| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uterine Cervical Neoplasms | D002583 | 10 associated lipids |
| Neoplasms, Experimental | D009374 | 10 associated lipids |
| Neoplasms, Radiation-Induced | D009381 | 3 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Carcinoma, Squamous Cell | D002294 | 14 associated lipids |
| Skin Neoplasms | D012878 | 12 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
hypericin
hypericin is a lipid of Polyketides (PK) class. Hypericin is associated with abnormalities such as Dermatitis, Phototoxic, Dehydration, Photosensitization, Morphologically altered structure and Myocardial Infarction. The involved functions are known as Cell Cycle Checkpoints, Apoptosis, Acetylation, Cell Survival and Caspase Activation. Hypericin often locates in insoluble fraction, Cytoplasmic matrix, Protoplasm, Tissue membrane and Cytoplasm. The associated genes with hypericin are CDC37 gene, HSPA8 gene, RAF1 gene, cyclin H and FK228. The related lipids are Phosphatidylserines.
Cross Reference
Introduction
To understand associated biological information of hypericin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with hypericin?
hypericin is suspected in Dermatitis, Phototoxic, Photosensitization, Pneumonia, Psoriasis, Phototoxicity, Chronic infectious disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with hypericin
PubChem Associated disorders and diseases
What pathways are associated with hypericin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with hypericin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with hypericin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with hypericin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with hypericin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with hypericin?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with hypericin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Dresler S et al. | Methodological aspects of biologically active compounds quantification in the genus Hypericum. | 2018 | J Pharm Biomed Anal | pmid:29621655 |
| Shih CM et al. | Hypericin inhibits hepatitis C virus replication via deacetylation and down-regulation of heme oxygenase-1. | 2018 | Phytomedicine | pmid:30097118 |
| Shao C et al. | Facile fabrication of hypericin-entrapped glyconanoparticles for targeted photodynamic therapy. | 2018 | Int J Nanomedicine | pmid:30087563 |
| Geng C et al. | Sonodynamic therapy: A potential treatment for atherosclerosis. | 2018 | Life Sci. | pmid:29940244 |
| Lopera AA et al. | Solution-combustion synthesis of doped TiO compounds and its potential antileishmanial activity mediated by photodynamic therapy. | 2018 | J. Photochem. Photobiol. B, Biol. | pmid:29689488 |
| Vargová J et al. | Hypericin affects cancer side populations via competitive inhibition of BCRP. | 2018 | Biomed. Pharmacother. | pmid:29665654 |
| Dalmizrak O et al. | Mechanistic and structural insights into the in vitro inhibitory action of hypericin on glutathione reductase purified from baker's yeast. | 2018 | J. Biochem. Mol. Toxicol. | pmid:29660796 |
| Kimáková K et al. | Relation between hypericin content and morphometric leaf parameters in Hypericum spp.: A case of cubic degree polynomial function. | 2018 | Plant Sci. | pmid:29650162 |
| Xu F et al. | Yield enhancement strategies of rare pharmaceutical metabolites from endophytes. | 2018 | Biotechnol. Lett. | pmid:29605937 |
| You MK et al. | St. John's Wort Regulates Proliferation and Apoptosis in MCF-7 Human Breast Cancer Cells by Inhibiting AMPK/mTOR and Activating the Mitochondrial Pathway. | 2018 | Int J Mol Sci | pmid:29570671 |
| Herraiz T and Guillén H | Monoamine Oxidase-A Inhibition and Associated Antioxidant Activity in Plant Extracts with Potential Antidepressant Actions. | 2018 | Biomed Res Int | pmid:29568754 |
| Keša P et al. | Excitation of triplet states of hypericin in water mediated by hydrotropic cromolyn sodium salt. | 2018 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:29241053 |
