| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uterine Cervical Neoplasms | D002583 | 10 associated lipids |
| Neoplasms, Experimental | D009374 | 10 associated lipids |
| Neoplasms, Radiation-Induced | D009381 | 3 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Carcinoma, Squamous Cell | D002294 | 14 associated lipids |
| Skin Neoplasms | D012878 | 12 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
hypericin
hypericin is a lipid of Polyketides (PK) class. Hypericin is associated with abnormalities such as Dermatitis, Phototoxic, Dehydration, Photosensitization, Morphologically altered structure and Myocardial Infarction. The involved functions are known as Cell Cycle Checkpoints, Apoptosis, Acetylation, Cell Survival and Caspase Activation. Hypericin often locates in insoluble fraction, Cytoplasmic matrix, Protoplasm, Tissue membrane and Cytoplasm. The associated genes with hypericin are CDC37 gene, HSPA8 gene, RAF1 gene, cyclin H and FK228. The related lipids are Phosphatidylserines.
Cross Reference
Introduction
To understand associated biological information of hypericin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with hypericin?
hypericin is suspected in Dermatitis, Phototoxic, Photosensitization, Pneumonia, Psoriasis, Phototoxicity, Chronic infectious disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with hypericin
PubChem Associated disorders and diseases
What pathways are associated with hypericin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with hypericin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with hypericin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with hypericin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with hypericin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with hypericin?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with hypericin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ritz R et al. | Hypericin uptake: a prognostic marker for survival in high-grade glioma. | 2008 | J Clin Neurosci | pmid:18394904 |
| Giganti A et al. | Murine and human autotaxin alpha, beta, and gamma isoforms: gene organization, tissue distribution, and biochemical characterization. | 2008 | J. Biol. Chem. | pmid:18175805 |
| Galati EM et al. | Antiinflammatory and antioxidant activity of Hypericum rumeliacum Boiss. subsp. apollinis (Boiss. & Heldr.) Robson & Strid methanol extract. | 2008 | Phytother Res | pmid:18446843 |
| Fernandes H et al. | Crystallization and preliminary crystallographic studies of Hyp-1, a St John's wort protein implicated in the biosynthesis of hypericin. | 2008 | Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. | pmid:18453712 |
| Kubin A et al. | How to make hypericin water-soluble. | 2008 | Pharmazie | pmid:18468384 |
| Bhuvaneswari R et al. | Molecular profiling of angiogenesis in hypericin mediated photodynamic therapy. | 2008 | Mol. Cancer | pmid:18549507 |
| Saw CL et al. | Potentiation of the photodynamic action of hypericin. | 2008 | J. Environ. Pathol. Toxicol. Oncol. | pmid:18551893 |
| Xu M et al. | Signal interaction between nitric oxide and hydrogen peroxide in heat shock-induced hypericin production of Hypericum perforatum suspension cells. | 2008 | Sci. China, C, Life Sci. | pmid:18677595 |
| Kleban J et al. | Mechanisms involved in the cell cycle and apoptosis of HT-29 cells pre-treated with MK-886 prior to photodynamic therapy with hypericin. | 2008 | J. Photochem. Photobiol. B, Biol. | pmid:18771933 |
| Bertoli A et al. | Bioactive constituent production in St. John's Wort in vitro hairy roots. Regenerated plant lines. | 2008 | J. Agric. Food Chem. | pmid:18553917 |
| Seitz G et al. | In vitro photodynamic therapy in pediatric epithelial liver tumors promoted by hypericin. | 2008 | Oncol. Rep. | pmid:18949433 |
