| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uterine Cervical Neoplasms | D002583 | 10 associated lipids |
| Neoplasms, Experimental | D009374 | 10 associated lipids |
| Neoplasms, Radiation-Induced | D009381 | 3 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Carcinoma, Squamous Cell | D002294 | 14 associated lipids |
| Skin Neoplasms | D012878 | 12 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
hypericin
hypericin is a lipid of Polyketides (PK) class. Hypericin is associated with abnormalities such as Dermatitis, Phototoxic, Dehydration, Photosensitization, Morphologically altered structure and Myocardial Infarction. The involved functions are known as Cell Cycle Checkpoints, Apoptosis, Acetylation, Cell Survival and Caspase Activation. Hypericin often locates in insoluble fraction, Cytoplasmic matrix, Protoplasm, Tissue membrane and Cytoplasm. The associated genes with hypericin are CDC37 gene, HSPA8 gene, RAF1 gene, cyclin H and FK228. The related lipids are Phosphatidylserines.
Cross Reference
Introduction
To understand associated biological information of hypericin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with hypericin?
hypericin is suspected in Dermatitis, Phototoxic, Photosensitization, Pneumonia, Psoriasis, Phototoxicity, Chronic infectious disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with hypericin
PubChem Associated disorders and diseases
What pathways are associated with hypericin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with hypericin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with hypericin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with hypericin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with hypericin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with hypericin?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with hypericin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sgarbossa A and Lenci F | Spectroscopic study of visible-light effects on hypericin-lens proteins systems. | 2001 | Photochem. Photobiol. | pmid:11547554 |
| Freeman D et al. | The structure of hypericin in solution. Searching for hypericin's 1,6 tautomer. | 2001 | Photochem. Photobiol. | pmid:11547556 |
| Obermüller RA et al. | Toward hypericin-derived potential photodynamic therapy agents. | 2001 | Photochem. Photobiol. | pmid:11547557 |
| Wills NJ et al. | Tumor cell toxicity of hypericin and related analogs. | 2001 | Photochem. Photobiol. | pmid:11547558 |
| Xie X et al. | Tumor-specific and photodependent cytotoxicity of hypericin in the human LNCaP prostate tumor model. | 2001 | Photochem. Photobiol. | pmid:11547559 |
| Bergonzi MC et al. | Variability in the content of the constituents of Hypericum perforatum L. and some commercial extracts. | 2001 | Drug Dev Ind Pharm | pmid:11548855 |
| Whiskey E et al. | A systematic review and meta-analysis of Hypericum perforatum in depression: a comprehensive clinical review. | 2001 | Int Clin Psychopharmacol | pmid:11552767 |
| Final report on the safety assessment of Hypericum perforatum extract and Hypericum perforatum oil. | 2001 | Int. J. Toxicol. | pmid:11558639 | |
| Peebles KA et al. | Catalytic inhibition of human DNA topoisomerase IIalpha by hypericin, a naphthodianthrone from St. John's wort (Hypericum perforatum). | 2001 | Biochem. Pharmacol. | pmid:11597574 |
| de los Reyes GC and Koda RT | Development of a simple, rapid and reproducible HPLC assay for the simultaneous determination of hypericins and stabilized hyperforin in commercial St. John's wort preparations. | 2001 | J Pharm Biomed Anal | pmid:11600308 |
| Sloley BD et al. | Chemical and pharmacological evaluation of Hypericum perforatum extracts. | 2000 | Acta Pharmacol. Sin. | pmid:11603291 |
