| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uterine Cervical Neoplasms | D002583 | 10 associated lipids |
| Neoplasms, Experimental | D009374 | 10 associated lipids |
| Neoplasms, Radiation-Induced | D009381 | 3 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Carcinoma, Squamous Cell | D002294 | 14 associated lipids |
| Skin Neoplasms | D012878 | 12 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
hypericin
hypericin is a lipid of Polyketides (PK) class. Hypericin is associated with abnormalities such as Dermatitis, Phototoxic, Dehydration, Photosensitization, Morphologically altered structure and Myocardial Infarction. The involved functions are known as Cell Cycle Checkpoints, Apoptosis, Acetylation, Cell Survival and Caspase Activation. Hypericin often locates in insoluble fraction, Cytoplasmic matrix, Protoplasm, Tissue membrane and Cytoplasm. The associated genes with hypericin are CDC37 gene, HSPA8 gene, RAF1 gene, cyclin H and FK228. The related lipids are Phosphatidylserines.
Cross Reference
Introduction
To understand associated biological information of hypericin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with hypericin?
hypericin is suspected in Dermatitis, Phototoxic, Photosensitization, Pneumonia, Psoriasis, Phototoxicity, Chronic infectious disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with hypericin
PubChem Associated disorders and diseases
What pathways are associated with hypericin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with hypericin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with hypericin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with hypericin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with hypericin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with hypericin?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with hypericin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Bhuvaneswari R et al. | Targeting EGFR with photodynamic therapy in combination with Erbitux enhances in vivo bladder tumor response. | 2009 | Mol. Cancer | pmid:19878607 |
| Karioti A et al. | Rapid and efficient purification of naphthodianthrones from St. John's wort extract by using liquid-liquid extraction and SEC. | 2009 | J Sep Sci | pmid:19360729 |
| Zeisser-Labouèbe M et al. | Benefits of nanoencapsulation for the hypercin-mediated photodetection of ovarian micrometastases. | 2009 | Eur J Pharm Biopharm | pmid:18977296 |
| Karakas O et al. | Effects of different concentrations of benzylaminopurine on shoot regeneration and hypericin content in Hypericum triquetrifolium Turra. | 2009 | Nat. Prod. Res. | pmid:18985513 |
| Hill K and Schaefer M | Ultraviolet light and photosensitising agents activate TRPA1 via generation of oxidative stress. | 2009 | Cell Calcium | pmid:18814910 |
| Breitenbach T et al. | Photosensitized production of singlet oxygen: spatially-resolved optical studies in single cells. | 2009 | Photochem. Photobiol. Sci. | pmid:19337656 |
| Sanovic R et al. | Time-resolved gene expression profiling of human squamous cell carcinoma cells during the apoptosis process induced by photodynamic treatment with hypericin. | 2009 | Int. J. Oncol. | pmid:19724930 |
| Kusari S et al. | Light-independent metabolomics of endophytic Thielavia subthermophila provides insight into microbial hypericin biosynthesis. | 2009 | J. Nat. Prod. | pmid:19746917 |
| Tadros MG et al. | Involvement of serotoninergic 5-HT1A/2A, alpha-adrenergic and dopaminergic D1 receptors in St. John's wort-induced prepulse inhibition deficit: a possible role of hyperforin. | 2009 | Behav. Brain Res. | pmid:19136030 |
| Schneider-Yin X et al. | Hypericin and 5-aminolevulinic acid-induced protoporphyrin IX induce enhanced phototoxicity in human endometrial cancer cells with non-coherent white light. | 2009 | Photodiagnosis Photodyn Ther | pmid:19447367 |
| Roelants M et al. | In vitro study of the photocytotoxicity of bathochromically-shifted hypericin derivatives. | 2009 | Photochem. Photobiol. Sci. | pmid:19492110 |
| Shibata Y | Comment on "Hypericin uptake: a prognostic marker for survival in high-grade glioma". | 2009 | J Clin Neurosci | pmid:19595595 |
| Davids LM et al. | Melanomas display increased cytoprotection to hypericin-mediated cytotoxicity through the induction of autophagy. | 2009 | Cell Biol. Int. | pmid:19596456 |
| Booth JN and McGwin G | The association between self-reported cataracts and St. John's Wort. | 2009 | Curr. Eye Res. | pmid:19895314 |
| Jendzelovský R et al. | Drug efflux transporters, MRP1 and BCRP, affect the outcome of hypericin-mediated photodynamic therapy in HT-29 adenocarcinoma cells. | 2009 | Photochem. Photobiol. Sci. | pmid:20024169 |
| Mikes J et al. | The role of p53 in the efficiency of photodynamic therapy with hypericin and subsequent long-term survival of colon cancer cells. | 2009 | Photochem. Photobiol. Sci. | pmid:19862414 |
| Thong PS et al. | Clinical application of fluorescence endoscopic imaging using hypericin for the diagnosis of human oral cavity lesions. | 2009 | Br. J. Cancer | pmid:19809432 |
| Hölscher D et al. | Matrix-free UV-laser desorption/ionization (LDI) mass spectrometric imaging at the single-cell level: distribution of secondary metabolites of Arabidopsis thaliana and Hypericum species. | 2009 | Plant J. | pmid:19732382 |
| Maury W et al. | Identification of light-independent inhibition of human immunodeficiency virus-1 infection through bioguided fractionation of Hypericum perforatum. | 2009 | Virol. J. | pmid:19594941 |
