hypericin

hypericin is a lipid of Polyketides (PK) class. Hypericin is associated with abnormalities such as Dermatitis, Phototoxic, Dehydration, Photosensitization, Morphologically altered structure and Myocardial Infarction. The involved functions are known as Cell Cycle Checkpoints, Apoptosis, Acetylation, Cell Survival and Caspase Activation. Hypericin often locates in insoluble fraction, Cytoplasmic matrix, Protoplasm, Tissue membrane and Cytoplasm. The associated genes with hypericin are CDC37 gene, HSPA8 gene, RAF1 gene, cyclin H and FK228. The related lipids are Phosphatidylserines.

Cross Reference

Introduction

To understand associated biological information of hypericin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with hypericin?

hypericin is suspected in Dermatitis, Phototoxic, Photosensitization, Pneumonia, Psoriasis, Phototoxicity, Chronic infectious disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with hypericin

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Uterine Cervical Neoplasms D002583 10 associated lipids
Neoplasms, Experimental D009374 10 associated lipids
Neoplasms, Radiation-Induced D009381 3 associated lipids
Adenocarcinoma D000230 166 associated lipids
Lung Neoplasms D008175 171 associated lipids
Carcinoma, Squamous Cell D002294 14 associated lipids
Skin Neoplasms D012878 12 associated lipids
Burns D002056 34 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Per page 10 20 50 | Total 38

PubChem Associated disorders and diseases

What pathways are associated with hypericin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with hypericin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with hypericin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with hypericin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with hypericin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with hypericin?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with hypericin

