Valeric acid is a lipid of Fatty Acyls (FA) class. Valeric acid is associated with abnormalities such as Papillon-Lefevre Disease, Obesity, Diabetes Mellitus, Non-Insulin-Dependent and Dehydration. The involved functions are known as Process, Odorant, Stimulus, Irritation and Phenomenon. Valeric acid often locates in Receptive field, soluble, Extracellular, Entire gastrointestinal tract and Body tissue. The associated genes with Valeric acid are Orthologous Gene, Fusion Gene and AS gene. The related lipids are Valerates, butyrate, Propionate, Caproates and Palmitates.
To understand associated biological information of Valeric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Valeric acid is suspected in Obesity, Papillon-Lefevre Disease, Diabetes Mellitus, Non-Insulin-Dependent, Dehydration and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Valeric acid
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Stomach Ulcer | D013276 | 75 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Peripheral Nervous System Diseases | D010523 | 33 associated lipids |
| Arthritis, Infectious | D001170 | 8 associated lipids |
| Anemia, Sickle Cell | D000755 | 34 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Reye Syndrome | D012202 | 14 associated lipids |
| Uterine Hemorrhage | D014592 | 6 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Saunders MJ et al. | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. | 2010 | Curr Protoc Cytom | pmid:20938917 |
| Janoria KG et al. | Biotin uptake by rabbit corneal epithelial cells: role of sodium-dependent multivitamin transporter (SMVT). | 2006 | Curr. Eye Res. | pmid:17038304 |
| Chang SC and Lee VH | Influence of chain length on the in vitro hydrolysis of model ester prodrugs by ocular esterases. | 1982-1983 | Curr. Eye Res. | pmid:7186434 |
| Saunders MJ et al. | Microsphere-based protease assays and screening application for lethal factor and factor Xa. | 2006 | Cytometry A | pmid:16604538 |
| Cañadillas-Delgado L et al. | Intramolecular ferro- and antiferromagnetic interactions in oxo-carboxylate bridged digadolinium(III) complexes. | 2010 | Dalton Trans | pmid:20593071 |
| Tan CP et al. | Selective small-molecule agonists of G protein-coupled receptor 40 promote glucose-dependent insulin secretion and reduce blood glucose in mice. | 2008 | Diabetes | pmid:18477808 |
| Sakata T et al. | Probiotic preparations dose-dependently increase net production rates of organic acids and decrease that of ammonia by pig cecal bacteria in batch culture. | 1999 | Dig. Dis. Sci. | pmid:10489936 |
| Sagar PM et al. | Acute pouchitis and deficiencies of fuel. | 1995 | Dis. Colon Rectum | pmid:7736879 |
| Carter LP et al. | Comparison of the behavioral effects of gamma-hydroxybutyric acid (GHB) and its 4-methyl-substituted analog, gamma-hydroxyvaleric acid (GHV). | 2005 | Drug Alcohol Depend | pmid:15769562 |
| Bijaya G et al. | Synthesis and evaluation of esmolol prodrugs for transdermal delivery. | Drug Deliv | pmid:20553111 | |
| Ekins S et al. | A predictive ligand-based Bayesian model for human drug-induced liver injury. | 2010 | Drug Metab. Dispos. | pmid:20843939 |
| Macha S and Mitra AK | Ocular disposition of ganciclovir and its monoester prodrugs following intravitreal administration using microdialysis. | 2002 | Drug Metab. Dispos. | pmid:12019194 |
| Subramanian R et al. | Structural characterization of in vivo rat glutathione adducts and a hydroxylated metabolite of simvastatin hydroxy acid. | 2002 | Drug Metab. Dispos. | pmid:11854137 |
| Prueksaritanont T et al. | beta-Oxidation of simvastatin in mouse liver preparations. | 2001 | Drug Metab. Dispos. | pmid:11560866 |
| Wellington K and Perry CM | Estradiol valerate/dienogest. | 2002 | Drugs | pmid:11827562 |
| Yen PM and Tashjian AH | Short chain fatty acids increase prolactin and growth hormone production and alter cell morphology in the GH3 strain of rat pituitary cells. | 1981 | Endocrinology | pmid:7238401 |
