hypericin

hypericin is a lipid of Polyketides (PK) class. Hypericin is associated with abnormalities such as Dermatitis, Phototoxic, Dehydration, Photosensitization, Morphologically altered structure and Myocardial Infarction. The involved functions are known as Cell Cycle Checkpoints, Apoptosis, Acetylation, Cell Survival and Caspase Activation. Hypericin often locates in insoluble fraction, Cytoplasmic matrix, Protoplasm, Tissue membrane and Cytoplasm. The associated genes with hypericin are CDC37 gene, HSPA8 gene, RAF1 gene, cyclin H and FK228. The related lipids are Phosphatidylserines.

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Introduction

To understand associated biological information of hypericin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with hypericin?

hypericin is suspected in Dermatitis, Phototoxic, Photosensitization, Pneumonia, Psoriasis, Phototoxicity, Chronic infectious disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with hypericin

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Uterine Cervical Neoplasms D002583 10 associated lipids
Neoplasms, Experimental D009374 10 associated lipids
Neoplasms, Radiation-Induced D009381 3 associated lipids
Adenocarcinoma D000230 166 associated lipids
Lung Neoplasms D008175 171 associated lipids
Carcinoma, Squamous Cell D002294 14 associated lipids
Skin Neoplasms D012878 12 associated lipids
Burns D002056 34 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Per page 10 20 50 | Total 38

PubChem Associated disorders and diseases

What pathways are associated with hypericin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with hypericin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with hypericin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with hypericin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with hypericin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with hypericin?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with hypericin

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Authors Title Published Journal PubMed Link
Dai T et al. Concepts and principles of photodynamic therapy as an alternative antifungal discovery platform. 2012 Front Microbiol pmid:22514547
Li JY et al. Management of cutaneous T cell lymphoma: new and emerging targets and treatment options. 2012 Cancer Manag Res pmid:22457602
Fasinu PS et al. An overview of the evidence and mechanisms of herb-drug interactions. 2012 Front Pharmacol pmid:22557968
Krammer B and Verwanger T Molecular response to hypericin-induced photodamage. 2012 Curr. Med. Chem. pmid:22214453
Dalmizrak O et al. Evaluation of the in vitro inhibitory impact of hypericin on placental glutathione S-transferase pi. 2012 Protein J. pmid:22810152
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Mondon K et al. MPEG-hexPLA micelles as novel carriers for hypericin, a fluorescent marker for use in cancer diagnostics. 2011 Mar-Apr Photochem. Photobiol. pmid:21166812
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Song S et al. Small-animal PET of tumor damage induced by photothermal ablation with 64Cu-bis-DOTA-hypericin. 2011 J. Nucl. Med. pmid:21498539
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Sharma KV et al. Photodynamic therapy-induced killing is enhanced in depigmented metastatic melanoma cells. 2011 Cell Biol. Int. pmid:21542806
Engelhardt V et al. Lipophilic rather than hydrophilic photosensitizers show strong adherence to standard cell culture microplates under cell-free conditions. 2011 J. Photochem. Photobiol. B, Biol. pmid:21507674
Sačková V et al. Enhanced antiproliferative and apoptotic response of HT-29 adenocarcinoma cells to combination of photoactivated hypericin and farnesyltransferase inhibitor manumycin A. 2011 Int J Mol Sci pmid:22272079
Kammerer R et al. Induction of immune mediators in glioma and prostate cancer cells by non-lethal photodynamic therapy. 2011 PLoS ONE pmid:21738796
Dewaele M et al. Autophagy pathways activated in response to PDT contribute to cell resistance against ROS damage. 2011 J. Cell. Mol. Med. pmid:20626525
Mozaffari S et al. Effects of Hypericum perforatum extract on rat irritable bowel syndrome. 2011 Pharmacogn Mag pmid:21969792
Hao PF et al. [Study on the enzyme extraction process of hypericin by pectinase]. 2011 Zhong Yao Cai pmid:22066412
Marysael T et al. Influence of the vascular damaging agents DMXAA and ZD6126 on hypericin distribution and accumulation in RIF-1 tumors. 2011 J. Cancer Res. Clin. Oncol. pmid:21858709
Onoue S et al. In vitro photochemical and phototoxicological characterization of major constituents in St. John's Wort (Hypericum perforatum) extracts. 2011 Phytochemistry pmid:21782201
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Helmja K et al. Variation in the composition of the essential oils, phenolic compounds and mineral elements of Hypericum perforatum L. growing in Estonia. 2011 Nat. Prod. Res. pmid:21391113
Rainha N et al. Comparison of the endemic Azorean Hypericum foliosum with other Hypericum species: antioxidant activity and phenolic profile. 2011 Nat. Prod. Res. pmid:21246439
Schwarz D et al. Inhibition of 17β-estradiol activation by CYP1A1: genotype- and regioselective inhibition by St. John's Wort and several natural polyphenols. 2011 Biochim. Biophys. Acta pmid:20883830
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Merhi F et al. Hyperforin inhibits Akt1 kinase activity and promotes caspase-mediated apoptosis involving Bad and Noxa activation in human myeloid tumor cells. 2011 PLoS ONE pmid:21998731
Martirosyan AS et al. Biphasic dose-response of antioxidants in hypericin-induced photohemolysis. 2011 Photodiagnosis Photodyn Ther pmid:21864803
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