| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uterine Cervical Neoplasms | D002583 | 10 associated lipids |
| Neoplasms, Experimental | D009374 | 10 associated lipids |
| Neoplasms, Radiation-Induced | D009381 | 3 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Carcinoma, Squamous Cell | D002294 | 14 associated lipids |
| Skin Neoplasms | D012878 | 12 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
hypericin
hypericin is a lipid of Polyketides (PK) class. Hypericin is associated with abnormalities such as Dermatitis, Phototoxic, Dehydration, Photosensitization, Morphologically altered structure and Myocardial Infarction. The involved functions are known as Cell Cycle Checkpoints, Apoptosis, Acetylation, Cell Survival and Caspase Activation. Hypericin often locates in insoluble fraction, Cytoplasmic matrix, Protoplasm, Tissue membrane and Cytoplasm. The associated genes with hypericin are CDC37 gene, HSPA8 gene, RAF1 gene, cyclin H and FK228. The related lipids are Phosphatidylserines.
Cross Reference
Introduction
To understand associated biological information of hypericin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with hypericin?
hypericin is suspected in Dermatitis, Phototoxic, Photosensitization, Pneumonia, Psoriasis, Phototoxicity, Chronic infectious disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with hypericin
PubChem Associated disorders and diseases
What pathways are associated with hypericin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with hypericin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with hypericin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with hypericin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with hypericin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with hypericin?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with hypericin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Van Kets V et al. | Laser light activation of a second-generation photosensitiser and its use as a potential photomodulatory agent in skin rejuvenation. | 2013 | Lasers Med Sci | pmid:22581390 |
| Rainha N et al. | Content of hypericins from plants and in vitro shoots of Hypericum undulatum Schousb. ex Willd. | 2013 | Nat. Prod. Res. | pmid:22617156 |
| Barrette K et al. | Pattern of sensitivity of progressive cutaneous squamous cell carcinoma cells to UVB and oxidative stress-induced cell death. | 2013 | Photochem. Photobiol. Sci. | pmid:22722579 |
| Li J et al. | Sequential systemic administrations of combretastatin A4 Phosphate and radioiodinated hypericin exert synergistic targeted theranostic effects with prolonged survival on SCID mice carrying bifocal tumor xenografts. | 2013 | Theranostics | pmid:23423247 |
| Kong M et al. | Necrosis affinity evaluation of 131I-hypericin in a rat model of induced necrosis. | 2013 | J Drug Target | pmid:23627568 |
| Zhang W et al. | Investigation of water-soluble inclusion complex of hypericin with β-cyclodextrin polymer. | 2013 | Carbohydr Polym | pmid:23618281 |
| Ocak Z et al. | Effect of hypericin on the ADAMTS-9 and ADAMTS-8 gene expression in MCF7 breast cancer cells. | 2013 | Eur Rev Med Pharmacol Sci | pmid:23690187 |
| StrejÄková A et al. | Spatial orientation and electric-field-driven transport of hypericin inside of bilayer lipid membranes. | 2013 | J Phys Chem B | pmid:23286583 |
| Klejdus B et al. | PAL inhibitor evokes different responses in two Hypericum species. | 2013 | Plant Physiol. Biochem. | pmid:23254282 |
| Galeotti N and Ghelardini C | Reversal of NO-induced nociceptive hypersensitivity by St. John's wort and hypericin: NF-κB, CREB and STAT1 as molecular targets. | 2013 | Psychopharmacology (Berl.) | pmid:23254377 |
| Penjweini R et al. | Modifying excitation light dose of novel photosensitizer PVP-Hypericin for photodynamic diagnosis and therapy. | 2013 | J. Photochem. Photobiol. B, Biol. | pmid:23375215 |
| Larisch P et al. | In vitro analysis of photosensitizer accumulation for assessment of applicability of fluorescence diagnosis of squamous cell carcinoma of epidermolysis bullosa patients. | 2013 | Biomed Res Int | pmid:23509735 |
| Ziegler V et al. | Photosensitizer adhered to cell culture microplates induces phototoxicity in carcinoma cells. | 2013 | Biomed Res Int | pmid:23509741 |
| Kashef N et al. | Photodynamic effect of hypericin on the microorganisms and primary human fibroblasts. | 2013 | Photodiagnosis Photodyn Ther | pmid:23769281 |
| Cona MM et al. | Comparative study of iodine-123-labeled hypericin and (99m)Tc-labeled hexakis [2-methoxy isobutyl isonitrile] in a rabbit model of myocardial infarction. | 2013 | J. Cardiovasc. Pharmacol. | pmid:23714775 |
| Verfaillie T et al. | Pro-apoptotic signaling induced by photo-oxidative ER stress is amplified by Noxa, not Bim. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23916707 |
| Mikešová L et al. | Conjunction of glutathione level, NAD(P)H/FAD redox status and hypericin content as a potential factor affecting colon cancer cell resistance to photodynamic therapy with hypericin. | 2013 | Photodiagnosis Photodyn Ther | pmid:24284100 |
| Noell S et al. | Microendoscopy for hypericin fluorescence tumor diagnosis in a subcutaneous glioma mouse model. | 2013 | Photodiagnosis Photodyn Ther | pmid:24284111 |
| Penjweini R et al. | Optimizing the antitumor selectivity of PVP-Hypericin re A549 cancer cells and HLF normal cells through pulsed blue light. | 2013 | Photodiagnosis Photodyn Ther | pmid:24284116 |
