with hypericin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with hypericin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with hypericin?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with hypericin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Lavie G et al. | A photodynamic pathway to apoptosis and necrosis induced by dimethyl tetrahydroxyhelianthrone and hypericin in leukaemic cells: possible relevance to photodynamic therapy. | 1999 | Br. J. Cancer | pmid:10027308 |
| Gulick RM et al. | Phase I studies of hypericin, the active compound in St. John's Wort, as an antiretroviral agent in HIV-infected adults. AIDS Clinical Trials Group Protocols 150 and 258. | 1999 | Ann. Intern. Med. | pmid:10075619 |
| Kleber E et al. | Biochemical activities of extracts from Hypericum perforatum L. 1st Communication: inhibition of dopamine-beta-hydroxylase. | 1999 | Arzneimittelforschung | pmid:10083977 |
| Denke A et al. | Biochemical activities of extracts from Hypericum perforatum L. 2nd Communication: inhibition of metenkephaline- and tyrosine-dimerization. | 1999 | Arzneimittelforschung | pmid:10083978 |
| Denke A et al. | Biochemical activities of extracts from Hypericum perforatum L. 4th Communication: influence of different cultivation methods. | 1999 | Arzneimittelforschung | pmid:10083980 |
| Assefa Z et al. | The activation of the c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signaling pathways protects HeLa cells from apoptosis following photodynamic therapy with hypericin. | 1999 | J. Biol. Chem. | pmid:10085120 |
| Delaey EM et al. | Confluence dependent resistance to photo-activated hypericin in HeLa cells. | 1999 | Int. J. Oncol. | pmid:10087326 |
| English DS et al. | Subcellular distributions and excited-state processes of hypericin in neurons. | 1999 | Photochem. Photobiol. | pmid:10089821 |
| Chi JD and Franklin M | Determination of hypericin in plasma by high-performance liquid chromatography. | 1999 | J. Chromatogr. B Biomed. Sci. Appl. | pmid:10202973 |
| Chaloupka R et al. | The effect of hypericin and hypocrellin-A on lipid membranes and membrane potential of 3T3 fibroblasts. | 1999 | Biochim. Biophys. Acta | pmid:10209209 |
| Bork PM et al. | Hypericin as a non-antioxidant inhibitor of NF-kappa B. | 1999 | Planta Med. | pmid:10364831 |
| Das K et al. | Photophysics of hypericin and hypocrellin A in complex with subcellular components: interactions with human serum albumin. | 1999 | Photochem. Photobiol. | pmid:10378001 |
| Calapai G et al. | Effects of Hypericum perforatum on levels of 5-hydroxytryptamine, noradrenaline and dopamine in the cortex, diencephalon and brainstem of the rat. | 1999 | J. Pharm. Pharmacol. | pmid:10454050 |
| Franklin M et al. | Neuroendocrine evidence for dopaminergic actions of hypericum extract (LI 160) in healthy volunteers. | 1999 | Biol. Psychiatry | pmid:10459411 |
| Schempp CM et al. | Hypericin levels in human serum and interstitial skin blister fluid after oral single-dose and steady-state administration of Hypericum perforatum extract (St. John's wort). | 1999 Sep-Oct | Skin Pharmacol. Appl. Skin Physiol. | pmid:10461100 |
| Weiner L et al. | Targeted cross-linking of a molten globule form of acetylcholinesterase by the virucidal agent hypericin. | 1999 | Biochemistry | pmid:10471290 |
| Fiebich BL et al. | Antibacterial activity of hyperforin from St John's wort. | 1999 | Lancet | pmid:10475222 |