| Lens PN et al. | Effect of the liquid upflow velocity on thermophilic sulphate reduction in acidifying granular sludge reactors. | 2001 | Environ Technol | pmid:11349377 |
| Duncan SH et al. | The role of pH in determining the species composition of the human colonic microbiota. | 2009 | Environ. Microbiol. | pmid:19397676 |
| Lemos PC et al. | Elucidation of metabolic pathways in glycogen-accumulating organisms with in vivo 13C nuclear magnetic resonance. | 2007 | Environ. Microbiol. | pmid:17922754 |
| Vujić JM et al. | Stereospecific ligands and their complexes. Part VII. Synthesis, characterization and in vitro antitumoral activity of platinum(II) complexes with O,O'-dialkyl esters of (S,S)-ethylenediamine-N,N'-di-2-(4-methyl)pentanoic acid. | 2011 | Eur J Med Chem | pmid:21840630 |
| Hand KV et al. | Examining acute and chronic effects of short- and long-chain fatty acids on peptide YY (PYY) gene expression, cellular storage and secretion in STC-1 cells. | 2013 | Eur J Nutr | pmid:22926626 |
| Jaschonek K et al. | Desensitization of platelets to iloprost. Loss of specific binding sites and heterologous desensitization of adenylate cyclase. | 1988 | Eur. J. Pharmacol. | pmid:2452749 |
| Youdim MB et al. | The glycine-prodrug, milacemide, increases the seizure threshold due to hyperbaric oxygen; prevention by 1-deprenyl. | 1988 | Eur. J. Pharmacol. | pmid:3138141 |
| Range SP et al. | Selectivity of cyclo-oxygenase inhibitors in human pulmonary epithelial and smooth muscle cells. | 2000 | Eur. Respir. J. | pmid:10780769 |
| van den Meerschaut L and Sünder A | The homeopathic preparation Nervoheel N can offer an alternative to lorazepam therapy for mild nervous disorders. | 2009 | Evid Based Complement Alternat Med | pmid:18955261 |
| Mueller A et al. | Body composition and bone mineral density in male-to-female transsexuals during cross-sex hormone therapy using gonadotrophin-releasing hormone agonist. | 2011 | Exp. Clin. Endocrinol. Diabetes | pmid:20625973 |
| Sigel H | The coordinating properties of d-biotin. | 1981 | Experientia | pmid:7286129 |
| Kuznetsov DD et al. | Intravesical valrubicin in the treatment of carcinoma in situ of the bladder. | 2001 | Expert Opin Pharmacother | pmid:11585003 |
| Kumar A et al. | Redox homeostasis in mycobacteria: the key to tuberculosis control? | 2011 | Expert Rev Mol Med | pmid:22172201 |
| Sorokin DY et al. | Propionate and butyrate dependent bacterial sulfate reduction at extremely haloalkaline conditions and description of Desulfobotulus alkaliphilus sp. nov. | 2010 | Extremophiles | pmid:19888546 |
| de Bernard M et al. | TPA and butyrate increase cell sensitivity to the vacuolating toxin of Helicobacter pylori. | 1998 | FEBS Lett. | pmid:9781682 |
| Guan LL et al. | Linkage of microbial ecology to phenotype: correlation of rumen microbial ecology to cattle's feed efficiency. | 2008 | FEMS Microbiol. Lett. | pmid:18785930 |
| Kendall MM et al. | Butyrate- and propionate-degrading syntrophs from permanently cold marine sediments in Skan Bay, Alaska, and description of Algorimarina butyrica gen. nov., sp. nov. | 2006 | FEMS Microbiol. Lett. | pmid:16907746 |
| Ghanem ME et al. | The effect of luteal phase support protocol on cycle outcome and luteal phase hormone profile in long agonist protocol intracytoplasmic sperm injection cycles: a randomized clinical trial. | 2009 | Fertil. Steril. | pmid:19464001 |
| Adaikan PG et al. | Efficacy of red clover isoflavones in the menopausal rabbit model. | 2009 | Fertil. Steril. | pmid:18973881 |
| Cruz G et al. | Temporal window in which exposure to estradiol permanently modifies ovarian function causing polycystic ovary morphology in rats. | 2012 | Fertil. Steril. | pmid:22854013 |
| Chen X and Chen SL | A woman with premature ovarian failure induced by Tripterygium wilfordii Hook.f. gives birth to a healthy child. | 2011 | Fertil. Steril. | pmid:21640345 |
| Seelig AS et al. | Comparison of cryopreservation outcome with gonadotropin-releasing hormone agonists or antagonists in the collecting cycle. | 2002 | Fertil. Steril. | pmid:11872197 |
