| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uterine Cervical Neoplasms | D002583 | 10 associated lipids |
| Neoplasms, Experimental | D009374 | 10 associated lipids |
| Neoplasms, Radiation-Induced | D009381 | 3 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Carcinoma, Squamous Cell | D002294 | 14 associated lipids |
| Skin Neoplasms | D012878 | 12 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
hypericin
hypericin is a lipid of Polyketides (PK) class. Hypericin is associated with abnormalities such as Dermatitis, Phototoxic, Dehydration, Photosensitization, Morphologically altered structure and Myocardial Infarction. The involved functions are known as Cell Cycle Checkpoints, Apoptosis, Acetylation, Cell Survival and Caspase Activation. Hypericin often locates in insoluble fraction, Cytoplasmic matrix, Protoplasm, Tissue membrane and Cytoplasm. The associated genes with hypericin are CDC37 gene, HSPA8 gene, RAF1 gene, cyclin H and FK228. The related lipids are Phosphatidylserines.
Cross Reference
Introduction
To understand associated biological information of hypericin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with hypericin?
hypericin is suspected in Dermatitis, Phototoxic, Photosensitization, Pneumonia, Psoriasis, Phototoxicity, Chronic infectious disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with hypericin
PubChem Associated disorders and diseases
What pathways are associated with hypericin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with hypericin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with hypericin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with hypericin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with hypericin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with hypericin?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with hypericin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Lavie G et al. | A photodynamic pathway to apoptosis and necrosis induced by dimethyl tetrahydroxyhelianthrone and hypericin in leukaemic cells: possible relevance to photodynamic therapy. | 1999 | Br. J. Cancer | pmid:10027308 |
| Gulick RM et al. | Phase I studies of hypericin, the active compound in St. John's Wort, as an antiretroviral agent in HIV-infected adults. AIDS Clinical Trials Group Protocols 150 and 258. | 1999 | Ann. Intern. Med. | pmid:10075619 |
| Kleber E et al. | Biochemical activities of extracts from Hypericum perforatum L. 1st Communication: inhibition of dopamine-beta-hydroxylase. | 1999 | Arzneimittelforschung | pmid:10083977 |
| Denke A et al. | Biochemical activities of extracts from Hypericum perforatum L. 2nd Communication: inhibition of metenkephaline- and tyrosine-dimerization. | 1999 | Arzneimittelforschung | pmid:10083978 |
| Denke A et al. | Biochemical activities of extracts from Hypericum perforatum L. 4th Communication: influence of different cultivation methods. | 1999 | Arzneimittelforschung | pmid:10083980 |
| Assefa Z et al. | The activation of the c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signaling pathways protects HeLa cells from apoptosis following photodynamic therapy with hypericin. | 1999 | J. Biol. Chem. | pmid:10085120 |
| Delaey EM et al. | Confluence dependent resistance to photo-activated hypericin in HeLa cells. | 1999 | Int. J. Oncol. | pmid:10087326 |
| English DS et al. | Subcellular distributions and excited-state processes of hypericin in neurons. | 1999 | Photochem. Photobiol. | pmid:10089821 |
| Chi JD and Franklin M | Determination of hypericin in plasma by high-performance liquid chromatography. | 1999 | J. Chromatogr. B Biomed. Sci. Appl. | pmid:10202973 |
| Chaloupka R et al. | The effect of hypericin and hypocrellin-A on lipid membranes and membrane potential of 3T3 fibroblasts. | 1999 | Biochim. Biophys. Acta | pmid:10209209 |
| Bork PM et al. | Hypericin as a non-antioxidant inhibitor of NF-kappa B. | 1999 | Planta Med. | pmid:10364831 |
| Das K et al. | Photophysics of hypericin and hypocrellin A in complex with subcellular components: interactions with human serum albumin. | 1999 | Photochem. Photobiol. | pmid:10378001 |
| Calapai G et al. | Effects of Hypericum perforatum on levels of 5-hydroxytryptamine, noradrenaline and dopamine in the cortex, diencephalon and brainstem of the rat. | 1999 | J. Pharm. Pharmacol. | pmid:10454050 |
| Franklin M et al. | Neuroendocrine evidence for dopaminergic actions of hypericum extract (LI 160) in healthy volunteers. | 1999 | Biol. Psychiatry | pmid:10459411 |
| Schempp CM et al. | Hypericin levels in human serum and interstitial skin blister fluid after oral single-dose and steady-state administration of Hypericum perforatum extract (St. John's wort). | 1999 Sep-Oct | Skin Pharmacol. Appl. Skin Physiol. | pmid:10461100 |
| Weiner L et al. | Targeted cross-linking of a molten globule form of acetylcholinesterase by the virucidal agent hypericin. | 1999 | Biochemistry | pmid:10471290 |
| Fiebich BL et al. | Antibacterial activity of hyperforin from St John's wort. | 1999 | Lancet | pmid:10475222 |
| Kocisová E et al. | Sequence specific interaction of the photoactive drug hypericin depends on the structural arrangement and the stability of the structure containing its specific 5AG3 target: a resonance Raman spectroscopy study. | 1999 | J. Biomol. Struct. Dyn. | pmid:10496421 |
