Valeric acid is a lipid of Fatty Acyls (FA) class. Valeric acid is associated with abnormalities such as Papillon-Lefevre Disease, Obesity, Diabetes Mellitus, Non-Insulin-Dependent and Dehydration. The involved functions are known as Process, Odorant, Stimulus, Irritation and Phenomenon. Valeric acid often locates in Receptive field, soluble, Extracellular, Entire gastrointestinal tract and Body tissue. The associated genes with Valeric acid are Orthologous Gene, Fusion Gene and AS gene. The related lipids are Valerates, butyrate, Propionate, Caproates and Palmitates.
To understand associated biological information of Valeric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Valeric acid is suspected in Obesity, Papillon-Lefevre Disease, Diabetes Mellitus, Non-Insulin-Dependent, Dehydration and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Valeric acid
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Anemia, Sickle Cell | D000755 | 34 associated lipids |
| Arthritis, Infectious | D001170 | 8 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Peripheral Nervous System Diseases | D010523 | 33 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Reye Syndrome | D012202 | 14 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Uterine Hemorrhage | D014592 | 6 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Nery J et al. | Influence of dietary protein content and source on colonic fermentative activity in dogs differing in body size and digestive tolerance. | 2012 | J. Anim. Sci. | pmid:22328724 |
| May ML et al. | Effects of dry-rolled or steam-flaked corn finishing diets with or without twenty-five percent dried distillers grains on ruminal fermentation and apparent total tract digestion. | 2009 | J. Anim. Sci. | pmid:19648506 |
| Goiri I et al. | Use of chitosans to modulate ruminal fermentation of a 50:50 forage-to-concentrate diet in sheep. | 2010 | J. Anim. Sci. | pmid:19854994 |
| Varel VH et al. | Odorant production and persistence of Escherichia coli in manure slurries from cattle fed zero, twenty, forty, or sixty percent wet distillers grains with solubles. | 2008 | J. Anim. Sci. | pmid:18676716 |
| Manzanilla EG et al. | Effect of plant extracts and formic acid on the intestinal equilibrium of early-weaned pigs. | 2004 | J. Anim. Sci. | pmid:15542467 |
| Kristensen NB and Harmon DL | Effect of increasing ruminal butyrate absorption on splanchnic metabolism of volatile fatty acids absorbed from the washed reticulorumen of steers. | 2004 | J. Anim. Sci. | pmid:15537776 |
| Kristensen NB and Harmon DL | Splanchnic metabolism of volatile fatty acids absorbed from the washed reticulorumen of steers. | 2004 | J. Anim. Sci. | pmid:15309950 |
| Rossi S et al. | Antimicrobial efficacy of a new antibiotic-loaded poly(hydroxybutyric-co-hydroxyvaleric acid) controlled release system. | 2004 | J. Antimicrob. Chemother. | pmid:15537698 |
| Chee JY et al. | Expression of Aeromonas caviae polyhydroxyalkanoate synthase gene in Burkholderia sp. USM (JCM15050) enables the biosynthesis of SCL-MCL PHA from palm oil products. | 2012 | J. Appl. Microbiol. | pmid:22054430 |
| Park MO et al. | Production of alternatives to fuel oil from organic waste by the alkane-producing bacterium, Vibrio furnissii M1. | 2005 | J. Appl. Microbiol. | pmid:15659187 |
| Bourriaud C et al. | Lactate is mainly fermented to butyrate by human intestinal microfloras but inter-individual variation is evident. | 2005 | J. Appl. Microbiol. | pmid:15960680 |
| Ruman J et al. | Severe hypertriglyceridemia and pancreatitis following hormone replacement prior to cryothaw transfer. | 2002 | J. Assist. Reprod. Genet. | pmid:11958513 |
| SampaÃo MA and Geber S | Births after transfer of zona-free blastocysts in oocyte donation cycles. | 2001 | J. Assist. Reprod. Genet. | pmid:11411431 |
| Schmidt J et al. | Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3. | 2011 | J. Biol. Chem. | pmid:21220428 |
| ZABIN I and BLOCH K | The formation of ketone bodies from isovaleric acid. | 1950 | J. Biol. Chem. | pmid:15436482 |
| ZABIN I and BLOCH K | The utilization of isovaleric acid for the synthesis of cholesterol. | 1950 | J. Biol. Chem. | pmid:15436483 |
| Massillon D et al. | Regulation of glucose-6-phosphatase gene expression in cultured hepatocytes and H4IIE cells by short-chain fatty acids: role of hepatic nuclear factor-4alpha. | 2003 | J. Biol. Chem. | pmid:12915406 |
| Ikeda Y et al. | Mechanism of action of short-chain, medium-chain, and long-chain acyl-CoA dehydrogenases. Direct evidence for carbanion formation as an intermediate step using enzyme-catalyzed C-2 proton/deuteron exchange in the absence of C-3 exchange. | 1985 | J. Biol. Chem. | pmid:3968064 |
| Brown AJ et al. | The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. | 2003 | J. Biol. Chem. | pmid:12496283 |
| Gadda G et al. | Identification of a cysteine residue in the active site of nitroalkane oxidase by modification with N-ethylmaleimide. | 2000 | J. Biol. Chem. | pmid:10913134 |