| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uterine Cervical Neoplasms | D002583 | 10 associated lipids |
| Neoplasms, Experimental | D009374 | 10 associated lipids |
| Neoplasms, Radiation-Induced | D009381 | 3 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Carcinoma, Squamous Cell | D002294 | 14 associated lipids |
| Skin Neoplasms | D012878 | 12 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
hypericin
hypericin is a lipid of Polyketides (PK) class. Hypericin is associated with abnormalities such as Dermatitis, Phototoxic, Dehydration, Photosensitization, Morphologically altered structure and Myocardial Infarction. The involved functions are known as Cell Cycle Checkpoints, Apoptosis, Acetylation, Cell Survival and Caspase Activation. Hypericin often locates in insoluble fraction, Cytoplasmic matrix, Protoplasm, Tissue membrane and Cytoplasm. The associated genes with hypericin are CDC37 gene, HSPA8 gene, RAF1 gene, cyclin H and FK228. The related lipids are Phosphatidylserines.
Cross Reference
Introduction
To understand associated biological information of hypericin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with hypericin?
hypericin is suspected in Dermatitis, Phototoxic, Photosensitization, Pneumonia, Psoriasis, Phototoxicity, Chronic infectious disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with hypericin
PubChem Associated disorders and diseases
What pathways are associated with hypericin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with hypericin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with hypericin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with hypericin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with hypericin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with hypericin?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with hypericin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Li X et al. | Hypericin-mediated sonodynamic therapy induces autophagy and decreases lipids in THP-1 macrophage by promoting ROS-dependent nuclear translocation of TFEB. | 2016 | Cell Death Dis | pmid:28005078 |
| Miranda Cona M et al. | Differential diagnosis of gallstones by using hypericin as a fluorescent optical imaging agent. | 2016 | World J. Gastroenterol. | pmid:27547012 |
| Singh S and Dubey VK | Quantitative Proteome Analysis of Leishmania donovani under Spermidine Starvation. | 2016 | PLoS ONE | pmid:27123864 |
| Wang Q et al. | Discovery of Radioiodinated Monomeric Anthraquinones as a Novel Class of Necrosis Avid Agents for Early Imaging of Necrotic Myocardium. | 2016 | Sci Rep | pmid:26878909 |
| Dementavicius D et al. | Application of mathematical models for bacterial inactivation curves using Hypericin-based photosensitization. | 2016 | J. Appl. Microbiol. | pmid:26972682 |
| Verebova V et al. | Deeper insights into the drug defense of glioma cells against hydrophobic molecules. | 2016 | Int J Pharm | pmid:26940808 |
| Garg AD et al. | Dendritic cell vaccines based on immunogenic cell death elicit danger signals and T cell-driven rejection of high-grade glioma. | 2016 | Sci Transl Med | pmid:26936504 |
| Feruszová J et al. | Photoactivated hypericin is not genotoxic. | 2016 | Gen. Physiol. Biophys. | pmid:26891274 |
| KucharÃková A et al. | Interspecific variation in localization of hypericins and phloroglucinols in the genus Hypericum as revealed by desorption electrospray ionization mass spectrometry imaging. | 2016 | Physiol Plant | pmid:26822391 |
| Lin S et al. | Enhancement of oxaliplatin sensitivity in human colorectal cancer by hypericin mediated photodynamic therapy via ROS-related mechanism. | 2016 | Int. J. Biochem. Cell Biol. | pmid:26673998 |
