Verjee S et al. |
Permeation Characteristics of Hypericin across Caco-2 Monolayers in the Absence or Presence of Quercitrin - A Mass Balance Study. |
2015 |
Planta Med. |
pmid:26018919
|
Butterweck V et al. |
Solubilized hypericin and pseudohypericin from Hypericum perforatum exert antidepressant activity in the forced swimming test. |
1998 |
Planta Med. |
pmid:9619107
|
Gray DE et al. |
Effect of acute drought stress and time of harvest on phytochemistry and dry weight of St. John's wort leaves and flowers. |
2003 |
Planta Med. |
pmid:14735441
|
Grundmann O et al. |
Effects of St. John's wort extract and single constituents on stress-induced hyperthermia in mice. |
2006 |
Planta Med. |
pmid:17051457
|
Poutaraud A et al. |
Effect of light on hypericins contents in fresh flowering top parts and in an extract of St. John's Wort (Hypericum perforatum). |
2001 |
Planta Med. |
pmid:11345698
|
Gutmann H et al. |
Hypericum perforatum: which constituents may induce intestinal MDR1 and CYP3A4 mRNA expression? |
2006 |
Planta Med. |
pmid:16755466
|
Böer U et al. |
CRE/CREB-driven up-regulation of gene expression by chronic social stress in CRE-luciferase transgenic mice: reversal by antidepressant treatment. |
2007 |
PLoS ONE |
pmid:17487276
|
Singh S and Dubey VK |
Quantitative Proteome Analysis of Leishmania donovani under Spermidine Starvation. |
2016 |
PLoS ONE |
pmid:27123864
|
Zhu M et al. |
Evaluation of the therapeutic efficacy of sequential therapy involving percutaneous microwave ablation in combination with 131I-hypericin using the VX2 rabbit breast solid tumor model. |
2015 |
PLoS ONE |
pmid:25799220
|
Kleemann B et al. |
St John's Wort (Hypericum perforatum L.) photomedicine: hypericin-photodynamic therapy induces metastatic melanoma cell death. |
2014 |
PLoS ONE |
pmid:25076130
|
Barliya T et al. |
Degradation of HIF-1alpha under hypoxia combined with induction of Hsp90 polyubiquitination in cancer cells by hypericin: a unique cancer therapy. |
2011 |
PLoS ONE |
pmid:21949677
|
Kammerer R et al. |
Induction of immune mediators in glioma and prostate cancer cells by non-lethal photodynamic therapy. |
2011 |
PLoS ONE |
pmid:21738796
|
Ritz R et al. |
In vitro comparison of hypericin and 5-aminolevulinic acid-derived protoporphyrin IX for photodynamic inactivation of medulloblastoma cells. |
2012 |
PLoS ONE |
pmid:23251668
|
Dror N et al. |
Unique anti-glioblastoma activities of hypericin are at the crossroad of biochemical and epigenetic events and culminate in tumor cell differentiation. |
2013 |
PLoS ONE |
pmid:24066060
|
He M et al. |
De novo sequencing of Hypericum perforatum transcriptome to identify potential genes involved in the biosynthesis of active metabolites. |
2012 |
PLoS ONE |
pmid:22860059
|
Spindler SR et al. |
Novel protein kinase signaling systems regulating lifespan identified by small molecule library screening using Drosophila. |
2012 |
PLoS ONE |
pmid:22363408
|
Cárdenas C et al. |
Anti-angiogenic and anti-inflammatory properties of kahweol, a coffee diterpene. |
2011 |
PLoS ONE |
pmid:21858104
|
Kumagai A et al. |
A potent inhibitor of SIK2, 3, 3', 7-trihydroxy-4'-methoxyflavon (4'-O-methylfisetin), promotes melanogenesis in B16F10 melanoma cells. |
2011 |
PLoS ONE |
pmid:22022544
|
Merhi F et al. |
Hyperforin inhibits Akt1 kinase activity and promotes caspase-mediated apoptosis involving Bad and Noxa activation in human myeloid tumor cells. |
2011 |
PLoS ONE |
pmid:21998731
|
de Vries E et al. |
