| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uterine Cervical Neoplasms | D002583 | 10 associated lipids |
| Neoplasms, Experimental | D009374 | 10 associated lipids |
| Neoplasms, Radiation-Induced | D009381 | 3 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Carcinoma, Squamous Cell | D002294 | 14 associated lipids |
| Skin Neoplasms | D012878 | 12 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
hypericin
hypericin is a lipid of Polyketides (PK) class. Hypericin is associated with abnormalities such as Dermatitis, Phototoxic, Dehydration, Photosensitization, Morphologically altered structure and Myocardial Infarction. The involved functions are known as Cell Cycle Checkpoints, Apoptosis, Acetylation, Cell Survival and Caspase Activation. Hypericin often locates in insoluble fraction, Cytoplasmic matrix, Protoplasm, Tissue membrane and Cytoplasm. The associated genes with hypericin are CDC37 gene, HSPA8 gene, RAF1 gene, cyclin H and FK228. The related lipids are Phosphatidylserines.
Cross Reference
Introduction
To understand associated biological information of hypericin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with hypericin?
hypericin is suspected in Dermatitis, Phototoxic, Photosensitization, Pneumonia, Psoriasis, Phototoxicity, Chronic infectious disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with hypericin
PubChem Associated disorders and diseases
What pathways are associated with hypericin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with hypericin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with hypericin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with hypericin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with hypericin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with hypericin?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with hypericin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Vance KM et al. | St. John's Wort enhances the synaptic activity of the nucleus of the solitary tract. | 2014 Jul-Aug | Nutrition | pmid:24985104 |
| Li Z et al. | Molecularly imprinted polymer for specific extraction of hypericin from Hypericum perforatum L. herbal extract. | 2014 | J Pharm Biomed Anal | pmid:24946147 |
| Zor M et al. | Does hypericin boost the efficacy of high-power laser? A preliminary experimental study on rats. | 2014 | Sao Paulo Med J | pmid:25351755 |
| Kleemann B et al. | St John's Wort (Hypericum perforatum L.) photomedicine: hypericin-photodynamic therapy induces metastatic melanoma cell death. | 2014 | PLoS ONE | pmid:25076130 |
| Lin S et al. | Development of a multifunctional luciferase reporters system for assessing endoplasmic reticulum-targeting photosensitive compounds. | 2014 | Cell Stress Chaperones | pmid:24984699 |
| Rašković A et al. | Interaction between different extracts of Hypericum perforatum L. from Serbia and pentobarbital, diazepam and paracetamol. | 2014 | Molecules | pmid:24686576 |
| Murthy HN et al. | Hypericins: biotechnological production from cell and organ cultures. | 2014 | Appl. Microbiol. Biotechnol. | pmid:25301586 |
| Joniova J et al. | Effect of PKCα expression on Bcl-2 phosphorylation and cell death by hypericin. | 2014 | Apoptosis | pmid:25300800 |
| Pillai PP and Nair AR | Hypericin biosynthesis in Hypericum hookerianum Wight and Arn: investigation on biochemical pathways using metabolite inhibitors and suppression subtractive hybridization. | 2014 | C. R. Biol. | pmid:25282172 |
| Feinweber D et al. | Applicability of new degradable hypericin-polymer-conjugates as photosensitizers: principal mode of action demonstrated by in vitro models. | 2014 | Photochem. Photobiol. Sci. | pmid:25257955 |