| Lopera AA et al. | Synthesis of calcium phosphate nanostructures by combustion in solution as a potential encapsulant system of drugs with photodynamic properties for the treatment of cutaneous leishmaniasis. | 2018 | Photodiagnosis Photodyn Ther | pmid:29198762 |
| Roschger C et al. | Reduction of cancer cell viability by synergistic combination of photodynamic treatment with the inhibition of the Id protein family. | 2018 | J. Photochem. Photobiol. B, Biol. | pmid:29245122 |
| Zhang JN et al. | Effect of photodynamic inactivation of Escherichia coli by hypericin. | 2018 | World J. Microbiol. Biotechnol. | pmid:29926201 |
| Li ZH et al. | Topically applied hypericin exhibits skin penetrability on nude mice. | 2018 | Lasers Med Sci | pmid:29915976 |
| Valletta E et al. | Distinct Hypericum perforatum L. total extracts exert different antitumour activity on erythroleukemic K562 cells. | 2018 | Phytother Res | pmid:29785769 |
| Abma E et al. | Biodistribution and tolerance of intravenous iodine-131-labelled hypericin in healthy dogs. | 2018 | Vet Comp Oncol | pmid:29314561 |
| de Andrade GP et al. | Comparative in vitro study of photodynamic activity of hypericin and hypericinates in MCF-7 cells. | 2017 | J. Photochem. Photobiol. B, Biol. | pmid:28865319 |
| Singh S et al. | Molecular events leading to death of Leishmania donovani under spermidine starvation after hypericin treatment. | 2017 | Chem Biol Drug Des | pmid:28509385 |
| Montanha MC et al. | Response surface method optimization of a novel Hypericin formulation in P123 micelles for colorectal cancer and antimicrobial photodynamic therapy. | 2017 | J. Photochem. Photobiol. B, Biol. | pmid:28454049 |
| Lin S et al. | Endoplasmic reticulum-targeting photosensitizer Hypericin confers chemo-sensitization towards oxaliplatin through inducing pro-death autophagy. | 2017 | Int. J. Biochem. Cell Biol. | pmid:28392376 |
| Joniova J et al. | Formation of Large Hypericin Aggregates in Giant Unilamellar Vesicles-Experiments and Modeling. | 2017 | Biophys. J. | pmid:28297655 |
| Huntosova V et al. | Assessing light-independent effects of hypericin on cell viability, ultrastructure and metabolism in human glioma and endothelial cells. | 2017 | Toxicol In Vitro | pmid:28087315 |
| Ng QX et al. | Clinical use of Hypericum perforatum (St John's wort) in depression: A meta-analysis. | 2017 | J Affect Disord | pmid:28064110 |
| Kimáková P et al. | Photoactivated hypericin increases the expression of SOD-2 and makes MCF-7 cells resistant to photodynamic therapy. | 2017 | Biomed. Pharmacother. | pmid:27923686 |
| Biteghe FN and Davids LM | A combination of photodynamic therapy and chemotherapy displays a differential cytotoxic effect on human metastatic melanoma cells. | 2017 | J. Photochem. Photobiol. B, Biol. | pmid:27852006 |
| Moritz MNO et al. | Semi-synthesis and PDT activities of a new amphiphilic chlorin derivative. | 2017 | Photodiagnosis Photodyn Ther | pmid:27769913 |
| Misuth M et al. | Estimation of PKCδ autophosphorylation in U87 MG glioma cells: combination of experimental, conceptual and numerical approaches. | 2017 | J Biophotonics | pmid:27158772 |
| Misuth M et al. | Synergism between PKCδ regulators hypericin and rottlerin enhances apoptosis in U87 MG glioma cells after light stimulation. | 2017 | Photodiagnosis Photodyn Ther | pmid:28373118 |
| Halaburková A et al. | Histone deacetylase inhibitors potentiate photodynamic therapy in colon cancer cells marked by chromatin-mediated epigenetic regulation of . | 2017 | Clin Epigenetics | pmid:28603560 |
| Ndhundhuma IM and Abrahamse H | Susceptibility of Melanoma Skin Cancer to Photoactivated Hypericin versus Aluminium(III) Phthalocyanine Chloride Tetrasulphonate. | 2017 | Biomed Res Int | pmid:29147654 |
| Gonçalves JLDS et al. | Hypericin cytotoxicity in tumor and non-tumor cell lines: A chemometric study. | 2017 | Photodiagnosis Photodyn Ther | pmid:28811224 |
| Moritz MNO et al. | Phototoxicity in a laryngeal cancer cell line enhanced by a targeting amphiphilic chlorin photosensitizer. | 2017 | Photodiagnosis Photodyn Ther | pmid:28716739 |
