| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uterine Cervical Neoplasms | D002583 | 10 associated lipids |
| Neoplasms, Experimental | D009374 | 10 associated lipids |
| Neoplasms, Radiation-Induced | D009381 | 3 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Carcinoma, Squamous Cell | D002294 | 14 associated lipids |
| Skin Neoplasms | D012878 | 12 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
hypericin
hypericin is a lipid of Polyketides (PK) class. Hypericin is associated with abnormalities such as Dermatitis, Phototoxic, Dehydration, Photosensitization, Morphologically altered structure and Myocardial Infarction. The involved functions are known as Cell Cycle Checkpoints, Apoptosis, Acetylation, Cell Survival and Caspase Activation. Hypericin often locates in insoluble fraction, Cytoplasmic matrix, Protoplasm, Tissue membrane and Cytoplasm. The associated genes with hypericin are CDC37 gene, HSPA8 gene, RAF1 gene, cyclin H and FK228. The related lipids are Phosphatidylserines.
Cross Reference
Introduction
To understand associated biological information of hypericin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with hypericin?
hypericin is suspected in Dermatitis, Phototoxic, Photosensitization, Pneumonia, Psoriasis, Phototoxicity, Chronic infectious disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with hypericin
PubChem Associated disorders and diseases
What pathways are associated with hypericin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with hypericin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with hypericin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with hypericin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with hypericin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with hypericin?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with hypericin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Schmitt AC et al. | Investigation of some Hypericum species native to Southern of Brazil for antiviral activity. | 2001 | J Ethnopharmacol | pmid:11535370 |
| Wilhelm KP et al. | Role of flavonoids in controlling the phototoxicity of Hypericum perforatum extracts. | 2001 | Phytomedicine | pmid:11515722 |
| Gao Q et al. | Effect of hypericin on confocal imaging of Ca2+ signaling in cultured human retinal pigment epithelium. | 2001 | Yan Ke Xue Bao | pmid:12567741 |
| Kang BY et al. | Inhibition of interleukin-12 production in lipopolysaccharide-activated mouse macrophages by hpyericin, an active component of Hypericum perforatum. | 2001 | Planta Med. | pmid:11458458 |
| Barnes J et al. | St John's wort (Hypericum perforatum L.): a review of its chemistry, pharmacology and clinical properties. | 2001 | J. Pharm. Pharmacol. | pmid:11370698 |
| Calapai G et al. | Serotonin, norepinephrine and dopamine involvement in the antidepressant action of hypericum perforatum. | 2001 | Pharmacopsychiatry | pmid:11302563 |
| Nathan PJ | Hypericum perforatum (St John's Wort): a non-selective reuptake inhibitor? A review of the recent advances in its pharmacology. | 2001 | J. Psychopharmacol. (Oxford) | pmid:11277608 |
| de los Reyes GC and Koda RT | Development of a simple, rapid and reproducible HPLC assay for the simultaneous determination of hypericins and stabilized hyperforin in commercial St. John's wort preparations. | 2001 | J Pharm Biomed Anal | pmid:11600308 |
| Yova D et al. | Photochemical effects and hypericin photosensitized processes in collagen. | 2001 | J Biomed Opt | pmid:11178580 |
| Southwell IA and Bourke CA | Seasonal variation in hypericin content of Hypericum perforatum L. (St. John's Wort). | 2001 | Phytochemistry | pmid:11261576 |
| Fox E et al. | Plasma pharmacokinetics and cerebrospinal fluid penetration of hypericin in nonhuman primates. | 2001 | Cancer Chemother. Pharmacol. | pmid:11221960 |
| Jacobson JM et al. | Pharmacokinetics, safety, and antiviral effects of hypericin, a derivative of St. John's wort plant, in patients with chronic hepatitis C virus infection. | 2001 | Antimicrob. Agents Chemother. | pmid:11158749 |
| Chen B et al. | Photodynamic therapy with hypericin in a mouse P388 tumor model: vascular effects determine the efficacy. | 2001 | Int. J. Oncol. | pmid:11251168 |