| de Melo Wde C et al. | Electroporation enhances antimicrobial photodynamic therapy mediated by the hydrophobic photosensitizer, hypericin. | 2013 | Photodiagnosis Photodyn Ther | pmid:24284122 |
| Dror N et al. | Unique anti-glioblastoma activities of hypericin are at the crossroad of biochemical and epigenetic events and culminate in tumor cell differentiation. | 2013 | PLoS ONE | pmid:24066060 |
| Righeschi C et al. | Microarray-based mRNA expression profiling of leukemia cells treated with the flavonoid, casticin. | 2012 May-Jun | Cancer Genomics Proteomics | pmid:22593249 |
| Yow CM et al. | Hypericin-mediated photodynamic antimicrobial effect on clinically isolated pathogens. | 2012 May-Jun | Photochem. Photobiol. | pmid:22233203 |
| Rezusta A et al. | In vitro fungicidal photodynamic effect of hypericin on Candida species. | 2012 May-Jun | Photochem. Photobiol. | pmid:22128758 |
| Youssef T et al. | Evaluation of hypericin-loaded solid lipid nanoparticles: physicochemical properties, photostability and phototoxicity. | 2012 Mar-Apr | Pharm Dev Technol | pmid:21047275 |
| Dai T et al. | Concepts and principles of photodynamic therapy as an alternative antifungal discovery platform. | 2012 | Front Microbiol | pmid:22514547 |
| Li JY et al. | Management of cutaneous T cell lymphoma: new and emerging targets and treatment options. | 2012 | Cancer Manag Res | pmid:22457602 |
| Olivo M et al. | Altered expression of cell adhesion molecules leads to differential uptake of hypericin in urothelial cancer. | 2012 | Urol. Oncol. | pmid:20933443 |
| Fasinu PS et al. | An overview of the evidence and mechanisms of herb-drug interactions. | 2012 | Front Pharmacol | pmid:22557968 |
| López-Chicón P et al. | On the mechanism of Candida spp. photoinactivation by hypericin. | 2012 | Photochem. Photobiol. Sci. | pmid:22566080 |
| Sharma KV and Davids LM | Depigmentation in melanomas increases the efficacy of hypericin-mediated photodynamic-induced cell death. | 2012 | Photodiagnosis Photodyn Ther | pmid:22594986 |
| Penjweini R et al. | Long-term monitoring of live cell proliferation in presence of PVP-Hypericin: a new strategy using ms pulses of LED and the fluorescent dye CFSE. | 2012 | J Microsc | pmid:21974829 |
| Mortensen T et al. | Investigating the effectiveness of St John's wort herb as an antimicrobial agent against mycobacteria. | 2012 | Phytother Res | pmid:22294548 |
| Nakajima N and Kawashima N | A basic study on hypericin-PDT in vitro. | 2012 | Photodiagnosis Photodyn Ther | pmid:22959799 |
| Marysael T et al. | Pretargeting of necrotic tumors with biotinylated hypericin using 123I-labeled avidin: evaluation of a two-step strategy. | 2012 | Invest New Drugs | pmid:22187204 |
| Garg AD et al. | Hypericin-based photodynamic therapy induces surface exposure of damage-associated molecular patterns like HSP70 and calreticulin. | 2012 | Cancer Immunol. Immunother. | pmid:22193987 |
| Krammer B and Verwanger T | Molecular response to hypericin-induced photodamage. | 2012 | Curr. Med. Chem. | pmid:22214453 |
| Dalmizrak O et al. | Evaluation of the in vitro inhibitory impact of hypericin on placental glutathione S-transferase pi. | 2012 | Protein J. | pmid:22810152 |
| Shi YW et al. | [Rapid cloning and functional characterization of hypericin synthase gene]. | 2012 | Yao Xue Xue Bao | pmid:22812015 |
| Huntosova V et al. | Development of a new LDL-based transport system for hydrophobic/amphiphilic drug delivery to cancer cells. | 2012 | Int J Pharm | pmid:22814227 |
| Cencic R et al. | Inhibitors of translation targeting eukaryotic translation initiation factor 4A. | 2012 | Meth. Enzymol. | pmid:22713332 |
| Ritz R et al. | In vitro comparison of hypericin and 5-aminolevulinic acid-derived protoporphyrin IX for photodynamic inactivation of medulloblastoma cells. | 2012 | PLoS ONE | pmid:23251668 |
| Besic Gyenge E et al. | Effects of hypericin and a chlorin based photosensitizer alone or in combination in squamous cell carcinoma cells in the dark. | 2012 | Photodiagnosis Photodyn Ther | pmid:23200013 |
| Valeri A et al. | Effects of St John's wort and its active constituents, hypericin and hyperforin, on isolated rat urinary bladder. | 2012 | J. Pharm. Pharmacol. | pmid:23146040 |
| Šemeláková M et al. | The pro-apoptotic and anti-invasive effects of hypericin-mediated photodynamic therapy are enhanced by hyperforin or aristoforin in HT-29 colon adenocarcinoma cells. | 2012 | J. Photochem. Photobiol. B, Biol. | pmid:23099482 |
| Sharma KV and Davids LM | Hypericin-PDT-induced rapid necrotic death in human squamous cell carcinoma cultures after multiple treatment. | 2012 | Cell Biol. Int. | pmid:23005701 |
| Olivo M et al. | New frontier in hypericin-mediated diagnosis of cancer with current optical technologies. | 2012 | Ann Biomed Eng | pmid:22124793 |
| Li JJ et al. | A single-dose toxicity study on non-radioactive iodinated hypericin for a targeted anticancer therapy in mice. | 2012 | Acta Pharmacol. Sin. | pmid:23103619 |
| He M et al. | De novo sequencing of Hypericum perforatum transcriptome to identify potential genes involved in the biosynthesis of active metabolites. | 2012 | PLoS ONE | pmid:22860059 |
| Spindler SR et al. | Novel protein kinase signaling systems regulating lifespan identified by small molecule library screening using Drosophila. | 2012 | PLoS ONE | pmid:22363408 |