| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uterine Cervical Neoplasms | D002583 | 10 associated lipids |
| Neoplasms, Experimental | D009374 | 10 associated lipids |
| Neoplasms, Radiation-Induced | D009381 | 3 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Carcinoma, Squamous Cell | D002294 | 14 associated lipids |
| Skin Neoplasms | D012878 | 12 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
hypericin
hypericin is a lipid of Polyketides (PK) class. Hypericin is associated with abnormalities such as Dermatitis, Phototoxic, Dehydration, Photosensitization, Morphologically altered structure and Myocardial Infarction. The involved functions are known as Cell Cycle Checkpoints, Apoptosis, Acetylation, Cell Survival and Caspase Activation. Hypericin often locates in insoluble fraction, Cytoplasmic matrix, Protoplasm, Tissue membrane and Cytoplasm. The associated genes with hypericin are CDC37 gene, HSPA8 gene, RAF1 gene, cyclin H and FK228. The related lipids are Phosphatidylserines.
Cross Reference
Introduction
To understand associated biological information of hypericin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with hypericin?
hypericin is suspected in Dermatitis, Phototoxic, Photosensitization, Pneumonia, Psoriasis, Phototoxicity, Chronic infectious disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with hypericin
PubChem Associated disorders and diseases
What pathways are associated with hypericin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with hypericin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with hypericin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with hypericin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with hypericin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with hypericin?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with hypericin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ritz R et al. | Hypericin uptake: a prognostic marker for survival in high-grade glioma. | 2008 | J Clin Neurosci | pmid:18394904 |
| Giganti A et al. | Murine and human autotaxin alpha, beta, and gamma isoforms: gene organization, tissue distribution, and biochemical characterization. | 2008 | J. Biol. Chem. | pmid:18175805 |
| Li S et al. | Chemical markers for the quality control of herbal medicines: an overview. | 2008 | Chin Med | pmid:18588699 |
| Xu M et al. | Signal interaction between nitric oxide and hydrogen peroxide in heat shock-induced hypericin production of Hypericum perforatum suspension cells. | 2008 | Sci. China, C, Life Sci. | pmid:18677595 |
| Kleban J et al. | Mechanisms involved in the cell cycle and apoptosis of HT-29 cells pre-treated with MK-886 prior to photodynamic therapy with hypericin. | 2008 | J. Photochem. Photobiol. B, Biol. | pmid:18771933 |
| Bertoli A et al. | Bioactive constituent production in St. John's Wort in vitro hairy roots. Regenerated plant lines. | 2008 | J. Agric. Food Chem. | pmid:18553917 |
| Sgarbossa A et al. | In vitro perturbation of aggregation processes in beta-amyloid peptides: a spectroscopic study. | 2008 | FEBS Lett. | pmid:18805418 |
| Theodossiou TA et al. | Molecular modeling and experimental evidence for hypericin as a substrate for mitochondrial complex III; mitochondrial photodamage as demonstrated using specific inhibitors. | 2008 | Free Radic. Biol. Med. | pmid:18852042 |
| Seitz G et al. | In vitro photodynamic therapy in pediatric epithelial liver tumors promoted by hypericin. | 2008 | Oncol. Rep. | pmid:18949433 |
| Fonge H et al. | Non-invasive detection and quantification of acute myocardial infarction in rabbits using mono-[123I]iodohypericin microSPECT. | 2008 | Eur. Heart J. | pmid:18156139 |
| Karppinen K et al. | Octaketide-producing type III polyketide synthase from Hypericum perforatum is expressed in dark glands accumulating hypericins. | 2008 | FEBS J. | pmid:18647343 |
| Fricker G | Drug interactions with natural products at the blood brain barrier. | 2008 | Curr. Drug Metab. | pmid:19075618 |
| Kober M et al. | Molecular mechanisms underlying St. John's wort drug interactions. | 2008 | Curr. Drug Metab. | pmid:19075619 |
| Ayan AK and Cirak C | Variation of hypericins in Hypericum triquetrifolium Turra growing in different locations of Turkey during plant growth. | 2008 | Nat. Prod. Res. | pmid:19085414 |
| Buytaert E et al. | Molecular effectors and modulators of hypericin-mediated cell death in bladder cancer cells. | 2008 | Oncogene | pmid:17952126 |
| Xenophontos M et al. | Influence of the habitat altitude on the (proto)hypericin and (proto)pseudohypericin levels of hypericum plants from Crete. | 2008 | Planta Med. | pmid:18671196 |
| Minnes R et al. | The effect of solution electrolytes on the uptake of photosensitizers by liposomal membranes: a salting-out effect. | 2008 | Chem. Phys. Lipids | pmid:18606157 |
