Valeric acid is a lipid of Fatty Acyls (FA) class. Valeric acid is associated with abnormalities such as Papillon-Lefevre Disease, Obesity, Diabetes Mellitus, Non-Insulin-Dependent and Dehydration. The involved functions are known as Process, Odorant, Stimulus, Irritation and Phenomenon. Valeric acid often locates in Receptive field, soluble, Extracellular, Entire gastrointestinal tract and Body tissue. The associated genes with Valeric acid are Orthologous Gene, Fusion Gene and AS gene. The related lipids are Valerates, butyrate, Propionate, Caproates and Palmitates.
To understand associated biological information of Valeric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Valeric acid is suspected in Obesity, Papillon-Lefevre Disease, Diabetes Mellitus, Non-Insulin-Dependent, Dehydration and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Valeric acid
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Stomach Ulcer | D013276 | 75 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Peripheral Nervous System Diseases | D010523 | 33 associated lipids |
| Arthritis, Infectious | D001170 | 8 associated lipids |
| Anemia, Sickle Cell | D000755 | 34 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Reye Syndrome | D012202 | 14 associated lipids |
| Uterine Hemorrhage | D014592 | 6 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| De Clerck F et al. | R 68 070: thromboxane A2 synthetase inhibition and thromboxane A2/prostaglandin endoperoxide receptor blockade combined in one molecule--II. Pharmacological effects in vivo and ex vivo. | 1989 | Thromb. Haemost. | pmid:2526385 |
| Burke TG et al. | A fluorescence study examining how 14-valerate side chain substitution modulates anthracycline binding to small unilamellar phospholipid vesicles. | 1989 | Biochim. Biophys. Acta | pmid:2742882 |
| Rachev E et al. | [Estrogen-gestagen prevention and treatment of uterine hemorrhages in the premenopause]. | 1989 | Akush Ginekol (Sofiia) | pmid:2802089 |
| Chen HM and Lifschitz CH | Preparation of fecal samples for assay of volatile fatty acids by gas-liquid chromatography and high-performance liquid chromatography. | 1989 | Clin. Chem. | pmid:2910583 |
| Kone P et al. | Effect of the combination of monensin and isoacids on rumen fermentation in vitro. | 1989 | J. Dairy Sci. | pmid:2600235 |
| Osterloh J et al. | Biochemical relationships between Reye's and Reye's-like metabolic and toxicological syndromes. | 1989 Jul-Aug | Med Toxicol Adverse Drug Exp | pmid:2671597 |
| Miller DM | Determination of the thickness of the unstirred layers in the moving-drop method for measuring aqueous-nonaqueous interfacial transport rates. | 1991 | Biochim. Biophys. Acta | pmid:2043653 |
| Yasin M and Tighe BJ | Polymers for biodegradable medical devices. VIII. Hydroxybutyrate-hydroxyvalerate copolymers: physical and degradative properties of blends with polycaprolactone. | 1992 | Biomaterials | pmid:1543811 |
| Page WJ et al. | Formation of poly(hydroxybutyrate-co-hydroxyvalerate) by Azotobacter vinelandii UWD. | 1992 | Appl. Environ. Microbiol. | pmid:1444399 |
| Lingaas F and Tveit B | Etiology of acetonemia in Norwegian cattle. 2. Effect of butyric acid, valeric acid, and putrescine. | 1992 | J. Dairy Sci. | pmid:1452847 |
| Kubota K and Maibach HI | In vitro percutaneous permeation of betamethasone and betamethasone 17-valerate. | 1993 | J Pharm Sci | pmid:8254489 |
| PospÃsil S et al. | Activity of the AIB factor observed in prokaryotic and eukaryotic microorganisms. | 1993 | Folia Microbiol. (Praha) | pmid:8375780 |
| Jackson DE and Srienc F | Novel methods to synthesize polyhydroxyalkanoates. | 1994 | Ann. N. Y. Acad. Sci. | pmid:7832504 |
| Ni X and Cole RD | Effects of various salts and pH on the stability of the nucleosome in chromatin fragments. | 1994 | Biochemistry | pmid:8049228 |
| Xu RX et al. | NMR determination of the structures of peroxycobalt(III) bleomycin and cobalt(III) bleomycin, products of the aerobic oxidation of cobalt(II) bleomycin by dioxygen. | 1994 | Biochemistry | pmid:7508261 |
| Liakopoulou E et al. | Stimulation of fetal hemoglobin production by short chain fatty acids. | 1995 | Blood | pmid:7579419 |
| Tune BM and Hsu CY | Effects of nephrotoxic beta-lactam antibiotics on the mitochondrial metabolism of monocarboxylic substrates. | 1995 | J. Pharmacol. Exp. Ther. | pmid:7616399 |
| Bryant BP and Moore PA | Factors affecting the sensitivity of the lingual trigeminal nerve to acids. | 1995 | Am. J. Physiol. | pmid:7840339 |
| Metherate R and Ashe JH | GABAergic suppression prevents the appearance and subsequent fatigue of an NMDA receptor-mediated potential in neocortex. | 1995 | Brain Res. | pmid:8616625 |
| Brauchli P et al. | Electrocortical and autonomic alteration by administration of a pleasant and an unpleasant odor. | 1995 | Chem. Senses | pmid:8564425 |
| Sagar PM et al. | Acute pouchitis and deficiencies of fuel. | 1995 | Dis. Colon Rectum | pmid:7736879 |
| Brady GP and Sharp KA | Decomposition of interaction free energies in proteins and other complex systems. | 1995 | J. Mol. Biol. | pmid:7473761 |