| Peebles KA et al. | Catalytic inhibition of human DNA topoisomerase IIalpha by hypericin, a naphthodianthrone from St. John's wort (Hypericum perforatum). | 2001 | Biochem. Pharmacol. | pmid:11597574 |
| Cavarga I et al. | Photodynamic therapy of murine fibrosarcoma with topical and systemic administration of hypericin. | 2001 | Phytomedicine | pmid:11695874 |
| Uzdensky AB et al. | Intracellular localisation of hypericin in human glioblastoma and carcinoma cell lines. | 2001 | Lasers Med Sci | pmid:11702633 |
| Chan LY et al. | A study of hypericin-induced teratogenicity during organogenesis using a whole rat embryo culture model. | 2001 | Fertil. Steril. | pmid:11704142 |
| Final report on the safety assessment of Hypericum perforatum extract and Hypericum perforatum oil. | 2001 | Int. J. Toxicol. | pmid:11558639 | |
| Butterweck V et al. | St John's wort, hypericin, and imipramine: a comparative analysis of mRNA levels in brain areas involved in HPA axis control following short-term and long-term administration in normal and stressed rats. | 2001 | Mol. Psychiatry | pmid:11526469 |
| Blank M et al. | Anti-cancer activities of hypericin in the dark. | 2001 | Photochem. Photobiol. | pmid:11547544 |
| Kamuhabwa AR et al. | Cellular photodestruction induced by hypericin in AY-27 rat bladder carcinoma cells. | 2001 | Photochem. Photobiol. | pmid:11547545 |
| Mirossay A et al. | The effect of quercetin on light-induced cytotoxicity of hypericin. | 2001 | Physiol Res | pmid:11829327 |
| Vantieghem A et al. | Different pathways mediate cytochrome c release after photodynamic therapy with hypericin. | 2001 | Photochem. Photobiol. | pmid:11547546 |
| Rahimipour S et al. | Hypericin derivatives: substituent effects on radical-anion formation. | 2001 | Photochem. Photobiol. | pmid:11547548 |
| Obermüller RA et al. | Toward hypericin-derived potential photodynamic therapy agents. | 2001 | Photochem. Photobiol. | pmid:11547557 |
| Wills NJ et al. | Tumor cell toxicity of hypericin and related analogs. | 2001 | Photochem. Photobiol. | pmid:11547558 |
| Xie X et al. | Tumor-specific and photodependent cytotoxicity of hypericin in the human LNCaP prostate tumor model. | 2001 | Photochem. Photobiol. | pmid:11547559 |
| Bergonzi MC et al. | Variability in the content of the constituents of Hypericum perforatum L. and some commercial extracts. | 2001 | Drug Dev Ind Pharm | pmid:11548855 |
| Whiskey E et al. | A systematic review and meta-analysis of Hypericum perforatum in depression: a comprehensive clinical review. | 2001 | Int Clin Psychopharmacol | pmid:11552767 |
| Paba V et al. | Photo-activation of hypericin with low doses of light promotes apparent photo-resistance in human histiocytic lymphoma U937 cells. | 2001 | J. Photochem. Photobiol. B, Biol. | pmid:11470563 |
| Wurglics M et al. | Batch-to-batch reproducibility of St. John's wort preparations. | 2001 | Pharmacopsychiatry | pmid:11518067 |
| Franklin M and Cowen PJ | Researching the antidepressant actions of Hypericum perforatum (St. John's wort) in animals and man. | 2001 | Pharmacopsychiatry | pmid:11518072 |
| Calapai G et al. | Interleukin-6 involvement in antidepressant action of Hypericum perforatum. | 2001 | Pharmacopsychiatry | pmid:11518082 |
| Ali SM et al. | Hypericin and hypocrellin induced apoptosis in human mucosal carcinoma cells. | 2001 | J. Photochem. Photobiol. B, Biol. | pmid:11748006 |
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| Perloff MD et al. | Saint John's wort: an in vitro analysis of P-glycoprotein induction due to extended exposure. | 2001 | Br. J. Pharmacol. | pmid:11739235 |
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| Bauer S et al. | Determination of hyperforin, hypericin, and pseudohypericin in human plasma using high-performance liquid chromatography analysis with fluorescence and ultraviolet detection. | 2001 | J. Chromatogr. B Biomed. Sci. Appl. | pmid:11817306 |
| Ali SM et al. | Induction of apoptosis by Hypericin through activation of caspase-3 in human carcinoma cells. | 2001 | Int. J. Mol. Med. | pmid:11605021 |
| Zupkó I et al. | In vivo photodynamic activity of hypericin in transitional cell carcinoma bladder tumors. | 2001 | Int. J. Oncol. | pmid:11295062 |
| Schempp CM et al. | Single-dose and steady-state administration of Hypericum perforatum extract (St John's Wort) does not influence skin sensitivity to UV radiation, visible light, and solar-simulated radiation. | 2001 | Arch Dermatol | pmid:11295948 |