| Hecka A et al. | Study of active naphtodianthrone St John's Wort compounds by electrospray ionization Fourier transform ion cyclotron resonance and multi-stage mass spectrometry in sustained off-resonance irradiation collision-induced dissociation and infrared multiphoton dissociation modes. | 2009 | Rapid Commun. Mass Spectrom. | pmid:19224526 |
| Ho YF et al. | Lipid-mediated preferential localization of hypericin in lipid membranes. | 2009 | Biochim. Biophys. Acta | pmid:19366588 |
| Kurihara T et al. | Retinal phototoxicity in a novel murine model of intraocular lens implantation. | 2009 | Mol. Vis. | pmid:20019883 |
| Wildeman MA et al. | Photodynamic therapy in the therapy for recurrent/persistent nasopharyngeal cancer. | 2009 | Head Neck Oncol | pmid:20017928 |
| Gao Q et al. | PKC alpha affects cell cycle progression and proliferation in human RPE cells through the downregulation of p27kip1. | 2009 | Mol. Vis. | pmid:20011080 |
| Borrelli F and Izzo AA | Herb-drug interactions with St John's wort (Hypericum perforatum): an update on clinical observations. | 2009 | AAPS J | pmid:19859815 |
| Fornaro M et al. | Medicine and psychiatry in Western culture: Ancient Greek myths and modern prejudices. | 2009 | Ann Gen Psychiatry | pmid:19811642 |
| Wright KE et al. | Peripheral neural cell sensitivity to mTHPC-mediated photodynamic therapy in a 3D in vitro model. | 2009 | Br. J. Cancer | pmid:19638975 |
| Galanou MC et al. | Interactive transport, subcellular relocation and enhanced phototoxicity of hypericin encapsulated in guanidinylated liposomes via molecular recognition. | 2008 Sep-Oct | Photochem. Photobiol. | pmid:18627515 |
| Kah JC et al. | Endoscopic image analysis of photosensitizer fluorescence as a promising noninvasive approach for pathological grading of bladder cancer in situ. | 2008 Sep-Oct | J Biomed Opt | pmid:19021402 |
| Kubin A et al. | Fluorescence diagnosis of bladder cancer with new water soluble hypericin bound to polyvinylpyrrolidone: PVP-hypericin. | 2008 Nov-Dec | Photochem. Photobiol. | pmid:18627521 |
| Kacerovská D et al. | Photodynamic therapy of nonmelanoma skin cancer with topical hypericum perforatum extract--a pilot study. | 2008 May-Jun | Photochem. Photobiol. | pmid:18179625 |
| Mukherjee P et al. | Accumulation and interaction of hypericin in low-density lipoprotein--a photophysical study. | 2008 May-Jun | Photochem. Photobiol. | pmid:18435618 |
| Ritz R et al. | Subcellular colocalization of hypericin with respect to endoplasmic reticulum and Golgi apparatus in glioblastoma cells. | 2008 Jul-Aug | Anticancer Res. | pmid:18751371 |
| Kascakova S et al. | High level of low-density lipoprotein receptors enhance hypericin uptake by U-87 MG cells in the presence of LDL. | 2008 Jan-Feb | Photochem. Photobiol. | pmid:18173711 |
| Wessels JT et al. | Photosensitizing and radiosensitizing effects of hypericin on human renal carcinoma cells in vitro. | 2008 Jan-Feb | Photochem. Photobiol. | pmid:18173725 |
| Li S et al. | Chemical markers for the quality control of herbal medicines: an overview. | 2008 | Chin Med | pmid:18588699 |
| Sgarbossa A et al. | In vitro perturbation of aggregation processes in beta-amyloid peptides: a spectroscopic study. | 2008 | FEBS Lett. | pmid:18805418 |
| Theodossiou TA et al. | Molecular modeling and experimental evidence for hypericin as a substrate for mitochondrial complex III; mitochondrial photodamage as demonstrated using specific inhibitors. | 2008 | Free Radic. Biol. Med. | pmid:18852042 |
| Xenophontos M et al. | Influence of the habitat altitude on the (proto)hypericin and (proto)pseudohypericin levels of hypericum plants from Crete. | 2008 | Planta Med. | pmid:18671196 |
| Minnes R et al. | The effect of solution electrolytes on the uptake of photosensitizers by liposomal membranes: a salting-out effect. | 2008 | Chem. Phys. Lipids | pmid:18606157 |
| Van de Putte M et al. | Hypericin as a marker for determination of tissue viability after intratumoral ethanol injection in a murine liver tumor model. | 2008 | Acad Radiol | pmid:18078913 |
| Boiy A et al. | Photosensitizing activity of hypericin and hypericin acetate after topical application on normal mouse skin. | 2008 | Br. J. Dermatol. | pmid:18047507 |
| Zhao J et al. | Photodynamic effect of hypericin on the conformation and catalytic activity of hemoglobin. | 2008 | Int J Mol Sci | pmid:19325739 |
| Aleisa AM | Cytological and biochemical effects of St. John's Wort supplement (a complex mixture of St. John's Wort, Rosemary and Spirulina) on somatic and germ cells of Swiss Albino mice. | 2008 | Int J Environ Res Public Health | pmid:19151436 |
| Guo X et al. | Increased p38-MAPK is responsible for chemotherapy resistance in human gastric cancer cells. | 2008 | BMC Cancer | pmid:19091131 |
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| Morgan AJ and Jorm AF | Self-help interventions for depressive disorders and depressive symptoms: a systematic review. | 2008 | Ann Gen Psychiatry | pmid:18710579 |
| Solár P et al. | Erythropoietin inhibits apoptosis induced by photodynamic therapy in ovarian cancer cells. | 2008 | Mol. Cancer Ther. | pmid:18687658 |
| Clauson KA et al. | Clinically relevant safety issues associated with St. John's wort product labels. | 2008 | BMC Complement Altern Med | pmid:18637192 |
| Weber W et al. | Hypericum perforatum (St John's wort) for attention-deficit/hyperactivity disorder in children and adolescents: a randomized controlled trial. | 2008 | JAMA | pmid:18544723 |