Dissection of the influenza A virus endocytic routes reveals macropinocytosis as an alternative entry pathway. |
2011 |
PLoS Pathog. |
pmid:21483486
|
Jankowski A et al. |
The action of photosensitizers and serum in a bactericidal process. II. The effects of dyes: hypericin, eosin Y and saphranine O. |
2005 |
Pol. J. Microbiol. |
pmid:16599305
|
Wolkenstein K et al. |
Preservation of hypericin and related polycyclic quinone pigments in fossil crinoids. |
2006 |
Proc. Biol. Sci. |
pmid:16615212
|
Lavie G et al. |
Studies of the mechanisms of action of the antiretroviral agents hypericin and pseudohypericin. |
1989 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:2548193
|
Meruelo D et al. |
Therapeutic agents with dramatic antiretroviral activity and little toxicity at effective doses: aromatic polycyclic diones hypericin and pseudohypericin. |
1988 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:2839837
|
Carpenter S et al. |
Chemiluminescent activation of the antiviral activity of hypericin: a molecular flashlight. |
1994 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:7991618
|
Lenard J et al. |
Photodynamic inactivation of infectivity of human immunodeficiency virus and other enveloped viruses using hypericin and rose bengal: inhibition of fusion and syncytia formation. |
1993 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:7678335
|
Moore LB et al. |
St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor. |
2000 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:10852961
|
Guilhermano LG et al. |
Commercially available Hypericum perforatum extracts do not decrease immobility of rats in the forced swimming test. |
2004 |
Prog. Neuropsychopharmacol. Biol. Psychiatry |
pmid:14687857
|
Guo L et al. |
Role of protein kinase C in 15-HETE-induced hypoxic pulmonary vasoconstriction. |
2009 Feb-Mar |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:19186045
|
Turk S et al. |
Purification of Glutathione S-Transferase pi from Erythrocytes and Evaluation of the Inhibitory Effect of Hypericin. |
2015 |
Protein J. |
pmid:26614503
|
Dalmizrak O et al. |
Evaluation of the in vitro inhibitory impact of hypericin on placental glutathione S-transferase pi. |
2012 |
Protein J. |
pmid:22810152
|
Millard CB et al. |
Stabilization of a metastable state of Torpedo californica acetylcholinesterase by chemical chaperones. |
2003 |
Protein Sci. |
pmid:14500892
|
Shin I et al. |
Thermal denaturation of Bungarus fasciatus acetylcholinesterase: Is aggregation a driving force in protein unfolding? |
2002 |
Protein Sci. |
pmid:12142456
|
Babić D |
Herbal medicine in the treatment of mental disorders. |
2007 |
Psychiatr Danub |
pmid:17914328
|
Galeotti N and Ghelardini C |
Reversal of NO-induced nociceptive hypersensitivity by St. John's wort and hypericin: NF-κB, CREB and STAT1 as molecular targets. |
2013 |
Psychopharmacology (Berl.) |
pmid:23254377
|
Putnik K et al. |
Enhanced radiation sensitivity and radiation recall dermatitis (RRD) after hypericin therapy -- case report and review of literature. |
2006 |
Radiat Oncol |
pmid:16948841
|
Solár P et al. |
Photoactivated hypericin induces downregulation of HER2 gene expression. |
2011 |
Radiat. Res. |
pmid:21175347
|
Qi X et al. |
Radiopharmaceutical study on Iodine-131-labelled hypericin in a canine model of hepatic RFA-induced coagulative necrosis. |
2015 |
Radiol Med |
pmid:25012473
|
Li J et al. |
A dual-targeting anticancer approach: soil and seed principle. |
