| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uterine Cervical Neoplasms | D002583 | 10 associated lipids |
| Neoplasms, Experimental | D009374 | 10 associated lipids |
| Neoplasms, Radiation-Induced | D009381 | 3 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Carcinoma, Squamous Cell | D002294 | 14 associated lipids |
| Skin Neoplasms | D012878 | 12 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
hypericin
hypericin is a lipid of Polyketides (PK) class. Hypericin is associated with abnormalities such as Dermatitis, Phototoxic, Dehydration, Photosensitization, Morphologically altered structure and Myocardial Infarction. The involved functions are known as Cell Cycle Checkpoints, Apoptosis, Acetylation, Cell Survival and Caspase Activation. Hypericin often locates in insoluble fraction, Cytoplasmic matrix, Protoplasm, Tissue membrane and Cytoplasm. The associated genes with hypericin are CDC37 gene, HSPA8 gene, RAF1 gene, cyclin H and FK228. The related lipids are Phosphatidylserines.
Cross Reference
Introduction
To understand associated biological information of hypericin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with hypericin?
hypericin is suspected in Dermatitis, Phototoxic, Photosensitization, Pneumonia, Psoriasis, Phototoxicity, Chronic infectious disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with hypericin
PubChem Associated disorders and diseases
What pathways are associated with hypericin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with hypericin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with hypericin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with hypericin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with hypericin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with hypericin?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with hypericin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kim JI et al. | Induction of differentiation of the human histocytic lymphoma cell line U-937 by hypericin. | 1998 | Arch. Pharm. Res. | pmid:9875513 |
| Machado RA et al. | [Experimental study of vitreoretinal proliferation inhibition by the use of hypericin]. | 2009 Sep-Oct | Arq Bras Oftalmol | pmid:20027403 |
| Denke A et al. | Biochemical activities of extracts from Hypericum perforatum L. 5th communication: dopamine-beta-hydroxylase-product quantification by HPLC and inhibition by hypericins and flavonoids. | 2000 | Arzneimittelforschung | pmid:10858868 |
| Okpanyi SN et al. | [Genotoxicity of a standardized Hypericum extract]. | 1990 | Arzneimittelforschung | pmid:2242075 |
| Müldner H and Zöller M | [Antidepressive effect of a Hypericum extract standardized to an active hypericine complex. Biochemical and clinical studies]. | 1984 | Arzneimittelforschung | pmid:6541928 |
| Schulz HU et al. | Investigation of the effect on photosensitivity following multiple oral dosing of two different hypericum extracts in healthy men. | 2006 | Arzneimittelforschung | pmid:16618014 |
| Kleber E et al. | Biochemical activities of extracts from Hypericum perforatum L. 1st Communication: inhibition of dopamine-beta-hydroxylase. | 1999 | Arzneimittelforschung | pmid:10083977 |
| Denke A et al. | Biochemical activities of extracts from Hypericum perforatum L. 2nd Communication: inhibition of metenkephaline- and tyrosine-dimerization. | 1999 | Arzneimittelforschung | pmid:10083978 |
| Denke A et al. | Biochemical activities of extracts from Hypericum perforatum L. 4th Communication: influence of different cultivation methods. | 1999 | Arzneimittelforschung | pmid:10083980 |
| Schulz HU et al. | Investigation of pharmacokinetic data of hypericin, pseudohypericin, hyperforin and the flavonoids quercetin and isorhamnetin revealed from single and multiple oral dose studies with a hypericum extract containing tablet in healthy male volunteers. | 2005 | Arzneimittelforschung | pmid:16294501 |
| Schulz HU et al. | Investigation of the bioavailability of hypericin, pseudohypericin, hyperforin and the flavonoids quercetin and isorhamnetin following single and multiple oral dosing of a hypericum extract containing tablet. | 2005 | Arzneimittelforschung | pmid:15727160 |
| Bourke CA and White JG | Reassessment of the toxicity of Hypericum perforatum (St John's wort) for cattle. | 2004 | Aust. Vet. J. | pmid:15977618 |
| Bourke CA | The effect of shade, shearing and wool type in the protection of Merino sheep from Hypericum perforatum (St John's wort) poisoning. | 2003 | Aust. Vet. J. | pmid:15086086 |
| Rubio N et al. | Spatiotemporal autophagic degradation of oxidatively damaged organelles after photodynamic stress is amplified by mitochondrial reactive oxygen species. | 2012 | Autophagy | pmid:22889744 |
| Garg AD et al. | ROS-induced autophagy in cancer cells assists in evasion from determinants of immunogenic cell death. | 2013 | Autophagy | pmid:23800749 |
| Tadros MG et al. | Involvement of serotoninergic 5-HT1A/2A, alpha-adrenergic and dopaminergic D1 receptors in St. John's wort-induced prepulse inhibition deficit: a possible role of hyperforin. | 2009 | Behav. Brain Res. | pmid:19136030 |
| Kraus GA et al. | Antiretroviral activity of synthetic hypericin and related analogs. | 1990 | Biochem. Biophys. Res. Commun. | pmid:1699534 |
| Takahashi I et al. | Hypericin and pseudohypericin specifically inhibit protein kinase C: possible relation to their antiretroviral activity. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2558652 |
| Agostinis P et al. | A comparative analysis of the photosensitized inhibition of growth-factor regulated protein kinases by hypericin-derivatives. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8607812 |
| Verfaillie T et al. | Pro-apoptotic signaling induced by photo-oxidative ER stress is amplified by Noxa, not Bim. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23916707 |