| Borghi-Pangoni FB et al. | Preparation and characterization of bioadhesive system containing hypericin for local photodynamic therapy. | 2017 | Photodiagnosis Photodyn Ther | pmid:28669792 |
| Chen E et al. | One-pot method to prepare a theranostic nanosystem with magnetic resonance imaging function and anticancer activity through multiple mechanisms. | 2017 | Dalton Trans | pmid:28280824 |
| Gattuso H et al. | Deciphering the photosensitization mechanisms of hypericin towards biological membranes. | 2017 | Phys Chem Chem Phys | pmid:28820528 |
| Mühleisen L et al. | Analysis of Hypericin-Mediated Effects and Implications for Targeted Photodynamic Therapy. | 2017 | Int J Mol Sci | pmid:28661430 |
| Duan X et al. | Radioiodinated hypericin disulfonic acid sodium salts as a DNA-binding probe for early imaging of necrotic myocardium. | 2017 | Eur J Pharm Biopharm | pmid:28414189 |
| Theodossiou TA et al. | The diverse roles of glutathione-associated cell resistance against hypericin photodynamic therapy. | 2017 | Redox Biol | pmid:28254657 |
| Misuth M et al. | The flashlights on a distinct role of protein kinase C δ: Phosphorylation of regulatory and catalytic domain upon oxidative stress in glioma cells. | 2017 | Cell. Signal. | pmid:28237688 |
| Lazzara S et al. | Arbuscular mycorrhizal fungi altered the hypericin, pseudohypericin, and hyperforin content in flowers of Hypericum perforatum grown under contrasting P availability in a highly organic substrate. | 2017 | Mycorrhiza | pmid:27999964 |
| Zeliou K et al. | Optimized and Validated HPLC Analysis of St. John's Wort Extract and Final Products by Simultaneous Determination of Major Ingredients. | 2017 | J Chromatogr Sci | pmid:28472287 |
| Li X et al. | Hypericin-mediated sonodynamic therapy induces autophagy and decreases lipids in THP-1 macrophage by promoting ROS-dependent nuclear translocation of TFEB. | 2016 | Cell Death Dis | pmid:28005078 |
| Miranda Cona M et al. | Differential diagnosis of gallstones by using hypericin as a fluorescent optical imaging agent. | 2016 | World J. Gastroenterol. | pmid:27547012 |
| Singh S and Dubey VK | Quantitative Proteome Analysis of Leishmania donovani under Spermidine Starvation. | 2016 | PLoS ONE | pmid:27123864 |
| Wang Q et al. | Discovery of Radioiodinated Monomeric Anthraquinones as a Novel Class of Necrosis Avid Agents for Early Imaging of Necrotic Myocardium. | 2016 | Sci Rep | pmid:26878909 |
| Zhang M et al. | Hypericin inhibits oligomeric amyloid β42-induced inflammation response in microglia and ameliorates cognitive deficits in an amyloid β injection mouse model of Alzheimer's disease by suppressing MKL1. | 2016 | Biochem. Biophys. Res. Commun. | pmid:27825966 |
| BurÃková M et al. | Hypericin fluorescence kinetics in the presence of low density lipoproteins: study on quail CAM assay for topical delivery. | 2016 | Gen. Physiol. Biophys. | pmid:27447402 |
| Maslaňáková M et al. | Anti- and Pro-apoptotic Bcl2 Proteins Distribution and Metabolic Profile in Human Coronary Aorta Endothelial Cells Before and After HypPDT. | 2016 | Cell Biochem. Biophys. | pmid:27314518 |
| Šemeláková M et al. | Drug membrane transporters and CYP3A4 are affected by hypericin, hyperforin or aristoforin in colon adenocarcinoma cells. | 2016 | Biomed. Pharmacother. | pmid:27261575 |
| Gyurászová K et al. | YM155, a small molecule inhibitor of survivin expression, sensitizes cancer cells to hypericin-mediated photodynamic therapy. | 2016 | Photochem. Photobiol. Sci. | pmid:27241169 |
| Singh RK et al. | Construction of Hypericin Gland-Specific cDNA Library via Suppression Subtractive Hybridization. | 2016 | Methods Mol. Biol. | pmid:27108327 |
| Bruňáková K and Čellárová E | Shoot Tip Meristem Cryopreservation of Hypericum Species. | 2016 | Methods Mol. Biol. | pmid:27108308 |
| Dementavicius D et al. | Application of mathematical models for bacterial inactivation curves using Hypericin-based photosensitization. | 2016 | J. Appl. Microbiol. | pmid:26972682 |
| Verebova V et al. | Deeper insights into the drug defense of glioma cells against hydrophobic molecules. | 2016 | Int J Pharm | pmid:26940808 |