2011 |
Radiology |
pmid:21712473
|
Tolonen A et al. |
Determination of naphthodianthrones and phloroglucinols from Hypericum perforatum extracts by liquid chromatography/tandem mass spectrometry. |
2002 |
Rapid Commun. Mass Spectrom. |
pmid:11857723
|
Piovan A et al. |
Flow injection analysis mass spectrometry, a tool to investigate the problems in the quantitative analysis of hypericin using reversed-phase high-performance liquid chromatography. |
2004 |
Rapid Commun. Mass Spectrom. |
pmid:14689570
|
Hecka A et al. |
Study of active naphtodianthrone St John's Wort compounds by electrospray ionization Fourier transform ion cyclotron resonance and multi-stage mass spectrometry in sustained off-resonance irradiation collision-induced dissociation and infrared multiphoton dissociation modes. |
2009 |
Rapid Commun. Mass Spectrom. |
pmid:19224526
|
Theodossiou TA et al. |
The diverse roles of glutathione-associated cell resistance against hypericin photodynamic therapy. |
2017 |
Redox Biol |
pmid:28254657
|
Crance JM et al. |
Inhibition of sandfly fever Sicilian virus (Phlebovirus) replication in vitro by antiviral compounds. |
1997 Sep-Oct |
Res. Virol. |
pmid:9403935
|
Zor M et al. |
Does hypericin boost the efficacy of high-power laser? A preliminary experimental study on rats. |
2014 |
Sao Paulo Med J |
pmid:25351755
|
Wang Q et al. |
Discovery of Radioiodinated Monomeric Anthraquinones as a Novel Class of Necrosis Avid Agents for Early Imaging of Necrotic Myocardium. |
2016 |
Sci Rep |
pmid:26878909
|
Zhang Q et al. |
Hypericin-photodynamic therapy induces human umbilical vein endothelial cell apoptosis. |
2015 |
Sci Rep |
pmid:26673286
|
Garg AD et al. |
Dendritic cell vaccines based on immunogenic cell death elicit danger signals and T cell-driven rejection of high-grade glioma. |
2016 |
Sci Transl Med |
pmid:26936504
|
Xu Y and Lu C |
Raman spectroscopic study on structure of human immunodeficiency virus (HIV) and hypericin-induced photosensitive damage of HIV. |
2005 |
Sci. China, C, Life Sci. |
pmid:15986884
|
Xu M et al. |
Signal interaction between nitric oxide and hydrogen peroxide in heat shock-induced hypericin production of Hypericum perforatum suspension cells. |
2008 |
Sci. China, C, Life Sci. |
pmid:18677595
|
|
Treating AIDS with worts. |
1991 |
Science |
pmid:1948026
|
Patel P et al. |
Emerging endoscopic and photodynamic techniques for bladder cancer detection and surveillance. |
2011 |
ScientificWorldJournal |
pmid:22235185
|
Camas N et al. |
Secondary metabolites of Hypericum leptophyllum Hochst., an endemic Turkish species. |
2012 |
ScientificWorldJournal |
pmid:22649295
|
Shrestha R et al. |
A high-precision micropipette sensor for cellular-level real-time thermal characterization. |
2011 |
Sensors (Basel) |
pmid:22164108
|
Xu MJ et al. |
[Enhancement of hypericin production and cell growth of Hypericum perforatum L. suspension cultures by nitric oxide]. |
2005 |
Sheng Wu Gong Cheng Xue Bao |
pmid:15859331
|
Schempp CM et al. |
Hypericin levels in human serum and interstitial skin blister fluid after oral single-dose and steady-state administration of Hypericum perforatum extract (St. John's wort). |
1999 Sep-Oct |
Skin Pharmacol. Appl. Skin Physiol. |
pmid:10461100
|
Keša P et al. |
Excitation of triplet states of hypericin in water mediated by hydrotropic cromolyn sodium salt. |
2018 |
Spectrochim Acta A Mol Biomol Spectrosc |
pmid:29241053
|
Kazemi SY and Abedirad SM |
