Valeric acid is a lipid of Fatty Acyls (FA) class. Valeric acid is associated with abnormalities such as Papillon-Lefevre Disease, Obesity, Diabetes Mellitus, Non-Insulin-Dependent and Dehydration. The involved functions are known as Process, Odorant, Stimulus, Irritation and Phenomenon. Valeric acid often locates in Receptive field, soluble, Extracellular, Entire gastrointestinal tract and Body tissue. The associated genes with Valeric acid are Orthologous Gene, Fusion Gene and AS gene. The related lipids are Valerates, butyrate, Propionate, Caproates and Palmitates.
To understand associated biological information of Valeric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Valeric acid is suspected in Obesity, Papillon-Lefevre Disease, Diabetes Mellitus, Non-Insulin-Dependent, Dehydration and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Valeric acid
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Stomach Ulcer | D013276 | 75 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Peripheral Nervous System Diseases | D010523 | 33 associated lipids |
| Arthritis, Infectious | D001170 | 8 associated lipids |
| Anemia, Sickle Cell | D000755 | 34 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Reye Syndrome | D012202 | 14 associated lipids |
| Uterine Hemorrhage | D014592 | 6 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Laerke HN and Jensen BB | D-tagatose has low small intestinal digestibility but high large intestinal fermentability in pigs. | 1999 | J. Nutr. | pmid:10222392 |
| Täuber VU | [Percutaneous absorption of diflucortolone valerate in guinea pigs and man (author's transl)]. | 1976 | Arzneimittelforschung | pmid:1036943 |
| Täuber VU et al. | [Comparative studies in man on the percutaneous absorption of diflucortolone valerate, betamethasone-17-valerate, beclomethasone dipropionate and fluocinolone acetonide]. | 1976 | Arzneimittelforschung | pmid:1036945 |
| Redden PR et al. | Acyloxymethyl acidic drug derivatives: in vitro hydrolytic reactivity. | 1999 | Int J Pharm | pmid:10370185 |
| Erskine PT et al. | The Schiff base complex of yeast 5-aminolaevulinic acid dehydratase with laevulinic acid. | 1999 | Protein Sci. | pmid:10386874 |
| Mitomo H et al. | Biosynthesis and characterization of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) produced by Burkholderia cepacia D1. | 1999 | Int. J. Biol. Macromol. | pmid:10408637 |
| Lotti M and Moretto A | Promotion of organophosphate induced delayed polyneuropathy by certain esterase inhibitors. | 1999 | Chem. Biol. Interact. | pmid:10421491 |
| Varela A et al. | Effects of pentanoate, 4-pentenoate, 3-hydroxybutyrate and insulin on the tissue-levels of long-chain acyl CoA and acylcarnitine in the oxygenated and hypoxic rat atria. | 1999 | Arch. Physiol. Biochem. | pmid:10455555 |
| Sakata T et al. | Probiotic preparations dose-dependently increase net production rates of organic acids and decrease that of ammonia by pig cecal bacteria in batch culture. | 1999 | Dig. Dis. Sci. | pmid:10489936 |
| Gysler A et al. | Skin penetration and metabolism of topical glucocorticoids in reconstructed epidermis and in excised human skin. | 1999 | Pharm. Res. | pmid:10496654 |
| Gadda G et al. | Identification of an essential tyrosine residue in nitroalkane oxidase by modification with tetranitromethane. | 2000 | Biochemistry | pmid:10653664 |
| Gadda G and Fitzpatrick PF | Mechanism of nitroalkane oxidase: 2. pH and kinetic isotope effects. | 2000 | Biochemistry | pmid:10684621 |
| Diwan AD et al. | Nitric oxide modulates fracture healing. | 2000 | J. Bone Miner. Res. | pmid:10703937 |
| Paassilta M et al. | Insulin-like growth factor binding protein-1 (IGFBP-1) and IGF-I during oral and transdermal estrogen replacement therapy: relation to lipoprotein(a) levels. | 2000 | Atherosclerosis | pmid:10704627 |