| Joniova J et al. | Kinetics of incorporation/redistribution of photosensitizer hypericin to/from high-density lipoproteins. | 2014 | Int J Pharm | pmid:25238911 |
| Namlı S et al. | Effects of UV-B radiation on total phenolic, flavonoid and hypericin contents in Hypericum retusum Aucher grown under in vitro conditions. | 2014 | Nat. Prod. Res. | pmid:25142873 |
| Paz-Cristobal MP et al. | In vitro fungicidal photodynamic effect of hypericin on Trichophyton spp. | 2014 | Mycopathologia | pmid:25129421 |
| Marrelli M et al. | Hypericum perforatum: Influences of the habitat on chemical composition, photo-induced cytotoxicity, and antiradical activity. | 2014 | Pharm Biol | pmid:24920234 |
| Huang LF et al. | Hypericin: chemical synthesis and biosynthesis. | 2014 | Chin J Nat Med | pmid:24636057 |
| Omar MA et al. | Proof-of-principle for simple microshelter-assisted buffer exchange in laser tweezers: interaction of hypericin with single cells. | 2014 | Lab Chip | pmid:24632728 |
| Dzurová L et al. | The role of anti-apoptotic protein kinase Cα in response to hypericin photodynamic therapy in U-87 MG cells. | 2014 | Photodiagnosis Photodyn Ther | pmid:24583280 |
| Larisch P et al. | The interrelation between a pro-inflammatory milieu and fluorescence diagnosis or photodynamic therapy of human skin cell lines. | 2014 | Photodiagnosis Photodyn Ther | pmid:24503057 |
| Ji Y et al. | Improvement of solubility and targetability of radioiodinated hypericin by using sodium cholate based solvent in rat models of necrosis. | 2014 | J Drug Target | pmid:24328682 |
| Rubio N et al. | p38(MAPK)-regulated induction of p62 and NBR1 after photodynamic therapy promotes autophagic clearance of ubiquitin aggregates and reduces reactive oxygen species levels by supporting Nrf2-antioxidant signaling. | 2014 | Free Radic. Biol. Med. | pmid:24269898 |
| Cona MM et al. | Targetability and biodistribution of radioiodinated hypericin: comparison between microdosing and carrier-added preparations. | 2014 | Anticancer Agents Med Chem | pmid:24102315 |
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| Paz-Cristobal MP et al. | Photodynamic fungicidal efficacy of hypericin and dimethyl methylene blue against azole-resistant Candida albicans strains. | 2014 | Mycoses | pmid:23905682 |
| Kazemi SY and Abedirad SM | Effect of glutathione on peroxyoxalate chemiluminescence of hypericin as the fluorophore. | 2014 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:24152863 |
| Cona MM et al. | Radioiodinated hypericin: its biodistribution, necrosis avidity and therapeutic efficacy are influenced by formulation. | 2014 | Pharm. Res. | pmid:23934256 |
| Ouyang Z et al. | Hypericin suppresses osteoclast formation and wear particle-induced osteolysis via modulating ERK signalling pathway. | 2014 | Biochem. Pharmacol. | pmid:24950468 |
| Höfle G et al. | Amethystin, the coloring principle of Stentor amethystinus. | 2014 | J. Nat. Prod. | pmid:24882688 |
| Galeotti N et al. | PKC-mediated potentiation of morphine analgesia by St. John's Wort in rodents and humans. | 2014 | J. Pharmacol. Sci. | pmid:24739262 |
| Garg AD and Agostinis P | ER stress, autophagy and immunogenic cell death in photodynamic therapy-induced anti-cancer immune responses. | 2014 | Photochem. Photobiol. Sci. | pmid:24493131 |
| Cona MM et al. | Biodistribution and radiation dosimetry of radioiodinated hypericin as a cancer therapeutic. | 2014 | Int. J. Oncol. | pmid:24366374 |
| Penjweini R et al. | Transport and accumulation of PVP-Hypericin in cancer and normal cells characterized by image correlation spectroscopy techniques. | 2014 | Biochim. Biophys. Acta | pmid:24480461 |
| Sayar H et al. | Comparison of efficacy of topical phenytoin with hypericin in second-degree burn wound healing: an experimental study in rats. | 2014 | Med Sci Monit Basic Res | pmid:24694757 |