| Van de Putte M et al. | Hypericin as a marker for determination of tissue viability after intratumoral ethanol injection in a murine liver tumor model. | 2008 | Acad Radiol | pmid:18078913 |
| Boiy A et al. | Photosensitizing activity of hypericin and hypericin acetate after topical application on normal mouse skin. | 2008 | Br. J. Dermatol. | pmid:18047507 |
| Zhao J et al. | Photodynamic effect of hypericin on the conformation and catalytic activity of hemoglobin. | 2008 | Int J Mol Sci | pmid:19325739 |
| Aleisa AM | Cytological and biochemical effects of St. John's Wort supplement (a complex mixture of St. John's Wort, Rosemary and Spirulina) on somatic and germ cells of Swiss Albino mice. | 2008 | Int J Environ Res Public Health | pmid:19151436 |
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| Morgan AJ and Jorm AF | Self-help interventions for depressive disorders and depressive symptoms: a systematic review. | 2008 | Ann Gen Psychiatry | pmid:18710579 |
| Solár P et al. | Erythropoietin inhibits apoptosis induced by photodynamic therapy in ovarian cancer cells. | 2008 | Mol. Cancer Ther. | pmid:18687658 |
| Clauson KA et al. | Clinically relevant safety issues associated with St. John's wort product labels. | 2008 | BMC Complement Altern Med | pmid:18637192 |
| Weber W et al. | Hypericum perforatum (St John's wort) for attention-deficit/hyperactivity disorder in children and adolescents: a randomized controlled trial. | 2008 | JAMA | pmid:18544723 |
| Huygens A et al. | Differential accumulation of hypericin in spheroids composed of T-24 transitional cell carcinoma cells expressing different levels of E-cadherin. | 2008 | J. Urol. | pmid:18355860 |
| Van de Putte M et al. | Exploration of the mechanism underlying the tumor necrosis avidity of hypericin. | 2008 | Oncol. Rep. | pmid:18357376 |
| Van de Putte M et al. | Hypericin as a marker for determination of tissue viability after radiofrequency ablation in a murine liver tumor model. | 2008 | Oncol. Rep. | pmid:18357377 |
| Sardella A et al. | Hypericum perforatum extract in burning mouth syndrome: a randomized placebo-controlled study. | 2008 | J. Oral Pathol. Med. | pmid:18331283 |
| Higuchi A et al. | Hypericin inhibits pathological retinal neovascularization in a mouse model of oxygen-induced retinopathy. | 2008 | Mol. Vis. | pmid:18334941 |
| Davids LM et al. | Hypericin phototoxicity induces different modes of cell death in melanoma and human skin cells. | 2008 | J. Photochem. Photobiol. B, Biol. | pmid:18342534 |
| Kleban J et al. | Modulation of hypericin photodynamic therapy by pretreatment with 12 various inhibitors of arachidonic acid metabolism in colon adenocarcinoma HT-29 cells. | 2007 Sep-Oct | Photochem. Photobiol. | pmid:17880512 |
| Wielgus AR et al. | Phototoxicity in human retinal pigment epithelial cells promoted by hypericin, a component of St. John's wort. | 2007 May-Jun | Photochem. Photobiol. | pmid:17576381 |
| Fonge H et al. | Evaluation of tumor affinity of mono-[(123)I]iodohypericin and mono-[(123)I]iodoprotohypericin in a mouse model with a RIF-1 tumor. | 2007 May-Jun | Contrast Media Mol Imaging | pmid:17546702 |
| Rückert U et al. | Simultaneous determination of total hypericin and hyperforin in St. John's wort extracts by HPLC with electrochemical detection. | 2007 May-Jun | Phytochem Anal | pmid:17500362 |
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| Soelberg J et al. | Hyperforin accumulates in the translucent glands of Hypericum perforatum. | 2007 | Ann. Bot. | pmid:17468113 |
| Chung DJ et al. | Black cohosh and St. John's wort (GYNO-Plus) for climacteric symptoms. | 2007 | Yonsei Med. J. | pmid:17461529 |
| Kosuth J et al. | Expression of the hyp-1 gene in early stages of development of Hypericum perforatum L. | 2007 | Plant Cell Rep. | pmid:16988829 |
| Koperdáková J et al. | Variation in the content of hypericins in four generations of seed progeny of Hypericum perforatum somaclones. | 2007 | J. Plant Res. | pmid:17072497 |
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| Bobrov N et al. | Histomorphological changes in murine fibrosarcoma after hypericin-based photodynamic therapy. | 2007 | Phytomedicine | pmid:17095201 |
| Saw CL et al. | Superiority of N-methyl pyrrolidone over albumin with hypericin for fluorescence diagnosis of human bladder cancer cells implanted in the chick chorioallantoic membrane model. | 2007 | J. Photochem. Photobiol. B, Biol. | pmid:17134910 |
| Kocanova S et al. | Induction of heme-oxygenase 1 requires the p38MAPK and PI3K pathways and suppresses apoptotic cell death following hypericin-mediated photodynamic therapy. | 2007 | Apoptosis | pmid:17219054 |
| Coenye T et al. | In vitro inhibition of Streptococcus mutans biofilm formation on hydroxyapatite by subinhibitory concentrations of anthraquinones. | 2007 | Antimicrob. Agents Chemother. | pmid:17220400 |