Download all related citations
Per page 10 20 50 100 | Total 1000
Authors Title Published Journal PubMed Link
Ott M et al. St. John's Wort constituents modulate P-glycoprotein transport activity at the blood-brain barrier. 2010 Pharm. Res. pmid:20229133
Golestani R et al. Small-animal SPECT and SPECT/CT: application in cardiovascular research. 2010 Eur. J. Nucl. Med. Mol. Imaging pmid:20069298
Guella G et al. Structures, biological activities and phylogenetic relationships of terpenoids from marine ciliates of the genus Euplotes. 2010 Mar Drugs pmid:20714425
Nahrstedt A and Butterweck V Lessons learned from herbal medicinal products: the example of St. John's Wort (perpendicular). 2010 J. Nat. Prod. pmid:20408551
Filippini R et al. Study of dynamic accumulation of secondary metabolites in three subspecies of Hypericum perforatum. 2010 Fitoterapia pmid:19686808
Wang D et al. Chemical constituents and antidepressant activity of the new species Hypericum enshiense occurring in China. 2010 Phytomedicine pmid:19699627
Michalska K et al. Crystal structure of Hyp-1, a St. John's wort protein implicated in the biosynthesis of hypericin. 2010 J. Struct. Biol. pmid:19853038
Sobolewski C et al. The role of cyclooxygenase-2 in cell proliferation and cell death in human malignancies. 2010 Int J Cell Biol pmid:20339581
Bramanti E et al. Effects of hypericin on the structure and aggregation properties of β-amyloid peptides. 2010 Eur. Biophys. J. pmid:20473492
Wang Y et al. Hypericin prolongs action potential duration in hippocampal neurons by acting on K+ channels. 2010 Br. J. Pharmacol. pmid:20233218
Vardapetyan HR et al. Interaction between hypericin and hemoglobin. 2010 J. Photochem. Photobiol. B, Biol. pmid:20634087
Tuna G et al. Inhibition characteristics of hypericin on rat small intestine glutathione-S-transferases. 2010 Chem. Biol. Interact. pmid:20637187
Berlanda J et al. Comparative in vitro study on the characteristics of different photosensitizers employed in PDT. 2010 J. Photochem. Photobiol. B, Biol. pmid:20599390
Wang X et al. Cellular and molecular mechanisms of photodynamic hypericin therapy for nasopharyngeal carcinoma cells. 2010 J. Pharmacol. Exp. Ther. pmid:20551295
da Conceição AO et al. Effect of St. John's Wort standardized extract and hypericin on in vitro placental calcium transport. 2010 J Med Food pmid:20553141
Boiy A et al. Topical treatment of disseminated superficial actinic porokeratosis with hypericin-photodynamic therapy: a case report. 2010 Photodiagnosis Photodyn Ther pmid:20510308
Aboukhatwa M et al. Antidepressants are a rational complementary therapy for the treatment of Alzheimer's disease. 2010 Mol Neurodegener pmid:20226030
Karppinen K et al. Optimization of protein extraction from Hypericum perforatum tissues and immunoblotting detection of Hyp-1 at different stages of leaf development. 2010 Mol. Biotechnol. pmid:20563670
Volak LP and Court MH Role for protein kinase C delta in the functional activity of human UGT1A6: implications for drug-drug interactions between PKC inhibitors and UGT1A6. 2010 Xenobiotica pmid:20196639
Prakash DJ et al. Effect of nanohypericum (Hypericum perforatum gold nanoparticles) treatment on restraint stressinduced behavioral and biochemical alteration in male albino mice. 2010 Pharmacognosy Res pmid:21713134
Schreiber S et al. Bilateral posterior RION after concomitant radiochemotherapy with temozolomide in a patient with glioblastoma multiforme: a case report. 2010 BMC Cancer pmid:20920315
Dolan LC et al. Naturally occurring food toxins. 2010 Toxins (Basel) pmid:22069686
Lee SY et al. TP53 regulates human AlkB homologue 2 expression in glioma resistance to Photofrin-mediated photodynamic therapy. 2010 Br. J. Cancer pmid:20661249
Kumar A et al. Effect of St. John's Wort (Hypericum perforatum) treatment on restraint stress-induced behavioral and biochemical alteration in mice. 2010 BMC Complement Altern Med pmid:20459658
Verfaillie T et al. Linking ER Stress to Autophagy: Potential Implications for Cancer Therapy. 2010 Int J Cell Biol pmid:20145727