| Ali SM et al. | Induction of apoptosis by Hypericin through activation of caspase-3 in human carcinoma cells. | 2001 | Int. J. Mol. Med. | pmid:11605021 |
| Jensen AG and Hansen SH | Separation of hypericins and hyperforins in extracts of Hypericum perforatum L. using non-aqueous capillary electrophoresis with reversed electro-osmotic flow. | 2002 | J Pharm Biomed Anal | pmid:11682223 |
| Cavarga I et al. | Photodynamic therapy of murine fibrosarcoma with topical and systemic administration of hypericin. | 2001 | Phytomedicine | pmid:11695874 |
| Blank M et al. | Effects of photodynamic therapy with hypericin in mice bearing highly invasive solid tumors. | 2000 | Oncol. Res. | pmid:11697819 |
| Uzdensky AB et al. | Intracellular localisation of hypericin in human glioblastoma and carcinoma cell lines. | 2001 | Lasers Med Sci | pmid:11702633 |
| Chan LY et al. | A study of hypericin-induced teratogenicity during organogenesis using a whole rat embryo culture model. | 2001 | Fertil. Steril. | pmid:11704142 |
| Hwang MS et al. | Inhibition of c-erbB-2 expression an activity in human ovarian carcinoma cells by hypericin. | 2001 Jul-Aug | Anticancer Res. | pmid:11724334 |
| Perloff MD et al. | Saint John's wort: an in vitro analysis of P-glycoprotein induction due to extended exposure. | 2001 | Br. J. Pharmacol. | pmid:11739235 |
| Derycke AS and De Witte PA | Transferrin-mediated targeting of hypericin embedded in sterically stabilized PEG-liposomes. | 2002 | Int. J. Oncol. | pmid:11743662 |
| Ekins S and Erickson JA | A pharmacophore for human pregnane X receptor ligands. | 2002 | Drug Metab. Dispos. | pmid:11744617 |
| Ali SM et al. | Hypericin and hypocrellin induced apoptosis in human mucosal carcinoma cells. | 2001 | J. Photochem. Photobiol. B, Biol. | pmid:11748006 |
| Kiniczky M | [Hyperici herba (Hypericum perforatum L]. | 2001 | Acta Pharm Hung | pmid:11769089 |
| Kamuhabwa AA et al. | Biodistribution of hypericin in orthotopic transitional cell carcinoma bladder tumors: implication for whole bladder wall photodynamic therapy. | 2002 | Int. J. Cancer | pmid:11774272 |
| Rayburn WF et al. | Impact of hypericum (St.-John's-wort) given prenatally on cognition of mice offspring. | Neurotoxicol Teratol | pmid:11792531 | |
| Poutaraud A et al. | Improved procedure for the quality control of Hypericum perforatum L. | 2001 Nov-Dec | Phytochem Anal | pmid:11793812 |
| Tekel'ová D and Mrlianová M | [Experimental cultivation of Hypericum perforatum L. in Bratislava]. | 2001 | Ceska Slov Farm | pmid:11797201 |
| Johne A et al. | Decreased plasma levels of amitriptyline and its metabolites on comedication with an extract from St. John's wort ( Hypericum perforatum ). | 2002 | J Clin Psychopharmacol | pmid:11799342 |
| Bauer S et al. | Determination of hyperforin, hypericin, and pseudohypericin in human plasma using high-performance liquid chromatography analysis with fluorescence and ultraviolet detection. | 2001 | J. Chromatogr. B Biomed. Sci. Appl. | pmid:11817306 |
| Klier CM et al. | St. John's wort (Hypericum perforatum)--is it safe during breastfeeding? | 2002 | Pharmacopsychiatry | pmid:11819157 |
| Mirossay A et al. | The effect of quercetin on light-induced cytotoxicity of hypericin. | 2001 | Physiol Res | pmid:11829327 |
| Pytel A and Schmeller N | New aspect of photodynamic diagnosis of bladder tumors: fluorescence cytology. | 2002 | Urology | pmid:11834388 |
| Agostinis P et al. | Hypericin in cancer treatment: more light on the way. | 2002 | Int. J. Biochem. Cell Biol. | pmid:11849990 |
| Varriale L et al. | Molecular aspects of photodynamic therapy: low energy pre-sensitization of hypericin-loaded human endometrial carcinoma cells enhances photo-tolerance, alters gene expression and affects the cell cycle. | 2002 | FEBS Lett. | pmid:11852097 |
