Valeric acid is a lipid of Fatty Acyls (FA) class. Valeric acid is associated with abnormalities such as Papillon-Lefevre Disease, Obesity, Diabetes Mellitus, Non-Insulin-Dependent and Dehydration. The involved functions are known as Process, Odorant, Stimulus, Irritation and Phenomenon. Valeric acid often locates in Receptive field, soluble, Extracellular, Entire gastrointestinal tract and Body tissue. The associated genes with Valeric acid are Orthologous Gene, Fusion Gene and AS gene. The related lipids are Valerates, butyrate, Propionate, Caproates and Palmitates.
To understand associated biological information of Valeric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Valeric acid is suspected in Obesity, Papillon-Lefevre Disease, Diabetes Mellitus, Non-Insulin-Dependent, Dehydration and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Valeric acid
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Anemia, Sickle Cell | D000755 | 34 associated lipids |
| Arthritis, Infectious | D001170 | 8 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Peripheral Nervous System Diseases | D010523 | 33 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Reye Syndrome | D012202 | 14 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Uterine Hemorrhage | D014592 | 6 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Schmidt J et al. | Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3. | 2011 | J. Biol. Chem. | pmid:21220428 |
| ZABIN I and BLOCH K | The formation of ketone bodies from isovaleric acid. | 1950 | J. Biol. Chem. | pmid:15436482 |
| ZABIN I and BLOCH K | The utilization of isovaleric acid for the synthesis of cholesterol. | 1950 | J. Biol. Chem. | pmid:15436483 |
| Ikeda Y et al. | Mechanism of action of short-chain, medium-chain, and long-chain acyl-CoA dehydrogenases. Direct evidence for carbanion formation as an intermediate step using enzyme-catalyzed C-2 proton/deuteron exchange in the absence of C-3 exchange. | 1985 | J. Biol. Chem. | pmid:3968064 |
| BUEDING E | Formation of tiglic and n-valeric acids by bacteria-free Ascaris lumbricoides. | 1953 | J. Biol. Chem. | pmid:13061475 |
| BERLINGUET L and GAUDRY R | Enzymatic resolution of DL-alpha amino-epsilon hydroxy-n caproic acid and DL-alpha amino-delta hydroxy-n-valeric acid. | 1952 | J. Biol. Chem. | pmid:12999793 |
| Ortiz-Caro J et al. | Modulation of thyroid hormone nuclear receptors by short-chain fatty acids in glial C6 cells. Role of histone acetylation. | 1986 | J. Biol. Chem. | pmid:3771518 |
| Gadda G et al. | Identification of a cysteine residue in the active site of nitroalkane oxidase by modification with N-ethylmaleimide. | 2000 | J. Biol. Chem. | pmid:10913134 |
| Park SO and Park BS | Bifidogenic effect of grain larvae extract on serum lipid, glucose and intestinal microflora in rats. | 2015 | J. Biosci. | pmid:26333397 |
| Chanprateep S and Kulpreecha S | Production and characterization of biodegradable terpolymer poly(3-hydroxybutyrate-co-3-hydroxyvalerate-co-4-hydroxybutyrate) by Alcaligenes sp. A-04. | 2006 | J. Biosci. Bioeng. | pmid:16503291 |
| Liu C et al. | Pentanoic acid, a novel protein synthesis stimulant for Chinese Hamster Ovary (CHO) cells. | 2001 | J. Biosci. Bioeng. | pmid:16232949 |
| Cho K et al. | Utilization of swine wastewater as a feedstock for the production of polyhydroxyalkanoates by Azotobacter vinelandii UWD. | 2001 | J. Biosci. Bioeng. | pmid:16232963 |
| Karlsson A et al. | Impact of trace element addition on degradation efficiency of volatile fatty acids, oleic acid and phenyl acetate and on microbial populations in a biogas digester. | 2012 | J. Biosci. Bioeng. | pmid:22683024 |
| Moita R and Lemos PC | Biopolymers production from mixed cultures and pyrolysis by-products. | 2012 | J. Biotechnol. | pmid:21983233 |
| Saha SP et al. | Studies on intracellular degradation of polyhydroxyalkanoic acid-polyethylene glycol copolymer accumulated by Azotobacter chroococcum MAL-201. | 2007 | J. Biotechnol. | pmid:17543409 |
| Iadevaia S and Mantzaris NV | Genetic network driven control of PHBV copolymer composition. | 2006 | J. Biotechnol. | pmid:16219380 |
| Fang HH and Yu H | Mesophilic acidification of gelatinaceous wastewater. | 2002 | J. Biotechnol. | pmid:11738717 |
| Pozo C et al. | Effects of culture conditions on the production of polyhydroxyalkanoates by Azotobacter chroococcum H23 in media containing a high concentration of alpechÃn (wastewater from olive oil mills) as primary carbon source. | 2002 | J. Biotechnol. | pmid:12067519 |
| Lemos PC et al. | Synthesis of polyhydroxyalkanoates from different short-chain fatty acids by mixed cultures submitted to aerobic dynamic feeding. | 2006 | J. Biotechnol. | pmid:16253370 |
| Bengtsson S et al. | Production of polyhydroxyalkanoates from fermented sugar cane molasses by a mixed culture enriched in glycogen accumulating organisms. | 2010 | J. Biotechnol. | pmid:19958801 |