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Hypericin damages the ectatic capillaries in a Roman cockscomb model and inhibits the growth of human endothelial cells more potently than hematoporphyrin does through induction of apoptosis. |
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Hypericin as a marker for determination of myocardial viability in a rat model of myocardial infarction. |
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Potential anticancer agent hypericin and its model compound emodin: interaction with DNA. |
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Luminescence |
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"Competitive quenching": a mechanism by which perihydroxylated perylenequinone photosensitizers can prevent adverse phototoxic damage caused by verteporfin during photodynamic therapy. |
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Temperature stress can alter the photosynthetic efficiency and secondary metabolite concentrations in St. John's wort. |
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Structural requirements for efficient cellular photoprotection by carotenoid derivatives. |
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An investigation of the type of photosensitization caused by the ingestion of St John's Wort (Hypericum perforatum) by calves. |
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pmid:7343570
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[Antidepressive effect of a Hypericum extract standardized to an active hypericine complex. Biochemical and clinical studies]. |
1984 |
Arzneimittelforschung |
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Inhibition of monoamine oxidase by hypericin. |
1984 |
Planta Med. |
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Hypericin and its photodynamic action. |
1986 |
Photochem. Photobiol. |
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Therapeutic agents with dramatic antiretroviral activity and little toxicity at effective doses: aromatic polycyclic diones hypericin and pseudohypericin. |
1988 |
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Studies of the mechanisms of action of the antiretroviral agents hypericin and pseudohypericin. |
1989 |
Proc. Natl. Acad. Sci. U.S.A. |
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Hypericin and pseudohypericin specifically inhibit protein kinase C: possible relation to their antiretroviral activity. |
1989 |
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1990 |
Adv. Second Messenger Phosphoprotein Res. |
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1990 |
Antiviral Res. |
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1990 |
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[Genotoxicity of a standardized Hypericum extract]. |
1990 |
Arzneimittelforschung |
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Photosensitization is required for inactivation of equine infectious anemia virus by hypericin. |
1991 |
Photochem. Photobiol. |
pmid:1707176
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New AIDS drugs. |
1991 |
Minn Med |
pmid:1724284
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A method for the quantitation of hypericin, an antiviral agent, in biological fluids by high-performance liquid chromatography. |
1991 |
Anal. Biochem. |
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1991 |
Antiviral Res. |
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1991 |
Antiviral Res. |
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Treating AIDS with worts. |
1991 |
Science |
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Antiviral activity of the photoactive plant pigment hypericin. |
1991 |
Photochem. Photobiol. |
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Photoactivation of hypericin generates singlet oxygen in mitochondria and inhibits succinoxidase. |
1992 |
Photochem. Photobiol. |
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Photosensitization of aqueous model systems by hypericin. |
1992 |
Biochim. Biophys. Acta |
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Inactivation of the human immunodeficiency virus by hypericin: evidence for photochemical alterations of p24 and a block in uncoating. |
1992 |
AIDS Res. Hum. Retroviruses |
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Evaluation of the antiviral activity of anthraquinones, anthrones and anthraquinone derivatives against human cytomegalovirus. |
1992 |
Antiviral Res. |
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Oxygen dependence of hypericin-induced phototoxicity to EMT6 mouse mammary carcinoma cells. |
1992 |
Photochem. Photobiol. |
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Resonance Raman and surface-enhanced resonance Raman spectroscopy of hypericin. |
1992 |
Photochem. Photobiol. |
pmid:1502258
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Studies of sheep experimentally poisoned with Hypericum perforatum. |
1993 |
Vet Hum Toxicol |
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Lowest excited triplet states of hypericin and isohypericin. |
1993 |
J. Photochem. Photobiol. B, Biol. |
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Photosensitization with anticancer agents. 17. EPR studies of photodynamic action of hypericin: formation of semiquinone radical and activated oxygen species on illumination. |
1993 |
Free Radic. Biol. Med. |
pmid:8381107
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Stevenson NR and Lenard J |
Antiretroviral activities of hypericin and rose bengal: photodynamic effects on Friend leukemia virus infection of mice. |
1993 |
Antiviral Res. |
pmid:8338350
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Hudson JB et al. |
The importance of light in the anti-HIV effect of hypericin. |