| Garg AD et al. | Dendritic cell vaccines based on immunogenic cell death elicit danger signals and T cell-driven rejection of high-grade glioma. | 2016 | Sci Transl Med | pmid:26936504 |
| Feruszová J et al. | Photoactivated hypericin is not genotoxic. | 2016 | Gen. Physiol. Biophys. | pmid:26891274 |
| KucharÃková A et al. | Interspecific variation in localization of hypericins and phloroglucinols in the genus Hypericum as revealed by desorption electrospray ionization mass spectrometry imaging. | 2016 | Physiol Plant | pmid:26822391 |
| Lin S et al. | Enhancement of oxaliplatin sensitivity in human colorectal cancer by hypericin mediated photodynamic therapy via ROS-related mechanism. | 2016 | Int. J. Biochem. Cell Biol. | pmid:26673998 |
| Florea AM et al. | An innovative approach to prepare hypericin molecularly imprinted pearls using a "phyto-template". | 2016 | Talanta | pmid:26653421 |
| Silva SM et al. | Effects of Hypericum perforatum extract and its main bioactive compounds on the cytotoxicity and expression of CYP1A2 and CYP2D6 in hepatic cells. | 2016 | Life Sci. | pmid:26612349 |
| Zhang D et al. | Effects of skeleton structure on necrosis targeting and clearance properties of radioiodinated dianthrones. | 2016 | J Drug Target | pmid:26586010 |
| Li J et al. | Synthesis and Preclinical Evaluation of Radioiodinated Hypericin Dicarboxylic Acid as a Necrosis Avid Agent in Rat Models of Induced Hepatic, Muscular, and Myocardial Necroses. | 2016 | Mol. Pharm. | pmid:26568406 |
| Li Y et al. | Co-delivery of siRNA and hypericin into cancer cells by hyaluronic acid modified PLGA-PEI nanoparticles. | 2016 | Drug Dev Ind Pharm | pmid:26472259 |
| Hu W et al. | Fluorescence Detection of DNA Based on Non-covalent π-π Stacking Interaction between 1-Pyrenebutanoic Acid and Hypericin. | 2016 | Anal Sci | pmid:27169651 |
| Gao L et al. | Improved therapeutic outcomes of thermal ablation on rat orthotopic liver allograft sarcoma models by radioiodinated hypericin induced necrosis targeted radiotherapy. | 2016 | Oncotarget | pmid:27285983 |
| Zhang Q et al. | Hypericin-photodynamic therapy induces human umbilical vein endothelial cell apoptosis. | 2015 | Sci Rep | pmid:26673286 |
| Unterweger H et al. | Hypericin-bearing magnetic iron oxide nanoparticles for selective drug delivery in photodynamic therapy. | 2015 | Int J Nanomedicine | pmid:26648714 |
| Xu Y et al. | Hypericin-mediated photodynamic therapy induces apoptosis in K562 human leukemia cells through JNK pathway modulation. | 2015 | Mol Med Rep | pmid:26330116 |
| Garg AD et al. | Resistance to anticancer vaccination effect is controlled by a cancer cell-autonomous phenotype that disrupts immunogenic phagocytic removal. | 2015 | Oncotarget | pmid:26314964 |
| Furuta A et al. | Identification of Hydroxyanthraquinones as Novel Inhibitors of Hepatitis C Virus NS3 Helicase. | 2015 | Int J Mol Sci | pmid:26262613 |
| Yi J et al. | Photoactivation of hypericin decreases the viability of RINm5F insulinoma cells through reduction in JNK/ERK phosphorylation and elevation of caspase-9/caspase-3 cleavage and Bax-to-Bcl-2 ratio. | 2015 | Biosci. Rep. | pmid:26182357 |
| Montoya A et al. | Development of a novel formulation with hypericin to treat cutaneous leishmaniasis based on photodynamic therapy in in vitro and in vivo studies. | 2015 | Antimicrob. Agents Chemother. | pmid:26169411 |
| Shao H et al. | Necrosis targeted radiotherapy with iodine-131-labeled hypericin to improve anticancer efficacy of vascular disrupting treatment in rabbit VX2 tumor models. | 2015 | Oncotarget | pmid:26036625 |
| Li Y et al. | Biliary and duodenal drainage for reducing the radiotoxic risk of antineoplastic 131I-hypericin in rat models. | 2015 | Exp. Biol. Med. (Maywood) | pmid:25956680 |
| Zhu M et al. | Evaluation of the therapeutic efficacy of sequential therapy involving percutaneous microwave ablation in combination with 131I-hypericin using the VX2 rabbit breast solid tumor model. | 2015 | PLoS ONE | pmid:25799220 |