| Chen B et al. | Photodynamic therapy with hypericin induces vascular damage and apoptosis in the RIF-1 mouse tumor model. | 2002 | Int. J. Cancer | pmid:11857421 |
| Tolonen A et al. | Determination of naphthodianthrones and phloroglucinols from Hypericum perforatum extracts by liquid chromatography/tandem mass spectrometry. | 2002 | Rapid Commun. Mass Spectrom. | pmid:11857723 |
| Schempp CM et al. | Phototoxic and apoptosis-inducing capacity of pseudohypericin. | 2002 | Planta Med. | pmid:11859473 |
| Butterweck V et al. | Long-term effects of St. John's wort and hypericin on monoamine levels in rat hypothalamus and hippocampus. | 2002 | Brain Res. | pmid:11879791 |
| Bray BJ et al. | Short term treatment with St. John's wort, hypericin or hyperforin fails to induce CYP450 isoforms in the Swiss Webster mouse. | 2002 | Life Sci. | pmid:11883710 |
| Miskovsky P | Hypericin--a new antiviral and antitumor photosensitizer: mechanism of action and interaction with biological macromolecules. | 2002 | Curr Drug Targets | pmid:11899265 |
| de los Reyes GC and Koda RT | Determining hyperforin and hypericin content in eight brands of St. John's wort. | 2002 | Am J Health Syst Pharm | pmid:11908248 |
| Smelcerovic A et al. | The separation of hypericine and pseudohypericine from Hypericum perforatum L. | 2002 | Pharmazie | pmid:11933846 |
| Zhao J et al. | [Studies on synthesis and anti-HIV RT activity of hypericin and ethylhypericin]. | 1998 | Yao Xue Xue Bao | pmid:11938940 |
| Ali SM et al. | Hypocrellins and Hypericin induced apoptosis in human tumor cells: a possible role of hydrogen peroxide. | 2002 | Int. J. Mol. Med. | pmid:11956650 |
| Mirossay A et al. | Potentiation of hypericin and hypocrellin-induced phototoxicity by omeprazole. | 1999 | Phytomedicine | pmid:11962536 |
| D'Hallewin MA et al. | Hypericin-based fluorescence diagnosis of bladder carcinoma. | 2002 | BJU Int. | pmid:11966641 |
| Cotterill JA | Severe phototoxic reaction to laser treatment in a patient taking St John's Wort. | 2001 | J Cosmet Laser Ther | pmid:12006194 |
| Langosch JM et al. | St John's wort (Hypericum perforatum) modulates evoked potentials in guinea pig hippocampal slices via AMPA and GABA receptors. | 2002 | Eur Neuropsychopharmacol | pmid:12007672 |
| Ali SM et al. | Hypericin induced death receptor-mediated apoptosis in photoactivated tumor cells. | 2002 | Int. J. Mol. Med. | pmid:12011977 |
| Hritz J et al. | Influence of structure of human, rat, and bovine serum albumins on binding properties of photoactive drug hypericin. | 2002 | Biopolymers | pmid:12012440 |
| Walker TS et al. | Jasmonic acid-induced hypericin production in cell suspension cultures of Hypericum perforatum L. (St. John's wort). | 2002 | Phytochemistry | pmid:12031448 |
| Du H et al. | Endogenous expression of interleukin-8 and interleukin-10 in nasopharyngeal carcinoma cells and the effect of photodynamic therapy. | 2002 | Int. J. Mol. Med. | pmid:12060853 |
| Morrey JD et al. | Identification of active antiviral compounds against a New York isolate of West Nile virus. | 2002 | Antiviral Res. | pmid:12076755 |
| von Eggelkraut-Gottanka SG et al. | Quantitative analysis of the active components and the by-products of eight dry extracts of Hypericum perforatum L. (St John's Wort). | 2002 May-Jun | Phytochem Anal | pmid:12099108 |
| Vantieghem A et al. | Phosphorylation of Bcl-2 in G2/M phase-arrested cells following photodynamic therapy with hypericin involves a CDK1-mediated signal and delays the onset of apoptosis. | 2002 | J. Biol. Chem. | pmid:12101183 |
| Droller MJ | Biodistribution of hypericin in orthotopic transitional cell carcinoma bladder tumors: implication for whole bladder wall photodynamic therapy. | 2002 | J. Urol. | pmid:12134841 |
| Shin I et al. | Thermal denaturation of Bungarus fasciatus acetylcholinesterase: Is aggregation a driving force in protein unfolding? | 2002 | Protein Sci. | pmid:12142456 |
