| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uterine Cervical Neoplasms | D002583 | 10 associated lipids |
| Neoplasms, Experimental | D009374 | 10 associated lipids |
| Neoplasms, Radiation-Induced | D009381 | 3 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Carcinoma, Squamous Cell | D002294 | 14 associated lipids |
| Skin Neoplasms | D012878 | 12 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
hypericin
hypericin is a lipid of Polyketides (PK) class. Hypericin is associated with abnormalities such as Dermatitis, Phototoxic, Dehydration, Photosensitization, Morphologically altered structure and Myocardial Infarction. The involved functions are known as Cell Cycle Checkpoints, Apoptosis, Acetylation, Cell Survival and Caspase Activation. Hypericin often locates in insoluble fraction, Cytoplasmic matrix, Protoplasm, Tissue membrane and Cytoplasm. The associated genes with hypericin are CDC37 gene, HSPA8 gene, RAF1 gene, cyclin H and FK228. The related lipids are Phosphatidylserines.
Cross Reference
Introduction
To understand associated biological information of hypericin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with hypericin?
hypericin is suspected in Dermatitis, Phototoxic, Photosensitization, Pneumonia, Psoriasis, Phototoxicity, Chronic infectious disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with hypericin
PubChem Associated disorders and diseases
What pathways are associated with hypericin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with hypericin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with hypericin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with hypericin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with hypericin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with hypericin?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with hypericin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Rayburn WF et al. | Impact of hypericum (St.-John's-wort) given prenatally on cognition of mice offspring. | Neurotoxicol Teratol | pmid:11792531 | |
| Li ZH et al. | Hypericin damages the ectatic capillaries in a Roman cockscomb model and inhibits the growth of human endothelial cells more potently than hematoporphyrin does through induction of apoptosis. | Photochem. Photobiol. | pmid:25065502 | |
| Jiang C et al. | Hypericin as a marker for determination of myocardial viability in a rat model of myocardial infarction. | Photochem. Photobiol. | pmid:24460608 | |
| StaniÄová J et al. | Interaction of a Potential Anticancer Agent Hypericin and its Model Compound Emodin with DNA and Bovine Serum Albumin. | In Vivo | pmid:30150427 | |
| StaniÄová J et al. | Potential anticancer agent hypericin and its model compound emodin: interaction with DNA. | Ceska Slov Farm | pmid:27118502 | |
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| Skyba M et al. | Physiological, biochemical and molecular characteristics of cryopreserved Hypericum perforatum L. shoot tips. | Cryo Letters | pmid:20919454 | |
| Bancirova M and Lasovský J | The photodynamic effect: the comparison of chemiexcitation by luminol and phthalhydrazide. | Luminescence | pmid:20853519 | |
| Lavie G et al. | "Competitive quenching": a mechanism by which perihydroxylated perylenequinone photosensitizers can prevent adverse phototoxic damage caused by verteporfin during photodynamic therapy. | Photochem. Photobiol. | pmid:17880523 | |
| Lobban CS et al. | Photophysics and multifunctionality of hypericin-like pigments in heterotrich ciliates: a phylogenetic perspective. | Photochem. Photobiol. | pmid:17880503 | |
| Zobayed SM et al. | Temperature stress can alter the photosynthetic efficiency and secondary metabolite concentrations in St. John's wort. | Plant Physiol. Biochem. | pmid:16310362 | |
| Krishnamoorthy G et al. | Synthesis of hydroxy and methoxy perylene quinones, their spectroscopic and computational characterization, and their antiviral activity. | Photochem. Photobiol. | pmid:15884972 | |
| Kanofsky JR and Sima PD | Structural requirements for efficient cellular photoprotection by carotenoid derivatives. | Photochem. Photobiol. | pmid:15623338 | |
| Bragin DE et al. | Photodynamic inactivation of isolated crayfish neuron requires protein kinase C, PI 3-kinase and Ca2+. | J. Photochem. Photobiol. B, Biol. | pmid:12849700 | |
| Araya OS and Ford EJ | An investigation of the type of photosensitization caused by the ingestion of St John's Wort (Hypericum perforatum) by calves. | 1981 | J. Comp. Pathol. | pmid:7343570 |
| Müldner H and Zöller M | [Antidepressive effect of a Hypericum extract standardized to an active hypericine complex. Biochemical and clinical studies]. | 1984 | Arzneimittelforschung | pmid:6541928 |
| Suzuki O et al. | Inhibition of monoamine oxidase by hypericin. | 1984 | Planta Med. | pmid:6484033 |
| Durán N and Song PS | Hypericin and its photodynamic action. | 1986 | Photochem. Photobiol. | pmid:3529141 |