| Elgindy EA et al. | Does luteal estradiol supplementation have a role in long agonist cycles? | 2010 | Fertil. Steril. | pmid:19243745 |
| El-Toukhy T et al. | The relationship between endometrial thickness and outcome of medicated frozen embryo replacement cycles. | 2008 | Fertil. Steril. | pmid:17681313 |
| Serhal PF and Craft IL | Ovum donation--a simplified approach. | 1987 | Fertil. Steril. | pmid:2440730 |
| Seidman DS et al. | Estradiol valerate as a possible endocrine reproductive disruptor: evidence from an in vivo rat model. | 2009 | Fertil. Steril. | pmid:18973879 |
| Lundström E et al. | Digitized assessment of mammographic breast density in patients who received low-dose intrauterine levonorgestrel in continuous combination with oral estradiol valerate: a pilot study. | 2006 | Fertil. Steril. | pmid:16580385 |
| Yang JH et al. | Hormone replacement therapy reverses the decrease in natural killer cytotoxicity but does not reverse the decreases in the T-cell subpopulation or interferon-gamma production in postmenopausal women. | 2000 | Fertil. Steril. | pmid:10927042 |
| Peron G et al. | The antiadhesive activity of cranberry phytocomplex studied by metabolomics: Intestinal PAC-A metabolites but not intact PAC-A are identified as markers in active urines against uropathogenic Escherichia coli. | 2017 | Fitoterapia | pmid:28844930 |
| PospÃsil S et al. | Activity of the AIB factor observed in prokaryotic and eukaryotic microorganisms. | 1993 | Folia Microbiol. (Praha) | pmid:8375780 |
| Barry KA et al. | The impact of commercial human infant formula on fecal attributes in a weanling pig model. | 2008 | Food Chem. Toxicol. | pmid:18221830 |
| Moen B et al. | Extrusion of barley and oat influence the fecal microbiota and SCFA profile of growing pigs. | 2016 | Food Funct | pmid:26758043 |
| Jang M et al. | Monitoring of urinary metabolites of JWH-018 and JWH-073 in legal cases. | 2013 | Forensic Sci. Int. | pmid:23890611 |
| Emerson B et al. | Gas chromatography-mass spectrometry of JWH-018 metabolites in urine samples with direct comparison to analytical standards. | 2013 | Forensic Sci. Int. | pmid:23683902 |
| Erol Öztürk Y et al. | Validation of JWH-018 and its metabolites in blood and urine by UPLC-MS/MS: Monitoring in forensic cases. | 2015 | Forensic Sci. Int. | pmid:25616218 |
| Rubino T and Parolaro D | Sexually dimorphic effects of cannabinoid compounds on emotion and cognition. | 2011 | Front Behav Neurosci | pmid:21991251 |
| Fichtel K et al. | Isolation of sulfate-reducing bacteria from sediments above the deep-subseafloor aquifer. | 2012 | Front Microbiol | pmid:22363336 |
| Suzzi G | From wild strain to domesticated strain: the philosophy of microbial diversity in foods. | 2011 | Front Microbiol | pmid:21887153 |
| Cleland TA et al. | Sequential mechanisms underlying concentration invariance in biological olfaction. | 2011 | Front Neuroeng | pmid:22287949 |
| PICCOLI B | [Action of alpha-amino-valeric acid in the local treatment of wounds; (experimental study)]. | 1951 | G Ital Chir | pmid:14860561 |
| Hynes MJ et al. | Genetic analysis of the role of peroxisomes in the utilization of acetate and fatty acids in Aspergillus nidulans. | 2008 | Genetics | pmid:18245820 |
| Dinalo JE and Relman DA | Cross-talk in the gut. | 2009 | Genome Biol. | pmid:19216729 |
| Kinross JM et al. | Gut microbiome-host interactions in health and disease. | 2011 | Genome Med | pmid:21392406 |
| Fatemi HM et al. | Addition of estradiol to progesterone for luteal supplementation in patients stimulated with GnRH antagonist/rFSH for IVF: a randomized controlled trial. | 2006 | Hum. Reprod. | pmid:16857887 |
| Son WY et al. | A 38 h interval between hCG priming and oocyte retrieval increases in vivo and in vitro oocyte maturation rate in programmed IVM cycles. | 2008 | Hum. Reprod. | pmid:18556681 |
| Dafopoulos K et al. | Changes in pituitary sensitivity to GnRH in estrogen-treated post-menopausal women: evidence that gonadotrophin surge attenuating factor plays a physiological role. | 2004 | Hum. Reprod. | pmid:15229199 |