| Florea AM et al. | An innovative approach to prepare hypericin molecularly imprinted pearls using a "phyto-template". | 2016 | Talanta | pmid:26653421 |
| Silva SM et al. | Effects of Hypericum perforatum extract and its main bioactive compounds on the cytotoxicity and expression of CYP1A2 and CYP2D6 in hepatic cells. | 2016 | Life Sci. | pmid:26612349 |
| Zhang D et al. | Effects of skeleton structure on necrosis targeting and clearance properties of radioiodinated dianthrones. | 2016 | J Drug Target | pmid:26586010 |
| Li J et al. | Synthesis and Preclinical Evaluation of Radioiodinated Hypericin Dicarboxylic Acid as a Necrosis Avid Agent in Rat Models of Induced Hepatic, Muscular, and Myocardial Necroses. | 2016 | Mol. Pharm. | pmid:26568406 |
| Li Y et al. | Co-delivery of siRNA and hypericin into cancer cells by hyaluronic acid modified PLGA-PEI nanoparticles. | 2016 | Drug Dev Ind Pharm | pmid:26472259 |
| Hu W et al. | Fluorescence Detection of DNA Based on Non-covalent π-π Stacking Interaction between 1-Pyrenebutanoic Acid and Hypericin. | 2016 | Anal Sci | pmid:27169651 |
| Gao L et al. | Improved therapeutic outcomes of thermal ablation on rat orthotopic liver allograft sarcoma models by radioiodinated hypericin induced necrosis targeted radiotherapy. | 2016 | Oncotarget | pmid:27285983 |
| Zhang Q et al. | Hypericin-photodynamic therapy induces human umbilical vein endothelial cell apoptosis. | 2015 | Sci Rep | pmid:26673286 |
| Unterweger H et al. | Hypericin-bearing magnetic iron oxide nanoparticles for selective drug delivery in photodynamic therapy. | 2015 | Int J Nanomedicine | pmid:26648714 |
| Xu Y et al. | Hypericin-mediated photodynamic therapy induces apoptosis in K562 human leukemia cells through JNK pathway modulation. | 2015 | Mol Med Rep | pmid:26330116 |
| Garg AD et al. | Resistance to anticancer vaccination effect is controlled by a cancer cell-autonomous phenotype that disrupts immunogenic phagocytic removal. | 2015 | Oncotarget | pmid:26314964 |
| Furuta A et al. | Identification of Hydroxyanthraquinones as Novel Inhibitors of Hepatitis C Virus NS3 Helicase. | 2015 | Int J Mol Sci | pmid:26262613 |
| Yi J et al. | Photoactivation of hypericin decreases the viability of RINm5F insulinoma cells through reduction in JNK/ERK phosphorylation and elevation of caspase-9/caspase-3 cleavage and Bax-to-Bcl-2 ratio. | 2015 | Biosci. Rep. | pmid:26182357 |
| Montoya A et al. | Development of a novel formulation with hypericin to treat cutaneous leishmaniasis based on photodynamic therapy in in vitro and in vivo studies. | 2015 | Antimicrob. Agents Chemother. | pmid:26169411 |
| Shao H et al. | Necrosis targeted radiotherapy with iodine-131-labeled hypericin to improve anticancer efficacy of vascular disrupting treatment in rabbit VX2 tumor models. | 2015 | Oncotarget | pmid:26036625 |
| Li Y et al. | Biliary and duodenal drainage for reducing the radiotoxic risk of antineoplastic 131I-hypericin in rat models. | 2015 | Exp. Biol. Med. (Maywood) | pmid:25956680 |
| Zhu M et al. | Evaluation of the therapeutic efficacy of sequential therapy involving percutaneous microwave ablation in combination with 131I-hypericin using the VX2 rabbit breast solid tumor model. | 2015 | PLoS ONE | pmid:25799220 |
| Li X et al. | The efficacy and mechanism of apoptosis induction by hypericin-mediated sonodynamic therapy in THP-1 macrophages. | 2015 | Int J Nanomedicine | pmid:25653524 |
| Singh S et al. | Probing the molecular mechanism of hypericin-induced parasite death provides insight into the role of spermidine beyond redox metabolism in Leishmania donovani. | 2015 | Antimicrob. Agents Chemother. | pmid:25313212 |