| Meruelo D et al. | Therapeutic agents with dramatic antiretroviral activity and little toxicity at effective doses: aromatic polycyclic diones hypericin and pseudohypericin. | 1988 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2839837 |
| Lavie G et al. | Studies of the mechanisms of action of the antiretroviral agents hypericin and pseudohypericin. | 1989 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2548193 |
| Takahashi I et al. | Hypericin and pseudohypericin specifically inhibit protein kinase C: possible relation to their antiretroviral activity. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2558652 |
| Tamaoki T et al. | Calphostin (UCN1028) and calphostin related compounds, a new class of specific and potent inhibitors of protein kinase C. | 1990 | Adv. Second Messenger Phosphoprotein Res. | pmid:1698411 |
| Tang J et al. | Virucidal activity of hypericin against enveloped and non-enveloped DNA and RNA viruses. | 1990 | Antiviral Res. | pmid:1699494 |
| Kraus GA et al. | Antiretroviral activity of synthetic hypericin and related analogs. | 1990 | Biochem. Biophys. Res. Commun. | pmid:1699534 |
| Okpanyi SN et al. | [Genotoxicity of a standardized Hypericum extract]. | 1990 | Arzneimittelforschung | pmid:2242075 |
| Carpenter S and Kraus GA | Photosensitization is required for inactivation of equine infectious anemia virus by hypericin. | 1991 | Photochem. Photobiol. | pmid:1707176 |
| New AIDS drugs. | 1991 | Minn Med | pmid:1724284 | |
| Liebes L et al. | A method for the quantitation of hypericin, an antiviral agent, in biological fluids by high-performance liquid chromatography. | 1991 | Anal. Biochem. | pmid:1888019 |
| Hudson JB et al. | Antiviral activities of hypericin. | 1991 | Antiviral Res. | pmid:1650164 |
| Andersen DO et al. | In vitro virucidal activity of selected anthraquinones and anthraquinone derivatives. | 1991 | Antiviral Res. | pmid:1665961 |
| Treating AIDS with worts. | 1991 | Science | pmid:1948026 | |
| Lopez-Bazzocchi I et al. | Antiviral activity of the photoactive plant pigment hypericin. | 1991 | Photochem. Photobiol. | pmid:1658826 |
| Thomas C et al. | Photoactivation of hypericin generates singlet oxygen in mitochondria and inhibits succinoxidase. | 1992 | Photochem. Photobiol. | pmid:1603850 |
| Senthil V et al. | Photosensitization of aqueous model systems by hypericin. | 1992 | Biochim. Biophys. Acta | pmid:1739734 |
| Degar S et al. | Inactivation of the human immunodeficiency virus by hypericin: evidence for photochemical alterations of p24 and a block in uncoating. | 1992 | AIDS Res. Hum. Retroviruses | pmid:1283309 |
| Barnard DL et al. | Evaluation of the antiviral activity of anthraquinones, anthrones and anthraquinone derivatives against human cytomegalovirus. | 1992 | Antiviral Res. | pmid:1310583 |
| Thomas C and Pardini RS | Oxygen dependence of hypericin-induced phototoxicity to EMT6 mouse mammary carcinoma cells. | 1992 | Photochem. Photobiol. | pmid:1409890 |
| Raser LN et al. | Resonance Raman and surface-enhanced resonance Raman spectroscopy of hypericin. | 1992 | Photochem. Photobiol. | pmid:1502258 |
| Kako MD et al. | Studies of sheep experimentally poisoned with Hypericum perforatum. | 1993 | Vet Hum Toxicol | pmid:8236746 |
| Angerhofer A et al. | Lowest excited triplet states of hypericin and isohypericin. | 1993 | J. Photochem. Photobiol. B, Biol. | pmid:8271114 |
| Diwu Z and Lown JW | Photosensitization with anticancer agents. 17. EPR studies of photodynamic action of hypericin: formation of semiquinone radical and activated oxygen species on illumination. | 1993 | Free Radic. Biol. Med. | pmid:8381107 |
| Stevenson NR and Lenard J | Antiretroviral activities of hypericin and rose bengal: photodynamic effects on Friend leukemia virus infection of mice. | 1993 | Antiviral Res. | pmid:8338350 |
| Hudson JB et al. | The importance of light in the anti-HIV effect of hypericin. | 1993 | Antiviral Res. | pmid:8460933 |
| Lenard J et al. | Photodynamic inactivation of infectivity of human immunodeficiency virus and other enveloped viruses using hypericin and rose bengal: inhibition of fusion and syncytia formation. | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7678335 |
| Moraleda G et al. | Inhibition of duck hepatitis B virus replication by hypericin. | 1993 | Antiviral Res. | pmid:8470884 |
| Degar S et al. | Photodynamic inactivation of radiation leukemia virus produced from hypericin-treated cells. | 1993 | Virology | pmid:7504371 |
| de Witte P et al. | Inhibition of epidermal growth factor receptor tyrosine kinase activity by hypericin. | 1993 | Biochem. Pharmacol. | pmid:8267642 |
| Redepenning J and Tao N | Measurement of formal potentials for hypericin in dimethylsulfoxide. | 1993 | Photochem. Photobiol. | pmid:8248327 |
| Thiede HM and Walper A | Inhibition of MAO and COMT by hypericum extracts and hypericin. | 1994 | J Geriatr Psychiatry Neurol | pmid:7857510 |
| Wagner H and Bladt S | Pharmaceutical quality of hypericum extracts. | 1994 | J Geriatr Psychiatry Neurol | pmid:7857515 |