| Bui CT et al. | Comparative study of reductive amination reaction on 5-(4-formyl-3,5-dimethoxyphenoxy)valeric acid and its monomethoxy analog using the Multipin approach. | 1998 | Mol. Divers. | pmid:10729900 |
| Range SP et al. | Selectivity of cyclo-oxygenase inhibitors in human pulmonary epithelial and smooth muscle cells. | 2000 | Eur. Respir. J. | pmid:10780769 |
| Wächtershäuser A et al. | PPAR-gamma is selectively upregulated in Caco-2 cells by butyrate. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10833422 |
| Palmeira CM et al. | Induction of the mitochondrial permeability transition in vitro by short-chain carboxylic acids. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10833431 |
| Propper DJ et al. | Phase II study of the oxygen saturation curve left shifting agent BW12C in combination with the hypoxia activated drug mitomycin C in advanced colorectal cancer. | 2000 | Br. J. Cancer | pmid:10839290 |
| Johnson BA and Leon M | Modular representations of odorants in the glomerular layer of the rat olfactory bulb and the effects of stimulus concentration. | 2000 | J. Comp. Neurol. | pmid:10861522 |
| Gadda G et al. | Identification of a cysteine residue in the active site of nitroalkane oxidase by modification with N-ethylmaleimide. | 2000 | J. Biol. Chem. | pmid:10913134 |
| Yang JH et al. | Hormone replacement therapy reverses the decrease in natural killer cytotoxicity but does not reverse the decreases in the T-cell subpopulation or interferon-gamma production in postmenopausal women. | 2000 | Fertil. Steril. | pmid:10927042 |
| Dessirier JM et al. | Sensitization, desensitization and stimulus-induced recovery of trigeminal neuronal responses to oral capsaicin and nicotine. | 2000 | J. Neurophysiol. | pmid:11024077 |
| Böttcher MF et al. | Microflora-associated characteristics in faeces from allergic and nonallergic infants. | 2000 | Clin. Exp. Allergy | pmid:11069568 |
| Snyder SE et al. | Radiolabeled cholinesterase substrates: in vitro methods for determining structure-activity relationships and identification of a positron emission tomography radiopharmaceutical for in vivo measurement of butyrylcholinesterase activity. | 2001 | J. Cereb. Blood Flow Metab. | pmid:11176278 |
| Trotsenko IuA and Belova LL | [Organization and regulation of polyhydroxybutyrate/valerate biosynthesis in bacteria]. | 2000 Nov-Dec | Mikrobiologiia | pmid:11195572 |
| Bandyk CA et al. | Effect of ruminal vs postruminal administration of degradable protein on utilization of low-quality forage by beef steers. | 2001 | J. Anim. Sci. | pmid:11204704 |
| Hübener F and Laska M | A two-choice discrimination method to assess olfactory performance in pigtailed macaques, Macaca nemestrina. | 2001 | Physiol. Behav. | pmid:11282134 |
| Gadda G et al. | Evidence for an essential arginine in the flavoprotein nitroalkane oxidase. | 2001 | J. Enzym. Inhib. | pmid:11342284 |
| Lens PN et al. | Effect of the liquid upflow velocity on thermophilic sulphate reduction in acidifying granular sludge reactors. | 2001 | Environ Technol | pmid:11349377 |
| Khang G et al. | Preparation and characterization of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) microspheres for the sustained release of 5-fluorouracil. | 2001 | Biomed Mater Eng | pmid:11352116 |
| Karagül-Yüceer Y et al. | Aroma-active components of nonfat dry milk. | 2001 | J. Agric. Food Chem. | pmid:11409991 |
| SampaÃo MA and Geber S | Births after transfer of zona-free blastocysts in oocyte donation cycles. | 2001 | J. Assist. Reprod. Genet. | pmid:11411431 |
| Etchebehere C et al. | Comamonas nitrativorans sp. nov., a novel denitrifier isolated from a denitrifying reactor treating landfill leachate. | 2001 | Int. J. Syst. Evol. Microbiol. | pmid:11411724 |
| Song C et al. | Production of poly(3-hydroxybutyrateco-3-hydroxyvalerate) from cottonseed oil and valeric acid in batch culture of Raistonia sp. strain JC-64. | 2001 | Appl. Biochem. Biotechnol. | pmid:11456295 |