| Kocisová E et al. | Sequence specific interaction of the photoactive drug hypericin depends on the structural arrangement and the stability of the structure containing its specific 5AG3 target: a resonance Raman spectroscopy study. | 1999 | J. Biomol. Struct. Dyn. | pmid:10496421 |
| Tahara YR et al. | The antidepressant hypericin inhibits progression of experimental proliferative vitreoretinopathy. | 1999 | Curr. Eye Res. | pmid:10520228 |
| Kersten B et al. | The application of the micronucleus test in Chinese hamster V79 cells to detect drug-induced photogenotoxicity. | 1999 | Mutat. Res. | pmid:10521691 |
| Kamuhabwa AR et al. | In vitro transport and uptake of protohypericin and hypericin in the Caco-2 model. | 1999 | Int J Pharm | pmid:10528085 |
| Mirossay L et al. | Hypericin-induced phototoxicity of human leukemic cell line HL-60 is potentiated by omeprazole, an inhibitor of H+K+-ATPase and 5'-(N,N-dimethyl)-amiloride, an inhibitor of Na+/H+ exchanger. | 1999 | Physiol Res | pmid:10534017 |
| Hudson JB et al. | Bromohypericins are potent photoactive antiviral agents. | 1999 | Photochem. Photobiol. | pmid:10568175 |
| Chaloupka R et al. | Over-expression of Bcl-2 does not protect cells from hypericin photo-induced mitochondrial membrane depolarization, but delays subsequent events in the apoptotic pathway. | 1999 | FEBS Lett. | pmid:10622714 |
| Delaey EM et al. | Photocytotoxicity of protohypericin after photoconversion to hypericin. | 1999 | Planta Med. | pmid:10630113 |
| Kraus GA et al. | Phenanthrenequinone antiretroviral agents. | 2000 | Bioorg. Med. Chem. Lett. | pmid:10636231 |
| Martens A et al. | In vitro and in vivo evaluation of hypericin for photodynamic therapy of equine sarcoids. | 2000 | Vet. J. | pmid:10640414 |
| Kamuhabwa AR et al. | Skin photosensitization with topical hypericin in hairless mice. | 1999 Nov-Dec | J. Photochem. Photobiol. B, Biol. | pmid:10672536 |
| Prince AM et al. | Strategies for evaluation of enveloped virus inactivation in red cell concentrates using hypericin. | 2000 | Photochem. Photobiol. | pmid:10687393 |
| Kirakosyan A et al. | Stimulation of the production of hypericins by mannan in Hypericum perforatum shoot cultures. | 2000 | Phytochemistry | pmid:10703055 |
| Lavie G et al. | Inhibition of the CD8+ T cell-mediated cytotoxicity reaction by hypericin: potential for treatment of T cell-mediated diseases. | 2000 | Int. Immunol. | pmid:10744649 |
| Lee KT et al. | Hypericin induces both differentiation and apoptosis in human promyelocytic leukemia HL-60 cells. | 1999 | Biol. Pharm. Bull. | pmid:10746153 |
| Chen B and de Witte PA | Photodynamic therapy efficacy and tissue distribution of hypericin in a mouse P388 lymphoma tumor model. | 2000 | Cancer Lett. | pmid:10755394 |
| Vandenbogaerde A et al. | Evidence that total extract of Hypericum perforatum affects exploratory behavior and exerts anxiolytic effects in rats. | 2000 | Pharmacol. Biochem. Behav. | pmid:10764915 |
| Puchner MJ and Giese A | Tamoxifen-resistant glioma-cell sub-populations are characterized by increased migration and proliferation. | 2000 | Int. J. Cancer | pmid:10797257 |
| Geng Y et al. | Chlamydia pneumoniae inhibits apoptosis in human peripheral blood mononuclear cells through induction of IL-10. | 2000 | J. Immunol. | pmid:10799921 |
| Agostinis P et al. | Apoptotic and anti-apoptotic signaling pathways induced by photodynamic therapy with hypericin. | 2000 | Adv. Enzyme Regul. | pmid:10828351 |
| Colasanti A et al. | Hypericin photosensitization of tumor and metastatic cell lines of human prostate. | 2000 | J. Photochem. Photobiol. B, Biol. | pmid:10836538 |