| Fonge H et al. | Non-invasive detection and quantification of acute myocardial infarction in rabbits using mono-[123I]iodohypericin microSPECT. | 2008 | Eur. Heart J. | pmid:18156139 |
| Karppinen K et al. | Octaketide-producing type III polyketide synthase from Hypericum perforatum is expressed in dark glands accumulating hypericins. | 2008 | FEBS J. | pmid:18647343 |
| Fricker G | Drug interactions with natural products at the blood brain barrier. | 2008 | Curr. Drug Metab. | pmid:19075618 |
| Kober M et al. | Molecular mechanisms underlying St. John's wort drug interactions. | 2008 | Curr. Drug Metab. | pmid:19075619 |
| Ayan AK and Cirak C | Variation of hypericins in Hypericum triquetrifolium Turra growing in different locations of Turkey during plant growth. | 2008 | Nat. Prod. Res. | pmid:19085414 |
| Buytaert E et al. | Molecular effectors and modulators of hypericin-mediated cell death in bladder cancer cells. | 2008 | Oncogene | pmid:17952126 |
| Moulharat N et al. | Molecular pharmacology of adipocyte-secreted autotaxin. | 2008 | Chem. Biol. Interact. | pmid:18282564 |
| Jocham D et al. | Photodynamic diagnosis in urology: state-of-the-art. | 2008 | Eur. Urol. | pmid:18096307 |
| Menegazzi M et al. | Protective effects of St. John's wort extract and its component hyperforin against cytokine-induced cytotoxicity in a pancreatic beta-cell line. | 2008 | Int. J. Biochem. Cell Biol. | pmid:18226577 |
| Cole CD et al. | Hypericin-mediated photodynamic therapy of pituitary tumors: preclinical study in a GH4C1 rat tumor model. | 2008 | J. Neurooncol. | pmid:18228116 |
| Tatsis EC et al. | 1H NMR determination of hypericin and pseudohypericin in complex natural mixtures by the use of strongly deshielded OH groups. | 2008 | Anal. Chim. Acta | pmid:18190811 |
| Kusari S et al. | An endophytic fungus from Hypericum perforatum that produces hypericin. | 2008 | J. Nat. Prod. | pmid:18220354 |
| Huygens A et al. | Differential accumulation of hypericin in spheroids composed of T-24 transitional cell carcinoma cells expressing different levels of E-cadherin. | 2008 | J. Urol. | pmid:18355860 |
| Van de Putte M et al. | Exploration of the mechanism underlying the tumor necrosis avidity of hypericin. | 2008 | Oncol. Rep. | pmid:18357376 |
| Robe A et al. | Quantum dots in axillary lymph node mapping: biodistribution study in healthy mice. | 2008 | BMC Cancer | pmid:18430208 |
| Van de Putte M et al. | Hypericin as a marker for determination of tissue viability after radiofrequency ablation in a murine liver tumor model. | 2008 | Oncol. Rep. | pmid:18357377 |
| Hird AE et al. | Radiation recall dermatitis: case report and review of the literature. | 2008 | Curr Oncol | pmid:18317586 |
| Sardella A et al. | Hypericum perforatum extract in burning mouth syndrome: a randomized placebo-controlled study. | 2008 | J. Oral Pathol. Med. | pmid:18331283 |
| Lin TH et al. | Berberine enhances inhibition of glioma tumor cell migration and invasiveness mediated by arsenic trioxide. | 2008 | BMC Cancer | pmid:18294404 |
| Higuchi A et al. | Hypericin inhibits pathological retinal neovascularization in a mouse model of oxygen-induced retinopathy. | 2008 | Mol. Vis. | pmid:18334941 |
| Franklin G et al. | Hypericum perforatum plant cells reduce Agrobacterium viability during co-cultivation. | 2008 | Planta | pmid:18247048 |
| Davids LM et al. | Hypericin phototoxicity induces different modes of cell death in melanoma and human skin cells. | 2008 | J. Photochem. Photobiol. B, Biol. | pmid:18342534 |
| Kleban J et al. | Modulation of hypericin photodynamic therapy by pretreatment with 12 various inhibitors of arachidonic acid metabolism in colon adenocarcinoma HT-29 cells. | 2007 Sep-Oct | Photochem. Photobiol. | pmid:17880512 |
| Wielgus AR et al. | Phototoxicity in human retinal pigment epithelial cells promoted by hypericin, a component of St. John's wort. | 2007 May-Jun | Photochem. Photobiol. | pmid:17576381 |