| Tahara YR et al. | The antidepressant hypericin inhibits progression of experimental proliferative vitreoretinopathy. | 1999 | Curr. Eye Res. | pmid:10520228 |
| Kersten B et al. | The application of the micronucleus test in Chinese hamster V79 cells to detect drug-induced photogenotoxicity. | 1999 | Mutat. Res. | pmid:10521691 |
| Kamuhabwa AR et al. | In vitro transport and uptake of protohypericin and hypericin in the Caco-2 model. | 1999 | Int J Pharm | pmid:10528085 |
| Mirossay L et al. | Hypericin-induced phototoxicity of human leukemic cell line HL-60 is potentiated by omeprazole, an inhibitor of H+K+-ATPase and 5'-(N,N-dimethyl)-amiloride, an inhibitor of Na+/H+ exchanger. | 1999 | Physiol Res | pmid:10534017 |
| Hudson JB et al. | Bromohypericins are potent photoactive antiviral agents. | 1999 | Photochem. Photobiol. | pmid:10568175 |
| Chaloupka R et al. | Over-expression of Bcl-2 does not protect cells from hypericin photo-induced mitochondrial membrane depolarization, but delays subsequent events in the apoptotic pathway. | 1999 | FEBS Lett. | pmid:10622714 |
| Delaey EM et al. | Photocytotoxicity of protohypericin after photoconversion to hypericin. | 1999 | Planta Med. | pmid:10630113 |
| Kraus GA et al. | Phenanthrenequinone antiretroviral agents. | 2000 | Bioorg. Med. Chem. Lett. | pmid:10636231 |
| Martens A et al. | In vitro and in vivo evaluation of hypericin for photodynamic therapy of equine sarcoids. | 2000 | Vet. J. | pmid:10640414 |
| Kamuhabwa AR et al. | Skin photosensitization with topical hypericin in hairless mice. | 1999 Nov-Dec | J. Photochem. Photobiol. B, Biol. | pmid:10672536 |
| Prince AM et al. | Strategies for evaluation of enveloped virus inactivation in red cell concentrates using hypericin. | 2000 | Photochem. Photobiol. | pmid:10687393 |
| Kirakosyan A et al. | Stimulation of the production of hypericins by mannan in Hypericum perforatum shoot cultures. | 2000 | Phytochemistry | pmid:10703055 |
| Lavie G et al. | Inhibition of the CD8+ T cell-mediated cytotoxicity reaction by hypericin: potential for treatment of T cell-mediated diseases. | 2000 | Int. Immunol. | pmid:10744649 |
| Lee KT et al. | Hypericin induces both differentiation and apoptosis in human promyelocytic leukemia HL-60 cells. | 1999 | Biol. Pharm. Bull. | pmid:10746153 |
| Chen B and de Witte PA | Photodynamic therapy efficacy and tissue distribution of hypericin in a mouse P388 lymphoma tumor model. | 2000 | Cancer Lett. | pmid:10755394 |
| Vandenbogaerde A et al. | Evidence that total extract of Hypericum perforatum affects exploratory behavior and exerts anxiolytic effects in rats. | 2000 | Pharmacol. Biochem. Behav. | pmid:10764915 |
| Puchner MJ and Giese A | Tamoxifen-resistant glioma-cell sub-populations are characterized by increased migration and proliferation. | 2000 | Int. J. Cancer | pmid:10797257 |
| Geng Y et al. | Chlamydia pneumoniae inhibits apoptosis in human peripheral blood mononuclear cells through induction of IL-10. | 2000 | J. Immunol. | pmid:10799921 |
| Agostinis P et al. | Apoptotic and anti-apoptotic signaling pathways induced by photodynamic therapy with hypericin. | 2000 | Adv. Enzyme Regul. | pmid:10828351 |
| Colasanti A et al. | Hypericin photosensitization of tumor and metastatic cell lines of human prostate. | 2000 | J. Photochem. Photobiol. B, Biol. | pmid:10836538 |
| Moore LB et al. | St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10852961 |
| Denke A et al. | Biochemical activities of extracts from Hypericum perforatum L. 5th communication: dopamine-beta-hydroxylase-product quantification by HPLC and inhibition by hypericins and flavonoids. | 2000 | Arzneimittelforschung | pmid:10858868 |
| Kamuhabwa AR et al. | Investigation of the absorption of hypericin into the skin of hairless mice. | 2000 | J. Pharm. Pharmacol. | pmid:10864135 |
| Obach RS | Inhibition of human cytochrome P450 enzymes by constituents of St. John's Wort, an herbal preparation used in the treatment of depression. | 2000 | J. Pharmacol. Exp. Ther. | pmid:10871299 |
| Schempp CM et al. | Effect of topical application of Hypericum perforatum extract (St. John's wort) on skin sensitivity to solar simulated radiation. | 2000 | Photodermatol Photoimmunol Photomed | pmid:10885442 |
| D'Hallewin MA et al. | Fluorescence detection of flat bladder carcinoma in situ after intravesical instillation of hypericin. | 2000 | J. Urol. | pmid:10893582 |
| Chung PS et al. | Intratumoral hypericin and KTP laser therapy for transplanted squamous cell carcinoma. | 2000 | Laryngoscope | pmid:10942132 |
| Liu CD et al. | Hypericin and photodynamic therapy decreases human pancreatic cancer in vitro and in vivo. | 2000 | J. Surg. Res. | pmid:10945955 |
| Schey KL et al. | Photooxidation of lens alpha-crystallin by hypericin (active ingredient in St. John's Wort). | 2000 | Photochem. Photobiol. | pmid:10946573 |
| Kamuhabwa AR et al. | Photodynamic activity of hypericin in human urinary bladder carcinoma cells. | 2000 Jul-Aug | Anticancer Res. | pmid:10953329 |
| Wentworth JM et al. | St John's wort, a herbal antidepressant, activates the steroid X receptor. | 2000 | J. Endocrinol. | pmid:10974665 |