| Poutaraud A et al. | Effect of light on hypericins contents in fresh flowering top parts and in an extract of St. John's Wort (Hypericum perforatum). | 2001 | Planta Med. | pmid:11345698 |
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| Schempp CM et al. | Hypericin photo-induced apoptosis involves the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and activation of caspase-8. | 2001 | FEBS Lett. | pmid:11277999 |
| Chen B et al. | Synergistic effect of photodynamic therapy with hypericin in combination with hyperthermia on loss of clonogenicity of RIF-1 cells. | 2001 | Int. J. Oncol. | pmid:11351263 |
| Kanofsky JR and Sima PD | Girard's reagent P derivative of beta-Apo-8'-carotenal: a potent photoprotective agent. | 2001 | Photochem. Photobiol. | pmid:11332029 |
| Hunt EJ et al. | Effect of St. John's wort on free radical production. | 2001 | Life Sci. | pmid:11441908 |
| Chen B et al. | Efficacy of antitumoral photodynamic therapy with hypericin: relationship between biodistribution and photodynamic effects in the RIF-1 mouse tumor model. | 2001 | Int. J. Cancer | pmid:11410877 |
| Dinkins MB et al. | Photosensitive chemical and laser light treatments decrease epizootic hemorrhagic disease virus associated with in vitro produced bovine embryos. | 2001 | Theriogenology | pmid:11393216 |
| Wirz A et al. | Absorbance data of hypericin and pseudohypericin used as reference compounds for medicinal plant analysis. | 2001 | Pharmazie | pmid:11210670 |
| Cotterill JA | Severe phototoxic reaction to laser treatment in a patient taking St John's Wort. | 2001 | J Cosmet Laser Ther | pmid:12006194 |
| Hwang MS et al. | Inhibition of c-erbB-2 expression an activity in human ovarian carcinoma cells by hypericin. | 2001 Jul-Aug | Anticancer Res. | pmid:11724334 |
| Pietta P et al. | Comparative evaluation of St. John's wort from different Italian regions. | 2001 May-Jul | Farmaco | pmid:11482784 |
| Poutaraud A et al. | Improved procedure for the quality control of Hypericum perforatum L. | 2001 Nov-Dec | Phytochem Anal | pmid:11793812 |
| Taher MM et al. | Mood-enhancing antidepressant St. John's wort inhibits the activation of human immunodeficiency virus gene expression by ultraviolet light. | 2002 | IUBMB Life | pmid:12665247 |
| Langosch JM et al. | St John's wort (Hypericum perforatum) modulates evoked potentials in guinea pig hippocampal slices via AMPA and GABA receptors. | 2002 | Eur Neuropsychopharmacol | pmid:12007672 |
| Tolonen A et al. | Determination of naphthodianthrones and phloroglucinols from Hypericum perforatum extracts by liquid chromatography/tandem mass spectrometry. | 2002 | Rapid Commun. Mass Spectrom. | pmid:11857723 |
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| Wada A et al. | Effects of St John's wort and hypericin on cytotoxicity of anticancer drugs. | 2002 | Drug Metab. Pharmacokinet. | pmid:15618698 |
| Kaltschmidt B et al. | Stimulus-dependent activation of NF-kappaB specifies apoptosis or neuroprotection in cerebellar granule cells. | 2002 | Neuromolecular Med. | pmid:12622408 |
| Pirker R et al. | Simultaneous determination of hypericin and hyperforin in human plasma and serum using liquid-liquid extraction, high-performance liquid chromatography and liquid chromatography-tandem mass spectrometry. | 2002 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:12270208 |
| Murch SJ et al. | An in vitro and hydroponic growing system for hypericin, pseudohypericin, and hyperforin production of St. John's wort (Hypericum perforatum CV new stem). | 2002 | Planta Med. | pmid:12494339 |
| Widy-Tyszkiewicz E et al. | Long term administration of Hypericum perforatum improves spatial learning and memory in the water maze. | 2002 | Biol. Pharm. Bull. | pmid:12392080 |
| Mirossay A et al. | Modulation of the phototoxic effect of hypericin in human leukemia CEM cell line by N-ethylmaleimide, amiloride and omeprazole. | 2002 | Physiol Res | pmid:12511190 |
| Siepmann M et al. | The effects of St John's wort extract on heart rate variability, cognitive function and quantitative EEG: a comparison with amitriptyline and placebo in healthy men. | 2002 | Br J Clin Pharmacol | pmid:12236848 |