1993 |
Antiviral Res. |
pmid:8460933
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Photodynamic inactivation of infectivity of human immunodeficiency virus and other enveloped viruses using hypericin and rose bengal: inhibition of fusion and syncytia formation. |
1993 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:7678335
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Moraleda G et al. |
Inhibition of duck hepatitis B virus replication by hypericin. |
1993 |
Antiviral Res. |
pmid:8470884
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Degar S et al. |
Photodynamic inactivation of radiation leukemia virus produced from hypericin-treated cells. |
1993 |
Virology |
pmid:7504371
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Inhibition of epidermal growth factor receptor tyrosine kinase activity by hypericin. |
1993 |
Biochem. Pharmacol. |
pmid:8267642
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Redepenning J and Tao N |
Measurement of formal potentials for hypericin in dimethylsulfoxide. |
1993 |
Photochem. Photobiol. |
pmid:8248327
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Schulz H and Jobert M |
Effects of hypericum extract on the sleep EEG in older volunteers. |
1994 |
J Geriatr Psychiatry Neurol |
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Pharmacokinetics of hypericin and pseudohypericin after oral intake of the hypericum perforatum extract LI 160 in healthy volunteers. |
1994 |
J Geriatr Psychiatry Neurol |
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Thiede HM and Walper A |
Inhibition of MAO and COMT by hypericum extracts and hypericin. |
1994 |
J Geriatr Psychiatry Neurol |
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Wagner H and Bladt S |
Pharmaceutical quality of hypericum extracts. |
1994 |
J Geriatr Psychiatry Neurol |
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Antiviral assays on phytochemicals: the influence of reaction parameters. |
1994 |
Planta Med. |
pmid:7938267
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Carpenter S et al. |
Chemiluminescent activation of the antiviral activity of hypericin: a molecular flashlight. |
1994 |
Proc. Natl. Acad. Sci. U.S.A. |
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Laser photosensitization of cells by hypericin. |
1994 |
Photochem. Photobiol. |
pmid:8041807
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Hudson JB et al. |
Hypocrellin, from Hypocrella bambuase, is phototoxic to human immunodeficiency virus. |
1994 |
Photochem. Photobiol. |
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Chung PS et al. |
Hypericin uptake in rabbits and nude mice transplanted with human squamous cell carcinomas: study of a new sensitizer for laser phototherapy. |
1994 |
Laryngoscope |
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Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C. |
1994 |
Cancer Res. |
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Couldwell WT et al. |
Hypericin: a potential antiglioma therapy. |
1994 |
Neurosurgery |
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Hypericin photosensitization in aqueous model systems. |
1994 |
Photochem. Photobiol. |
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A multiwell assay for inhibitors of phosphatidylinositol-3-kinase and the identification of natural product inhibitors. |
1994 Nov-Dec |
Anticancer Res. |
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Utsumi T et al. |
Light-dependent inhibition of protein kinase C and superoxide generation of neutrophils by hypericin, an antiretroviral agent. |
1995 |
Arch. Biochem. Biophys. |
pmid:7840655
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Lavie G et al. |
The chemical and biological properties of hypericin--a compound with a broad spectrum of biological activities. |
1995 |
Med Res Rev |
pmid:7739292
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Vyas GN |
Inactivation and removal of blood-borne viruses. |
1995 |
Transfusion |
pmid:7740604
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Lavie G et al. |
Hypericin as an inactivator of infectious viruses in blood components. |
1995 |
Transfusion |
pmid:7740610
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Hadjur C et al. |
Photodynamically induced cytotoxicity of hypericin dye on human fibroblast cell line MRC5. |
1995 |
J. Photochem. Photobiol. B, Biol. |
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Miskovsky P et al. |
Subcellular distribution of hypericin in human cancer cells. |
1995 |
Photochem. Photobiol. |
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Miskovsky P et al. |
Hypericin site specific interactions within polynucleotides used as DNA model compounds. |
1995 |
J. Biomol. Struct. Dyn. |
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Gopalakrishna R et al. |
Modifications of cysteine-rich regions in protein kinase C induced by oxidant tumor promoters and enzyme-specific inhibitors. |
1995 |
Meth. Enzymol. |
pmid:7476346
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Fehr MJ et al. |
Roles of oxygen and photoinduced acidification in the light-dependent antiviral activity of hypocrellin A. |
1995 |
Biochemistry |
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Inhibition of neutrophil superoxide generation by hypericin, an antiretroviral agent. |
1995 |
Arch. Biochem. Biophys. |
pmid:7487096
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Zhang W et al. |
Growth inhibition and apoptosis in human neuroblastoma SK-N-SH cells induced by hypericin, a potent inhibitor of protein kinase C. |
1995 |
Cancer Lett. |
pmid:7553605
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Lenci F et al. |
Spectroscopic and photoacoustic studies of hypericin embedded in liposomes as a photoreceptor model. |