| Li X et al. | The efficacy and mechanism of apoptosis induction by hypericin-mediated sonodynamic therapy in THP-1 macrophages. | 2015 | Int J Nanomedicine | pmid:25653524 |
| Singh S et al. | Probing the molecular mechanism of hypericin-induced parasite death provides insight into the role of spermidine beyond redox metabolism in Leishmania donovani. | 2015 | Antimicrob. Agents Chemother. | pmid:25313212 |
| Turk S et al. | Purification of Glutathione S-Transferase pi from Erythrocytes and Evaluation of the Inhibitory Effect of Hypericin. | 2015 | Protein J. | pmid:26614503 |
| Penjweini R et al. | Intracellular localization and dynamics of Hypericin loaded PLLA nanocarriers by image correlation spectroscopy. | 2015 | J Control Release | pmid:26435453 |
| Alnawaiseh M et al. | [Effect of Hypericin on the Function of the Neuroretina: An Electroretinographic Study]. | 2015 | Klin Monbl Augenheilkd | pmid:26197957 |
| Popovic A et al. | Differential susceptibility of primary cultured human skin cells to hypericin PDT in an in vitro model. | 2015 | J. Photochem. Photobiol. B, Biol. | pmid:26114219 |
| Verjee S et al. | Permeation Characteristics of Hypericin across Caco-2 Monolayers in the Absence or Presence of Quercitrin - A Mass Balance Study. | 2015 | Planta Med. | pmid:26018919 |
| Kuchárová B et al. | Potentiation of hypericin-mediated photodynamic therapy cytotoxicity by MK-886: focus on ABC transporters, GDF-15 and redox status. | 2015 | Photodiagnosis Photodyn Ther | pmid:26003114 |
| Zhai XJ et al. | LC-MS/MS based studies on the anti-depressant effect of hypericin in the chronic unpredictable mild stress rat model. | 2015 | J Ethnopharmacol | pmid:25957811 |
| Kusari S et al. | Spatial chemo-profiling of hypericin and related phytochemicals in Hypericum species using MALDI-HRMS imaging. | 2015 | Anal Bioanal Chem | pmid:25912460 |
| Bernal C et al. | Photodynamic efficiency of hypericin compared with chlorin and hematoporphyrin derivatives in HEp-2 and Vero epithelial cell lines. | 2015 | Photodiagnosis Photodyn Ther | pmid:25910552 |
| Kashef N et al. | Phototoxic effect of hypericin alone and in combination with acetylcysteine on Staphylococcus aureus biofilms. | 2015 | Photodiagnosis Photodyn Ther | pmid:25892001 |
| Hohmann MS et al. | Hypericum perforatum Reduces Paracetamol-Induced Hepatotoxicity and Lethality in Mice by Modulating Inflammation and Oxidative Stress. | 2015 | Phytother Res | pmid:25851311 |
| GarcÃa I et al. | Antimicrobial photodynamic activity of hypericin against methicillin-susceptible and resistant Staphylococcus aureus biofilms. | 2015 | Future Microbiol | pmid:25812458 |
| Liu W et al. | Biodistribution and anti-tumor efficacy of intratumorally injected necrosis-avid theranostic agent radioiodinated hypericin in rodent tumor models. | 2015 | J Drug Target | pmid:25572455 |
| RodrÃguez-Amigo B et al. | The complex of hypericin with β-lactoglobulin has antimicrobial activity with potential applications in dairy industry. | 2015 | J. Dairy Sci. | pmid:25465550 |
| Liu X et al. | Evaluation of hypericin: effect of aggregation on targeting biodistribution. | 2015 | J Pharm Sci | pmid:25395358 |
| Straub M et al. | A phase IIA dose-finding study of PVP-hypericin fluorescence cystoscopy for detection of nonmuscle-invasive bladder cancer. | 2015 | J. Endourol. | pmid:25222735 |
| Urla C et al. | Successful in vivo tumor visualization using fluorescence laparoscopy in a mouse model of disseminated alveolar rhabdomyosarcoma. | 2015 | Surg Endosc | pmid:25149634 |
| Qi X et al. | Radiopharmaceutical study on Iodine-131-labelled hypericin in a canine model of hepatic RFA-induced coagulative necrosis. | 2015 | Radiol Med | pmid:25012473 |
| Laffers W et al. | Photosensitizing effects of hypericin on head neck squamous cell carcinoma in vitro. | 2015 | Eur Arch Otorhinolaryngol | pmid:24687800 |
| Cona MM et al. | Sodium cholate, a solubilizing agent for the necrosis avid radioiodinated hypericin in rabbits with acute myocardial infarction. | 2015 | Drug Deliv | pmid:24417698 |
| Choi YM et al. | Photodynamic therapy for psoriasis. | 2015 | J Dermatolog Treat | pmid:24881473 |