Effect of glutathione on peroxyoxalate chemiluminescence of hypericin as the fluorophore. |
2014 |
Spectrochim Acta A Mol Biomol Spectrosc |
pmid:24152863
|
Urla C et al. |
Successful in vivo tumor visualization using fluorescence laparoscopy in a mouse model of disseminated alveolar rhabdomyosarcoma. |
2015 |
Surg Endosc |
pmid:25149634
|
Florea AM et al. |
An innovative approach to prepare hypericin molecularly imprinted pearls using a "phyto-template". |
2016 |
Talanta |
pmid:26653421
|
Saw CL et al. |
Effects of N-methyl pyrrolidone on the uptake of hypericin in human bladder carcinoma and co-staining with DAPI investigated by confocal microscopy. |
2007 |
Technol. Cancer Res. Treat. |
pmid:17877426
|
Li J et al. |
Sequential systemic administrations of combretastatin A4 Phosphate and radioiodinated hypericin exert synergistic targeted theranostic effects with prolonged survival on SCID mice carrying bifocal tumor xenografts. |
2013 |
Theranostics |
pmid:23423247
|
Jiang B et al. |
Necrosis avidity: a newly discovered feature of hypericin and its preclinical applications in necrosis imaging. |
2013 |
Theranostics |
pmid:24052807
|
Dinkins MB et al. |
Photosensitive chemical and laser light treatments decrease epizootic hemorrhagic disease virus associated with in vitro produced bovine embryos. |
2001 |
Theriogenology |
pmid:11393216
|
Huntosova V et al. |
Assessing light-independent effects of hypericin on cell viability, ultrastructure and metabolism in human glioma and endothelial cells. |
2017 |
Toxicol In Vitro |
pmid:28087315
|
Jendželovská Z et al. |
Single pre-treatment with hypericin, a St. John's wort secondary metabolite, attenuates cisplatin- and mitoxantrone-induced cell death in A2780, A2780cis and HL-60 cells. |
2014 |
Toxicol In Vitro |
pmid:24994473
|
Traynor NJ et al. |
Photogenotoxicity of hypericin in HaCaT keratinocytes: implications for St. John's Wort supplements and high dose UVA-1 therapy. |
2005 |
Toxicol. Lett. |
pmid:15890476
|
Dolan LC et al. |
Naturally occurring food toxins. |
2010 |
Toxins (Basel) |
pmid:22069686
|
Vyas GN |
Inactivation and removal of blood-borne viruses. |
1995 |
Transfusion |
pmid:7740604
|
Lavie G et al. |
Hypericin as an inactivator of infectious viruses in blood components. |
1995 |
Transfusion |
pmid:7740610
|
Makovets'ka OIu et al. |
[Electronic structure and energetics of transitions in absorption spectra of hypericin]. |
2000 Nov-Dec |
Ukr Biokhim Zh (1999) |
pmid:11392782
|
Jichlinski P and Leisinger HJ |
Fluorescence cystoscopy in the management of bladder cancer: a help for the urologist! |
2005 |
Urol. Int. |
pmid:15756058
|
Olivo M et al. |
Altered expression of cell adhesion molecules leads to differential uptake of hypericin in urothelial cancer. |
2012 |
Urol. Oncol. |
pmid:20933443
|
Capasso R et al. |
Inhibitory effect of the antidepressant St. John's wort (hypericum perforatum) on rat bladder contractility in vitro. |
2004 |
Urology |
pmid:15245964
|
Pytel A and Schmeller N |
New aspect of photodynamic diagnosis of bladder tumors: fluorescence cytology. |
2002 |
Urology |
pmid:11834388
|
Abma E et al. |
Biodistribution and tolerance of intravenous iodine-131-labelled hypericin in healthy dogs. |
2018 |
Vet Comp Oncol |
pmid:29314561
|
Kako MD et al. |
Studies of sheep experimentally poisoned with Hypericum perforatum. |
1993 |
Vet Hum Toxicol |
pmid:8236746
|
Martens A et al. |
In vitro and in vivo evaluation of hypericin for photodynamic therapy of equine sarcoids. |