| Moore LB et al. | St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10852961 |
| Denke A et al. | Biochemical activities of extracts from Hypericum perforatum L. 5th communication: dopamine-beta-hydroxylase-product quantification by HPLC and inhibition by hypericins and flavonoids. | 2000 | Arzneimittelforschung | pmid:10858868 |
| Kamuhabwa AR et al. | Investigation of the absorption of hypericin into the skin of hairless mice. | 2000 | J. Pharm. Pharmacol. | pmid:10864135 |
| Obach RS | Inhibition of human cytochrome P450 enzymes by constituents of St. John's Wort, an herbal preparation used in the treatment of depression. | 2000 | J. Pharmacol. Exp. Ther. | pmid:10871299 |
| Schempp CM et al. | Effect of topical application of Hypericum perforatum extract (St. John's wort) on skin sensitivity to solar simulated radiation. | 2000 | Photodermatol Photoimmunol Photomed | pmid:10885442 |
| D'Hallewin MA et al. | Fluorescence detection of flat bladder carcinoma in situ after intravesical instillation of hypericin. | 2000 | J. Urol. | pmid:10893582 |
| Chung PS et al. | Intratumoral hypericin and KTP laser therapy for transplanted squamous cell carcinoma. | 2000 | Laryngoscope | pmid:10942132 |
| Liu CD et al. | Hypericin and photodynamic therapy decreases human pancreatic cancer in vitro and in vivo. | 2000 | J. Surg. Res. | pmid:10945955 |
| Schey KL et al. | Photooxidation of lens alpha-crystallin by hypericin (active ingredient in St. John's Wort). | 2000 | Photochem. Photobiol. | pmid:10946573 |
| Kamuhabwa AR et al. | Photodynamic activity of hypericin in human urinary bladder carcinoma cells. | 2000 Jul-Aug | Anticancer Res. | pmid:10953329 |
| Wentworth JM et al. | St John's wort, a herbal antidepressant, activates the steroid X receptor. | 2000 | J. Endocrinol. | pmid:10974665 |
| Gray DE et al. | Simultaneous determination of the predominant hyperforins and hypericins in St. John's Wort (Hypericum perforatum L.) by liquid chromatography. | 2000 Jul-Aug | J AOAC Int | pmid:10995119 |
| Girzu-Amblard M et al. | [Flavonoid and dianthranoid levels of the St.-John's-wort flowering tops]. | 2000 | Ann Pharm Fr | pmid:11060411 |
| Delaey E et al. | Photocytotoxicity of hypericin in normoxic and hypoxic conditions. | 2000 | J. Photochem. Photobiol. B, Biol. | pmid:11073312 |
| Chowdhury PK et al. | Effect of pH on the fluorescence and absorption spectra of hypericin in reverse micelles. | 2000 | Photochem. Photobiol. | pmid:11107845 |
| Draves AH and Walker SE | Determination of hypericin and pseudohypericin in pharmaceutical preparations by liquid chromatography with fluorescence detection. | 2000 | J. Chromatogr. B Biomed. Sci. Appl. | pmid:11129079 |
| Sgarbossa A et al. | The uptake, location and fluorescence of hypericin in bovine intact lens. | 2000 | Curr. Eye Res. | pmid:11148595 |
| Roslaniec M et al. | Liposome binding constants and singlet oxygen quantum yields of hypericin, tetrahydroxy helianthrone and their derivatives: studies in organic solutions and in liposomes. | 2000 | J. Photochem. Photobiol. B, Biol. | pmid:11154081 |
| Jacobson JM et al. | Pharmacokinetics, safety, and antiviral effects of hypericin, a derivative of St. John's wort plant, in patients with chronic hepatitis C virus infection. | 2001 | Antimicrob. Agents Chemother. | pmid:11158749 |
| Yova D et al. | Photochemical effects and hypericin photosensitized processes in collagen. | 2001 | J Biomed Opt | pmid:11178580 |