| Tateoka R et al. | Significance of substrate hydrophobicity for recognition by an oligopeptide transporter (PEPT1). | Bioconjug. Chem. | pmid:11459451 | |
| Wilbur DS et al. | Biotin reagents for antibody pretargeting. 5. Additional studies of biotin conjugate design to provide biotinidase stability. | 2001 Jul-Aug | Bioconjug. Chem. | pmid:11459467 |
| Besong S et al. | Influence of supplemental chromium on concentrations of liver triglyceride, blood metabolites and rumen VFA profile in steers fed a moderately high fat diet. | 2001 | J. Dairy Sci. | pmid:11467818 |
| Koivu TA et al. | The relation of oxidized LDL autoantibodies and long-term hormone replacement therapy to ultrasonographically assessed atherosclerotic plaque quantity and severity in postmenopausal women. | 2001 | Atherosclerosis | pmid:11472749 |
| Dangel BD et al. | Selective functionalization of amino acids in water: a synthetic method via catalytic C-H bond activation. | 2001 | J. Am. Chem. Soc. | pmid:11506585 |
| Chen FP et al. | Comparison of transdermal and oral estrogen-progestin replacement therapy: effects on cardiovascular risk factors. | 2001 Sep-Oct | Menopause | pmid:11528361 |
| Prueksaritanont T et al. | beta-Oxidation of simvastatin in mouse liver preparations. | 2001 | Drug Metab. Dispos. | pmid:11560866 |
| Kristensen NB | Rumen microbial sequestration of [2-(13)C]acetate in cattle. | 2001 | J. Anim. Sci. | pmid:11583438 |
| Kuznetsov DD et al. | Intravesical valrubicin in the treatment of carcinoma in situ of the bladder. | 2001 | Expert Opin Pharmacother | pmid:11585003 |
| Vitale C et al. | Effect of estradiol valerate alone or in association with cyproterone acetate upon vascular function of postmenopausal women at increased risk for cardiovascular disease. | 2001 | Maturitas | pmid:11731185 |
| Fang HH and Yu H | Mesophilic acidification of gelatinaceous wastewater. | 2002 | J. Biotechnol. | pmid:11738717 |
| Kang HO et al. | Cometabolic biosynthesis of copolyesters consisting of 3-hydroxyvalerate and medium-chain-length 3-hydroxyalkanoates by Pseudomonas sp. DSY-82. | 2001 | Antonie Van Leeuwenhoek | pmid:11759051 |
| Karagül-Yüceer Y et al. | Volatile flavor components of stored nonfat dry milk. | 2002 | J. Agric. Food Chem. | pmid:11782199 |
| Wellington K and Perry CM | Estradiol valerate/dienogest. | 2002 | Drugs | pmid:11827562 |
| Subramanian R et al. | Structural characterization of in vivo rat glutathione adducts and a hydroxylated metabolite of simvastatin hydroxy acid. | 2002 | Drug Metab. Dispos. | pmid:11854137 |
| Nguyen S et al. | Thermal degradation of poly(3-hydroxyalkanoates): preparation of well-defined oligomers. | Biomacromolecules | pmid:11866577 | |
| Seelig AS et al. | Comparison of cryopreservation outcome with gonadotropin-releasing hormone agonists or antagonists in the collecting cycle. | 2002 | Fertil. Steril. | pmid:11872197 |
| Schneider IC et al. | Fermentation of cottonseed and other feedstuffs in cattle rumen fluid. | 2002 | J. Agric. Food Chem. | pmid:11929282 |
| Soto-Cruz O et al. | Modeling of growth, lactate consumption, and volatile fatty acid production by Megasphaera elsdenii cultivated in minimal and complex media. | Biotechnol. Prog. | pmid:11934285 | |
| Ruman J et al. | Severe hypertriglyceridemia and pancreatitis following hormone replacement prior to cryothaw transfer. | 2002 | J. Assist. Reprod. Genet. | pmid:11958513 |
| Castillo P et al. | Comparative study of differentiation levels and valepotriate content of in vitro cultures and regenerated and wild plants of Valeriana edulis ssp.procera. | 2002 | J. Nat. Prod. | pmid:11975504 |
| Araki Y et al. | In vitro alterations in fecal short chain fatty acids and organic anions induced by the destruction of intestinal microflora under hypotonic and aerobic conditions. | 2002 | Int. J. Mol. Med. | pmid:12011980 |
