| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uterine Cervical Neoplasms | D002583 | 10 associated lipids |
| Neoplasms, Experimental | D009374 | 10 associated lipids |
| Neoplasms, Radiation-Induced | D009381 | 3 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Carcinoma, Squamous Cell | D002294 | 14 associated lipids |
| Skin Neoplasms | D012878 | 12 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
hypericin
hypericin is a lipid of Polyketides (PK) class. Hypericin is associated with abnormalities such as Dermatitis, Phototoxic, Dehydration, Photosensitization, Morphologically altered structure and Myocardial Infarction. The involved functions are known as Cell Cycle Checkpoints, Apoptosis, Acetylation, Cell Survival and Caspase Activation. Hypericin often locates in insoluble fraction, Cytoplasmic matrix, Protoplasm, Tissue membrane and Cytoplasm. The associated genes with hypericin are CDC37 gene, HSPA8 gene, RAF1 gene, cyclin H and FK228. The related lipids are Phosphatidylserines.
Cross Reference
Introduction
To understand associated biological information of hypericin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with hypericin?
hypericin is suspected in Dermatitis, Phototoxic, Photosensitization, Pneumonia, Psoriasis, Phototoxicity, Chronic infectious disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with hypericin
PubChem Associated disorders and diseases
What pathways are associated with hypericin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with hypericin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with hypericin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with hypericin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with hypericin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with hypericin?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with hypericin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Takahashi I et al. | Hypericin and pseudohypericin specifically inhibit protein kinase C: possible relation to their antiretroviral activity. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2558652 |
| Agostinis P et al. | A comparative analysis of the photosensitized inhibition of growth-factor regulated protein kinases by hypericin-derivatives. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8607812 |
| Piette J et al. | Cell death and growth arrest in response to photodynamic therapy with membrane-bound photosensitizers. | 2003 | Biochem. Pharmacol. | pmid:14555246 |
| Richter A and Davies DE | Effects of anthralin and hypericin on growth factor signalling and cell proliferation in vitro. | 1995 | Biochem. Pharmacol. | pmid:8849331 |
| Agostinis P et al. | Photosensitized inhibition of growth factor-regulated protein kinases by hypericin. | 1995 | Biochem. Pharmacol. | pmid:7786302 |
| Utsumi T et al. | Effect of the antiretroviral agent hypericin on rat liver mitochondria. | 1995 | Biochem. Pharmacol. | pmid:7669068 |
| de Witte P et al. | Inhibition of epidermal growth factor receptor tyrosine kinase activity by hypericin. | 1993 | Biochem. Pharmacol. | pmid:8267642 |
| Peebles KA et al. | Catalytic inhibition of human DNA topoisomerase IIalpha by hypericin, a naphthodianthrone from St. John's wort (Hypericum perforatum). | 2001 | Biochem. Pharmacol. | pmid:11597574 |
| Galeotti N et al. | St. John's Wort reduces neuropathic pain through a hypericin-mediated inhibition of the protein kinase Cgamma and epsilon activity. | 2010 | Biochem. Pharmacol. | pmid:20045676 |
| Ouyang Z et al. | Hypericin suppresses osteoclast formation and wear particle-induced osteolysis via modulating ERK signalling pathway. | 2014 | Biochem. Pharmacol. | pmid:24950468 |
| Lu WD and Atkins WM | A novel antioxidant role for ligandin behavior of glutathione S-transferases: attenuation of the photodynamic effects of hypericin. | 2004 | Biochemistry | pmid:15461448 |
| Fehr MJ et al. | Roles of oxygen and photoinduced acidification in the light-dependent antiviral activity of hypocrellin A. | 1995 | Biochemistry | pmid:7495816 |
| Weiner L et al. | Targeted cross-linking of a molten globule form of acetylcholinesterase by the virucidal agent hypericin. | 1999 | Biochemistry | pmid:10471290 |
| Senthil V et al. | Photosensitization of aqueous model systems by hypericin. | 1992 | Biochim. Biophys. Acta | pmid:1739734 |
| Chaloupka R et al. | The effect of hypericin and hypocrellin-A on lipid membranes and membrane potential of 3T3 fibroblasts. | 1999 | Biochim. Biophys. Acta | pmid:10209209 |
| Penjweini R et al. | Transport and accumulation of PVP-Hypericin in cancer and normal cells characterized by image correlation spectroscopy techniques. | 2014 | Biochim. Biophys. Acta | pmid:24480461 |
| Schwarz D et al. | Inhibition of 17β-estradiol activation by CYP1A1: genotype- and regioselective inhibition by St. John's Wort and several natural polyphenols. | 2011 | Biochim. Biophys. Acta | pmid:20883830 |
| Richard AJ et al. | St. John's Wort inhibits insulin signaling in murine and human adipocytes. | 2012 | Biochim. Biophys. Acta | pmid:22198320 |
| Ho YF et al. | Lipid-mediated preferential localization of hypericin in lipid membranes. | 2009 | Biochim. Biophys. Acta | pmid:19366588 |
| Kapinus EI | [Absorption and fluorescence spectra of hypericin sodium salt in complexes with albumins]. | 2010 Mar-Apr | Biofizika | pmid:20429274 |