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| Ung CY et al. | In silico prediction of pregnane X receptor activators by machine learning approaches. | 2007 | Mol. Pharmacol. | pmid:17003167 |
| Hu ZP et al. | A mechanistic study on altered pharmacokinetics of irinotecan by St. John's wort. | 2007 | Curr. Drug Metab. | pmid:17305494 |
| Galabov AS | Virucidal agents in the eve of manorapid synergy. | 2007 | GMS Krankenhhyg Interdiszip | pmid:20200679 |
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| Xenophontos M et al. | Influence of the developmental stage on the (proto)-hypericin and (proto)pseudohypericin levels of Hypericum plants from Crete. | 2007 | Planta Med. | pmid:17893828 |
| Boiy A et al. | Influence of application and formulation factors on the penetration of hypericin in normal mouse skin and UV induced skin tumors. | 2007 | J. Photochem. Photobiol. B, Biol. | pmid:17983765 |
| Sauviat MP et al. | Hypericin activates L-type Ca2+ channels in cardiac myocytes. | 2007 | J. Nat. Prod. | pmid:17291039 |
| Kornfeld A et al. | The production of hypericins in two selected Hypericum perforatum shoot cultures is related to differences in black gland structure. | 2007 | Plant Physiol. Biochem. | pmid:17300946 |
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| Du HY et al. | Hypericin photoactivation triggers down-regulation of matrix metalloproteinase-9 expression in well-differentiated human nasopharyngeal cancer cells. | 2007 | Cell. Mol. Life Sci. | pmid:17385073 |
| Laggner H et al. | The main components of St John's Wort inhibit low-density lipoprotein atherogenic modification: a beneficial "side effect" of an OTC antidepressant drug? | 2007 | Free Radic. Res. | pmid:17364950 |
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| Saczko J et al. | Cytosolic superoxide dismutase activity after photodynamic therapy, intracellular distribution of Photofrin II and hypericin, and P-glycoprotein localization in human colon adenocarcinoma. | 2007 | Folia Histochem. Cytobiol. | pmid:17597022 |
| PavlÃk M et al. | Hypericin and hyperforin production in St. John's wort in vitro culture: influence of saccharose, polyethylene glycol, methyl jasmonate, and Agrobacterium tumefaciens. | 2007 | J. Agric. Food Chem. | pmid:17608493 |
| Sosa S et al. | Topical anti-inflammatory activity of extracts and compounds from Hypericum perforatum L. | 2007 | J. Pharm. Pharmacol. | pmid:17524236 |
| Seitz G et al. | In vitro photodynamic therapy of childhood rhabdomyosarcoma. | 2007 | Int. J. Oncol. | pmid:17273762 |
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| Bhuvaneswari R et al. | Hypericin-mediated photodynamic therapy in combination with Avastin (bevacizumab) improves tumor response by downregulating angiogenic proteins. | 2007 | Photochem. Photobiol. Sci. | pmid:18046482 |
| Bhuvaneswari R et al. | Effect of hypericin-mediated photodynamic therapy on the expression of vascular endothelial growth factor in human nasopharyngeal carcinoma. | 2007 | Int. J. Mol. Med. | pmid:17786271 |
| Huygens A et al. | Influence of the glycosaminoglycan layer on the permeation of hypericin in rat bladders in vivo. | 2007 | BJU Int. | pmid:17868424 |
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| Kocanova S et al. | Characterization of the interaction of hypericin with protein kinase C in U-87 MG human glioma cells. | 2006 May-Jun | Photochem. Photobiol. | pmid:16396605 |
| Rückert U et al. | A high-performance liquid chromatography with electrochemical detection for the determination of total hypericin in extracts of St. John's Wort. | 2006 May-Jun | Phytochem Anal | pmid:16749423 |
| Schipper ML et al. | Evaluation of firefly luciferase bioluminescence mediated photodynamic toxicity in cancer cells. | 2006 Jul-Aug | Mol Imaging Biol | pmid:16791748 |
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| Putnik K et al. | Enhanced radiation sensitivity and radiation recall dermatitis (RRD) after hypericin therapy -- case report and review of literature. | 2006 | Radiat Oncol | pmid:16948841 |
| Portolés A et al. | Effects of Hypericum perforatum on ivabradine pharmacokinetics in healthy volunteers: an open-label, pharmacokinetic interaction clinical trial. | 2006 | J Clin Pharmacol | pmid:16988208 |
| Du HY et al. | Differential up-regulation of metallothionein isoforms in well-differentiated nasopharyngeal cancer cells in vitro by photoactivated hypericin. | 2006 | Oncol. Rep. | pmid:17089067 |
| Huck CW et al. | Comparative analysis of naphthodianthrone and phloroglucine derivatives in St. John's Wort extracts by near infrared spectroscopy, high-performance liquid chromatography and capillary electrophoresis. | 2006 | Anal. Chim. Acta | pmid:17723777 |
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