| Turk S et al. | Purification of Glutathione S-Transferase pi from Erythrocytes and Evaluation of the Inhibitory Effect of Hypericin. | 2015 | Protein J. | pmid:26614503 |
| Penjweini R et al. | Intracellular localization and dynamics of Hypericin loaded PLLA nanocarriers by image correlation spectroscopy. | 2015 | J Control Release | pmid:26435453 |
| Alnawaiseh M et al. | [Effect of Hypericin on the Function of the Neuroretina: An Electroretinographic Study]. | 2015 | Klin Monbl Augenheilkd | pmid:26197957 |
| Popovic A et al. | Differential susceptibility of primary cultured human skin cells to hypericin PDT in an in vitro model. | 2015 | J. Photochem. Photobiol. B, Biol. | pmid:26114219 |
| Verjee S et al. | Permeation Characteristics of Hypericin across Caco-2 Monolayers in the Absence or Presence of Quercitrin - A Mass Balance Study. | 2015 | Planta Med. | pmid:26018919 |
| Kuchárová B et al. | Potentiation of hypericin-mediated photodynamic therapy cytotoxicity by MK-886: focus on ABC transporters, GDF-15 and redox status. | 2015 | Photodiagnosis Photodyn Ther | pmid:26003114 |
| Zhai XJ et al. | LC-MS/MS based studies on the anti-depressant effect of hypericin in the chronic unpredictable mild stress rat model. | 2015 | J Ethnopharmacol | pmid:25957811 |
| Kusari S et al. | Spatial chemo-profiling of hypericin and related phytochemicals in Hypericum species using MALDI-HRMS imaging. | 2015 | Anal Bioanal Chem | pmid:25912460 |
| Bernal C et al. | Photodynamic efficiency of hypericin compared with chlorin and hematoporphyrin derivatives in HEp-2 and Vero epithelial cell lines. | 2015 | Photodiagnosis Photodyn Ther | pmid:25910552 |
| Kashef N et al. | Phototoxic effect of hypericin alone and in combination with acetylcysteine on Staphylococcus aureus biofilms. | 2015 | Photodiagnosis Photodyn Ther | pmid:25892001 |
| Hohmann MS et al. | Hypericum perforatum Reduces Paracetamol-Induced Hepatotoxicity and Lethality in Mice by Modulating Inflammation and Oxidative Stress. | 2015 | Phytother Res | pmid:25851311 |
| GarcÃa I et al. | Antimicrobial photodynamic activity of hypericin against methicillin-susceptible and resistant Staphylococcus aureus biofilms. | 2015 | Future Microbiol | pmid:25812458 |
| Liu W et al. | Biodistribution and anti-tumor efficacy of intratumorally injected necrosis-avid theranostic agent radioiodinated hypericin in rodent tumor models. | 2015 | J Drug Target | pmid:25572455 |
| RodrÃguez-Amigo B et al. | The complex of hypericin with β-lactoglobulin has antimicrobial activity with potential applications in dairy industry. | 2015 | J. Dairy Sci. | pmid:25465550 |
| Liu X et al. | Evaluation of hypericin: effect of aggregation on targeting biodistribution. | 2015 | J Pharm Sci | pmid:25395358 |
| Straub M et al. | A phase IIA dose-finding study of PVP-hypericin fluorescence cystoscopy for detection of nonmuscle-invasive bladder cancer. | 2015 | J. Endourol. | pmid:25222735 |
| Urla C et al. | Successful in vivo tumor visualization using fluorescence laparoscopy in a mouse model of disseminated alveolar rhabdomyosarcoma. | 2015 | Surg Endosc | pmid:25149634 |
| Qi X et al. | Radiopharmaceutical study on Iodine-131-labelled hypericin in a canine model of hepatic RFA-induced coagulative necrosis. | 2015 | Radiol Med | pmid:25012473 |
| Laffers W et al. | Photosensitizing effects of hypericin on head neck squamous cell carcinoma in vitro. | 2015 | Eur Arch Otorhinolaryngol | pmid:24687800 |
| Cona MM et al. | Sodium cholate, a solubilizing agent for the necrosis avid radioiodinated hypericin in rabbits with acute myocardial infarction. | 2015 | Drug Deliv | pmid:24417698 |
| Choi YM et al. | Photodynamic therapy for psoriasis. | 2015 | J Dermatolog Treat | pmid:24881473 |