| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uterine Cervical Neoplasms | D002583 | 10 associated lipids |
| Neoplasms, Experimental | D009374 | 10 associated lipids |
| Neoplasms, Radiation-Induced | D009381 | 3 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Carcinoma, Squamous Cell | D002294 | 14 associated lipids |
| Skin Neoplasms | D012878 | 12 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
hypericin
hypericin is a lipid of Polyketides (PK) class. Hypericin is associated with abnormalities such as Dermatitis, Phototoxic, Dehydration, Photosensitization, Morphologically altered structure and Myocardial Infarction. The involved functions are known as Cell Cycle Checkpoints, Apoptosis, Acetylation, Cell Survival and Caspase Activation. Hypericin often locates in insoluble fraction, Cytoplasmic matrix, Protoplasm, Tissue membrane and Cytoplasm. The associated genes with hypericin are CDC37 gene, HSPA8 gene, RAF1 gene, cyclin H and FK228. The related lipids are Phosphatidylserines.
Cross Reference
Introduction
To understand associated biological information of hypericin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with hypericin?
hypericin is suspected in Dermatitis, Phototoxic, Photosensitization, Pneumonia, Psoriasis, Phototoxicity, Chronic infectious disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with hypericin
PubChem Associated disorders and diseases
What pathways are associated with hypericin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with hypericin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with hypericin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with hypericin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with hypericin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with hypericin?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with hypericin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chong K et al. | Enhancement of the photocytotoxic efficiency of sub-12 nm therapeutic polymeric micelles with increased co-localisation in mitochondria. | 2013 | Chem. Commun. (Camb.) | pmid:24064984 |
| Van Kets V et al. | Laser light activation of a second-generation photosensitiser and its use as a potential photomodulatory agent in skin rejuvenation. | 2013 | Lasers Med Sci | pmid:22581390 |
| Rainha N et al. | Content of hypericins from plants and in vitro shoots of Hypericum undulatum Schousb. ex Willd. | 2013 | Nat. Prod. Res. | pmid:22617156 |
| Búzová D et al. | Solubilization of poorly soluble photosensitizer hypericin by polymeric micelles and polyethylene glycol. | 2013 | Gen. Physiol. Biophys. | pmid:23479449 |
| Nafee N et al. | Antibiotic-free nanotherapeutics: hypericin nanoparticles thereof for improved in vitro and in vivo antimicrobial photodynamic therapy and wound healing. | 2013 | Int J Pharm | pmid:23834835 |
| Lima AM et al. | Hypericin encapsulated in solid lipid nanoparticles: phototoxicity and photodynamic efficiency. | 2013 | J. Photochem. Photobiol. B, Biol. | pmid:23816959 |
| Garg AD et al. | ROS-induced autophagy in cancer cells assists in evasion from determinants of immunogenic cell death. | 2013 | Autophagy | pmid:23800749 |
| Barathan M et al. | Hypericin-photodynamic therapy leads to interleukin-6 secretion by HepG2 cells and their apoptosis via recruitment of BH3 interacting-domain death agonist and caspases. | 2013 | Cell Death Dis | pmid:23807226 |
| Kong M et al. | Necrosis affinity evaluation of 131I-hypericin in a rat model of induced necrosis. | 2013 | J Drug Target | pmid:23627568 |
| Zhang W et al. | Investigation of water-soluble inclusion complex of hypericin with β-cyclodextrin polymer. | 2013 | Carbohydr Polym | pmid:23618281 |
| Cona MM et al. | Improved clearance of radioiodinated hypericin as a targeted anticancer agent by using a duodenal drainage catheter in rats. | 2013 | Exp. Biol. Med. (Maywood) | pmid:24146264 |
| Righeschi C et al. | Microarray-based mRNA expression profiling of leukemia cells treated with the flavonoid, casticin. | 2012 May-Jun | Cancer Genomics Proteomics | pmid:22593249 |
| Yow CM et al. | Hypericin-mediated photodynamic antimicrobial effect on clinically isolated pathogens. | 2012 May-Jun | Photochem. Photobiol. | pmid:22233203 |
| Rezusta A et al. | In vitro fungicidal photodynamic effect of hypericin on Candida species. | 2012 May-Jun | Photochem. Photobiol. | pmid:22128758 |
| Youssef T et al. | Evaluation of hypericin-loaded solid lipid nanoparticles: physicochemical properties, photostability and phototoxicity. | 2012 Mar-Apr | Pharm Dev Technol | pmid:21047275 |
| Sharma KV and Davids LM | Depigmentation in melanomas increases the efficacy of hypericin-mediated photodynamic-induced cell death. | 2012 | Photodiagnosis Photodyn Ther | pmid:22594986 |
| Penjweini R et al. | Long-term monitoring of live cell proliferation in presence of PVP-Hypericin: a new strategy using ms pulses of LED and the fluorescent dye CFSE. | 2012 | J Microsc | pmid:21974829 |
| Mortensen T et al. | Investigating the effectiveness of St John's wort herb as an antimicrobial agent against mycobacteria. | 2012 | Phytother Res | pmid:22294548 |
| Nakajima N and Kawashima N | A basic study on hypericin-PDT in vitro. | 2012 | Photodiagnosis Photodyn Ther | pmid:22959799 |
| Ritz R et al. | In vitro comparison of hypericin and 5-aminolevulinic acid-derived protoporphyrin IX for photodynamic inactivation of medulloblastoma cells. | 2012 | PLoS ONE | pmid:23251668 |