| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uterine Cervical Neoplasms | D002583 | 10 associated lipids |
| Neoplasms, Experimental | D009374 | 10 associated lipids |
| Neoplasms, Radiation-Induced | D009381 | 3 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Carcinoma, Squamous Cell | D002294 | 14 associated lipids |
| Skin Neoplasms | D012878 | 12 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
hypericin
hypericin is a lipid of Polyketides (PK) class. Hypericin is associated with abnormalities such as Dermatitis, Phototoxic, Dehydration, Photosensitization, Morphologically altered structure and Myocardial Infarction. The involved functions are known as Cell Cycle Checkpoints, Apoptosis, Acetylation, Cell Survival and Caspase Activation. Hypericin often locates in insoluble fraction, Cytoplasmic matrix, Protoplasm, Tissue membrane and Cytoplasm. The associated genes with hypericin are CDC37 gene, HSPA8 gene, RAF1 gene, cyclin H and FK228. The related lipids are Phosphatidylserines.
Cross Reference
Introduction
To understand associated biological information of hypericin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with hypericin?
hypericin is suspected in Dermatitis, Phototoxic, Photosensitization, Pneumonia, Psoriasis, Phototoxicity, Chronic infectious disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with hypericin
PubChem Associated disorders and diseases
What pathways are associated with hypericin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with hypericin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with hypericin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with hypericin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with hypericin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with hypericin?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with hypericin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chaloupka R et al. | Over-expression of Bcl-2 does not protect cells from hypericin photo-induced mitochondrial membrane depolarization, but delays subsequent events in the apoptotic pathway. | 1999 | FEBS Lett. | pmid:10622714 |
| Hudson JB et al. | Bromohypericins are potent photoactive antiviral agents. | 1999 | Photochem. Photobiol. | pmid:10568175 |
| Lee KT et al. | Hypericin induces both differentiation and apoptosis in human promyelocytic leukemia HL-60 cells. | 1999 | Biol. Pharm. Bull. | pmid:10746153 |
| Chaloupka R et al. | The effect of hypericin and hypocrellin-A on lipid membranes and membrane potential of 3T3 fibroblasts. | 1999 | Biochim. Biophys. Acta | pmid:10209209 |
| Gulick RM et al. | Phase I studies of hypericin, the active compound in St. John's Wort, as an antiretroviral agent in HIV-infected adults. AIDS Clinical Trials Group Protocols 150 and 258. | 1999 | Ann. Intern. Med. | pmid:10075619 |
| Lavie G et al. | A photodynamic pathway to apoptosis and necrosis induced by dimethyl tetrahydroxyhelianthrone and hypericin in leukaemic cells: possible relevance to photodynamic therapy. | 1999 | Br. J. Cancer | pmid:10027308 |
| Kleber E et al. | Biochemical activities of extracts from Hypericum perforatum L. 1st Communication: inhibition of dopamine-beta-hydroxylase. | 1999 | Arzneimittelforschung | pmid:10083977 |
| Denke A et al. | Biochemical activities of extracts from Hypericum perforatum L. 2nd Communication: inhibition of metenkephaline- and tyrosine-dimerization. | 1999 | Arzneimittelforschung | pmid:10083978 |
| Denke A et al. | Biochemical activities of extracts from Hypericum perforatum L. 4th Communication: influence of different cultivation methods. | 1999 | Arzneimittelforschung | pmid:10083980 |