| Fonge H et al. | Evaluation of tumor affinity of mono-[(123)I]iodohypericin and mono-[(123)I]iodoprotohypericin in a mouse model with a RIF-1 tumor. | 2007 May-Jun | Contrast Media Mol Imaging | pmid:17546702 |
| Rückert U et al. | Simultaneous determination of total hypericin and hyperforin in St. John's wort extracts by HPLC with electrochemical detection. | 2007 May-Jun | Phytochem Anal | pmid:17500362 |
| Kabingu E et al. | CD8+ T cell-mediated control of distant tumours following local photodynamic therapy is independent of CD4+ T cells and dependent on natural killer cells. | 2007 | Br. J. Cancer | pmid:17505510 |
| Böer U et al. | CRE/CREB-driven up-regulation of gene expression by chronic social stress in CRE-luciferase transgenic mice: reversal by antidepressant treatment. | 2007 | PLoS ONE | pmid:17487276 |
| Soelberg J et al. | Hyperforin accumulates in the translucent glands of Hypericum perforatum. | 2007 | Ann. Bot. | pmid:17468113 |
| Chung DJ et al. | Black cohosh and St. John's wort (GYNO-Plus) for climacteric symptoms. | 2007 | Yonsei Med. J. | pmid:17461529 |
| Kosuth J et al. | Expression of the hyp-1 gene in early stages of development of Hypericum perforatum L. | 2007 | Plant Cell Rep. | pmid:16988829 |
| Koperdáková J et al. | Variation in the content of hypericins in four generations of seed progeny of Hypericum perforatum somaclones. | 2007 | J. Plant Res. | pmid:17072497 |
| Savikin K et al. | Antiinflammatory activity of ethanol extracts of Hypericum perforatum L., H. barbatum Jacq., H. hirsutum L., H. richeri Vill. and H. androsaemum L. in rats. | 2007 | Phytother Res | pmid:17143926 |
| Bobrov N et al. | Histomorphological changes in murine fibrosarcoma after hypericin-based photodynamic therapy. | 2007 | Phytomedicine | pmid:17095201 |
| Saw CL et al. | Superiority of N-methyl pyrrolidone over albumin with hypericin for fluorescence diagnosis of human bladder cancer cells implanted in the chick chorioallantoic membrane model. | 2007 | J. Photochem. Photobiol. B, Biol. | pmid:17134910 |
| Kocanova S et al. | Induction of heme-oxygenase 1 requires the p38MAPK and PI3K pathways and suppresses apoptotic cell death following hypericin-mediated photodynamic therapy. | 2007 | Apoptosis | pmid:17219054 |
| Coenye T et al. | In vitro inhibition of Streptococcus mutans biofilm formation on hydroxyapatite by subinhibitory concentrations of anthraquinones. | 2007 | Antimicrob. Agents Chemother. | pmid:17220400 |
| Crnolatac I et al. | In vitro accumulation and permeation of hypericin and lipophilic analogues in 2-D and 3-D cellular systems. | 2007 | Int. J. Oncol. | pmid:17203212 |
| Ung CY et al. | In silico prediction of pregnane X receptor activators by machine learning approaches. | 2007 | Mol. Pharmacol. | pmid:17003167 |
| Hu ZP et al. | A mechanistic study on altered pharmacokinetics of irinotecan by St. John's wort. | 2007 | Curr. Drug Metab. | pmid:17305494 |
| Galabov AS | Virucidal agents in the eve of manorapid synergy. | 2007 | GMS Krankenhhyg Interdiszip | pmid:20200679 |
| Lans C et al. | Ethnoveterinary medicines used for ruminants in British Columbia, Canada. | 2007 | J Ethnobiol Ethnomed | pmid:17324258 |
| Wang Y et al. | Cellular pharmacological properties of gold(III) porphyrin 1a, a potential anticancer drug lead. | 2007 | Eur. J. Pharmacol. | pmid:17116302 |
| Babić D | Herbal medicine in the treatment of mental disorders. | 2007 | Psychiatr Danub | pmid:17914328 |
| Xenophontos M et al. | Influence of the developmental stage on the (proto)-hypericin and (proto)pseudohypericin levels of Hypericum plants from Crete. | 2007 | Planta Med. | pmid:17893828 |
| Boiy A et al. | Influence of application and formulation factors on the penetration of hypericin in normal mouse skin and UV induced skin tumors. | 2007 | J. Photochem. Photobiol. B, Biol. | pmid:17983765 |