1995 |
Photochem. Photobiol. |
pmid:7638267
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Diwu Z |
Novel therapeutic and diagnostic applications of hypocrellins and hypericins. |
1995 |
Photochem. Photobiol. |
pmid:7568399
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Richter A and Davies DE |
Effects of anthralin and hypericin on growth factor signalling and cell proliferation in vitro. |
1995 |
Biochem. Pharmacol. |
pmid:8849331
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Agostinis P et al. |
Photosensitized inhibition of growth factor-regulated protein kinases by hypericin. |
1995 |
Biochem. Pharmacol. |
pmid:7786302
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Utsumi T et al. |
Effect of the antiretroviral agent hypericin on rat liver mitochondria. |
1995 |
Biochem. Pharmacol. |
pmid:7669068
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Kuhn D |
Hypericin: an answer for safer blood? |
1995 |
Common Factor |
pmid:11362353
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Dwyer JT et al. |
The use of unconventional remedies among HIV-positive men living in California. |
1995 Jan-Feb |
J Assoc Nurses AIDS Care |
pmid:7734719
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VanderWerf QM et al. |
Hypericin: a new laser phototargeting agent for human cancer cells. |
1996 |
Laryngoscope |
pmid:8614225
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Micali G et al. |
High-performance liquid chromatographic determination of the biologically active principle hypericin in phytotherapeutic vegetable extracts and alcoholic beverages. |
1996 |
J Chromatogr A |
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Agostinis P et al. |
A comparative analysis of the photosensitized inhibition of growth-factor regulated protein kinases by hypericin-derivatives. |
1996 |
Biochem. Biophys. Res. Commun. |
pmid:8607812
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Cohen PA et al. |
Antiviral activities of anthraquinones, bianthrones and hypericin derivatives from lichens. |
1996 |
Experientia |
pmid:8608821
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Hamilton HB et al. |
Inhibition of cellular growth and induction of apoptosis in pituitary adenoma cell lines by the protein kinase C inhibitor hypericin: potential therapeutic application. |
1996 |
J. Neurosurg. |
pmid:8755764
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Hadjur C et al. |
Photodynamic effects of hypericin on lipid peroxidation and antioxidant status in melanoma cells. |
1996 |
Photochem. Photobiol. |
pmid:8760577
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al-Akhras MA and Grossweiner LI |
Sensitization of photohemolysis by hypericin and Photofrin. |
1996 |
J. Photochem. Photobiol. B, Biol. |
pmid:8810534
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Yu H et al. |
Hypericin-induced phototoxicity in cultured fibroblasts and swine erythrocytes. |
1996 |
Photochem. Photobiol. |
pmid:8787010
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Harris MS et al. |
Hypericin inhibits cell growth and induces apoptosis in retinal pigment epithelial cells: possible involvement of protein kinase C. |
1996 |
Curr. Eye Res. |
pmid:8654105
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Samel D et al. |
The effect of purified extract of Fagopyrum esculentum (buckwheat) on protein kinases involved in signal transduction pathways. |
1996 |
Planta Med. |
pmid:8657738
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Kartnig T et al. |
Production of hypericin, pseudohypericin and flavonoids in cell cultures of various Hypericum species and their chemotypes. |
1996 |
Planta Med. |
pmid:8720388
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Kerb R et al. |
Single-dose and steady-state pharmacokinetics of hypericin and pseudohypericin. |
1996 |
Antimicrob. Agents Chemother. |
pmid:8878586
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Zhang W et al. |
Malignant glioma sensitivity to radiotherapy, high-dose tamoxifen, and hypericin: corroborating clinical response in vitro: case report. |
1996 |
Neurosurgery |
pmid:8837815
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Koren H et al. |
Hypericin in phototherapy. |
1996 |
J. Photochem. Photobiol. B, Biol. |
pmid:9002247
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Kubin A et al. |
Wavelength-dependent photoresponse of biological and aqueous model systems using the photodynamic plant pigment hypericin. |
1996 |
J. Photochem. Photobiol. B, Biol. |
pmid:9002246
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Zhang W et al. |
Enhancement of radiosensitivity in human malignant glioma cells by hypericin in vitro. |
1996 |
Clin. Cancer Res. |
pmid:9816239
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Vandenbogaerde AL et al. |
Antitumour activity of photosensitized hypericin on A431 cell xenografts. |
1996 Jul-Aug |
Anticancer Res. |
pmid:8712679
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Müller K et al. |
Simple analogues of anthralin: unusual specificity of structure and antiproliferative activity. |
1997 |
J. Med. Chem. |
pmid:9371243
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Brockmöller J et al. |
Hypericin and pseudohypericin: pharmacokinetics and effects on photosensitivity in humans. |
1997 |
Pharmacopsychiatry |
pmid:9342768
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Sattler S et al. |
Binding, uptake, and transport of hypericin by Caco-2 cell monolayers. |
1997 |
J Pharm Sci |
pmid:9344168
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Eshraghi AA et al. |
Laser chemotherapy of human carcinoma cells with three new anticancer drugs. |
1997 |
J Clin Laser Med Surg |
pmid:9467337
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