| Siavoshian S et al. | Comparison of the effect of different short chain fatty acids on the growth and differentiation of human colonic carcinoma cell lines in vitro. | 1997 | Cell Biol. Int. | pmid:9243803 |
| Bui CT et al. | Comparative study of reductive amination reaction on 5-(4-formyl-3,5-dimethoxyphenoxy)valeric acid and its monomethoxy analog using the Multipin approach. | 1998 | Mol. Divers. | pmid:10729900 |
| de Bernard M et al. | TPA and butyrate increase cell sensitivity to the vacuolating toxin of Helicobacter pylori. | 1998 | FEBS Lett. | pmid:9781682 |
| Sakata T et al. | Probiotic preparations dose-dependently increase net production rates of organic acids and decrease that of ammonia by pig cecal bacteria in batch culture. | 1999 | Dig. Dis. Sci. | pmid:10489936 |
| Lotti M and Moretto A | Promotion of organophosphate induced delayed polyneuropathy by certain esterase inhibitors. | 1999 | Chem. Biol. Interact. | pmid:10421491 |
| Laerke HN and Jensen BB | D-tagatose has low small intestinal digestibility but high large intestinal fermentability in pigs. | 1999 | J. Nutr. | pmid:10222392 |
| Gysler A et al. | Skin penetration and metabolism of topical glucocorticoids in reconstructed epidermis and in excised human skin. | 1999 | Pharm. Res. | pmid:10496654 |
| Varela A et al. | Effects of pentanoate, 4-pentenoate, 3-hydroxybutyrate and insulin on the tissue-levels of long-chain acyl CoA and acylcarnitine in the oxygenated and hypoxic rat atria. | 1999 | Arch. Physiol. Biochem. | pmid:10455555 |
| Erskine PT et al. | The Schiff base complex of yeast 5-aminolaevulinic acid dehydratase with laevulinic acid. | 1999 | Protein Sci. | pmid:10386874 |
| Redden PR et al. | Acyloxymethyl acidic drug derivatives: in vitro hydrolytic reactivity. | 1999 | Int J Pharm | pmid:10370185 |
| Mitomo H et al. | Biosynthesis and characterization of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) produced by Burkholderia cepacia D1. | 1999 | Int. J. Biol. Macromol. | pmid:10408637 |
| Diwan AD et al. | Nitric oxide modulates fracture healing. | 2000 | J. Bone Miner. Res. | pmid:10703937 |
| Paassilta M et al. | Insulin-like growth factor binding protein-1 (IGFBP-1) and IGF-I during oral and transdermal estrogen replacement therapy: relation to lipoprotein(a) levels. | 2000 | Atherosclerosis | pmid:10704627 |
| Gadda G and Fitzpatrick PF | Mechanism of nitroalkane oxidase: 2. pH and kinetic isotope effects. | 2000 | Biochemistry | pmid:10684621 |
| Wächtershäuser A et al. | PPAR-gamma is selectively upregulated in Caco-2 cells by butyrate. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10833422 |
| Palmeira CM et al. | Induction of the mitochondrial permeability transition in vitro by short-chain carboxylic acids. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10833431 |
| Gadda G et al. | Identification of an essential tyrosine residue in nitroalkane oxidase by modification with tetranitromethane. | 2000 | Biochemistry | pmid:10653664 |
| Range SP et al. | Selectivity of cyclo-oxygenase inhibitors in human pulmonary epithelial and smooth muscle cells. | 2000 | Eur. Respir. J. | pmid:10780769 |
| Böttcher MF et al. | Microflora-associated characteristics in faeces from allergic and nonallergic infants. | 2000 | Clin. Exp. Allergy | pmid:11069568 |
| Dessirier JM et al. | Sensitization, desensitization and stimulus-induced recovery of trigeminal neuronal responses to oral capsaicin and nicotine. | 2000 | J. Neurophysiol. | pmid:11024077 |
| Johnson BA and Leon M | Modular representations of odorants in the glomerular layer of the rat olfactory bulb and the effects of stimulus concentration. | 2000 | J. Comp. Neurol. | pmid:10861522 |
| Propper DJ et al. | Phase II study of the oxygen saturation curve left shifting agent BW12C in combination with the hypoxia activated drug mitomycin C in advanced colorectal cancer. | 2000 | Br. J. Cancer | pmid:10839290 |
| Yang JH et al. | Hormone replacement therapy reverses the decrease in natural killer cytotoxicity but does not reverse the decreases in the T-cell subpopulation or interferon-gamma production in postmenopausal women. | 2000 | Fertil. Steril. | pmid:10927042 |
| Gadda G et al. | Identification of a cysteine residue in the active site of nitroalkane oxidase by modification with N-ethylmaleimide. | 2000 | J. Biol. Chem. | pmid:10913134 |
| Trotsenko IuA and Belova LL | [Organization and regulation of polyhydroxybutyrate/valerate biosynthesis in bacteria]. | 2000 Nov-Dec | Mikrobiologiia | pmid:11195572 |
| Liu C et al. | Pentanoic acid, a novel protein synthesis stimulant for Chinese Hamster Ovary (CHO) cells. | 2001 | J. Biosci. Bioeng. | pmid:16232949 |
| Cho K et al. | Utilization of swine wastewater as a feedstock for the production of polyhydroxyalkanoates by Azotobacter vinelandii UWD. | 2001 | J. Biosci. Bioeng. | pmid:16232963 |
| Kristensen NB | Rumen microbial sequestration of [2-(13)C]acetate in cattle. | 2001 | J. Anim. Sci. | pmid:11583438 |