| Jendželovská Z et al. | Single pre-treatment with hypericin, a St. John's wort secondary metabolite, attenuates cisplatin- and mitoxantrone-induced cell death in A2780, A2780cis and HL-60 cells. | 2014 | Toxicol In Vitro | pmid:24994473 |
| Galeotti N et al. | St. John's Wort seed and feverfew flower extracts relieve painful diabetic neuropathy in a rat model of diabetes. | 2014 | Fitoterapia | pmid:24125916 |
| De Saint-Hubert M et al. | In vivo molecular imaging of apoptosis and necrosis in atherosclerotic plaques using microSPECT-CT and microPET-CT imaging. | 2014 | Mol Imaging Biol | pmid:23979833 |
| ÄŒavarga I et al. | Photodynamic effect of hypericin after topical application in the ex ovo quail chorioallantoic membrane model. | 2014 | Planta Med. | pmid:24414308 |
| Gyenge EB et al. | Photodynamic mechanisms induced by a combination of hypericin and a chlorin based-photosensitizer in head and neck squamous cell carcinoma cells. | 2013 Jan-Feb | Photochem. Photobiol. | pmid:22882495 |
| Chong K et al. | Enhancement of the photocytotoxic efficiency of sub-12 nm therapeutic polymeric micelles with increased co-localisation in mitochondria. | 2013 | Chem. Commun. (Camb.) | pmid:24064984 |
| Van Kets V et al. | Laser light activation of a second-generation photosensitiser and its use as a potential photomodulatory agent in skin rejuvenation. | 2013 | Lasers Med Sci | pmid:22581390 |
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| Barrette K et al. | Pattern of sensitivity of progressive cutaneous squamous cell carcinoma cells to UVB and oxidative stress-induced cell death. | 2013 | Photochem. Photobiol. Sci. | pmid:22722579 |
| Li J et al. | Sequential systemic administrations of combretastatin A4 Phosphate and radioiodinated hypericin exert synergistic targeted theranostic effects with prolonged survival on SCID mice carrying bifocal tumor xenografts. | 2013 | Theranostics | pmid:23423247 |
| Ehrenshaft M et al. | Hypericin-mediated photooxidative damage of α-crystallin in human lens epithelial cells. | 2013 | Free Radic. Biol. Med. | pmid:23453985 |
| Souza MI et al. | Structural and photophysical properties of peptide micro/nanotubes functionalized with hypericin. | 2013 | J Phys Chem B | pmid:23402475 |
| Balogová L et al. | Bcl-2 proapoptotic proteins distribution in U-87 MG glioma cells before and after hypericin photodynamic action. | 2013 | Gen. Physiol. Biophys. | pmid:23479448 |
| Búzová D et al. | Solubilization of poorly soluble photosensitizer hypericin by polymeric micelles and polyethylene glycol. | 2013 | Gen. Physiol. Biophys. | pmid:23479449 |
| Nafee N et al. | Antibiotic-free nanotherapeutics: hypericin nanoparticles thereof for improved in vitro and in vivo antimicrobial photodynamic therapy and wound healing. | 2013 | Int J Pharm | pmid:23834835 |
| Lima AM et al. | Hypericin encapsulated in solid lipid nanoparticles: phototoxicity and photodynamic efficiency. | 2013 | J. Photochem. Photobiol. B, Biol. | pmid:23816959 |
| Garg AD et al. | ROS-induced autophagy in cancer cells assists in evasion from determinants of immunogenic cell death. | 2013 | Autophagy | pmid:23800749 |
| Barathan M et al. | Hypericin-photodynamic therapy leads to interleukin-6 secretion by HepG2 cells and their apoptosis via recruitment of BH3 interacting-domain death agonist and caspases. | 2013 | Cell Death Dis | pmid:23807226 |
| Kong M et al. | Necrosis affinity evaluation of 131I-hypericin in a rat model of induced necrosis. | 2013 | J Drug Target | pmid:23627568 |
| Zhang W et al. | Investigation of water-soluble inclusion complex of hypericin with β-cyclodextrin polymer. | 2013 | Carbohydr Polym | pmid:23618281 |