| Seenivasan A et al. | Microbial production and biomedical applications of lovastatin. | 2008 | Indian J Pharm Sci | pmid:21369428 |
| Falber A et al. | Routes to new hafnium(IV) tetraaryl porphyrins and crystal structures of unusual phosphate-, sulfate-, and peroxide-bridged dimers. | 2008 | Inorg Chem | pmid:18088113 |
| Nascimento FJ et al. | Topical betamethasone and hyaluronidase in the treatment of phimosis in boys: a double-blind, randomized, placebo-controlled trial. | 2011 May-Jun | Int Braz J Urol | pmid:21756378 |
| Giavaresi G et al. | Natural and synthetic polyesters for musculoskeletal tissue repair: experimental in vitro and in vivo evaluations. | 2004 | Int J Artif Organs | pmid:15521220 |
| McGuinness M and Dowling D | Plant-associated bacterial degradation of toxic organic compounds in soil. | 2009 | Int J Environ Res Public Health | pmid:19742157 |
| Yildiz MF et al. | Effects of raloxifene, hormone therapy, and soy isoflavone on serum high-sensitive C-reactive protein in postmenopausal women. | 2005 | Int J Gynaecol Obstet | pmid:15970291 |
| Zhang J et al. | Synthesis and insecticidal activities of new ester-derivatives of Celangulin-V. | 2011 | Int J Mol Sci | pmid:22272151 |
| Dalla-Betta P and Schulte M | Calculation of the aqueous thermodynamic properties of citric acid cycle intermediates and precursors and the estimation of high temperature and pressure equation of state parameters. | 2009 | Int J Mol Sci | pmid:19582231 |
| Zhang YZ et al. | Biomimetic and bioactive nanofibrous scaffolds from electrospun composite nanofibers. | 2007 | Int J Nanomedicine | pmid:18203429 |
| Redden PR et al. | Acyloxymethyl acidic drug derivatives: in vitro hydrolytic reactivity. | 1999 | Int J Pharm | pmid:10370185 |
| Jacob TJ et al. | Psychophysical evaluation of responses to pleasant and mal-odour stimulation in human subjects; adaptation, dose response and gender differences. | 2003 | Int J Psychophysiol | pmid:12694902 |
| Kuldeep C et al. | Randomized comparison of topical betamethasone valerate foam, intralesional triamcinolone acetonide and tacrolimus ointment in management of localized alopecia areata. | 2011 | Int J Trichology | pmid:21769231 |
| Kiley JW and Shulman LP | Estradiol valerate and dienogest: a new approach to oral contraception. | 2011 | Int J Womens Health | pmid:21892339 |
| Loo CY and Sudesh K | Biosynthesis and native granule characteristics of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) in Delftia acidovorans. | 2007 | Int. J. Biol. Macromol. | pmid:17207850 |
| Cal AJ et al. | Methanotrophic production of polyhydroxybutyrate-co-hydroxyvalerate with high hydroxyvalerate content. | 2016 | Int. J. Biol. Macromol. | pmid:26920242 |
| Mitomo H et al. | Biosynthesis and characterization of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) produced by Burkholderia cepacia D1. | 1999 | Int. J. Biol. Macromol. | pmid:10408637 |
| Mancuso G et al. | Efficacy of betamethasone valerate foam formulation in comparison with betamethasone dipropionate lotion in the treatment of mild-to-moderate alopecia areata: a multicenter, prospective, randomized, controlled, investigator-blinded trial. | 2003 | Int. J. Dermatol. | pmid:12839615 |
| Araki Y et al. | In vitro alterations in fecal short chain fatty acids and organic anions induced by the destruction of intestinal microflora under hypotonic and aerobic conditions. | 2002 | Int. J. Mol. Med. | pmid:12011980 |
| Wallace RJ et al. | Eubacterium pyruvativorans sp. nov., a novel non-saccharolytic anaerobe from the rumen that ferments pyruvate and amino acids, forms caproate and utilizes acetate and propionate. | 2003 | Int. J. Syst. Evol. Microbiol. | pmid:12892112 |
| Etchebehere C et al. | Comamonas nitrativorans sp. nov., a novel denitrifier isolated from a denitrifying reactor treating landfill leachate. | 2001 | Int. J. Syst. Evol. Microbiol. | pmid:11411724 |