| Sauviat MP et al. | Hypericin activates L-type Ca2+ channels in cardiac myocytes. | 2007 | J. Nat. Prod. | pmid:17291039 |
| Kornfeld A et al. | The production of hypericins in two selected Hypericum perforatum shoot cultures is related to differences in black gland structure. | 2007 | Plant Physiol. Biochem. | pmid:17300946 |
| Song X et al. | [The development of secondary cells in the callus of Hypericum perforatum L. and hypericins accumulation]. | 2007 | Fen Zi Xi Bao Sheng Wu Xue Bao | pmid:17357449 |
| Du HY et al. | Hypericin photoactivation triggers down-regulation of matrix metalloproteinase-9 expression in well-differentiated human nasopharyngeal cancer cells. | 2007 | Cell. Mol. Life Sci. | pmid:17385073 |
| Laggner H et al. | The main components of St John's Wort inhibit low-density lipoprotein atherogenic modification: a beneficial "side effect" of an OTC antidepressant drug? | 2007 | Free Radic. Res. | pmid:17364950 |
| Gödtel-Armbrust U et al. | Variability in PXR-mediated induction of CYP3A4 by commercial preparations and dry extracts of St. John's wort. | 2007 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:17593354 |
| Saczko J et al. | Cytosolic superoxide dismutase activity after photodynamic therapy, intracellular distribution of Photofrin II and hypericin, and P-glycoprotein localization in human colon adenocarcinoma. | 2007 | Folia Histochem. Cytobiol. | pmid:17597022 |
| PavlÃk M et al. | Hypericin and hyperforin production in St. John's wort in vitro culture: influence of saccharose, polyethylene glycol, methyl jasmonate, and Agrobacterium tumefaciens. | 2007 | J. Agric. Food Chem. | pmid:17608493 |
| Sosa S et al. | Topical anti-inflammatory activity of extracts and compounds from Hypericum perforatum L. | 2007 | J. Pharm. Pharmacol. | pmid:17524236 |
| Seitz G et al. | In vitro photodynamic therapy of childhood rhabdomyosarcoma. | 2007 | Int. J. Oncol. | pmid:17273762 |
| Ritz R et al. | Photodynamic therapy of malignant glioma with hypericin: comprehensive in vitro study in human glioblastoma cell lines. | 2007 | Int. J. Oncol. | pmid:17273767 |
| Cecchini C et al. | Antimicrobial activity of seven hypericum entities from central Italy. | 2007 | Planta Med. | pmid:17516331 |
| Sun DL et al. | [Morphological identification of 20 medicinal species in Hypericum]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:17655138 |
| Mikes J et al. | Necrosis predominates in the cell death of human colon adenocarcinoma HT-29 cells treated under variable conditions of photodynamic therapy with hypericin. | 2007 | Photochem. Photobiol. Sci. | pmid:17609769 |
| Dasgupta A et al. | Drug-herb interaction: effect of St John's wort on bioavailability and metabolism of procainamide in mice. | 2007 | Arch. Pathol. Lab. Med. | pmid:17616997 |
| Vacek J et al. | [Hypericin and hyperforin: bioactive components of St. John's Wort (Hypericum perforatum). Their isolation, analysis and study of physiological effect]. | 2007 | Ceska Slov Farm | pmid:17619301 |
| Adigbli DK et al. | Photochemical internalisation of chemotherapy potentiates killing of multidrug-resistant breast and bladder cancer cells. | 2007 | Br. J. Cancer | pmid:17667930 |
| Fu CY et al. | Fluorescence detection of bladder cancer using urine cytology. | 2007 | Int. J. Oncol. | pmid:17671678 |
| Bhuvaneswari R et al. | Hypericin-mediated photodynamic therapy in combination with Avastin (bevacizumab) improves tumor response by downregulating angiogenic proteins. | 2007 | Photochem. Photobiol. Sci. | pmid:18046482 |
| Bhuvaneswari R et al. | Effect of hypericin-mediated photodynamic therapy on the expression of vascular endothelial growth factor in human nasopharyngeal carcinoma. | 2007 | Int. J. Mol. Med. | pmid:17786271 |
| Huygens A et al. | Influence of the glycosaminoglycan layer on the permeation of hypericin in rat bladders in vivo. | 2007 | BJU Int. | pmid:17868424 |