| Chen B et al. | Antivascular tumor eradication by hypericin-mediated photodynamic therapy. | 2002 | Photochem. Photobiol. | pmid:12462645 |
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| de los Reyes GC and Koda RT | Determining hyperforin and hypericin content in eight brands of St. John's wort. | 2002 | Am J Health Syst Pharm | pmid:11908248 |
| Agostinis P et al. | Hypericin in cancer treatment: more light on the way. | 2002 | Int. J. Biochem. Cell Biol. | pmid:11849990 |
| Varriale L et al. | Molecular aspects of photodynamic therapy: low energy pre-sensitization of hypericin-loaded human endometrial carcinoma cells enhances photo-tolerance, alters gene expression and affects the cell cycle. | 2002 | FEBS Lett. | pmid:11852097 |
| Chen B et al. | Photodynamic therapy with hypericin induces vascular damage and apoptosis in the RIF-1 mouse tumor model. | 2002 | Int. J. Cancer | pmid:11857421 |
| Schempp CM et al. | Phototoxic and apoptosis-inducing capacity of pseudohypericin. | 2002 | Planta Med. | pmid:11859473 |
| Pytel A and Schmeller N | New aspect of photodynamic diagnosis of bladder tumors: fluorescence cytology. | 2002 | Urology | pmid:11834388 |
| Butterweck V et al. | Long-term effects of St. John's wort and hypericin on monoamine levels in rat hypothalamus and hippocampus. | 2002 | Brain Res. | pmid:11879791 |
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| Derycke AS and De Witte PA | Transferrin-mediated targeting of hypericin embedded in sterically stabilized PEG-liposomes. | 2002 | Int. J. Oncol. | pmid:11743662 |
| Kamuhabwa AA et al. | Biodistribution of hypericin in orthotopic transitional cell carcinoma bladder tumors: implication for whole bladder wall photodynamic therapy. | 2002 | Int. J. Cancer | pmid:11774272 |
| Ali SM and Olivo M | Bio-distribution and subcellular localization of Hypericin and its role in PDT induced apoptosis in cancer cells. | 2002 | Int. J. Oncol. | pmid:12168096 |
| Wen J et al. | Toward the molecular flashlight: preparation, properties, and photophysics of a hypericin-luciferin tethered molecule. | 2002 | Photochem. Photobiol. | pmid:12194210 |
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| Ali SM et al. | Hypocrellins and Hypericin induced apoptosis in human tumor cells: a possible role of hydrogen peroxide. | 2002 | Int. J. Mol. Med. | pmid:11956650 |
| Smelcerovic A et al. | The separation of hypericine and pseudohypericine from Hypericum perforatum L. | 2002 | Pharmazie | pmid:11933846 |
| Ali SM et al. | Hypericin induced death receptor-mediated apoptosis in photoactivated tumor cells. | 2002 | Int. J. Mol. Med. | pmid:12011977 |
| Hritz J et al. | Influence of structure of human, rat, and bovine serum albumins on binding properties of photoactive drug hypericin. | 2002 | Biopolymers | pmid:12012440 |
| D'Hallewin MA et al. | Hypericin-based fluorescence diagnosis of bladder carcinoma. | 2002 | BJU Int. | pmid:11966641 |
| Vantieghem A et al. | Phosphorylation of Bcl-2 in G2/M phase-arrested cells following photodynamic therapy with hypericin involves a CDK1-mediated signal and delays the onset of apoptosis. | 2002 | J. Biol. Chem. | pmid:12101183 |
| Morrey JD et al. | Identification of active antiviral compounds against a New York isolate of West Nile virus. | 2002 | Antiviral Res. | pmid:12076755 |
| Walker TS et al. | Jasmonic acid-induced hypericin production in cell suspension cultures of Hypericum perforatum L. (St. John's wort). | 2002 | Phytochemistry | pmid:12031448 |
| Conforti F et al. | Antioxidant activity of methanolic extract of Hypericum triquetrifolium Turra aerial part. | 2002 | Fitoterapia | pmid:12385870 |
| Wierrani F et al. | Photodynamic action of some sensitizers by photooxidation of luminol. | 2002 | Naturwissenschaften | pmid:12384722 |
| Siboni G et al. | The correlation between hydrophilicity of hypericins and helianthrone: internalization mechanisms, subcellular distribution and photodynamic action in colon carcinoma cells. | 2002 | Photochem. Photobiol. Sci. | pmid:12659159 |
| Chen B et al. | Enhancing the antitumoral effect of hypericin-mediated photodynamic therapy by hyperthermia. | 2002 | Lasers Surg Med | pmid:12224088 |
| Droller MJ | Biodistribution of hypericin in orthotopic transitional cell carcinoma bladder tumors: implication for whole bladder wall photodynamic therapy. | 2002 | J. Urol. | pmid:12134841 |