| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uterine Cervical Neoplasms | D002583 | 10 associated lipids |
| Neoplasms, Experimental | D009374 | 10 associated lipids |
| Neoplasms, Radiation-Induced | D009381 | 3 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Carcinoma, Squamous Cell | D002294 | 14 associated lipids |
| Skin Neoplasms | D012878 | 12 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
hypericin
hypericin is a lipid of Polyketides (PK) class. Hypericin is associated with abnormalities such as Dermatitis, Phototoxic, Dehydration, Photosensitization, Morphologically altered structure and Myocardial Infarction. The involved functions are known as Cell Cycle Checkpoints, Apoptosis, Acetylation, Cell Survival and Caspase Activation. Hypericin often locates in insoluble fraction, Cytoplasmic matrix, Protoplasm, Tissue membrane and Cytoplasm. The associated genes with hypericin are CDC37 gene, HSPA8 gene, RAF1 gene, cyclin H and FK228. The related lipids are Phosphatidylserines.
Cross Reference
Introduction
To understand associated biological information of hypericin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with hypericin?
hypericin is suspected in Dermatitis, Phototoxic, Photosensitization, Pneumonia, Psoriasis, Phototoxicity, Chronic infectious disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with hypericin
PubChem Associated disorders and diseases
What pathways are associated with hypericin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with hypericin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with hypericin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with hypericin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with hypericin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with hypericin?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with hypericin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Agostinis P et al. | A comparative analysis of the photosensitized inhibition of growth-factor regulated protein kinases by hypericin-derivatives. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8607812 |
| Cohen PA et al. | Antiviral activities of anthraquinones, bianthrones and hypericin derivatives from lichens. | 1996 | Experientia | pmid:8608821 |
| VanderWerf QM et al. | Hypericin: a new laser phototargeting agent for human cancer cells. | 1996 | Laryngoscope | pmid:8614225 |
| Micali G et al. | High-performance liquid chromatographic determination of the biologically active principle hypericin in phytotherapeutic vegetable extracts and alcoholic beverages. | 1996 | J Chromatogr A | pmid:8646329 |
| Harris MS et al. | Hypericin inhibits cell growth and induces apoptosis in retinal pigment epithelial cells: possible involvement of protein kinase C. | 1996 | Curr. Eye Res. | pmid:8654105 |
| Samel D et al. | The effect of purified extract of Fagopyrum esculentum (buckwheat) on protein kinases involved in signal transduction pathways. | 1996 | Planta Med. | pmid:8657738 |
| Vandenbogaerde AL et al. | Antitumour activity of photosensitized hypericin on A431 cell xenografts. | 1996 Jul-Aug | Anticancer Res. | pmid:8712679 |
| Kartnig T et al. | Production of hypericin, pseudohypericin and flavonoids in cell cultures of various Hypericum species and their chemotypes. | 1996 | Planta Med. | pmid:8720388 |
| Hamilton HB et al. | Inhibition of cellular growth and induction of apoptosis in pituitary adenoma cell lines by the protein kinase C inhibitor hypericin: potential therapeutic application. | 1996 | J. Neurosurg. | pmid:8755764 |
| Hadjur C et al. | Photodynamic effects of hypericin on lipid peroxidation and antioxidant status in melanoma cells. | 1996 | Photochem. Photobiol. | pmid:8760577 |
| Yu H et al. | Hypericin-induced phototoxicity in cultured fibroblasts and swine erythrocytes. | 1996 | Photochem. Photobiol. | pmid:8787010 |
| al-Akhras MA and Grossweiner LI | Sensitization of photohemolysis by hypericin and Photofrin. | 1996 | J. Photochem. Photobiol. B, Biol. | pmid:8810534 |
| Miskovsky P et al. | Hypericin site specific interactions within polynucleotides used as DNA model compounds. | 1995 | J. Biomol. Struct. Dyn. | pmid:8825735 |
| Zhang W et al. | Malignant glioma sensitivity to radiotherapy, high-dose tamoxifen, and hypericin: corroborating clinical response in vitro: case report. | 1996 | Neurosurgery | pmid:8837815 |
| Richter A and Davies DE | Effects of anthralin and hypericin on growth factor signalling and cell proliferation in vitro. | 1995 | Biochem. Pharmacol. | pmid:8849331 |
| Kerb R et al. | Single-dose and steady-state pharmacokinetics of hypericin and pseudohypericin. | 1996 | Antimicrob. Agents Chemother. | pmid:8878586 |
| Kubin A et al. | Wavelength-dependent photoresponse of biological and aqueous model systems using the photodynamic plant pigment hypericin. | 1996 | J. Photochem. Photobiol. B, Biol. | pmid:9002246 |
| Koren H et al. | Hypericin in phototherapy. | 1996 | J. Photochem. Photobiol. B, Biol. | pmid:9002247 |
| Vandenbogaerde AL et al. | Differential cytotoxic effects induced after photosensitization by hypericin. | 1997 | J. Photochem. Photobiol. B, Biol. | pmid:9203374 |
| Baureithel KH et al. | Inhibition of benzodiazepine binding in vitro by amentoflavone, a constituent of various species of Hypericum. | 1997 | Pharm Acta Helv | pmid:9204773 |
