| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uterine Cervical Neoplasms | D002583 | 10 associated lipids |
| Neoplasms, Experimental | D009374 | 10 associated lipids |
| Neoplasms, Radiation-Induced | D009381 | 3 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Carcinoma, Squamous Cell | D002294 | 14 associated lipids |
| Skin Neoplasms | D012878 | 12 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
hypericin
hypericin is a lipid of Polyketides (PK) class. Hypericin is associated with abnormalities such as Dermatitis, Phototoxic, Dehydration, Photosensitization, Morphologically altered structure and Myocardial Infarction. The involved functions are known as Cell Cycle Checkpoints, Apoptosis, Acetylation, Cell Survival and Caspase Activation. Hypericin often locates in insoluble fraction, Cytoplasmic matrix, Protoplasm, Tissue membrane and Cytoplasm. The associated genes with hypericin are CDC37 gene, HSPA8 gene, RAF1 gene, cyclin H and FK228. The related lipids are Phosphatidylserines.
Cross Reference
Introduction
To understand associated biological information of hypericin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with hypericin?
hypericin is suspected in Dermatitis, Phototoxic, Photosensitization, Pneumonia, Psoriasis, Phototoxicity, Chronic infectious disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with hypericin
PubChem Associated disorders and diseases
What pathways are associated with hypericin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with hypericin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with hypericin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with hypericin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with hypericin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with hypericin?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with hypericin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
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| Cona MM et al. | Targetability and biodistribution of radioiodinated hypericin: comparison between microdosing and carrier-added preparations. | 2014 | Anticancer Agents Med Chem | pmid:24102315 |
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| Frew T et al. | A multiwell assay for inhibitors of phosphatidylinositol-3-kinase and the identification of natural product inhibitors. | 1994 Nov-Dec | Anticancer Res. | pmid:7872663 |
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| Vandenbogaerde AL et al. | Antitumour activity of photosensitized hypericin on A431 cell xenografts. | 1996 Jul-Aug | Anticancer Res. | pmid:8712679 |
| Alecu M et al. | Photodynamic treatment of basal cell carcinoma and squamous cell carcinoma with hypericin. | 1998 Nov-Dec | Anticancer Res. | pmid:9891535 |
| Ritz R et al. | Subcellular colocalization of hypericin with respect to endoplasmic reticulum and Golgi apparatus in glioblastoma cells. | 2008 Jul-Aug | Anticancer Res. | pmid:18751371 |
| Hwang MS et al. | Inhibition of c-erbB-2 expression an activity in human ovarian carcinoma cells by hypericin. | 2001 Jul-Aug | Anticancer Res. | pmid:11724334 |
| Montoya A et al. | Development of a novel formulation with hypericin to treat cutaneous leishmaniasis based on photodynamic therapy in in vitro and in vivo studies. | 2015 | Antimicrob. Agents Chemother. | pmid:26169411 |
| Singh S et al. | Probing the molecular mechanism of hypericin-induced parasite death provides insight into the role of spermidine beyond redox metabolism in Leishmania donovani. | 2015 | Antimicrob. Agents Chemother. | pmid:25313212 |
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| Stevenson NR and Lenard J | Antiretroviral activities of hypericin and rose bengal: photodynamic effects on Friend leukemia virus infection of mice. | 1993 | Antiviral Res. | pmid:8338350 |
| Hudson JB et al. | The importance of light in the anti-HIV effect of hypericin. | 1993 | Antiviral Res. | pmid:8460933 |
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| Morrey JD et al. | Identification of active antiviral compounds against a New York isolate of West Nile virus. | 2002 | Antiviral Res. | pmid:12076755 |