Cheng YW et al. Proliferation of retinal pigment epithelial cells induced by (R,R)-XY-10 and (S,S)-XY-10 and their action mechanisms. 2010 Int J Ophthalmol pmid:22553508
Devi VK et al. Importance of novel drug delivery systems in herbal medicines. 2010 Pharmacogn Rev pmid:22228938
Kello M et al. PUFAs enhance oxidative stress and apoptosis in tumour cells exposed to hypericin-mediated PDT. 2010 Photochem. Photobiol. Sci. pmid:20714672
Kim DS et al. Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method. 2010 Healthc Inform Res pmid:21818443
Chan PS et al. Role of p38 MAPKs in hypericin photodynamic therapy-induced apoptosis of nasopharyngeal carcinoma cells. 2009 Sep-Oct Photochem. Photobiol. pmid:19496992
Hager B et al. Cationic hypericin derivatives as novel agents with photobactericidal activity: synthesis and photodynamic inactivation of Propionibacterium acnes. 2009 Sep-Oct Photochem. Photobiol. pmid:19659921
Machado RA et al. [Experimental study of vitreoretinal proliferation inhibition by the use of hypericin]. 2009 Sep-Oct Arq Bras Oftalmol pmid:20027403
Theodossiou TA et al. The multifaceted photocytotoxic profile of hypericin. 2009 Nov-Dec Mol. Pharm. pmid:19739671
Gbur P et al. Time-resolved luminescence and singlet oxygen formation after illumination of the hypericin-low-density lipoprotein complex. 2009 May-Jun Photochem. Photobiol. pmid:19076308
Youssef T Fluorescence study on the interaction between hypericin and lens protein "alpha-crystallin". 2009 Jul-Aug Photochem. Photobiol. pmid:19175752
Alali FQ et al. LC-MS and LC-PDA analysis of Hypericum empetrifolium and Hypericum sinaicum. 2009 Jul-Aug Z. Naturforsch., C, J. Biosci. pmid:19791496
Liu J et al. Study of interaction of hypericin and its pharmaceutical preparation by fluorescence techniques. 2009 Jan-Feb J Biomed Opt pmid:19256691
Guo L et al. Role of protein kinase C in 15-HETE-induced hypoxic pulmonary vasoconstriction. 2009 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:19186045
Bhuvaneswari R et al. Targeting EGFR with photodynamic therapy in combination with Erbitux enhances in vivo bladder tumor response. 2009 Mol. Cancer pmid:19878607
Karioti A et al. Rapid and efficient purification of naphthodianthrones from St. John's wort extract by using liquid-liquid extraction and SEC. 2009 J Sep Sci pmid:19360729
Zeisser-Labouèbe M et al. Screening of nanoparticulate delivery systems for the photodetection of cancer in a simple and cost-effective model. 2009 Nanomedicine (Lond) pmid:19193181
Stupáková V et al. Photodynamic effect of hypericin in primary cultures of human umbilical endothelial cells and glioma cell lines. 2009 Phytother Res pmid:19173218
Wang XD et al. Impact of the haplotypes of the human pregnane X receptor gene on the basal and St John's wort-induced activity of cytochrome P450 3A4 enzyme. 2009 Br J Clin Pharmacol pmid:19173680
De Saint-Hubert M et al. Molecular imaging of cell death. 2009 Methods pmid:19362149
Zeisser-Labouèbe M et al. Benefits of nanoencapsulation for the hypercin-mediated photodetection of ovarian micrometastases. 2009 Eur J Pharm Biopharm pmid:18977296
Karakas O et al. Effects of different concentrations of benzylaminopurine on shoot regeneration and hypericin content in Hypericum triquetrifolium Turra. 2009 Nat. Prod. Res. pmid:18985513
Hill K and Schaefer M Ultraviolet light and photosensitising agents activate TRPA1 via generation of oxidative stress. 2009 Cell Calcium pmid:18814910
Breitenbach T et al. Photosensitized production of singlet oxygen: spatially-resolved optical studies in single cells. 2009 Photochem. Photobiol. Sci. pmid:19337656
Zhou C et al. The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism. 2009 Nucl Recept Signal pmid:19240808
Sanovic R et al. Time-resolved gene expression profiling of human squamous cell carcinoma cells during the apoptosis process induced by photodynamic treatment with hypericin. 2009 Int. J. Oncol. pmid:19724930
Kusari S et al. Light-independent metabolomics of endophytic Thielavia subthermophila provides insight into microbial hypericin biosynthesis. 2009 J. Nat. Prod. pmid:19746917