| Zhao JS et al. | Shewanella canadensis sp. nov. and Shewanella atlantica sp. nov., manganese dioxide- and hexahydro-1,3,5-trinitro-1,3,5-triazine-reducing, psychrophilic marine bacteria. | 2007 | Int. J. Syst. Evol. Microbiol. | pmid:17766891 |
| Iino T et al. | Oscillibacter valericigenes gen. nov., sp. nov., a valerate-producing anaerobic bacterium isolated from the alimentary canal of a Japanese corbicula clam. | 2007 | Int. J. Syst. Evol. Microbiol. | pmid:17684268 |
| Baena S et al. | Desulfosoma caldarium gen. nov., sp. nov., a thermophilic sulfate-reducing bacterium from a terrestrial hot spring. | 2011 | Int. J. Syst. Evol. Microbiol. | pmid:20418410 |
| Kashefi K et al. | Geoglobus ahangari gen. nov., sp. nov., a novel hyperthermophilic archaeon capable of oxidizing organic acids and growing autotrophically on hydrogen with Fe(III) serving as the sole electron acceptor. | 2002 | Int. J. Syst. Evol. Microbiol. | pmid:12054231 |
| Ganesan A et al. | Cloacibacillus evryensis gen. nov., sp. nov., a novel asaccharolytic, mesophilic, amino-acid-degrading bacterium within the phylum 'Synergistetes', isolated from an anaerobic sludge digester. | 2008 | Int. J. Syst. Evol. Microbiol. | pmid:18768595 |
| Suzuki D et al. | Desulfovibrio butyratiphilus sp. nov., a Gram-negative, butyrate-oxidizing, sulfate-reducing bacterium isolated from an anaerobic municipal sewage sludge digester. | 2010 | Int. J. Syst. Evol. Microbiol. | pmid:19654341 |
| Graue J et al. | Degradation of cyanobacterial biomass in anoxic tidal-flat sediments: a microcosm study of metabolic processes and community changes. | 2012 | ISME J | pmid:21918576 |
| WALKER DF | Alpha-chloro-delta-aryloxyvaleric acids. | 1950 | J Am Pharm Assoc Am Pharm Assoc | pmid:15428379 |
| HIGUCHI T and LACH JL | Investigation of some complexes formed in solution by caffeine. V. Interactions between caffeine and p-aminobenzoic acid, m-hydroxybenzoic acid, picric acid, o-phthalic acid, suberic acid, and valeric acid. | 1954 | J Am Pharm Assoc Am Pharm Assoc | pmid:13201472 |
| Woodworth JR et al. | Quantitative analysis of phencyclidine and metabolites by capillary column gas chromatography. | 1984 Jan-Feb | J Anal Toxicol | pmid:6708471 |
| AbuGhazaleh AA et al. | The effect of replacing corn with glycerol on ruminal bacteria in continuous culture fermenters. | 2011 | J Anim Physiol Anim Nutr (Berl) | pmid:20880288 |
| Hashemi J et al. | Synergistic effect of PEGylation and pentoxifylline addition on immunoprotection of pancreatic islets. | 2017 | J Biomater Sci Polym Ed | pmid:27683968 |
| Chung TC et al. | A sensitive liquid chromatographic method for the analysis of isovaleric and valeric acids in urine as fluorescent derivatives. | 2007 | J Chromatogr A | pmid:17374376 |
| Larreta J et al. | Experimental design to optimise the analysis of organic volatile compounds in cow slurry by headspace solid-phase microextraction-gas chromatography-mass spectrometry. | 2006 | J Chromatogr A | pmid:17049541 |
| de Oliveira CP et al. | Multiple headspace-solid-phase microextraction as a powerful tool for the quantitative determination of volatile radiolysis products in a multilayer food packaging material sterilized with γ-radiation. | 2012 | J Chromatogr A | pmid:22609166 |
| Du XL et al. | Design and synthesis of a novel fluorescent reagent, 6-oxy-(ethylpiperazine)-9-(2'-methoxycarbonyl) fluorescein, for carboxylic acids and its application in food samples using high-performance liquid chromatography. | 2008 | J Chromatogr A | pmid:18067902 |
| Ezquerro O et al. | Development of a headspace solid-phase microextraction-gas chromatography-mass spectrometry method for the identification of odour-causing volatile compounds in packaging materials. | 2002 | J Chromatogr A | pmid:12187994 |
| Carlier J et al. | Quantification of [1-(5-fluoropentyl)-1H-indol-3-yl](naphthalene-1-yl)methanone (AM-2201) and 13 metabolites in human and rat plasma by liquid chromatography-tandem mass spectrometry. | 2016 | J Chromatogr A | pmid:27208987 |