Valeric acid is a lipid of Fatty Acyls (FA) class. Valeric acid is associated with abnormalities such as Papillon-Lefevre Disease, Obesity, Diabetes Mellitus, Non-Insulin-Dependent and Dehydration. The involved functions are known as Process, Odorant, Stimulus, Irritation and Phenomenon. Valeric acid often locates in Receptive field, soluble, Extracellular, Entire gastrointestinal tract and Body tissue. The associated genes with Valeric acid are Orthologous Gene, Fusion Gene and AS gene. The related lipids are Valerates, butyrate, Propionate, Caproates and Palmitates.
To understand associated biological information of Valeric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Valeric acid is suspected in Obesity, Papillon-Lefevre Disease, Diabetes Mellitus, Non-Insulin-Dependent, Dehydration and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Valeric acid
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Stomach Ulcer | D013276 | 75 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Peripheral Nervous System Diseases | D010523 | 33 associated lipids |
| Arthritis, Infectious | D001170 | 8 associated lipids |
| Anemia, Sickle Cell | D000755 | 34 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Reye Syndrome | D012202 | 14 associated lipids |
| Uterine Hemorrhage | D014592 | 6 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
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| Nguyen S et al. | Thermal degradation of poly(3-hydroxyalkanoates): preparation of well-defined oligomers. | Biomacromolecules | pmid:11866577 | |
| Flotats X et al. | Parameter identification of thermophilic anaerobic degradation of valerate. | Appl. Biochem. Biotechnol. | pmid:12794283 | |
| pmid: | ||||
| Tateoka R et al. | Significance of substrate hydrophobicity for recognition by an oligopeptide transporter (PEPT1). | Bioconjug. Chem. | pmid:11459451 | |
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| DEICHMANN WB et al. | Observations on the effects of gamma-valero-lactone upon experimental animals. | 1945 | J Ind Hyg Toxicol | pmid:21007121 |
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| CORSE J et al. | Alpha-Amino-beta-mercapto-n-valeric acid hydrochloride. | 1948 | J. Am. Chem. Soc. | pmid:18918849 |
| STADTMAN ER et al. | Tracer experiments on the mechanism of synthesis of valeric and caproic acids by Clostridium kluyveri. | 1949 | J. Biol. Chem. | pmid:18116989 |
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| MEISTER A | Studies on d- and tau-alpha-keto-beta-methylvaleric acids. | 1951 | J. Biol. Chem. | pmid:14841174 |
| GAUDRY R | The synthesis of amino acids from 2,3-dihydrofuran DL-ornithine, DL-proline, and DL-alpha-amino-delta-hydroxyvaleric acid. | 1951 | Can J Chem | pmid:14848757 |
| PICCOLI B | [Action of alpha-amino-valeric acid in the local treatment of wounds; (experimental study)]. | 1951 | G Ital Chir | pmid:14860561 |
| BERLINGUET L and GAUDRY R | Enzymatic resolution of DL-alpha amino-epsilon hydroxy-n caproic acid and DL-alpha amino-delta hydroxy-n-valeric acid. | 1952 | J. Biol. Chem. | pmid:12999793 |
| ANNISON EF and PENNINGTON RJ | The metabolism of n-valeric acid and some branched chain acids by sheep tissues in vitro. | 1952 | Biochem. J. | pmid:13018194 |
| BROUWER E and NIJKAMP HJ | Occurrence of two valeric acids (beta-methylbutyric acid and alpha-methylbutyric acid) in the hair grease of the dog. | 1953 | Biochem. J. | pmid:13105653 |
| BUEDING E | Formation of tiglic and n-valeric acids by bacteria-free Ascaris lumbricoides. | 1953 | J. Biol. Chem. | pmid:13061475 |
