| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uterine Cervical Neoplasms | D002583 | 10 associated lipids |
| Neoplasms, Experimental | D009374 | 10 associated lipids |
| Neoplasms, Radiation-Induced | D009381 | 3 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Carcinoma, Squamous Cell | D002294 | 14 associated lipids |
| Skin Neoplasms | D012878 | 12 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
hypericin
hypericin is a lipid of Polyketides (PK) class. Hypericin is associated with abnormalities such as Dermatitis, Phototoxic, Dehydration, Photosensitization, Morphologically altered structure and Myocardial Infarction. The involved functions are known as Cell Cycle Checkpoints, Apoptosis, Acetylation, Cell Survival and Caspase Activation. Hypericin often locates in insoluble fraction, Cytoplasmic matrix, Protoplasm, Tissue membrane and Cytoplasm. The associated genes with hypericin are CDC37 gene, HSPA8 gene, RAF1 gene, cyclin H and FK228. The related lipids are Phosphatidylserines.
Cross Reference
Introduction
To understand associated biological information of hypericin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with hypericin?
hypericin is suspected in Dermatitis, Phototoxic, Photosensitization, Pneumonia, Psoriasis, Phototoxicity, Chronic infectious disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with hypericin
PubChem Associated disorders and diseases
What pathways are associated with hypericin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with hypericin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with hypericin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with hypericin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with hypericin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with hypericin?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with hypericin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sgarbossa A et al. | Photosensitized structural modifications of the lens protein alpha-crystallin: do all modifications impair chaperone-like activity? | 2003 | Photochem. Photobiol. | pmid:12812302 |
| Degar S et al. | Inactivation of the human immunodeficiency virus by hypericin: evidence for photochemical alterations of p24 and a block in uncoating. | 1992 | AIDS Res. Hum. Retroviruses | pmid:1283309 |
| Hostanska K et al. | Hyperforin a constituent of St John's wort (Hypericum perforatum L.) extract induces apoptosis by triggering activation of caspases and with hypericin synergistically exerts cytotoxicity towards human malignant cell lines. | 2003 | Eur J Pharm Biopharm | pmid:12837490 |
| Bragin DE et al. | Photodynamic inactivation of isolated crayfish neuron requires protein kinase C, PI 3-kinase and Ca2+. | J. Photochem. Photobiol. B, Biol. | pmid:12849700 | |
| Delaey E et al. | Comparison of hexamethylhypericin and tetrabromohypericin to hypericin for their in vivo efficacy as PDT tools. | 2003 | Int. J. Oncol. | pmid:12851704 |
| Wen J et al. | Does solvent influence the ground-state tautomeric population of hypericin? | 2003 | Photochem. Photobiol. | pmid:12856875 |
| Siboni G et al. | Specificity of photosensitizer accumulation in undifferentiated versus differentiated colon carcinoma cells. | 2003 | Cancer Lett. | pmid:12860290 |
| Butterweck V et al. | Hyperforin-containing extracts of St John's wort fail to alter gene transcription in brain areas involved in HPA axis control in a long-term treatment regimen in rats. | 2003 | Neuropsychopharmacology | pmid:12865894 |
| Kelleher DK et al. | Enhanced effects of aminolaevulinic acid-based photodynamic therapy through local hyperthermia in rat tumours. | 2003 | Br. J. Cancer | pmid:12865936 |
| Luksiene Z and de Witte PA | Hypericin as novel and promising photodynamic therapy tool: studies on intracellular accumulation capacity and growth inhibition efficiency. | 2003 | Medicina (Kaunas) | pmid:12878823 |
| Wahlman J et al. | Focal length variability and protein leakage as tools for measuring photooxidative damage to the lens. | 2003 | Photochem. Photobiol. | pmid:12929754 |
| Olivo M et al. | Macro-microscopic fluorescence of human bladder cancer using hypericin fluorescence cystoscopy and laser confocal microscopy. | 2003 | Int. J. Oncol. | pmid:12963977 |
| Barnard DL et al. | Evaluation of the antiviral activity of anthraquinones, anthrones and anthraquinone derivatives against human cytomegalovirus. | 1992 | Antiviral Res. | pmid:1310583 |
| Thomas C and Pardini RS | Oxygen dependence of hypericin-induced phototoxicity to EMT6 mouse mammary carcinoma cells. | 1992 | Photochem. Photobiol. | pmid:1409890 |
| Millard CB et al. | Stabilization of a metastable state of Torpedo californica acetylcholinesterase by chemical chaperones. | 2003 | Protein Sci. | pmid:14500892 |
| Draves AH and Walker SE | Analysis of the hypericin and pseudohypericin content of commercially available St John's Wort preparations. | 2003 | Can J Clin Pharmacol | pmid:14506510 |
| Kamuhabwa AA et al. | Whole bladder wall photodynamic therapy of transitional cell carcinoma rat bladder tumors using intravesically administered hypericin. | 2003 | Int. J. Cancer | pmid:14506748 |
| Tolonen A et al. | Fast high-performance liquid chromatographic analysis of naphthodianthrones and phloroglucinols from Hypericum perforatum extracts. | 2003 Sep-Oct | Phytochem Anal | pmid:14516003 |