| Agrosi M et al. | Oral bioavailability of active principles from herbal products in humans. A study on Hypericum perforatum extracts using the soft gelatin capsule technology. | 2000 | Phytomedicine | pmid:11194173 |
| Mirossay A et al. | Hypocrellin and hypericin-induced phototoxicity of HL-60 cells: apoptosis or necrosis? | 2000 | Phytomedicine | pmid:11194175 |
| Franklin M et al. | Acute effects of LI 160 (extract of Hypericum perforatum, St John's wort) and two of its constituents on neuroendocrine responses in the rat. | 2000 | J. Psychopharmacol. (Oxford) | pmid:11198053 |
| Wirz A et al. | Absorbance data of hypericin and pseudohypericin used as reference compounds for medicinal plant analysis. | 2001 | Pharmazie | pmid:11210670 |
| Fox E et al. | Plasma pharmacokinetics and cerebrospinal fluid penetration of hypericin in nonhuman primates. | 2001 | Cancer Chemother. Pharmacol. | pmid:11221960 |
| Chen B et al. | Photodynamic therapy with hypericin in a mouse P388 tumor model: vascular effects determine the efficacy. | 2001 | Int. J. Oncol. | pmid:11251168 |
| Southwell IA and Bourke CA | Seasonal variation in hypericin content of Hypericum perforatum L. (St. John's Wort). | 2001 | Phytochemistry | pmid:11261576 |
| Park J et al. | Is the excited-state H-atom transfer in hypericin concerted? | 2001 | Photochem. Photobiol. | pmid:11272722 |
| Weitman H et al. | Solvatochromic effects in the electronic absorption and nuclear magnetic resonance spectra of hypericin in organic solvents and in lipid bilayers. | 2001 | Photochem. Photobiol. | pmid:11272723 |
| Nathan PJ | Hypericum perforatum (St John's Wort): a non-selective reuptake inhibitor? A review of the recent advances in its pharmacology. | 2001 | J. Psychopharmacol. (Oxford) | pmid:11277608 |
| Schempp CM et al. | Hypericin photo-induced apoptosis involves the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and activation of caspase-8. | 2001 | FEBS Lett. | pmid:11277999 |
| Zupkó I et al. | In vivo photodynamic activity of hypericin in transitional cell carcinoma bladder tumors. | 2001 | Int. J. Oncol. | pmid:11295062 |
| Schempp CM et al. | Single-dose and steady-state administration of Hypericum perforatum extract (St John's Wort) does not influence skin sensitivity to UV radiation, visible light, and solar-simulated radiation. | 2001 | Arch Dermatol | pmid:11295948 |
| Calapai G et al. | Serotonin, norepinephrine and dopamine involvement in the antidepressant action of hypericum perforatum. | 2001 | Pharmacopsychiatry | pmid:11302563 |
| Schulz V | Incidence and clinical relevance of the interactions and side effects of Hypericum preparations. | 2001 | Phytomedicine | pmid:11315759 |
| Kanofsky JR and Sima PD | Girard's reagent P derivative of beta-Apo-8'-carotenal: a potent photoprotective agent. | 2001 | Photochem. Photobiol. | pmid:11332029 |
| Poutaraud A et al. | Effect of light on hypericins contents in fresh flowering top parts and in an extract of St. John's Wort (Hypericum perforatum). | 2001 | Planta Med. | pmid:11345698 |
| Chen B et al. | Synergistic effect of photodynamic therapy with hypericin in combination with hyperthermia on loss of clonogenicity of RIF-1 cells. | 2001 | Int. J. Oncol. | pmid:11351263 |
| Kuhn D | Hypericin: an answer for safer blood? | 1995 | Common Factor | pmid:11362353 |
| Mareková M et al. | Light-induced photoactivation of hypericin inhibits cellular growth in pituitary adenoma cell line AtT20/D16v-F2 (hypericin inhibits cellular growth of AtT20/D16v-F2). | 2001 | Acta Medica (Hradec Kralove) | pmid:11367893 |