| Assefa Z et al. | The activation of the c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signaling pathways protects HeLa cells from apoptosis following photodynamic therapy with hypericin. | 1999 | J. Biol. Chem. | pmid:10085120 |
| Delaey EM et al. | Confluence dependent resistance to photo-activated hypericin in HeLa cells. | 1999 | Int. J. Oncol. | pmid:10087326 |
| English DS et al. | Subcellular distributions and excited-state processes of hypericin in neurons. | 1999 | Photochem. Photobiol. | pmid:10089821 |
| Tahara YR et al. | The antidepressant hypericin inhibits progression of experimental proliferative vitreoretinopathy. | 1999 | Curr. Eye Res. | pmid:10520228 |
| Kersten B et al. | The application of the micronucleus test in Chinese hamster V79 cells to detect drug-induced photogenotoxicity. | 1999 | Mutat. Res. | pmid:10521691 |
| Kocisová E et al. | Sequence specific interaction of the photoactive drug hypericin depends on the structural arrangement and the stability of the structure containing its specific 5AG3 target: a resonance Raman spectroscopy study. | 1999 | J. Biomol. Struct. Dyn. | pmid:10496421 |
| Fiebich BL et al. | Antibacterial activity of hyperforin from St John's wort. | 1999 | Lancet | pmid:10475222 |
| Mirossay L et al. | Hypericin-induced phototoxicity of human leukemic cell line HL-60 is potentiated by omeprazole, an inhibitor of H+K+-ATPase and 5'-(N,N-dimethyl)-amiloride, an inhibitor of Na+/H+ exchanger. | 1999 | Physiol Res | pmid:10534017 |
| Weiner L et al. | Targeted cross-linking of a molten globule form of acetylcholinesterase by the virucidal agent hypericin. | 1999 | Biochemistry | pmid:10471290 |
| Kamuhabwa AR et al. | In vitro transport and uptake of protohypericin and hypericin in the Caco-2 model. | 1999 | Int J Pharm | pmid:10528085 |
| Calapai G et al. | Effects of Hypericum perforatum on levels of 5-hydroxytryptamine, noradrenaline and dopamine in the cortex, diencephalon and brainstem of the rat. | 1999 | J. Pharm. Pharmacol. | pmid:10454050 |
| Franklin M et al. | Neuroendocrine evidence for dopaminergic actions of hypericum extract (LI 160) in healthy volunteers. | 1999 | Biol. Psychiatry | pmid:10459411 |
| Bork PM et al. | Hypericin as a non-antioxidant inhibitor of NF-kappa B. | 1999 | Planta Med. | pmid:10364831 |
| Schempp CM et al. | In vitro and in vivo activation of hypericin with the incoherent light source PDT 1200 SOA (520-750 nm) and with solar simulated radiation (290-2500 nm). | 1999 | Photodermatol Photoimmunol Photomed | pmid:9990663 |
| Alecu M et al. | Photodynamic treatment of basal cell carcinoma and squamous cell carcinoma with hypericin. | 1998 Nov-Dec | Anticancer Res. | pmid:9891535 |
| Ugwu F et al. | A comparative study on the photocytotoxicity of hypericin on A431 cells using three different assays. | 1998 Mar-Apr | Anticancer Res. | pmid:9615785 |
| Butterweck V et al. | Solubilized hypericin and pseudohypericin from Hypericum perforatum exert antidepressant activity in the forced swimming test. | 1998 | Planta Med. | pmid:9619107 |
| Vandenbogaerde AL et al. | Cytotoxicity and antiproliferative effect of hypericin and derivatives after photosensitization. | 1998 | Photochem. Photobiol. | pmid:9477769 |
| Vandenbogaerde AL et al. | Photocytotoxic effect of pseudohypericin versus hypericin. | 1998 | J. Photochem. Photobiol. B, Biol. | pmid:9868799 |
| Kim JI et al. | Induction of differentiation of the human histocytic lymphoma cell line U-937 by hypericin. | 1998 | Arch. Pharm. Res. | pmid:9875513 |
| Park J et al. | The role of oxygen in the antiviral activity of hypericin and hypocrellin. | 1998 | Photochem. Photobiol. | pmid:9796444 |