| Solár P et al. | Effect of acetazolamide on hypericin photocytotoxicity. | 2002 | Planta Med. | pmid:12143007 |
| Ali SM and Olivo M | Bio-distribution and subcellular localization of Hypericin and its role in PDT induced apoptosis in cancer cells. | 2002 | Int. J. Oncol. | pmid:12168096 |
| Wen J et al. | Toward the molecular flashlight: preparation, properties, and photophysics of a hypericin-luciferin tethered molecule. | 2002 | Photochem. Photobiol. | pmid:12194210 |
| Romerio F and Zella D | MEK and ERK inhibitors enhance the anti-proliferative effect of interferon-alpha2b. | 2002 | FASEB J. | pmid:12206994 |
| Chen B et al. | Enhancing the antitumoral effect of hypericin-mediated photodynamic therapy by hyperthermia. | 2002 | Lasers Surg Med | pmid:12224088 |
| Wirz A et al. | Solubility of hypericin in methanol and methanol-pyridine. | 2002 | Pharmazie | pmid:12227194 |
| Siepmann M et al. | The effects of St John's wort extract on heart rate variability, cognitive function and quantitative EEG: a comparison with amitriptyline and placebo in healthy men. | 2002 | Br J Clin Pharmacol | pmid:12236848 |
| Gertsch J et al. | Relative quantification of mRNA levels in Jurkat T cells with RT-real time-PCR (RT-rt-PCR): new possibilities for the screening of anti-inflammatory and cytotoxic compounds. | 2002 | Pharm. Res. | pmid:12240952 |
| Pirker R et al. | Simultaneous determination of hypericin and hyperforin in human plasma and serum using liquid-liquid extraction, high-performance liquid chromatography and liquid chromatography-tandem mass spectrometry. | 2002 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:12270208 |
| Wierrani F et al. | Photodynamic action of some sensitizers by photooxidation of luminol. | 2002 | Naturwissenschaften | pmid:12384722 |
| Conforti F et al. | Antioxidant activity of methanolic extract of Hypericum triquetrifolium Turra aerial part. | 2002 | Fitoterapia | pmid:12385870 |
| Widy-Tyszkiewicz E et al. | Long term administration of Hypericum perforatum improves spatial learning and memory in the water maze. | 2002 | Biol. Pharm. Bull. | pmid:12392080 |
| Uzdensky AB et al. | Photobleaching of hypericin bound to human serum albumin, cultured adenocarcinoma cells and nude mice skin. | 2002 | Photochem. Photobiol. | pmid:12403454 |
| Blank M et al. | Wavelength-dependent properties of photodynamic therapy using hypericin in vitro and in an animal model. | 2002 | Photochem. Photobiol. | pmid:12403456 |
| D'Hallewin MA et al. | Fluorescence detection of bladder cancer: a review. | 2002 | Eur. Urol. | pmid:12429148 |
| Chen B et al. | Antivascular tumor eradication by hypericin-mediated photodynamic therapy. | 2002 | Photochem. Photobiol. | pmid:12462645 |
| Murch SJ et al. | An in vitro and hydroponic growing system for hypericin, pseudohypericin, and hyperforin production of St. John's wort (Hypericum perforatum CV new stem). | 2002 | Planta Med. | pmid:12494339 |
| von Eggelkraut-Gottanka SG et al. | Roller compaction and tabletting of St. John's wort plant dry extract using a gap width and force controlled roller compactor. I. Granulation and tabletting of eight different extract batches. | 2002 | Pharm Dev Technol | pmid:12503525 |
| Simmen U et al. | Antagonist effect of pseudohypericin at CRF1 receptors. | 2003 | Eur. J. Pharmacol. | pmid:12504780 |
| Mirossay A et al. | Modulation of the phototoxic effect of hypericin in human leukemia CEM cell line by N-ethylmaleimide, amiloride and omeprazole. | 2002 | Physiol Res | pmid:12511190 |
| Glisson JK et al. | Clinic at the health food store? Employee recommendations and product analysis. | 2003 | Pharmacotherapy | pmid:12523461 |
| Rahimipour S et al. | Chemical and photochemical electron transfer of new helianthrone derivatives: aspects of their photodynamic activity. | 2003 | J. Am. Chem. Soc. | pmid:12553841 |
