Aloe-emodin is a lipid of Polyketides (PK) class. Aloe-emodin is associated with abnormalities such as Wiskott-Aldrich Syndrome. The involved functions are known as Anabolism, Phosphorylation, Signal Transduction, Cell Proliferation and Cell Survival. Aloe-emodin often locates in Body tissue, Cell Fraction, Mitochondria, Micronucleus and Microsomes, Liver. The associated genes with Aloe-emodin are MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 2, RICTOR gene, PI3 gene, PRR5 gene and MANEA gene.
To understand associated biological information of Aloe-emodin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Aloe-emodin is suspected in and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Aloe-emodin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Poliomyelitis | D011051 | 2 associated lipids |
| Tongue Neoplasms | D014062 | 15 associated lipids |
| Alcoholic Intoxication | D000435 | 15 associated lipids |
| Micronuclei, Chromosome-Defective | D048629 | 33 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
| Neuroectodermal Tumors | D017599 | 4 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sun Y et al. | Cytochrome P450 mediated metabolic activation of chrysophanol. | 2018 | Chem. Biol. Interact. | pmid:29698620 |
| Trybus W et al. | Induction of Mitotic Catastrophe in Human Cervical Cancer Cells After Administration of Aloe-emodin. | 2018 | Anticancer Res. | pmid:29599321 |
| Melucci D et al. | A Comparative Assessment of Biological Effects and Chemical Profile of Italian Asphodeline lutea Extracts. | 2018 | Molecules | pmid:29463056 |
| Liu YQ et al. | Inhibitory effect of aloe emodin mediated photodynamic therapy on human oral mucosa carcinoma in vitro and in vivo. | 2018 | Biomed. Pharmacother. | pmid:29102913 |
| Chen Q et al. | Photodynamic Therapy Mediated by Aloe-Emodin Inhibited Angiogenesis and Cell Metastasis Through Activating MAPK Signaling Pathway on HUVECs. | 2018 | Technol. Cancer Res. Treat. | pmid:30068242 |
| Ji H et al. | LC-MS based urinary metabolomics study of the intervention effect of aloe-emodin on hyperlipidemia rats. | 2018 | J Pharm Biomed Anal | pmid:29698861 |
| Kumar S et al. | Antiplasmodial potential and quantification of aloin and aloe-emodin in Aloe vera collected from different climatic regions of India. | 2017 | BMC Complement Altern Med | pmid:28716028 |
| Dong X et al. | Induction of Apoptosis in HepaRG Cell Line by Aloe-Emodin through Generation of Reactive Oxygen Species and the Mitochondrial Pathway. | 2017 | Cell. Physiol. Biochem. | pmid:28618413 |
| Cheng J et al. | Quantitative Nonaqueous Capillary Electrophoresis-Mass Spectrometry Method for Determining Active Ingredients in Plant Extracts. | 2017 | Anal. Chem. | pmid:28208307 |
| Zhang YM et al. | Pharmacokinetics and pharmacodynamics of Da-Cheng-Qi decoction in the liver of rats with severe acute pancreatitis. | 2017 | World J. Gastroenterol. | pmid:28293083 |