2000 |
Vet. J. |
pmid:10640414
|
Maury W et al. |
Identification of light-independent inhibition of human immunodeficiency virus-1 infection through bioguided fractionation of Hypericum perforatum. |
2009 |
Virol. J. |
pmid:19594941
|
Degar S et al. |
Photodynamic inactivation of radiation leukemia virus produced from hypericin-treated cells. |
1993 |
Virology |
pmid:7504371
|
Butterweck V and Schmidt M |
St. John's wort: role of active compounds for its mechanism of action and efficacy. |
2007 |
Wien Med Wochenschr |
pmid:17704987
|
Head CS et al. |
Photodynamic therapy and tumor imaging of hypericin-treated squamous cell carcinoma. |
2006 |
World J Surg Oncol |
pmid:17147827
|
Witjes JA |
Topic issue on new treatments in bladder cancer. |
2009 |
World J Urol |
pmid:19229539
|
Miranda Cona M et al. |
Differential diagnosis of gallstones by using hypericin as a fluorescent optical imaging agent. |
2016 |
World J. Gastroenterol. |
pmid:27547012
|
Zhang JN et al. |
Effect of photodynamic inactivation of Escherichia coli by hypericin. |
2018 |
World J. Microbiol. Biotechnol. |
pmid:29926201
|
Volak LP and Court MH |
Role for protein kinase C delta in the functional activity of human UGT1A6: implications for drug-drug interactions between PKC inhibitors and UGT1A6. |
2010 |
Xenobiotica |
pmid:20196639
|
Gao Q et al. |
Effect of hypericin on confocal imaging of Ca2+ signaling in cultured human retinal pigment epithelium. |
2001 |
Yan Ke Xue Bao |
pmid:12567741
|
Gao Q et al. |
[Effects of hypericin on traumatic proliferative vitreoretinopathy in rabbits]. |
2002 |
Yan Ke Xue Bao |
pmid:15515769
|
Shi YW et al. |
[Rapid cloning and functional characterization of hypericin synthase gene]. |
2012 |
Yao Xue Xue Bao |
pmid:22812015
|
Zhao J et al. |
[Studies on synthesis and anti-HIV RT activity of hypericin and ethylhypericin]. |
1998 |
Yao Xue Xue Bao |
pmid:11938940
|
Chung DJ et al. |
Black cohosh and St. John's wort (GYNO-Plus) for climacteric symptoms. |
2007 |
Yonsei Med. J. |
pmid:17461529
|
Alali FQ et al. |
LC-MS and LC-PDA analysis of Hypericum empetrifolium and Hypericum sinaicum. |
2009 Jul-Aug |
Z. Naturforsch., C, J. Biosci. |
pmid:19791496
|
Hao PF et al. |
[Study on the enzyme extraction process of hypericin by pectinase]. |
2011 |
Zhong Yao Cai |
pmid:22066412
|
Cai W et al. |
[Influence of luyoutal on serum cytokines in patients with depression]. |
2003 |
Zhongguo Zhong Xi Yi Jie He Za Zhi |
pmid:14666775
|
Chen ML et al. |
[Determining the quantity of hypericin in medicinal materials and asepsis seedings of Hypericum perforatum by HPLC]. |
2003 |
Zhongguo Zhong Yao Za Zhi |
pmid:15615403
|
Xu MS et al. |
[Effect of factors on callus biomass and synthetic mass of hypericin in Hypericum perforatum]. |
2003 |
Zhongguo Zhong Yao Za Zhi |
pmid:15620179
|
Sun DL et al. |
[Morphological identification of 20 medicinal species in Hypericum]. |
2007 |
Zhongguo Zhong Yao Za Zhi |
pmid:17655138
|
Xu MS et al. |
[Induction of callus of Hypericum perforatum L. and qualitative identification of active constituents of its callus]. |
2001 |
Zhongguo Zhong Yao Za Zhi |
pmid:12776326
|
Sun YX et al. |
[Effects of hypericin associated with light irradiation on human laryngeal squamous cell carcinoma strain Hep-2]. |
2005 |
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi |
pmid:16429734
|
Hao GY and Zhang YH |
[Fluorescence technique on diagnosis of urinary bladder carcinoma]. |
2003 |
Zhonghua Yi Xue Za Zhi |
pmid:14723217
|