| Wong PA et al. | Production of specific copolymers of polyhydroxyalkanoates from industrial waste. | 2002 | Appl. Biochem. Biotechnol. | pmid:12018290 |
| Kim JK et al. | Mass production of methane from food wastes with concomitant wastewater treatment. | 2002 | Appl. Biochem. Biotechnol. | pmid:12018299 |
| Khalili H and Huhtanen P | Effect of casein infusion in the rumen, duodenum or both sites on factors affecting forage intake and performance of dairy cows fed red clover-grass silage. | 2002 | J. Dairy Sci. | pmid:12018436 |
| Macha S and Mitra AK | Ocular disposition of ganciclovir and its monoester prodrugs following intravitreal administration using microdialysis. | 2002 | Drug Metab. Dispos. | pmid:12019194 |
| Akay V et al. | NutriDense and waxy corn hybrids: effects on site and extent of disappearance of nutrients in sheep. | 2002 | J. Anim. Sci. | pmid:12019623 |
| Njagi PG and Torto B | Evidence for a compound in Comstock-Kellog glands modulating premating behavior in male desert locust, Schistocerca gregaria. | 2002 | J. Chem. Ecol. | pmid:12049227 |
| Kashefi K et al. | Geoglobus ahangari gen. nov., sp. nov., a novel hyperthermophilic archaeon capable of oxidizing organic acids and growing autotrophically on hydrogen with Fe(III) serving as the sole electron acceptor. | 2002 | Int. J. Syst. Evol. Microbiol. | pmid:12054231 |
| Pozo C et al. | Effects of culture conditions on the production of polyhydroxyalkanoates by Azotobacter chroococcum H23 in media containing a high concentration of alpechÃn (wastewater from olive oil mills) as primary carbon source. | 2002 | J. Biotechnol. | pmid:12067519 |
| Arcidiacono S et al. | A rapid selective extraction procedure for the outer membrane protein (OmpF) from Escherichia coli. | 2002 | Protein Expr. Purif. | pmid:12071708 |
| Sanjuán A et al. | Cyproterone acetate could counteract the benefits of estradiol valerate in oophorectomized cholesterol-fed rabbits. | 2002 Jul-Aug | Menopause | pmid:12082364 |
| Sudo S et al. | Sensitization of trigeminal caudalis neuronal responses to intraoral acid and salt stimuli and desensitization by nicotine. | 2002 | Pain | pmid:12127029 |
| Seki M et al. | A novel synthesis of (+)-biotin from L-cysteine. | 2002 | J. Org. Chem. | pmid:12153250 |
| Ezquerro O et al. | Development of a headspace solid-phase microextraction-gas chromatography-mass spectrometry method for the identification of odour-causing volatile compounds in packaging materials. | 2002 | J Chromatogr A | pmid:12187994 |
| Miller-Webster T et al. | Influence of yeast culture on ruminal microbial metabolism in continuous culture. | 2002 | J. Dairy Sci. | pmid:12214993 |
| Suzuki-Mizushima Y et al. | Enhancement of NGF- and cholera toxin-induced neurite outgrowth by butyrate in PC12 cells. | 2002 | Brain Res. | pmid:12270499 |
| Saletu B et al. | Hormone replacement therapy and vigilance: double-blind, placebo-controlled EEG-mapping studies with an estrogen-progestogen combination (Climodien, Lafamme) versus estrogen alone in menopausal syndrome patients. | 2002 | Maturitas | pmid:12443834 |
| Crublet ML et al. | Acylated triterpenoid saponins from the stem bark of Foetidia africana. | 2002 | J. Nat. Prod. | pmid:12444677 |
| Brown AJ et al. | The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. | 2003 | J. Biol. Chem. | pmid:12496283 |
| Cherry N et al. | Oestrogen therapy for prevention of reinfarction in postmenopausal women: a randomised placebo controlled trial. | 2002 Dec 21-28 | Lancet | pmid:12504395 |
| Embleton JK and Tighe BJ | Polymers for biodegradable medical devices XI. Microencapsulation studies: characterization of hydrocortisone-loaded poly-hydroxybutyrate-hydroxyvalerate microspheres. | 2002 Nov-Dec | J Microencapsul | pmid:12569022 |
| Anderer P et al. | Effects of hormone replacement therapy on perceptual and cognitive event-related potentials in menopausal insomnia. | 2003 | Psychoneuroendocrinology | pmid:12573306 |