| Ocak Z et al. | Effect of hypericin on the ADAMTS-9 and ADAMTS-8 gene expression in MCF7 breast cancer cells. | 2013 | Eur Rev Med Pharmacol Sci | pmid:23690187 |
| StrejÄková A et al. | Spatial orientation and electric-field-driven transport of hypericin inside of bilayer lipid membranes. | 2013 | J Phys Chem B | pmid:23286583 |
| Klejdus B et al. | PAL inhibitor evokes different responses in two Hypericum species. | 2013 | Plant Physiol. Biochem. | pmid:23254282 |
| Galeotti N and Ghelardini C | Reversal of NO-induced nociceptive hypersensitivity by St. John's wort and hypericin: NF-κB, CREB and STAT1 as molecular targets. | 2013 | Psychopharmacology (Berl.) | pmid:23254377 |
| Penjweini R et al. | Modifying excitation light dose of novel photosensitizer PVP-Hypericin for photodynamic diagnosis and therapy. | 2013 | J. Photochem. Photobiol. B, Biol. | pmid:23375215 |
| Larisch P et al. | In vitro analysis of photosensitizer accumulation for assessment of applicability of fluorescence diagnosis of squamous cell carcinoma of epidermolysis bullosa patients. | 2013 | Biomed Res Int | pmid:23509735 |
| Ziegler V et al. | Photosensitizer adhered to cell culture microplates induces phototoxicity in carcinoma cells. | 2013 | Biomed Res Int | pmid:23509741 |
| Kashef N et al. | Photodynamic effect of hypericin on the microorganisms and primary human fibroblasts. | 2013 | Photodiagnosis Photodyn Ther | pmid:23769281 |
| Cona MM et al. | Comparative study of iodine-123-labeled hypericin and (99m)Tc-labeled hexakis [2-methoxy isobutyl isonitrile] in a rabbit model of myocardial infarction. | 2013 | J. Cardiovasc. Pharmacol. | pmid:23714775 |
| Verfaillie T et al. | Pro-apoptotic signaling induced by photo-oxidative ER stress is amplified by Noxa, not Bim. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23916707 |
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| Noell S et al. | Microendoscopy for hypericin fluorescence tumor diagnosis in a subcutaneous glioma mouse model. | 2013 | Photodiagnosis Photodyn Ther | pmid:24284111 |
| Penjweini R et al. | Optimizing the antitumor selectivity of PVP-Hypericin re A549 cancer cells and HLF normal cells through pulsed blue light. | 2013 | Photodiagnosis Photodyn Ther | pmid:24284116 |
| de Melo Wde C et al. | Electroporation enhances antimicrobial photodynamic therapy mediated by the hydrophobic photosensitizer, hypericin. | 2013 | Photodiagnosis Photodyn Ther | pmid:24284122 |
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| Jiang B et al. | Necrosis avidity: a newly discovered feature of hypericin and its preclinical applications in necrosis imaging. | 2013 | Theranostics | pmid:24052807 |
| Barras A et al. | Hypericin-loaded lipid nanocapsules for photodynamic cancer therapy in vitro. | 2013 | Nanoscale | pmid:24056802 |
| Cona MM et al. | Improved clearance of radioiodinated hypericin as a targeted anticancer agent by using a duodenal drainage catheter in rats. | 2013 | Exp. Biol. Med. (Maywood) | pmid:24146264 |
| Righeschi C et al. | Microarray-based mRNA expression profiling of leukemia cells treated with the flavonoid, casticin. | 2012 May-Jun | Cancer Genomics Proteomics | pmid:22593249 |
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| Kairyte K et al. | Effective inactivation of food pathogens Listeria monocytogenes and Salmonella enterica by combined treatment of hypericin-based photosensitization and high power pulsed light. | 2012 | J. Appl. Microbiol. | pmid:22469030 |
| Besic Gyenge E et al. | Effects of hypericin and a chlorin based photosensitizer alone or in combination in squamous cell carcinoma cells in the dark. | 2012 | Photodiagnosis Photodyn Ther | pmid:23200013 |
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