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| Du HY et al. | Hypericin-mediated photodynamic therapy induces lipid peroxidation and necrosis in nasopharyngeal cancer. | 2003 | Int. J. Oncol. | pmid:14532982 |
| Kamuhabwa AA et al. | Photodynamic therapy of transitional cell carcinoma multicellular tumor spheroids with hypericin. | 2003 | Int. J. Oncol. | pmid:14532989 |
| Piette J et al. | Cell death and growth arrest in response to photodynamic therapy with membrane-bound photosensitizers. | 2003 | Biochem. Pharmacol. | pmid:14555246 |
| Chen B et al. | Potentiation of photodynamic therapy with hypericin by mitomycin C in the radiation-induced fibrosarcoma-1 mouse tumor model. | 2003 | Photochem. Photobiol. | pmid:14556315 |
| Hendrickx N et al. | Up-regulation of cyclooxygenase-2 and apoptosis resistance by p38 MAPK in hypericin-mediated photodynamic therapy of human cancer cells. | 2003 | J. Biol. Chem. | pmid:14557269 |
| Olivo M et al. | Novel photodynamic diagnosis of bladder cancer: ex vivo fluorescence cytology using hypericin. | 2003 | Int. J. Oncol. | pmid:14612919 |
| Schwarz D et al. | St. John's wort extracts and some of their constituents potently inhibit ultimate carcinogen formation from benzo[a]pyrene-7,8-dihydrodiol by human CYP1A1. | 2003 | Cancer Res. | pmid:14633740 |
| Uzdensky AB et al. | Photodynamic effect of hypericin and a water-soluble derivative on isolated crayfish neuron and surrounding glial cells. | 2003 | J. Photochem. Photobiol. B, Biol. | pmid:14644563 |
| Usai M et al. | Hypericum perforatum subspecies angustifolium shows a protective activity on the consequences of unavoidable stress exposure at lower doses than Hypericum perforatum perforatum. | 2003 | Pharmacopsychiatry | pmid:14663651 |
| Cai W et al. | [Influence of luyoutal on serum cytokines in patients with depression]. | 2003 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:14666775 |
| Simbrey K et al. | Extracts of St. John's wort and various constituents affect beta-adrenergic binding in rat frontal cortex. | 2004 | Life Sci. | pmid:14672758 |
| Blank M et al. | Enhanced ubiquitinylation of heat shock protein 90 as a potential mechanism for mitotic cell death in cancer cells induced with hypericin. | 2003 | Cancer Res. | pmid:14678981 |
| Guilhermano LG et al. | Commercially available Hypericum perforatum extracts do not decrease immobility of rats in the forced swimming test. | 2004 | Prog. Neuropsychopharmacol. Biol. Psychiatry | pmid:14687857 |
| Piovan A et al. | Flow injection analysis mass spectrometry, a tool to investigate the problems in the quantitative analysis of hypericin using reversed-phase high-performance liquid chromatography. | 2004 | Rapid Commun. Mass Spectrom. | pmid:14689570 |
| Hao GY and Zhang YH | [Fluorescence technique on diagnosis of urinary bladder carcinoma]. | 2003 | Zhonghua Yi Xue Za Zhi | pmid:14723217 |
| Gray DE et al. | Effect of acute drought stress and time of harvest on phytochemistry and dry weight of St. John's wort leaves and flowers. | 2003 | Planta Med. | pmid:14735441 |
| Huygens A et al. | Accumulation and photocytotoxicity of hypericin and analogs in two- and three-dimensional cultures of transitional cell carcinoma cells. | 2003 | Photochem. Photobiol. | pmid:14743871 |
| Roscetti G et al. | Cytotoxic activity of Hypericum perforatum L. on K562 erythroleukemic cells: differential effects between methanolic extract and hypericin. | 2004 | Phytother Res | pmid:14750204 |
| Piovan A et al. | Detection of hypericins in the "red glands" of Hypericum elodes by ESI-MS/MS. | 2004 | Phytochemistry | pmid:14759533 |
| Du H et al. | Modulation of Matrix metalloproteinase-1 in nasopharyngeal cancer cells by photoactivation of hypericin. | 2004 | Int. J. Oncol. | pmid:14767550 |
| Sirvent TM et al. | Induction of hypericins and hyperforins in Hypericum perforatum in response to damage by herbivores. | 2003 | J. Chem. Ecol. | pmid:14969354 |
| Wang EJ et al. | Quantitative characterization of direct P-glycoprotein inhibition by St John's wort constituents hypericin and hyperforin. | 2004 | J. Pharm. Pharmacol. | pmid:14980009 |
| Alali F et al. | Determination of hypericin content in Hypericum triquetrifolium Turra (Hypericaceae) growing wild in Jordan. | 2004 | Nat. Prod. Res. | pmid:14984088 |
| Raser LN et al. | Resonance Raman and surface-enhanced resonance Raman spectroscopy of hypericin. | 1992 | Photochem. Photobiol. | pmid:1502258 |
| Du HY et al. | Photoactivation of hypericin down-regulates glutathione S-transferase activity in nasopharyngeal cancer cells. | 2004 | Cancer Lett. | pmid:15072826 |
| Bourke CA | The effect of shade, shearing and wool type in the protection of Merino sheep from Hypericum perforatum (St John's wort) poisoning. | 2003 | Aust. Vet. J. | pmid:15086086 |
| Komoroski BJ et al. | Induction and inhibition of cytochromes P450 by the St. John's wort constituent hyperforin in human hepatocyte cultures. | 2004 | Drug Metab. Dispos. | pmid:15100173 |
| Avato P et al. | Extracts from St John's Wort and their antimicrobial activity. | 2004 | Phytother Res | pmid:15103670 |
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| Mennini T and Gobbi M | The antidepressant mechanism of Hypericum perforatum. | 2004 | Life Sci. | pmid:15207650 |
| Blank M et al. | Antimetastatic activity of the photodynamic agent hypericin in the dark. | 2004 | Int. J. Cancer | pmid:15239139 |