| Gökçe M et al. | Left ventricular diastolic function assessment by tissue Doppler echocardiography in relation to hormonal replacement therapy in postmenopausal women with diastolic dysfunction. | Am J Ther | pmid:12629588 | |
| Sutton JD et al. | Effect of method of application of a fibrolytic enzyme product on digestive processes and milk production in Holstein-Friesian cows. | 2003 | J. Dairy Sci. | pmid:12647961 |
| Sudo S et al. | Activation of neurons in trigeminal caudalis by noxious oral acidic or salt stimuli is not reduced by amiloride. | 2003 | Brain Res. | pmid:12676384 |
| Nilsson NE et al. | Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12684041 |
| Nadeau JA et al. | Effects of hydrochloric, valeric, and other volatile fatty acids on pathogenesis of ulcers in the nonglandular portion of the stomach of horses. | 2003 | Am. J. Vet. Res. | pmid:12693529 |
| Jacob TJ et al. | Psychophysical evaluation of responses to pleasant and mal-odour stimulation in human subjects; adaptation, dose response and gender differences. | 2003 | Int J Psychophysiol | pmid:12694902 |
| Pind PF et al. | Dynamics of the anaerobic process: effects of volatile fatty acids. | 2003 | Biotechnol. Bioeng. | pmid:12701145 |
| Schroeder JW | Optimizing the level of wet corn gluten feed in the diet of lactating dairy cows. | 2003 | J. Dairy Sci. | pmid:12703621 |
| Simons CT et al. | Lack of quinine-evoked activity in rat trigeminal subnucleus caudalis. | 2003 | Chem. Senses | pmid:12714448 |
| Vuotto ML et al. | Improvement of (+)-catechin inhibitory activity on human PMN respiratory burst by (+)-3-O-propionyl and (-)-3-O-valeryl substitution. | 2003 | J. Pharm. Pharmacol. | pmid:12724048 |
| Zini E et al. | Heterogeneous acylation of flax fibers. Reaction kinetics and surface properties. | Biomacromolecules | pmid:12741804 | |
| Flotats X et al. | Parameter identification of thermophilic anaerobic degradation of valerate. | Appl. Biochem. Biotechnol. | pmid:12794283 | |
| Mancuso G et al. | Efficacy of betamethasone valerate foam formulation in comparison with betamethasone dipropionate lotion in the treatment of mild-to-moderate alopecia areata: a multicenter, prospective, randomized, controlled, investigator-blinded trial. | 2003 | Int. J. Dermatol. | pmid:12839615 |
| Choi GG et al. | Production of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) with high molar fractions of 3-hydroxyvalerate by a threonine-overproducing mutant of Alcaligenes sp. SH-69. | 2003 | Biotechnol. Lett. | pmid:12882163 |
| Lakshman K and Shamala TR | Enhanced biosynthesis of polyhydroxyalkanoates in a mutant strain of Rhizobium meliloti. | 2003 | Biotechnol. Lett. | pmid:12882285 |
| Song R et al. | Synthesis and cytotoxicity of new platinum(IV) complexes of mixed carboxylates. | 2003 | J. Inorg. Biochem. | pmid:12888269 |
| Wallace RJ et al. | Eubacterium pyruvativorans sp. nov., a novel non-saccharolytic anaerobe from the rumen that ferments pyruvate and amino acids, forms caproate and utilizes acetate and propionate. | 2003 | Int. J. Syst. Evol. Microbiol. | pmid:12892112 |
| Massillon D et al. | Regulation of glucose-6-phosphatase gene expression in cultured hepatocytes and H4IIE cells by short-chain fatty acids: role of hepatic nuclear factor-4alpha. | 2003 | J. Biol. Chem. | pmid:12915406 |
| Rishel MJ et al. | Conformationally constrained analogues of bleomycin A5. | 2003 | J. Am. Chem. Soc. | pmid:12926941 |
| Donzello MP et al. | Synthesis, X-ray crystal structure, UV/visible linear and nonlinear (optical limiting) spectral properties of symmetrical and unsymmetrical porphyrazines with annulated 1,2,5-thiadiazole and 1,4-diamyloxybenzene moieties. | 2003 | Chemistry | pmid:12953187 |
| Batstone DJ et al. | Kinetics of thermophilic, anaerobic oxidation of straight and branched chain butyrate and valerate. | 2003 | Biotechnol. Bioeng. | pmid:12966576 |