| Johnson SA et al. | Time-course of hypericin phototoxicity and effect on mitochondrial energies in EMT6 mouse mammary carcinoma cells. | 1998 | Free Radic. Biol. Med. | pmid:9667489 |
| Kocisova E et al. | Sequence specific interaction of the antiretrovirally active drug hypericin with 5'ATGGCAGGATAT3' oligonucleotide: a resonance Raman spectroscopy study. | 1998 | J. Biomol. Struct. Dyn. | pmid:9669559 |
| Raffa RB | Screen of receptor and uptake-site activity of hypericin component of St. John's wort reveals sigma receptor binding. | 1998 | Life Sci. | pmid:9585174 |
| Johnson SA and Pardini RS | Antioxidant enzyme response to hypericin in EMT6 mouse mammary carcinoma cells. | 1998 | Free Radic. Biol. Med. | pmid:9586812 |
| [Therapy of mild to medium degree depression]. | 1998 | Nervenarzt | pmid:9631128 | |
| Ehrenberg B et al. | Kinetics and yield of singlet oxygen photosensitized by hypericin in organic and biological media. | 1998 | Photochem. Photobiol. | pmid:9723207 |
| Fox FE et al. | Photoactivated hypericin is an anti-proliferative agent that induces a high rate of apoptotic death of normal, transformed, and malignant T lymphocytes: implications for the treatment of cutaneous lymphoproliferative and inflammatory disorders. | 1998 | J. Invest. Dermatol. | pmid:9699738 |
| Vantieghem A et al. | Hypericin-induced photosensitization of HeLa cells leads to apoptosis or necrosis. Involvement of cytochrome c and procaspase-3 activation in the mechanism of apoptosis. | 1998 | FEBS Lett. | pmid:9862416 |
| Miccoli L et al. | Light-induced photoactivation of hypericin affects the energy metabolism of human glioma cells by inhibiting hexokinase bound to mitochondria. | 1998 | Cancer Res. | pmid:9865736 |
| Farnet CM et al. | Human immunodeficiency virus type 1 cDNA integration: new aromatic hydroxylated inhibitors and studies of the inhibition mechanism. | 1998 | Antimicrob. Agents Chemother. | pmid:9736543 |
| Schellenberg R et al. | Pharmacodynamic effects of two different hypericum extracts in healthy volunteers measured by quantitative EEG. | 1998 | Pharmacopsychiatry | pmid:9684947 |
| Cott JM and Fugh-Berman A | Is St. John's wort (Hypericum perforatum) an effective antidepressant? | 1998 | J. Nerv. Ment. Dis. | pmid:9717868 |
| Zhao J et al. | [Studies on synthesis and anti-HIV RT activity of hypericin and ethylhypericin]. | 1998 | Yao Xue Xue Bao | pmid:11938940 |
| Crance JM et al. | Inhibition of sandfly fever Sicilian virus (Phlebovirus) replication in vitro by antiviral compounds. | 1997 Sep-Oct | Res. Virol. | pmid:9403935 |
| Müller K et al. | Simple analogues of anthralin: unusual specificity of structure and antiproliferative activity. | 1997 | J. Med. Chem. | pmid:9371243 |
| Baureithel KH et al. | Inhibition of benzodiazepine binding in vitro by amentoflavone, a constituent of various species of Hypericum. | 1997 | Pharm Acta Helv | pmid:9204773 |
| Brockmöller J et al. | Hypericin and pseudohypericin: pharmacokinetics and effects on photosensitivity in humans. | 1997 | Pharmacopsychiatry | pmid:9342768 |
| Sattler S et al. | Binding, uptake, and transport of hypericin by Caco-2 cell monolayers. | 1997 | J Pharm Sci | pmid:9344168 |
| Eshraghi AA et al. | Laser chemotherapy of human carcinoma cells with three new anticancer drugs. | 1997 | J Clin Laser Med Surg | pmid:9467337 |
| Piperopoulos G et al. | Determination of naphthodianthrones in plant extracts from Hypericum perforatum L. by liquid chromatography-electrospray mass spectrometry. | 1997 | J. Chromatogr. B Biomed. Sci. Appl. | pmid:9300867 |