| HIGUCHI T and LACH JL | Investigation of some complexes formed in solution by caffeine. V. Interactions between caffeine and p-aminobenzoic acid, m-hydroxybenzoic acid, picric acid, o-phthalic acid, suberic acid, and valeric acid. | 1954 | J Am Pharm Assoc Am Pharm Assoc | pmid:13201472 |
| THOAI NV and LACOMBE G | [Presence of delta-guanido-n-valeric acid in human urine]. | 1958 | Biochim. Biophys. Acta | pmid:13572369 |
| VERBEKE R et al. | Incorporation of DL-[1-14C]leucine and [1-14C]liso valeric acid into milk constituents by the perfused cow's udder. | 1959 | Biochem. J. | pmid:13855213 |
| GERSON T et al. | The role of n-valeric acid in the synthesis of the higher saturated straight-chain acids containing an odd number of carbon atoms in bovine milk fat. | 1960 | Biochem. J. | pmid:13827621 |
| Babenko GA and Vandzhura IP | [Use of zinc valerate in the complex treatment of ischemic disease]. | 1971 | Vrach Delo | pmid:5143053 |
| Baisden LA et al. | n-Valeric acid in stomachs and on unwashed hair of swine. | 1972 | J. Anim. Sci. | pmid:5039919 |
| Baisden LA et al. | Comparison of pepsin and alkali digestion methods for determining n-valeric acid in trichinous swine muscle. | 1972 | J. Parasitol. | pmid:4562322 |
| Weber G | Letter: The treatment of cavernous haemangioma with topical betamethasone 17 valerate. | 1973 | Br. J. Dermatol. | pmid:4802519 |
| Holland PC and Sherratt HS | Biochemical effects of the hypoglycaemic compound pent-4-enoic acid and related non-hypoglycaemic fatty acids. Effects of the free acids and their carnitine esters on coenzyme A-dependent oxidations in rat liver mitochondria. | 1973 | Biochem. J. | pmid:4772622 |
| Bassett JM et al. | Regulation of insulin secretion in the ovine foetus in utero. Effects of sodium valerate on secretion and of adrenocorticotrophin-induced premature parturition on the insulin secretory response to glucose. | 1973 | J. Endocrinol. | pmid:4345761 |
| Chen S and Engel PC | Protection of glutamate dehydrogenase by nicotinamide-adenine dinucleotide against reversible inactivation by pyridoxal 5'-phosphate as a sensitive indicator of conformational change induced by substrates and substrate analogues. | 1974 | Biochem. J. | pmid:4376949 |
| Tomlinson EB | Progressive myoclonic epilepsy. The response to sodium di -- n -- propylacetate. | 1974 | Proc Aust Assoc Neurol | pmid:4620029 |
| Hiller EJ and Milner AD | Betamethasone 17 valerate aerosol and disodium chromoglycate in severe childhood asthma. | 1975 | Br J Dis Chest | pmid:806293 |
| Kapp VJ et al. | [Studies on the Pharmacology of 6alpha,9-difluoro-11beta-hydroxy-16alpha-methyl-21-valeryloxy-1,4-pregnadiene-3,20-dione (diflucortolon valerate) (author's transl)]. | 1976 | Arzneimittelforschung | pmid:188428 |
| Täuber VU | [Percutaneous absorption of diflucortolone valerate in guinea pigs and man (author's transl)]. | 1976 | Arzneimittelforschung | pmid:1036943 |
| Täuber VU et al. | [Comparative studies in man on the percutaneous absorption of diflucortolone valerate, betamethasone-17-valerate, beclomethasone dipropionate and fluocinolone acetonide]. | 1976 | Arzneimittelforschung | pmid:1036945 |
| Smith RV et al. | GLC determination of indoprofen in plasma. | 1977 | J Pharm Sci | pmid:299889 |
| Nielsen FH et al. | Changes in serum lipids during treatment with norgestrel, oestradiol-valerate and cycloprogynon. | 1977 | Acta Obstet Gynecol Scand | pmid:602705 |
| Munro DD et al. | Betamethasone valerate ointment compared with fluocinonide FAPG. | 1977 | Arch Dermatol | pmid:856049 |
| Hölzle E and Plewig G | Effects of dermatitis, stripping, and steroids on the morphology of corneocytes. A new bioassay. | 1977 | J. Invest. Dermatol. | pmid:864272 |