Tadros MG et al. Involvement of serotoninergic 5-HT1A/2A, alpha-adrenergic and dopaminergic D1 receptors in St. John's wort-induced prepulse inhibition deficit: a possible role of hyperforin. 2009 Behav. Brain Res. pmid:19136030
Schneider-Yin X et al. Hypericin and 5-aminolevulinic acid-induced protoporphyrin IX induce enhanced phototoxicity in human endometrial cancer cells with non-coherent white light. 2009 Photodiagnosis Photodyn Ther pmid:19447367
Roelants M et al. In vitro study of the photocytotoxicity of bathochromically-shifted hypericin derivatives. 2009 Photochem. Photobiol. Sci. pmid:19492110
Shibata Y Comment on "Hypericin uptake: a prognostic marker for survival in high-grade glioma". 2009 J Clin Neurosci pmid:19595595
Davids LM et al. Melanomas display increased cytoprotection to hypericin-mediated cytotoxicity through the induction of autophagy. 2009 Cell Biol. Int. pmid:19596456
Zeisser-Labouèbe M et al. Quenching-induced deactivation of photosensitizer by nanoencapsulation to improve phototherapy of cancer. 2009 J Drug Target pmid:19589125
Lavialle F et al. Nanovesicles released by Dictyostelium cells: a potential carrier for drug delivery. 2009 Int J Pharm pmid:19589376
Sarris J and Kavanagh DJ Kava and St. John's Wort: current evidence for use in mood and anxiety disorders. 2009 J Altern Complement Med pmid:19614563
Kusari S et al. Positive correlations between hypericin and putative precursors detected in the quantitative secondary metabolite spectrum of Hypericum. 2009 Phytochemistry pmid:19683774
Ozmen A et al. In vitro anti-neoplastic activity of the ethno-pharmaceutical plant Hypericum adenotrichum Spach endemic to Western Turkey. 2009 Oncol. Rep. pmid:19724864
Booth JN and McGwin G The association between self-reported cataracts and St. John's Wort. 2009 Curr. Eye Res. pmid:19895314
Jendzelovský R et al. Drug efflux transporters, MRP1 and BCRP, affect the outcome of hypericin-mediated photodynamic therapy in HT-29 adenocarcinoma cells. 2009 Photochem. Photobiol. Sci. pmid:20024169
Mikes J et al. The role of p53 in the efficiency of photodynamic therapy with hypericin and subsequent long-term survival of colon cancer cells. 2009 Photochem. Photobiol. Sci. pmid:19862414
Thong PS et al. Clinical application of fluorescence endoscopic imaging using hypericin for the diagnosis of human oral cavity lesions. 2009 Br. J. Cancer pmid:19809432
Hölscher D et al. Matrix-free UV-laser desorption/ionization (LDI) mass spectrometric imaging at the single-cell level: distribution of secondary metabolites of Arabidopsis thaliana and Hypericum species. 2009 Plant J. pmid:19732382
Maury W et al. Identification of light-independent inhibition of human immunodeficiency virus-1 infection through bioguided fractionation of Hypericum perforatum. 2009 Virol. J. pmid:19594941
Hecka A et al. Study of active naphtodianthrone St John's Wort compounds by electrospray ionization Fourier transform ion cyclotron resonance and multi-stage mass spectrometry in sustained off-resonance irradiation collision-induced dissociation and infrared multiphoton dissociation modes. 2009 Rapid Commun. Mass Spectrom. pmid:19224526
Ho YF et al. Lipid-mediated preferential localization of hypericin in lipid membranes. 2009 Biochim. Biophys. Acta pmid:19366588
Cirak C et al. Chemical constituents of Hypericum adenotrichum Spach, an endemic Turkish species. 2009 Nat. Prod. Res. pmid:19731137
Kurihara T et al. Retinal phototoxicity in a novel murine model of intraocular lens implantation. 2009 Mol. Vis. pmid:20019883
Wildeman MA et al. Photodynamic therapy in the therapy for recurrent/persistent nasopharyngeal cancer. 2009 Head Neck Oncol pmid:20017928
Gao Q et al. PKC alpha affects cell cycle progression and proliferation in human RPE cells through the downregulation of p27kip1. 2009 Mol. Vis. pmid:20011080
Borrelli F and Izzo AA Herb-drug interactions with St John's wort (Hypericum perforatum): an update on clinical observations. 2009 AAPS J pmid:19859815
Fornaro M et al. Medicine and psychiatry in Western culture: Ancient Greek myths and modern prejudices. 2009 Ann Gen Psychiatry pmid:19811642
