hypericin

hypericin is a lipid of Polyketides (PK) class. Hypericin is associated with abnormalities such as Dermatitis, Phototoxic, Dehydration, Photosensitization, Morphologically altered structure and Myocardial Infarction. The involved functions are known as Cell Cycle Checkpoints, Apoptosis, Acetylation, Cell Survival and Caspase Activation. Hypericin often locates in insoluble fraction, Cytoplasmic matrix, Protoplasm, Tissue membrane and Cytoplasm. The associated genes with hypericin are CDC37 gene, HSPA8 gene, RAF1 gene, cyclin H and FK228. The related lipids are Phosphatidylserines.

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Introduction

To understand associated biological information of hypericin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with hypericin?

hypericin is suspected in Dermatitis, Phototoxic, Photosensitization, Pneumonia, Psoriasis, Phototoxicity, Chronic infectious disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with hypericin

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Uterine Cervical Neoplasms D002583 10 associated lipids
Neoplasms, Experimental D009374 10 associated lipids
Neoplasms, Radiation-Induced D009381 3 associated lipids
Adenocarcinoma D000230 166 associated lipids
Lung Neoplasms D008175 171 associated lipids
Carcinoma, Squamous Cell D002294 14 associated lipids
Skin Neoplasms D012878 12 associated lipids
Burns D002056 34 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Per page 10 20 50 | Total 38

PubChem Associated disorders and diseases

What pathways are associated with hypericin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with hypericin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with hypericin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with hypericin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with hypericin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with hypericin?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with hypericin

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Authors Title Published Journal PubMed Link
Hao GY and Zhang YH [Fluorescence technique on diagnosis of urinary bladder carcinoma]. 2003 Zhonghua Yi Xue Za Zhi pmid:14723217
Sun YX et al. [Effects of hypericin associated with light irradiation on human laryngeal squamous cell carcinoma strain Hep-2]. 2005 Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi pmid:16429734
Chen ML et al. [Determining the quantity of hypericin in medicinal materials and asepsis seedings of Hypericum perforatum by HPLC]. 2003 Zhongguo Zhong Yao Za Zhi pmid:15615403
Xu MS et al. [Effect of factors on callus biomass and synthetic mass of hypericin in Hypericum perforatum]. 2003 Zhongguo Zhong Yao Za Zhi pmid:15620179
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Gao Q et al. Effect of hypericin on confocal imaging of Ca2+ signaling in cultured human retinal pigment epithelium. 2001 Yan Ke Xue Bao pmid:12567741
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Volak LP and Court MH Role for protein kinase C delta in the functional activity of human UGT1A6: implications for drug-drug interactions between PKC inhibitors and UGT1A6. 2010 Xenobiotica pmid:20196639
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Maury W et al. Identification of light-independent inhibition of human immunodeficiency virus-1 infection through bioguided fractionation of Hypericum perforatum. 2009 Virol. J. pmid:19594941
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Abma E et al. Biodistribution and tolerance of intravenous iodine-131-labelled hypericin in healthy dogs. 2018 Vet Comp Oncol pmid:29314561
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Jendželovská Z et al. Single pre-treatment with hypericin, a St. John's wort secondary metabolite, attenuates cisplatin- and mitoxantrone-induced cell death in A2780, A2780cis and HL-60 cells. 2014 Toxicol In Vitro pmid:24994473
Dinkins MB et al. Photosensitive chemical and laser light treatments decrease epizootic hemorrhagic disease virus associated with in vitro produced bovine embryos. 2001 Theriogenology pmid:11393216
Li J et al. Sequential systemic administrations of combretastatin A4 Phosphate and radioiodinated hypericin exert synergistic targeted theranostic effects with prolonged survival on SCID mice carrying bifocal tumor xenografts. 2013 Theranostics pmid:23423247
Jiang B et al. Necrosis avidity: a newly discovered feature of hypericin and its preclinical applications in necrosis imaging. 2013 Theranostics pmid:24052807
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Florea AM et al. An innovative approach to prepare hypericin molecularly imprinted pearls using a "phyto-template". 2016 Talanta pmid:26653421
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Kazemi SY and Abedirad SM Effect of glutathione on peroxyoxalate chemiluminescence of hypericin as the fluorophore. 2014 Spectrochim Acta A Mol Biomol Spectrosc pmid:24152863
Schempp CM et al. Hypericin levels in human serum and interstitial skin blister fluid after oral single-dose and steady-state administration of Hypericum perforatum extract (St. John's wort). 1999 Sep-Oct Skin Pharmacol. Appl. Skin Physiol. pmid:10461100
Xu MJ et al. [Enhancement of hypericin production and cell growth of Hypericum perforatum L. suspension cultures by nitric oxide]. 2005 Sheng Wu Gong Cheng Xue Bao pmid:15859331
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