| Gao Q et al. | Effect of hypericin on confocal imaging of Ca2+ signaling in cultured human retinal pigment epithelium. | 2001 | Yan Ke Xue Bao | pmid:12567741 |
| Schmitt J | [Dangerous interaction of St. John's wort with chemotherapy?]. | 2003 | Pharm Unserer Zeit | pmid:12577753 |
| Schempp CM et al. | Effect of oral administration ofHypericum perforatum extract (St. John's Wort) on skin erythema and pigmentation induced by UVB, UVA, visible light and solar simulated radiation. | 2003 | Phytother Res | pmid:12601676 |
| Schmidt AH | Use of an on-line, precolumn photochemical reactor in high-performance liquid chromatography of naphthodianthrones in Hypericum perforatum preparations. | 2003 | J Chromatogr A | pmid:12613810 |
| Kaltschmidt B et al. | Stimulus-dependent activation of NF-kappaB specifies apoptosis or neuroprotection in cerebellar granule cells. | 2002 | Neuromolecular Med. | pmid:12622408 |
| Ali SM and Olivo M | Nitric oxide mediated photo-induced cell death in human malignant cells. | 2003 | Int. J. Oncol. | pmid:12632064 |
| Kamuhabwa AA et al. | Microscopic quantification of hypercin fluorescence in an orthotopic rat bladder tumor model after intravesical instillation. | 2003 | Int. J. Oncol. | pmid:12632090 |
| Siboni G et al. | The correlation between hydrophilicity of hypericins and helianthrone: internalization mechanisms, subcellular distribution and photodynamic action in colon carcinoma cells. | 2002 | Photochem. Photobiol. Sci. | pmid:12659159 |
| Piperopoulos G et al. | [Methyl-D3]2hypericin as internal standard for quantification in human plasma. | 2003 | Anal Bioanal Chem | pmid:12664172 |
| Taher MM et al. | Mood-enhancing antidepressant St. John's wort inhibits the activation of human immunodeficiency virus gene expression by ultraviolet light. | 2002 | IUBMB Life | pmid:12665247 |
| Höpfner M et al. | Hypericin activated by an incoherent light source has photodynamic effects on esophageal cancer cells. | 2003 | Int J Colorectal Dis | pmid:12673490 |
| Butterweck V et al. | Plasma levels of hypericin in presence of procyanidin B2 and hyperoside: a pharmacokinetic study in rats. | 2003 | Planta Med. | pmid:12677519 |
| Du HY et al. | Biodistribution and photodynamic therapy with hypericin in a human NPC murine tumor model. | 2003 | Int. J. Oncol. | pmid:12684667 |
| Jürgenliemk G and Nahrstedt A | Dissolution, solubility and cooperativity of phenolic compounds from Hypericum perforatum L. in aqueous systems. | 2003 | Pharmazie | pmid:12685814 |
| Chen TC et al. | Combination therapy with irinotecan and protein kinase C inhibitors in malignant glioma. | 2003 | Cancer | pmid:12712458 |
| Ali SM and Olivo M | Mechanisms of action of phenanthroperylenequinones in photodynamic therapy (review). | 2003 | Int. J. Oncol. | pmid:12738982 |
| Butterweck V et al. | Step by step removal of hyperforin and hypericin: activity profile of different Hypericum preparations in behavioral models. | 2003 | Life Sci. | pmid:12770617 |
| Xu MS et al. | [Induction of callus of Hypericum perforatum L. and qualitative identification of active constituents of its callus]. | 2001 | Zhongguo Zhong Yao Za Zhi | pmid:12776326 |
| Schmidt PC | [Formulation of St. John's wort extract. A medicinal obstacle course]. | 2003 | Pharm Unserer Zeit | pmid:12784540 |
| Cakir A et al. | Isolation and characterization of antioxidant phenolic compounds from the aerial parts of Hypericum hyssopifolium L. by activity-guided fractionation. | 2003 | J Ethnopharmacol | pmid:12787957 |
| Bais HP et al. | Molecular and biochemical characterization of an enzyme responsible for the formation of hypericin in St. John's wort (Hypericum perforatum L.). | 2003 | J. Biol. Chem. | pmid:12799379 |