| Barnes J et al. | St John's wort (Hypericum perforatum L.): a review of its chemistry, pharmacology and clinical properties. | 2001 | J. Pharm. Pharmacol. | pmid:11370698 |
| Makovets'ka OIu et al. | [Electronic structure and energetics of transitions in absorption spectra of hypericin]. | 2000 Nov-Dec | Ukr Biokhim Zh (1999) | pmid:11392782 |
| Dinkins MB et al. | Photosensitive chemical and laser light treatments decrease epizootic hemorrhagic disease virus associated with in vitro produced bovine embryos. | 2001 | Theriogenology | pmid:11393216 |
| Chen B et al. | Efficacy of antitumoral photodynamic therapy with hypericin: relationship between biodistribution and photodynamic effects in the RIF-1 mouse tumor model. | 2001 | Int. J. Cancer | pmid:11410877 |
| Hunt EJ et al. | Effect of St. John's wort on free radical production. | 2001 | Life Sci. | pmid:11441908 |
| Kang BY et al. | Inhibition of interleukin-12 production in lipopolysaccharide-activated mouse macrophages by hpyericin, an active component of Hypericum perforatum. | 2001 | Planta Med. | pmid:11458458 |
| Paba V et al. | Photo-activation of hypericin with low doses of light promotes apparent photo-resistance in human histiocytic lymphoma U937 cells. | 2001 | J. Photochem. Photobiol. B, Biol. | pmid:11470563 |
| Pietta P et al. | Comparative evaluation of St. John's wort from different Italian regions. | 2001 May-Jul | Farmaco | pmid:11482784 |
| Wilhelm KP et al. | Role of flavonoids in controlling the phototoxicity of Hypericum perforatum extracts. | 2001 | Phytomedicine | pmid:11515722 |
| Wurglics M et al. | Batch-to-batch reproducibility of St. John's wort preparations. | 2001 | Pharmacopsychiatry | pmid:11518067 |
| Franklin M and Cowen PJ | Researching the antidepressant actions of Hypericum perforatum (St. John's wort) in animals and man. | 2001 | Pharmacopsychiatry | pmid:11518072 |
| Calapai G et al. | Interleukin-6 involvement in antidepressant action of Hypericum perforatum. | 2001 | Pharmacopsychiatry | pmid:11518082 |
| Butterweck V et al. | St John's wort, hypericin, and imipramine: a comparative analysis of mRNA levels in brain areas involved in HPA axis control following short-term and long-term administration in normal and stressed rats. | 2001 | Mol. Psychiatry | pmid:11526469 |
| Schmitt AC et al. | Investigation of some Hypericum species native to Southern of Brazil for antiviral activity. | 2001 | J Ethnopharmacol | pmid:11535370 |
| Blank M et al. | Anti-cancer activities of hypericin in the dark. | 2001 | Photochem. Photobiol. | pmid:11547544 |
| Kamuhabwa AR et al. | Cellular photodestruction induced by hypericin in AY-27 rat bladder carcinoma cells. | 2001 | Photochem. Photobiol. | pmid:11547545 |
| Vantieghem A et al. | Different pathways mediate cytochrome c release after photodynamic therapy with hypericin. | 2001 | Photochem. Photobiol. | pmid:11547546 |
| Rahimipour S et al. | Hypericin derivatives: substituent effects on radical-anion formation. | 2001 | Photochem. Photobiol. | pmid:11547548 |
| Showalter BM et al. | Identification of a vibrational frequency corresponding to H-atom translocation in hypericin. | 2001 | Photochem. Photobiol. | pmid:11547549 |
| Delaey EM et al. | In vitro study of the photocytotoxicity of some hypericin analogs on different cell lines. | 2001 | Photochem. Photobiol. | pmid:11547550 |
| Miskovsky P et al. | Interaction of hypericin with serum albumins: surface-enhanced Raman spectroscopy, resonance Raman spectroscopy and molecular modeling study. | 2001 | Photochem. Photobiol. | pmid:11547551 |