Wright KE et al. Peripheral neural cell sensitivity to mTHPC-mediated photodynamic therapy in a 3D in vitro model. 2009 Br. J. Cancer pmid:19638975
Witjes JA Topic issue on new treatments in bladder cancer. 2009 World J Urol pmid:19229539
Galanou MC et al. Interactive transport, subcellular relocation and enhanced phototoxicity of hypericin encapsulated in guanidinylated liposomes via molecular recognition. 2008 Sep-Oct Photochem. Photobiol. pmid:18627515
Kah JC et al. Endoscopic image analysis of photosensitizer fluorescence as a promising noninvasive approach for pathological grading of bladder cancer in situ. 2008 Sep-Oct J Biomed Opt pmid:19021402
Kubin A et al. Fluorescence diagnosis of bladder cancer with new water soluble hypericin bound to polyvinylpyrrolidone: PVP-hypericin. 2008 Nov-Dec Photochem. Photobiol. pmid:18627521
Kacerovská D et al. Photodynamic therapy of nonmelanoma skin cancer with topical hypericum perforatum extract--a pilot study. 2008 May-Jun Photochem. Photobiol. pmid:18179625
Mukherjee P et al. Accumulation and interaction of hypericin in low-density lipoprotein--a photophysical study. 2008 May-Jun Photochem. Photobiol. pmid:18435618
Ritz R et al. Subcellular colocalization of hypericin with respect to endoplasmic reticulum and Golgi apparatus in glioblastoma cells. 2008 Jul-Aug Anticancer Res. pmid:18751371
Kascakova S et al. High level of low-density lipoprotein receptors enhance hypericin uptake by U-87 MG cells in the presence of LDL. 2008 Jan-Feb Photochem. Photobiol. pmid:18173711
Wessels JT et al. Photosensitizing and radiosensitizing effects of hypericin on human renal carcinoma cells in vitro. 2008 Jan-Feb Photochem. Photobiol. pmid:18173725
Ritz R et al. Hypericin uptake: a prognostic marker for survival in high-grade glioma. 2008 J Clin Neurosci pmid:18394904
Li S et al. Chemical markers for the quality control of herbal medicines: an overview. 2008 Chin Med pmid:18588699
Sgarbossa A et al. In vitro perturbation of aggregation processes in beta-amyloid peptides: a spectroscopic study. 2008 FEBS Lett. pmid:18805418
Theodossiou TA et al. Molecular modeling and experimental evidence for hypericin as a substrate for mitochondrial complex III; mitochondrial photodamage as demonstrated using specific inhibitors. 2008 Free Radic. Biol. Med. pmid:18852042
Xenophontos M et al. Influence of the habitat altitude on the (proto)hypericin and (proto)pseudohypericin levels of hypericum plants from Crete. 2008 Planta Med. pmid:18671196
Van de Putte M et al. Hypericin as a marker for determination of tissue viability after intratumoral ethanol injection in a murine liver tumor model. 2008 Acad Radiol pmid:18078913
Boiy A et al. Photosensitizing activity of hypericin and hypericin acetate after topical application on normal mouse skin. 2008 Br. J. Dermatol. pmid:18047507
Zhao J et al. Photodynamic effect of hypericin on the conformation and catalytic activity of hemoglobin. 2008 Int J Mol Sci pmid:19325739
Aleisa AM Cytological and biochemical effects of St. John's Wort supplement (a complex mixture of St. John's Wort, Rosemary and Spirulina) on somatic and germ cells of Swiss Albino mice. 2008 Int J Environ Res Public Health pmid:19151436
Guo X et al. Increased p38-MAPK is responsible for chemotherapy resistance in human gastric cancer cells. 2008 BMC Cancer pmid:19091131
Radauer C et al. The Bet v 1 fold: an ancient, versatile scaffold for binding of large, hydrophobic ligands. 2008 BMC Evol. Biol. pmid:18922149
Morgan AJ and Jorm AF Self-help interventions for depressive disorders and depressive symptoms: a systematic review. 2008 Ann Gen Psychiatry pmid:18710579
Solár P et al. Erythropoietin inhibits apoptosis induced by photodynamic therapy in ovarian cancer cells. 2008 Mol. Cancer Ther. pmid:18687658
Clauson KA et al. Clinically relevant safety issues associated with St. John's wort product labels. 2008 BMC Complement Altern Med pmid:18637192
Weber W et al. Hypericum perforatum (St John's wort) for attention-deficit/hyperactivity disorder in children and adolescents: a randomized controlled trial. 2008 JAMA pmid:18544723