| Saw CL et al. | Effects of N-methyl pyrrolidone on the uptake of hypericin in human bladder carcinoma and co-staining with DAPI investigated by confocal microscopy. | 2007 | Technol. Cancer Res. Treat. | pmid:17877426 |
| Schmidbauer J and Marberger M | Recent developments in fluorescence cystoscopy: do novel agents bring a benefit? | 2007 | Curr Opin Urol | pmid:17762629 |
| Butterweck V and Schmidt M | St. John's wort: role of active compounds for its mechanism of action and efficacy. | 2007 | Wien Med Wochenschr | pmid:17704987 |
| Calapai G and Caputi AP | Herbal medicines: can we do without pharmacologist? | 2007 | Evid Based Complement Alternat Med | pmid:18227932 |
| Bletter N | A quantitative synthesis of the medicinal ethnobotany of the Malinké of Mali and the Asháninka of Peru, with a new theoretical framework. | 2007 | J Ethnobiol Ethnomed | pmid:18053260 |
| Sacková V et al. | Hypericin-induced photocytotoxicity is connected with G2/M arrest in HT-29 and S-phase arrest in U937 cells. | 2006 Sep-Oct | Photochem. Photobiol. | pmid:16740057 |
| Vardapetian GR et al. | [The influence of some elicitors on growth and morphogenesis of Hypericum perforatum callus cultures]. | 2006 Nov-Dec | Ontogenez | pmid:17168377 |
| Kocanova S et al. | Characterization of the interaction of hypericin with protein kinase C in U-87 MG human glioma cells. | 2006 May-Jun | Photochem. Photobiol. | pmid:16396605 |
| Rückert U et al. | A high-performance liquid chromatography with electrochemical detection for the determination of total hypericin in extracts of St. John's Wort. | 2006 May-Jun | Phytochem Anal | pmid:16749423 |
| Schipper ML et al. | Evaluation of firefly luciferase bioluminescence mediated photodynamic toxicity in cancer cells. | 2006 Jul-Aug | Mol Imaging Biol | pmid:16791748 |
| Sobaci G et al. | Hypericin-enhanced argon laser photocoagulation for subfoveal choroidal neovascular membrane in age-related macular degeneration: a pilot study. | 2006 Jan-Feb | Eur J Ophthalmol | pmid:16496255 |
| Kasper S et al. | Superior efficacy of St John's wort extract WS 5570 compared to placebo in patients with major depression: a randomized, double-blind, placebo-controlled, multi-center trial [ISRCTN77277298]. | 2006 | BMC Med | pmid:16796730 |
| Cooper EL | Stem cells and CAM. | 2006 | Evid Based Complement Alternat Med | pmid:16786045 |
| Schmitt LA et al. | Evaluation of the light-sensitive cytotoxicity of Hypericum perforatum extracts, fractions, and pure compounds. | 2006 | J. Agric. Food Chem. | pmid:16608204 |
| Saw CL et al. | Delivery of hypericin for photodynamic applications. | 2006 | Cancer Lett. | pmid:16303248 |
| Berlanda J et al. | Characterization of apoptosis induced by photodynamic treatment with hypericin in A431 human epidermoid carcinoma cells. | 2006 | J. Environ. Pathol. Toxicol. Oncol. | pmid:16566716 |
| Olivo M and Chin W | Perylenequinones in photodynamic therapy: cellular versus vascular response. | 2006 | J. Environ. Pathol. Toxicol. Oncol. | pmid:16566720 |
| Smelcerovic A et al. | Comparison of methods for the exhaustive extraction of hypericins, flavonoids, and hyperforin from Hypericum perforatum L. | 2006 | J. Agric. Food Chem. | pmid:16569071 |
| Williams FB et al. | Development and evaluation of methods for determination of naphthodianthrones and flavonoids in St. John's wort. | 2006 | J Chromatogr A | pmid:16554056 |
| Tirillini B et al. | Induction of hypericins in Hypericum perforatum in response to chromium. | 2006 | Fitoterapia | pmid:16554124 |
| Mueller SC et al. | The extent of induction of CYP3A by St. John's wort varies among products and is linked to hyperforin dose. | 2006 | Eur. J. Clin. Pharmacol. | pmid:16341856 |
| Smelcerovic A et al. | Phytochemical analysis and genetic characterization of six Hypericum species from Serbia. | 2006 | Phytochemistry | pmid:16324730 |