| Piperopoulos G et al. | Determination of naphthodianthrones in plant extracts from Hypericum perforatum L. by liquid chromatography-electrospray mass spectrometry. | 1997 | J. Chromatogr. B Biomed. Sci. Appl. | pmid:9300867 |
| Weller M et al. | Hypericin-induced apoptosis of human malignant glioma cells is light-dependent, independent of bcl-2 expression, and does not require wild-type p53. | 1997 | Neurol. Res. | pmid:9329022 |
| Kimura H et al. | Hypericin inhibits choroidal endothelial cell proliferation and cord formation in vitro. | 1997 | Curr. Eye Res. | pmid:9330847 |
| Brockmöller J et al. | Hypericin and pseudohypericin: pharmacokinetics and effects on photosensitivity in humans. | 1997 | Pharmacopsychiatry | pmid:9342768 |
| Sattler S et al. | Binding, uptake, and transport of hypericin by Caco-2 cell monolayers. | 1997 | J Pharm Sci | pmid:9344168 |
| Müller K et al. | Simple analogues of anthralin: unusual specificity of structure and antiproliferative activity. | 1997 | J. Med. Chem. | pmid:9371243 |
| Crance JM et al. | Inhibition of sandfly fever Sicilian virus (Phlebovirus) replication in vitro by antiviral compounds. | 1997 Sep-Oct | Res. Virol. | pmid:9403935 |
| Eshraghi AA et al. | Laser chemotherapy of human carcinoma cells with three new anticancer drugs. | 1997 | J Clin Laser Med Surg | pmid:9467337 |
| Vandenbogaerde AL et al. | Cytotoxicity and antiproliferative effect of hypericin and derivatives after photosensitization. | 1998 | Photochem. Photobiol. | pmid:9477769 |
| Zhang W et al. | Inhibition of human malignant glioma cell motility and invasion in vitro by hypericin, a potent protein kinase C inhibitor. | 1997 | Cancer Lett. | pmid:9570383 |
| Raffa RB | Screen of receptor and uptake-site activity of hypericin component of St. John's wort reveals sigma receptor binding. | 1998 | Life Sci. | pmid:9585174 |
| Johnson SA and Pardini RS | Antioxidant enzyme response to hypericin in EMT6 mouse mammary carcinoma cells. | 1998 | Free Radic. Biol. Med. | pmid:9586812 |
| Ugwu F et al. | A comparative study on the photocytotoxicity of hypericin on A431 cells using three different assays. | 1998 Mar-Apr | Anticancer Res. | pmid:9615785 |
| Butterweck V et al. | Solubilized hypericin and pseudohypericin from Hypericum perforatum exert antidepressant activity in the forced swimming test. | 1998 | Planta Med. | pmid:9619107 |
| [Therapy of mild to medium degree depression]. | 1998 | Nervenarzt | pmid:9631128 | |
| Johnson SA et al. | Time-course of hypericin phototoxicity and effect on mitochondrial energies in EMT6 mouse mammary carcinoma cells. | 1998 | Free Radic. Biol. Med. | pmid:9667489 |
| Kocisova E et al. | Sequence specific interaction of the antiretrovirally active drug hypericin with 5'ATGGCAGGATAT3' oligonucleotide: a resonance Raman spectroscopy study. | 1998 | J. Biomol. Struct. Dyn. | pmid:9669559 |
| Schellenberg R et al. | Pharmacodynamic effects of two different hypericum extracts in healthy volunteers measured by quantitative EEG. | 1998 | Pharmacopsychiatry | pmid:9684947 |
| Fox FE et al. | Photoactivated hypericin is an anti-proliferative agent that induces a high rate of apoptotic death of normal, transformed, and malignant T lymphocytes: implications for the treatment of cutaneous lymphoproliferative and inflammatory disorders. | 1998 | J. Invest. Dermatol. | pmid:9699738 |
| Cott JM and Fugh-Berman A | Is St. John's wort (Hypericum perforatum) an effective antidepressant? | 1998 | J. Nerv. Ment. Dis. | pmid:9717868 |
| Ehrenberg B et al. | Kinetics and yield of singlet oxygen photosensitized by hypericin in organic and biological media. | 1998 | Photochem. Photobiol. | pmid:9723207 |
| Farnet CM et al. | Human immunodeficiency virus type 1 cDNA integration: new aromatic hydroxylated inhibitors and studies of the inhibition mechanism. | 1998 | Antimicrob. Agents Chemother. | pmid:9736543 |
| Park J et al. | The role of oxygen in the antiviral activity of hypericin and hypocrellin. | 1998 | Photochem. Photobiol. | pmid:9796444 |
| Zhang W et al. | Enhancement of radiosensitivity in human malignant glioma cells by hypericin in vitro. | 1996 | Clin. Cancer Res. | pmid:9816239 |
| Vantieghem A et al. | Hypericin-induced photosensitization of HeLa cells leads to apoptosis or necrosis. Involvement of cytochrome c and procaspase-3 activation in the mechanism of apoptosis. | 1998 | FEBS Lett. | pmid:9862416 |
| Miccoli L et al. | Light-induced photoactivation of hypericin affects the energy metabolism of human glioma cells by inhibiting hexokinase bound to mitochondria. | 1998 | Cancer Res. | pmid:9865736 |
| Vandenbogaerde AL et al. | Photocytotoxic effect of pseudohypericin versus hypericin. | 1998 | J. Photochem. Photobiol. B, Biol. | pmid:9868799 |
| Kim JI et al. | Induction of differentiation of the human histocytic lymphoma cell line U-937 by hypericin. | 1998 | Arch. Pharm. Res. | pmid:9875513 |
| Alecu M et al. | Photodynamic treatment of basal cell carcinoma and squamous cell carcinoma with hypericin. | 1998 Nov-Dec | Anticancer Res. | pmid:9891535 |
| Schempp CM et al. | In vitro and in vivo activation of hypericin with the incoherent light source PDT 1200 SOA (520-750 nm) and with solar simulated radiation (290-2500 nm). | 1999 | Photodermatol Photoimmunol Photomed | pmid:9990663 |